Peer-Reviewed Articles


J. A. Ruszkiewicz, G. Teixeira de Macedo, A. Miranda-Vizuete, A. B. Bowman, J. Bornhorst, T. Schwerdtle, F. A. Antunes Soares, M. Aschner,
Sex-Specific Response of Caenorhabditis elegans to Methylmercury Toxicity.
Neurotox Res,
2019 Jan, 35, 1, 208-216, doi: 10.1007/s12640-018-9949-4


T. V. Peres, K. J. Horning, J. Bornhorst, T. Schwerdtle, A. B. Bowman, M. Aschner,
Small Molecule Modifiers of In Vitro Manganese Transport Alter Toxicity In Vivo.
Biol Trace Elem Res, 2018 Sep 28, doi: 10.1007/s12011-018-1531-7

J. A. Ruszkiewicz, G. Teixeira de Macedo, A. Miranda-Vizuete, J. B. Teixeira da Rocha, A. B. Bowman, J. Bornhorst, T. Schwerdtle, M. Aschner,
The cytoplasmic thioredoxin system in Caenorhabditis elegans affords protection from methylmercury in an age-specific manner.
, 2018 Sep, 68, 189-202, doi: 10.1016/j.neuro.2018.08.007

P. Chen, J. Bornhorst, M. Diana Neely, D. S. Avila,
Mechanisms and Disease Pathogenesis Underlying Metal-Induced Oxidative Stress.
Oxid Med Cell Longev,
2018 Sep 18, 2018,  doi: 10.1155/2018/7612172

T. V. Peres, L. P. Arantes, M. R. Miah, J. Bornhorst, T. Schwerdtle, A. B. Bowman, R. B. Leal, M. Aschner,
Role of Caenorhabditis elegans AKT-1/2 and SGK-1 in Manganese Toxicity,
Neurotox Res, 2018, Epub ahead of print, doi: 10.1007/s12640-018-9915-1

B. Ferrer, T. V. Peres, A. A. Dos Santos, J. Bornhorst, P. Morcillo, C. L. Gonçalves, M. Aschner, Methylmercury Affects the Expression of Hypothalamic Neuropeptides That Control Body Weight in C57BL/6J Mice,
Toxicol Sci
, 2018, 163, 2, 557-568, doi: 10.1093/toxsci/kfy052

I. Rohn, T. A. Marschall, N. Kroepfl, K. B. Jensen, M. Aschner, S. Tuck, D. Kuehnelt, T. Schwerdtle, J. Bornhorst,
Selenium species-dependent toxicity, bioavailability and metabolic transformations in Caenorhabditis elegans,
, 2018, 10, 6, 818-827, doi: 10.1039/c8mt00066b

P. Gubert , B. Puntel , T. Lehmen, J. P. Fessel, P. Cheng, J. Bornhorst, L. S. Trindade, D. S. Avila , M. Aschner, F. A. A. Soares,
Metabolic effects of manganese in the nematode Caenorhabditis elegans through DAergic pathway and transcription factors activation,
, 2018, 67, 65-72, doi: 10.1016/j.neuro.2018.04.008

P. Chen, J. Bornhorst, M. Aschner,
Manganese metabolism in humans,
Frontiers in bioscience
2018, 23, 1655-1679, PMID: 29293455

K. Nowotny, J. P. Castro, M. Hugo, S. Braune, D. Weber, M. Pignitter, V. Somoza, J. Bornhorst, T. Schwerdtle, T. Grune,
Oxidants produced by methylglyoxal-modified collagen trigger ER stress and apoptosis in skin fibroblasts,
Free radical biology & medicine
2018, 120, 102-113, doi: 10.1016/j.freeradbiomed.2018.03.022

S. M. Müller, F. Ebert, J. Bornhorst, H. J. Galla, K.A. Francesconi, T. Schwerdtle,
Arsenic-containing hydrocarbons disrupt a model in vitro blood-cerebrospinal fluid barrier,
Journal of trace elements in medicine and biology
2018, doi: 10.1016/j.jtemb.2018.01.020

S. M. Müller, F. Ebert, G. Raber, S. Meyer, J. Bornhorst, S. Hüwel, H.J. Galla, K.A. Francesconi, T. Schwerdtle,
Effects of arsenolipids on in vitro blood-brain barrier model,
Archives of toxicology 2018, 92, 823-832, doi: 10.1007/s00204-017-2085-8


J. Bornhorst, A.P. Kipp, H. Haase, S. Meyer, T. Schwerdtle,
The crux of inept biomarkers for risks and benefits of trace elements,
Trends in Analytical Chemistry, 2017, Accepted Manuscript in Press,

J. Strehlau, T. Weber, C. Lürenbaum, J. Bornhorst, H. J. Galla, T. Schwerdtle, M. Winter, S. Nowak, Towards quantification of toxicity of lithium ion battery electrolytes - development and validation of a liquid-liquid extraction GC-MS method for the determination of organic carbonates in cell culture materials, Anal Bioanal Chem. 2017, Aug 3. doi: 10.1007/s00216-017-0549-6

B. Witt, J. Bornhorst, H. Mitze, F. Ebert, S. Meyer, K. A. Francesconi, T. Schwerdtle, Arsenolipids exert less toxicity in a human neuron astrocyte co-culture as compared to the respective monocultures, Metallomics 2017, 9, 5, 442-446, doi: 10.1039/c7mt00036g


T.A. Marschall, N. Kroepf, K.B. Jensen, J. Bornhorst, B. Meermann, D. Kuehnelt, T. Schwerdtle,
Tracing cytotoxic effects of small organic Se species in human liver cells back to total cellular Se and Se metabolites,
Metallomics, 2017, doi: 10.1039/c6mt00300a [Epub ahead of print]

M. Aschner, C. Palinski, M. Sperling, U. Karst, T. Schwerdtle, J. Bornhorst,
Imaging metals in Caenorhabditis elegans,
Metallomics, 2017, doi: 10.1039/c6mt00265j [Epub ahead of print]


H. Lohren, J. Bornhorst, R. Fitkau, G. Pohl, T. Schwerdtle,
Effects on and transfer across the blood-brain barrier in vitro-Comparison of organic and inorganic mercury species,
BMC Pharmacol Toxicol, 2016, 17(1):63, doi: 10.1186/s40360-016-0106-5

A. Henze, T. Homann, I. Rohn, M. Aschner, C. D. Link, B. Kleuser, F. Schweigert, T. Schwerdtle, J. Bornhorst,
Caenorhabditis elegans
as a model system to study post-translational modifications of human transthyretin,
Scientific Reports, 2016, 6:37346, doi: 10.1038/srep37346

D. S. Avila, A. Benedetto, C. Au, J. Bornhorst, M. Aschner,
Involvement of heat shock proteins on Mn-induced toxicity in Caenorhabditis elegans,
BMC Pharmacol Toxicol, 2016 17(1):54, doi: 10.1186/s40360-016-0097-2

P. Gubert, B. Puntel, T. Lehmen, J. Bornhorst, D. S. Avila, M. Aschner, F. A. Soares,
Reversible reprotoxic effects of manganese through DAF-16 transcription factor activation and vitellogenin downregulation in Caenorhabditis elegans,
Life Sci
, 2016, 151:218-23, doi: 10.1016/j.lfs.2016.03.016

T. A. Marschall, J. Bornhorst, D. Kühnelt, T. Schwerdtle,
Differing cytotoxicity and bioavailability of selenite, methylselenocysteine, selenomethionine, selenosugar 1 and trimethylselenonium ion and their underlying metabolic transformations in human cells,
Molecular Nutrition and Food Research, 2016, 60(12), 2622-2632, doi:10.1002/mnfr.201600422


T.V. Peres, H. Eyng, S.C. Lopes, D. Colle, F.M. Gonçalves, D.K. Venske, M.W. Lopes, J. Ben, J. Bornhorst, T. Schwerdtle, M. Aschner, M. Farina, R.D. Prediger, R. B. Leal,
Developmental exposure to manganese induces lasting motor and cognitive impairment in rats,
, 2015, 50:28-37, doi: 10.1016/j.neuro.2015.07.005

F. Schumacher, S. Chakraborty, B. Kleuser, E. Gulbins, T. Schwerdtle, M. Aschner, J. Bornhorst,
Highly sensitive isotope-dilution liquid-chromatography–electrospray ionization tandem-mass spectrometry approach to study the drug-mediated modulation of dopamine and serotonin levels in Caenorhabditis elegans,
Talanta, 2015, 144, 71-7, doi: 10.1016/j.talanta.2015.05.057

B. Crone, M. Aschner, T. Schwerdtle, U. Karst, J. Bornhorst,
Elemental bioimaging of Cisplatin in Caenorhabditis elegans by LA-ICP-MS,
Metallomics, 2015, 7(7): 1189-9, doi: 10.1039/c5mt00096c

S. Chakraborty, P. Chen, J. Bornhorst, T. Schwerdtle, F. Schumacher, B. Kleuser, A. B. Bowman, M. Aschner,
Loss of pdr-1/parkin influences Mn homeostasis through altered ferroportin expression in C. elegans,
Metallomics, 2015, 7(5): 847-56, doi: 10.1039/c5mt00052a

H. Lohren, J. Bornhorst, H.-J. Galla, T. Schwerdtle,
The blood-cerebrospinal fluid barrier - first evidence for an active transport of organic mercury compounds out of the brain,
Metallomics, 2015, 7(10):1420-30, doi: 10.1039/c5mt00171d

K. K. Kumar, C. R. Goodwin, M. A. Uhouse, J. Bornhorst, T. Schwerdtle, M. Aschner, J. A. McLeanb, A. B. Bowman,
Untargeted metabolic profiling identifies interactions between Huntington’s disease and neuronal manganese status,
Metallomics, 2015, 7(2):363-70, doi: 10.1039/C4MT00223G


P. Chen, M. R. DeWitt, J. Bornhorst, F. A. Soares, S. Mukhopadhyay, A. B. Bowman, M. Aschner,
Age- and manganese-dependent modulation of dopaminergic phenotypes in a C. elegans DJ-1 genetic model of Parkinson's disease,
Metallomics, 2014, doi: 10.1039/c4mt00292j

S. Cramer, S. Tacke, J. Bornhorst, A. K Sachan, J. Klingauf, T. Schwerdtle, H.-J. Galla,
The Influence of Silver Nanoparticles on the Blood-Brain and the Blood-Cerebrospinal Fluid Barrier in vitro,
J Nanomed Nanotechnol, 2014, 5:225, doi: 10.4172/2157-7439.1000225

I. Pieper, C. A. Wehe, J. Bornhorst, F. Ebert, L. Leffers, M. Holtkamp, P. Höseler, T. Weber, A. Mangerich, A. Bürkle, U. Karst, T. Schwerdtle,
Mechanisms of Hg species induced toxicity in cultured human astrocytes: genotoxicity and DNA-damage response,
Metallomics, 2014 Mar,6(3):662-71, doi: 10.1039/c3mt00337j

S. Große Brinkhaus, J. Bornhorst, S. Chakraborty, C.A. Wehe, R. Niehaus, O. Reifschneider, M. Aschner, U. Karst,
Elemental bioimaging of manganese uptake in C. elegans,
Metallomics, 2014, 6(3):617-21. doi: 10.1039/c3mt00334e

J. Bornhorst§ , S. Chakraborty§, S. Meyer, H. Lohren, S. Große Brinkhaus, A.L. Knight, K.A. Caldwell, G.A. Caldwell, U. Karst, T. Schwerdtle, A. Bowman, M. Aschner,
§ Both authors contributed equally to this study
The effects of pdr1, djr1.1 and pink1 loss in manganese-induced toxicity and the role of α-synuclein in C. elegans,
, 2014 Jan 22., 6 (3), 476-490, doi: 10.1039/c3mt00325f


S. Chakraborty, J. Bornhorst, T. T. Nguyen, M. Aschner,
Oxidative Stress Mechanisms Underlying Parkinson’s Disease-Associated Neurodegeneration in C. elegans,
Int. J. Mol. Sci
., 2013 Nov 21;14(11):23103-28. doi: 10.3390/ijms141123103

P. Chen, E. J. Martinez-Finley, J. Bornhorst, S. Chakraborty, M. Aschner,
Metal-induced neurodegeneration in C. elegans,
Front. Aging Neurosci
., 2013 May 20;5:18. doi: 10.3389/fnagi.2013.00018

J. Bornhorst, S. Meyer, T. Weber, C. Böker, T. Marschall, A. Mangerich, S. Beneke, A. Bürkle, T. Schwerdtle,
Molecular mechanisms of Mn induced neurotoxicity: RONS generation, genotoxicity, and DNA-damage response,
Mol Nutr Food Res., 2013 Jul;57(7):1255-69. doi: 10.1002/mnfr.201200758


J. Bornhorst, C. A. Wehe, S. Hüwel, H.-J. Galla, U. Karst, T. Schwerdtle,
Impact of manganese on and transfer across the blood-brain and blood-CSF barrier in vitro,
The Journal of Biological Chemistry, 2012, 287(21), 17140-51, doi: 10.1074/jbc.M112.344093

J. Bornhorst*, F. Ebert*, H. Lohren, H.-U. Humpf, U. Karst, T. Schwerdtle,
*Both authors contributed equally to this study
Effects of manganese and arsenic species on the level of energy related nucleotides in human cells,
Metallomics, 2012, 4(3), 297-306, doi: 10.1039/c2mt00164k


K. Isfort, F. Ebert, J. Bornhorst, S. Sargin, R. Kardakaris, M. Pasparakis, M. Bähler, T. Schwerdtle, A. Schwab, P. Hanley,
Real-time imaging reveals that P2Y2 and P2Y12 receptor agonists are not chemoattractants and macrophage chemotaxis to complement C5a is Phosphatidylinositol 3-Kinase (PI3K)- and p38 mitogen-activated protein kinase (MAPK)-independent,
The Journal of Biological Chemistry, 2011, 286(52), 44776-87, doi: 10.1074/jbc.M111.289793

C.A. Wehe, J. Bornhorst, M. Holtkamp, M. Sperling, H.-J. Galla, T. Schwerdtle, U. Karst,
Fast and low sample consuming quantification of manganese in cell nutrient solutions by flow injection ICP-QMS,
, 2011, 3(12), 1291-6, doi: 10.1039/c1mt00170a


J. Bornhorst, F. Ebert, A. Hartwig, B Michalke, T. Schwerdtle,
Manganese and poly(ADP-ribosyl)ation in human cells: a possible mechanism behind manganese-induced toxicity?
Journal of Environmental Monitoring, 2010, 12(11), 2062-9, doi: 10.1039/c0em00252f

Book chapters

S. Meyer, T. Weber, R. Haferkorn-Starke, T. Schwerdtle, J. Bornhorst,
Organic metal species as risk factor for neurological diseases (Chapter 5),
in Environmental Determinants of Human Health, J. M. Pacyna, E. G. Pacyna (Editors), 2016, ISBN: 978-3-319-43142-0, doi: 10.1007/978-3-319-43142-0

K. Neth, J. Bornhorst, B. Michalke,
Neurodegeneration with focus on manganese and iron speciation,
Metallomics: Analytical Techniques and Speciation Methods, 2016, Bernhard Michalke (Editor), Wiley-VCH Verlag Weinheim, ISBN: 978-3-527-33969-3

M. Leigh Ackland, Ellen K. Silbergeld, Julia Bornhorst, Georgios Dedoussis, Rodney R. Dietert, Jerome O. Nriagu, Jozef M. Pacyna, John M. Pettifor,
Metals in the Environment as Risk Factors for Infectious Diseases
in “ESF 16: Heavy Metals and Infectious Diseases”, Gruppe 3, Ernst Strüngmann Forum, 2015, Jerome O. Nriagu and Eric P. Skaar (Editors), ISBN 978-0-262-02919-3

J. Bornhorst, T. Schwerdtl,
DNA damage induced by manganese in “manganese in health and disease”,
RSC Publishing, 2015, Michael Aschner and Lucio G. Costa (Editors), ISBN 978-1-84973-943-6

J. Bornhorst, W. Nie, T. Schwerdtle,
Cytotoxicity of manganese in different cultured mammalian cells,
Proceedings of the 25th annual GMS meeting, 2010, C. Mair, W. Windisch, K. Schedle (Editors), ISBN 978-3-8316-4090-4, 68-74

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