Exploring cardiac phase response curve in health prognoses
Early Stage Researcher: Çağdaş Topçu
Principle Investigators: Maximilian Moser (Graz, MUG – major institution), Arkady Pikovsky and Michael Rosenblum (Potsdam, UP – partner institution)
Cardiac phase response curves are a novel tool to investigate the mutual coordination between heartbeat and respiration. They are obtained under free-running conditions from high precision recordings of respiratory flow and cardiac cycles. In the project such data will be obtained experimentally using equipment developed originally for space medical experiments.
The experimental data recorded in different conditions will be used to determine the cardiac phase response curve characterizing the response of the cardiac cycle to respiratory influence in healthy subjects as well as for those with light to moderate health problems without a clear diagnosis. Methods for the analysis of different frequency ranges of heart rate variability and respiratory variability will be further developed and applied.
Characterisation of early sub-health patterns by the behavior of biological oscillators in the cardio-respiratory interaction will be performed and the quality of recreation of the subjects will be evaluated for different states, including sleep. The possibility to detect common diseases earlier and with parameters not yet in use will be checked. A method for cleansing the heart rate variability present in the heart-beat pattern from respiratory-related component in the cardio-dynamics will be developed and tested.
- Kralemann, B; Frühwirth, M; Pikovsky, A; Rosenblum, M; Kenner, T; Schaefer, J; Moser, M In vivo cardiac phase response curve elucidates human respiratory heart rate variability. Nat Commun. 2013; 4(10):2418-2418 (for preprint see http://www.stat.physik.uni-potsdam.de/~mros/pdf/NatCommPRC.pdf)
- Cysarz, D; Zerm, R; Bettermann, H; Frühwirth, M; Moser, M; Kröz, M , Comparison of respiratory rates derived from heart rate variability, ECG amplitude, and nasal/oral airflow. Ann Biomed Eng. 2008; 36(12): 2085-2094.
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- Moser, M; Penter, R; Fruehwirth, M; Kenner, T . Why life oscillates–biological rhythms and health. Conf Proc IEEE Eng Med Biol Soc. 2006; 1: 424-428.
- Cysarz, D; von Bonin, D; Lackner, H; Heusser, P; Moser, M; Bettermann, H. Oscillations of heart rate and respiration synchronize during poetry recitation. AMER J PHYSIOL-HEART CIRC PHY. 2004; 287(2): H579-H587.
- Bettermann, H; von Bonin, D; Frühwirth, M; Cysarz, D; Moser, M. Effects of speech therapy with poetry on heart rate rhythmicity and cardiorespiratory coordination. Int J Cardiol. 2002; 84(1):77-88
- Strauss-Blasche, G; Moser, M; Voica, M; McLeod, DR; Klammer, N; Marktl, W. Relative timing of inspiration and expiration affects respiratory sinus arrhythmia. Clin Exp Pharmacol Physiol. 2000; 27(8):601-606
- Gallasch, E; Moser, M; Kozlovskaya, IB; Kenner, T; Noordergraaf, A. Effects of an eight-day space flight on microvibration and physiological tremor. AMER J PHYSIOL, REGUL INTEGR C. 1997; 273(1 Pt 2): R86-R92.
- Moser, M; Lehofer, M; Hildebrandt, G; Voica, M; Egner, S; Kenner, T. Phase and Frequency Coordination of Cardiac-Function and Respiratory-Function. BIOL RHYTHM RES 1995 26: 100-111.