Publikationen

2020

  • Cencetti F, Bruno G, Bernacchioni C, Japtok L, Puliti E, Donati C, Bruni P. Sphingosine 1-phosphate lyase blockade elicits myogenic differentiation of murine myoblasts acting via Spns2/S1P(2) receptor axis. Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Jun 19;1865(9):158759. doi: 10.1016/j.bbalip.2020.158759.
  • Solger F, Kunz TC, Fink J, Paprotka K, Pfister P, Hagen F, Schumacher F, Kleuser B, Seibel J, Rudel T. A Role of Sphingosine in the Intracellular Survival of Neisseria gonorrhoeae. Front Cell Infect Microbiol. 2020 May 12;10:215. doi: 10.3389/fcimb.2020.00215.
  • Zoicas I, Schumacher F, Kleuser B, Reichel M, Gulbins E, Fejtova A, Kornhuber J, Rhein C. The Forebrain-Specific Overexpression of Acid Sphingomyelinase Induces Depressive-Like Symptoms in Mice. Cells. 2020 May 18;9(5). pii: E1244. doi: 10.3390/cells9051244.
  • Schwerbel K, Kamitz A, Krahmer N, Hallahan N, Jähnert M, Gottmann P, Lebek S, Schallschmidt T, Arends D, Schumacher F, Kleuser B, Haltenhof T, Heyd F, Gancheva S, Broman KW, Roden M, Joost HG, Chadt A, Al-Hasani H, Vogel H, Jonas W, Schürmann A. Immunity-related GTPase induces lipophagy to prevent excess hepatic lipid accumulation. J Hepatol. 2020 May 3. pii: S0168-8278(20)30275-0. doi: 10.1016/j.jhep.2020.04.031. [Epub ahead of print]
  • Halilbasic E, Fuerst E, Heiden D, Japtok L, Diesner SC, Trauner M, Kulu A, Jaksch P, Hoetzenecker K, Kleuser B, Kazemi-Shirazi L, Untersmayr E. Plasma Levels of the Bioactive Sphingolipid Metabolite S1P in Adult Cystic Fibrosis Patients: Potential Target for Immunonutrition? Nutrients. 2020 Mar 14;12(3). pii: E765. doi: 10.3390/nu12030765.
  • Ebenezer DL, Fu P, Ramchandran R, Ha AW, Putherickal V, Sudhadevi T, Harijith A, Schumacher F, Kleuser B, Natarajan V. S1P and Plasmalogen Derived Fatty Aldehydes in Cellular Signaling and Functions. Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Mar 11:158681. doi: 10.1016/j.bbalip.2020.158681. [Epub ahead of print]
  • Lang J, Bohn P, Bhat H, Jastrow H, Walkenfort B, Cansiz F, Fink J, Bauer M, Olszewski D, Ramos-Nascimento A, Duhan V, Friedrich SK, Becker KA, Krawczyk A, Edwards MJ, Burchert A, Huber M, Friebus-Kardash J, Göthert JR, Hardt C, Probst HC, Schumacher F, Köhrer K, Kleuser B, Babiychuk EB, Sodeik B, Seibel J, Greber UF, Lang PA, Gulbins E, Lang KS. Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease. Nat Commun. 2020 Mar 12;11(1):1338. doi: 10.1038/s41467-020-15072-8.
  • Naser E, Kadow S, Schumacher F, Mohamed ZH, Kappe C, Hessler G, Pollmeier B, Kleuser B, Arenz C, Becker KA, Gulbins E, Carpinteiro A. Characterization of the small molecule ARC39, a direct and specific inhibitor of acid sphingomyelinase in vitro. J Lipid Res. 2020 Mar 10. pii: jlr.RA120000682. doi: 10.1194/jlr.RA120000682. [Epub ahead of print]
  • Dwi Putra SE, Reichetzeder C, Hasan AA, Slowinski T, Chu C, Krämer BK, Kleuser B, Hocher B. Being Born Large for Gestational Age is Associated with Increased Global Placental DNA Methylation. Sci Rep. 2020 Jan 22;10(1):927. doi: 10.1038/s41598-020-57725-0.
  • Wetzel A, Scholtka B, Gerecke C, Kleuser B. Epigenetic histone modulation contributes to improvements in inflammatory bowel disease via EBI3. Cell Mol Life Sci. 2020 Jan 18. doi: 10.1007/s00018-020-03451-9. [Epub ahead of print]
  • Yong-Ping L, Reichetzeder C, Prehn C, Yin LH, Chu C, Elitok S, Krämer BK, Adamski J, Hocher B. Impact of Maternal Smoking Associated Lyso-phosphatidylcholine 20:3 on Offspring Brain Development. J Steroid Biochem Mol Biol. 2020 Jan 15:105591. doi: 10.1016/j.jsbmb.2020.105591. [Epub ahead of print]

2019

  • Carstens H, Schumacher F, Keitsch S, Kramer M, Kühn C, Sehl C, Soddemann M, Wilker B, Herrmann D, Swaidan A, Kleuser B, Verhaegh R, Hilken G, Edwards MJ, Dubicanac M, Carpinteiro A, Wissmann A, Becker KA, Kamler M, Gulbins E. Clinical Development of Sphingosine as Anti-Bacterial Drug: Inhalation of Sphingosine in Mini Pigs has no Adverse Side Effects. Cell Physiol Biochem. 2019;53(6):1015-1028. doi: 10.33594/000000194.
  • Beckmann N, Becker KA, Kadow S, Schumacher F, Kramer M, Kühn C, Schulz-Schaeffer WJ, Edwards MJ, Kleuser B, Gulbins E, Carpinteiro A. Acid Sphingomyelinase Deficiency Ameliorates Farber Disease. Int J Mol Sci. 2019 Dec 11;20(24). pii: E6253. doi: 10.3390/ijms20246253.
  • Börtlein C, Schumacher F, Kleuser B, Dölken L, Avota E. Role of Neutral Sphingomyelinase-2 (NSM 2) in the Control of T Cell Plasma Membrane Lipid Composition and Cholesterol Homeostasis. Front Cell Dev Biol. 2019 Oct 15;7:226. doi: 10.3389/fcell.2019.00226. eCollection 2019.
  • Grafen A, Schumacher F, Chithelen J, Kleuser B, Beyersdorf N, Schneider-Schaulies J. Use of Acid Ceramidase and Sphingosine Kinase Inhibitors as Antiviral Compounds Against Measles Virus Infection of Lymphocytes in vitro. Front Cell Dev Biol. 2019 Oct 1;7:218. doi: 10.3389/fcell.2019.00218. eCollection 2019.
  • Wigger D, Gulbins E, Kleuser B, Schumacher F. Monitoring the Sphingolipid de novo Synthesis by Stable-Isotope Labeling and Liquid Chromatography-Mass Spectrometry. Front Cell Dev Biol. 2019 Oct 1;7:210. doi: 10.3389/fcell.2019.00210. eCollection 2019.
  • Gerecke C, Schumacher F, Berndzen A, Homann T, Kleuser B. Vitamin C in combination with inhibition of mutant IDH1 synergistically activates TET enzymes and epigenetically modulates gene silencing in colon cancer cells. Epigenetics. 2019 Sep 17:1-16. doi: 10.1080/15592294.2019.1666652. [Epub ahead of print]
  • Rancan F, Volkmann H, Giulbudagian M, Schumacher F, Stanko JI, Kleuser B, Blume-Peytavi U, Calderón M, Vogt A. Dermal Delivery of the High-Molecular-Weight Drug Tacrolimus by Means of Polyglycerol-Based Nanogels. Pharmaceutics. 2019 Aug 5;11(8). pii: E394. doi: 10.3390/pharmaceutics11080394.
  • Zeitler S, Ye L, Andreyeva A, Schumacher F, Monti J, Nürnberg B, Nowak G, Kleuser B, Reichel M, Fejtová A, Kornhuber J, Rhein C, Friedland K. Acid Sphingomyelinase - a Regulator of TRPC6 Channel Activity. J Neurochem. 2019 Jul 16. doi: 10.1111/jnc.14823. [Epub ahead of print]
  • Morris MC, Kassam F, Bercz A, Beckmann N, Schumacher F, Gulbins E, Makley AT, Goodman MD. The Role of Chemoprophylactic Agents in Modulating Platelet Aggregability After Traumatic Brain Injury. J Surg Res. 2019 Jul 3;244:1-8. doi: 10.1016/j.jss.2019.06.022. [Epub ahead of print]
  • Meiners J, Palmieri V, Klopfleisch R, Ebel JF, Japtok L, Schumacher F, Yusuf AM, Becker KA, Zöller J, Hose M, Kleuser B, Hermann DM, Kolesnick RN, Buer J, Hansen W, Westendorf AM. Intestinal Acid Sphingomyelinase Protects From Severe Pathogen-Driven Colitis. Front Immunol. 2019 Jun 19;10:1386. doi: 10.3389/fimmu.2019.01386. eCollection 2019.
  • Derakhshani S, Kurz A, Japtok L, Schumacher F, Pilgram L, Steinke M, Kleuser B, Sauer M, Schneider-Schaulies S, Avota E. Measles Virus Infection Fosters Dendritic Cell Motility in a 3D Environment to Enhance Transmission to Target Cells in the Respiratory Epithelium. Front Immunol. 2019 Jun 5;10:1294. doi: 10.3389/fimmu.2019.01294. eCollection 2019.
  • Seitz AP, Schumacher F, Baker J, Soddemann M, Wilker B, Caldwell CC, Gobble RM, Kamler M, Becker KA, Beck S, Kleuser B, Edwards MJ, Gulbins E. Sphingosine-coating of plastic surfaces prevents ventilator-associated pneumonia. J Mol Med (Berl). 2019 Jun 20. doi: 10.1007/s00109-019-01800-1. [Epub ahead of print]
  • Tian M, Reichetzeder C, Li J, Hocher B. Low birth weight, a risk factor for diseases in later life, is a surrogate of insulin resistance at birth. J Hypertens. 2019 May 30. doi: 10.1097/HJH.0000000000002156. [Epub ahead of print]
  • Wanjiku B, Yamamoto K, Klossek A, Schumacher F, Pischon H, Mundhenk L, Rancan  F, Judd MM, Ahmed M, Zoschke C, Kleuser B, Rühl E, Schäfer-Korting M. Qualifying X-ray and Stimulated Raman Spectromicroscopy for Mapping Cutaneous Drug Penetration. Anal Chem. 2019 May 15. doi: 10.1021/acs.analchem.9b00519. [Epub ahead of print]
  • Warrington NM, Beaumont RN, Horikoshi M, Day FR, Helgeland Ø, Laurin C, Bacelis J, Peng S, Hao K, Feenstra B, Wood AR, Mahajan A, Tyrrell J, Robertson NR, Rayner NW, Qiao Z, Moen GH, Vaudel M, Marsit CJ, Chen J, Nodzenski M, Schnurr TM, Zafarmand MH, Bradfield JP, Grarup N, Kooijman MN, Li-Gao R, Geller F, Ahluwalia TS, Paternoster L, Rueedi R, Huikari V, Hottenga JJ, Lyytikäinen LP, Cavadino A, Metrustry S, Cousminer DL, Wu Y, Thiering E, Wang CA, Have CT, Vilor-Tejedor N, Joshi PK, Painter JN, Ntalla I, Myhre R, Pitkänen N, van Leeuwen EM, Joro R, Lagou V, Richmond RC, Espinosa A, Barton SJ, Inskip HM, Holloway JW, Santa-Marina L, Estivill X, Ang W, Marsh JA, Reichetzeder C, Marullo L, Hocher B, Lunetta KL, Murabito JM, Relton CL, Kogevinas M, Chatzi L, Allard C, Bouchard L, Hivert MF, Zhang G, Muglia LJ, Heikkinen J; EGG Consortium, Morgen CS, van Kampen AHC, van Schaik BDC, Mentch FD, Langenberg C, Luan J, Scott RA, Zhao JH, Hemani G, Ring SM, Bennett AJ, Gaulton KJ, Fernandez-Tajes J, van Zuydam NR, Medina-Gomez C, de Haan HG, Rosendaal FR, Kutalik Z, Marques-Vidal P, Das S, Willemsen G, Mbarek H, Müller-Nurasyid M, Standl M, Appel EVR, Fonvig CE, Trier C, van Beijsterveldt CEM, Murcia M, Bustamante M, Bonas-Guarch S, Hougaard DM, Mercader JM, Linneberg A, Schraut KE, Lind PA, Medland SE, Shields BM, Knight BA, Chai JF, Panoutsopoulou K, Bartels M, Sánchez F, Stokholm J, Torrents D, Vinding RK, Willems SM, Atalay M, Chawes BL, Kovacs P, Prokopenko I, Tuke MA, Yaghootkar H, Ruth KS, Jones SE, Loh PR, Murray A, Weedon MN, Tönjes A, Stumvoll M, Michaelsen KF, Eloranta AM, Lakka TA, van Duijn CM, Kiess W, Körner A, Niinikoski H, Pahkala K, Raitakari OT, Jacobsson B, Zeggini E, Dedoussis GV, Teo YY, Saw SM, Montgomery GW, Campbell H, Wilson JF, Vrijkotte TGM, Vrijheid M, de Geus EJCN, Hayes MG, Kadarmideen HN, Holm JC, Beilin LJ, Pennell CE, Heinrich J, Adair LS, Borja JB, Mohlke KL, Eriksson JG, Widén EE, Hattersley AT, Spector TD, Kähönen M, Viikari JS, Lehtimäki T, Boomsma DI, Sebert S, Vollenweider P, Sørensen TIA, Bisgaard H, Bønnelykke K, Murray JC, Melbye M, Nohr EA, Mook-Kanamori DO, Rivadeneira F, Hofman A, Felix JF, Jaddoe VWV, Hansen T, Pisinger C, Vaag AA, Pedersen O, Uitterlinden AG, Järvelin MR, Power C, Hyppönen E, Scholtens DM, Lowe WL Jr, Davey Smith G, Timpson NJ, Morris AP, Wareham NJ, Hakonarson H, Grant SFA, Frayling TM, Lawlor DA, Njølstad PR, Johansson S, Ong KK, McCarthy MI, Perry JRB, Evans DM, Freathy RM. Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors. Nat Genet. 2019 May 1. doi: 10.1038/s41588-019-0403-1. [Epub ahead of print]
  • Gohlke S, Zagoriy V, Cuadros Inostroza A, Méret M, Mancini C, Japtok L, Schumacher F, Kuhlow D, Graja A, Stephanowitz H, Jähnert M, Krause E, Wernitz A, Petzke KJ, Schürmann A, Kleuser B, Schulz TJ. Identification of functional lipid metabolism biomarkers of brown adipose tissue aging. Mol Metab. 2019 Apr 4. pii: S2212-8778(18)31191-8. doi: 10.1016/j.molmet.2019.03.011. [Epub ahead of print]
  • Wiesner-Reinhold M, Barknowitz G, Florian S, Mewis I, Schumacher F, Schreiner M, Glatt H. 1-Methoxy-3-indolylmethyl DNA adducts in six tissues, and blood protein adducts, in mice under pak choi diet: time course and persistence. Arch Toxicol. 2019 Apr 15. doi: 10.1007/s00204-019-02452-3. [Epub ahead of print]
  • Hasan AA, von Websky K, Reichetzeder C, Tsuprykov O, Gaballa MMS, Guo J, Zeng S, Delić D, Tammen H, Klein T, Kleuser B, Hocher B. Mechanisms of GLP-1 receptor-independent renoprotective effects of the dipeptidyl peptidase type 4 inhibitor linagliptin in GLP-1 receptor knockout mice with 5/6 nephrectomy. Kidney Int. 2019 Feb 27. pii: S0085-2538(19)30052-3. doi: 10.1016/j.kint.2019.01.010. [Epub ahead of print]
  • Castaño-Martinez T, Schumacher F, Schumacher S, Kochlik B, Weber D, Grune T, Biemann R, McCann A, Abraham K, Weikert C, Kleuser B, Schürmann A, Laeger T. Methionine restriction prevents onset of type 2 diabetes in NZO mice. FASEB J. 2019 Mar 6:fj201900150R. doi: 10.1096/fj.201900150R. [Epub ahead of print]
  • Hausmann C, Zoschke C, Wolff C, Darvin ME, Sochorová M, Kováčik A, Wanjiku B, Schumacher F, Tigges J, Kleuser B, Lademann J, Fritsche E, Vávrová K, Ma N, Schäfer-Korting M. Fibroblast origin shapes tissue homeostasis, epidermal differentiation, and drug uptake. Sci Rep. 2019 Feb 27;9(1):2913. doi: 10.1038/s41598-019-39770-6.
  • Frombach J, Unbehauen M, Kurniasih IN, Schumacher F, Volz P, Hadam S, Rancan F, Blume-Peytavi U, Kleuser B, Haag R, Alexiev U, Vogt A. Core-multishell nanocarriers enhance drug penetration and reach keratinocytes and antigen-presenting cells in intact human skin. J Control Release. 2019 Feb 21. pii: S0168-3659(19)30109-9. doi: 10.1016/j.jconrel.2019.02.028. [Epub ahead of print]
  • Gronke K, Hernández PP, Zimmermann J, Klose CSN, Kofoed-Branzk M, Guendel F, Witkowski M, Tizian C, Amann L, Schumacher F, Glatt H, Triantafyllopoulou A, Diefenbach A. Interleukin-22 protects intestinal stem cells against genotoxic stress. Nature. 2019 Jan 30. doi: 10.1038/s41586-019-0899-7. [Epub ahead of print]

2018

  • Gulbins A, Schumacher F, Becker KA, Wilker B, Soddemann M, Boldrin F, Müller CP, Edwards MJ, Goodman M, Caldwell CC, Kleuser B, Kornhuber J, Szabo I, Gulbins E. Antidepressants regulate autophagy by targeting acid sphingomyelinase. Mol Psychiatry. 2018 Dec;23(12):2251.
    Editor-invited Image
  • Plöhn S, Edelmann B, Japtok L, He X, Hose M, Hansen W, Schuchman EH, Eckstein  A, Berchner-Pfannschmidt U. CD40 Enhances Sphingolipids in Orbital Fibroblasts: Potential Role of Sphingosine-1-Phosphate in Inflammatory T-Cell Migration in Graves' Orbitopathy. Invest Ophthalmol Vis Sci. 2018 Nov 1;59(13):5391-5397. doi: 10.1167/iovs.18-25466.
  • Reichel M, Rhein C, Hofmann LM, Monti J, Japtok L, Langgartner D, Füchsl AM, Kleuser B, Gulbins E, Hellerbrand C, Reber SO, Kornhuber J. Chronic Psychosocial Stress in Mice Is Associated With Increased Acid Sphingomyelinase Activity in Liver and Serum and With Hepatic C16:0-Ceramide Accumulation. Front Psychiatry. 2018 Oct 16;9:496. doi: 10.3389/fpsyt.2018.00496.
  • Wienhold SM, Macrì M, Nouailles G, Dietert K, Gurtner C, Gruber AD, Heimesaat MM, Lienau J, Schumacher F, Kleuser B, Opitz B, Suttorp N, Witzenrath M, Müller-Redetzky HC. Ventilator-induced lung injury is aggravated by antibiotic mediated microbiota depletion in mice. Crit Care. 2018 Oct 29;22(1):282. doi: 10.1186/s13054-018-2213-8.
  • Kleuser B. The Enigma of Sphingolipids in Health and Disease. Int J Mol Sci. 2018 Oct 12;19(10). pii: E3126. doi: 10.3390/ijms19103126.
  • Nitezki T, Kleuser B, Krämer S. Fatal gastric distension in a gold thioglucose mouse model of obesity. Lab Anim. 2018 Oct 5. doi: 10.1177/0023677218803384. [Epub ahead of print]
  • Gerecke C, Schumacher F, Edlich A, Wetzel A, Yealland G, Neubert LK, Scholtka B, Homann T, Kleuser B. Vitamin C promotes decitabine or azacytidine induced DNA hydroxymethylation and subsequent reactivation of the epigenetically silenced tumour suppressor CDKN1A in colon cancer cells. Oncotarget. 2018 Aug 28;9(67):32822-32840. doi: 10.18632/oncotarget.25999.
  • Zabihi F, Graff P, Schumacher F, Kleuser B, Hedtrich S, Haag R. Synthesis of poly(lactide-co-glycerol) as a biodegradable and biocompatible polymer with high loading capacity for dermal drug delivery. Nanoscale. 2018 Aug 31. doi: 10.1039/c8nr05536j. [Epub ahead of print]
  • Gulbins A, Schumacher F, Becker KA, Wilker B, Soddemann M, Boldrin F, Müller CP, Edwards MJ, Goodman M, Caldwell CC, Kleuser B, Kornhuber J, Szabo I, Gulbins E. Antidepressants act by inducing autophagy controlled by sphingomyelin-ceramide. Mol Psychiatry. 2018 Jul 23. doi: 10.1038/s41380-018-0090-9. [Epub ahead of print]
  • Schoenauer R, Larpin Y, Babiychuk EB, Drücker P, Babiychuk VS, Avota E, Schneider-Schaulies S, Schumacher F, Kleuser B, Köffel R, Draeger A. Down-regulation of acid sphingomyelinase and neutral sphingomyelinase-2 inversely determines the cellular resistance to plasmalemmal injury by pore forming toxins. FASEB J. 2018 Jul 6. doi: 10.1096/fj.201800033R. [Epub ahead of print]
  • Beckmann N, Kadow S, Schumacher F, Göthert JR, Kesper S, Draeger A, Schulz-Schaeffer WJ, Wang J, Becker JU, Kramer M, Kühn C, Kleuser B, Becker KA, Gulbins E, Carpinteiro A. Pathological manifestations of Farber disease in a new mouse model. Biol Chem. 2018 Jun 1. doi: 10.1515/hsz-2018-0170. [Epub ahead of print]
  • Li J, Lu YP, Tsuprykov O, Hasan AA, Reichetzeder C, Tian M, Zhang XL, Zhang Q, Sun GY, Guo J, Gaballa MMS, Peng XN, Lin G, Hocher B. Folate treatment of pregnant rat dams abolishes metabolic effects in female offspring induced by a paternal pre-conception unhealthy diet. Diabetologia. 2018 May 18. doi: 10.1007/s00125-018-4635-x. [Epub ahead of print]
  • Becker KA, Riethmüller J, Seitz AP, Gardner A, Boudreau R, Kamler M, Kleuser B, Schuchman E, Caldwell CC, Edwards MJ, Grassmé H, Brodlie M, Gulbins E. Sphingolipids as targets for inhalation treatment of cystic fibrosis. Adv Drug Deliv Rev. 2018 Apr 23. pii: S0169-409X(18)30075-9. doi: 10.1016/j.addr.2018.04.015. [Epub ahead of print]
  • Nitezki T, Schulz N, Krämer S. Color matters: They would choose if they could (see)! Lab Anim. 2018 Jan 1:23677218766370. doi: 10.1177/0023677218766370. [Epub ahead of print]
  • Müller SM, Finke H, Ebert F, Kopp JF, Schumacher F, Kleuser B, Francesconi KA, Raber G, Schwerdtle T. Arsenic-containing hydrocarbons: effects on gene expression, epigenetics, and biotransformation in HepG2 cells. Arch Toxicol. 2018 Mar 30. [Epub ahead of print] doi: 10.1007/s00204-018-2194-z.
  • Prommer HU, Maurer J, von Websky K, Freise C, Sommer K, Nasser H, Samapati R,  Reglin B, Guimarães P, Pries AR, Querfeld U. Chronic kidney disease induces a systemic microangiopathy, tissue hypoxia and dysfunctional angiogenesis.Sci Rep. 2018 Mar 28;8(1):5317. doi: 10.1038/s41598-018-23663-1.
  • Laeger T, Castaño-Martinez T, Werno MW, Japtok L, Baumeier C, Jonas W, Kleuser B, Schürmann A. Dietary carbohydrates impair the protective effect of protein restriction against diabetes in NZO mice used as a model of type 2 diabetes. Diabetologia. 2018 Mar 17. doi: 10.1007/s00125-018-4595-1.
  • Kleuser B. Divergent Role of Sphingosine 1-Phosphate in Liver Health and Disease. Int J Mol Sci. 2018 Mar 3;19(3). pii: E722. doi: 10.3390/ijms19030722.
  • Edlich A, Volz P, Brodwolf R, Unbehauen M, Mundhenk L, Gruber AD, Hedtrich S,  Haag R, Alexiev U, Kleuser B. Crosstalk between core-multishell nanocarriers for cutaneous drug delivery and antigen-presenting cells of the skin. Biomaterials. 2018 Feb 3;162:60-70. doi: 10.1016/j.biomaterials.2018.01.058.
  • Lu YP, Reichetzeder C, Prehn C, von Websky K, Slowinski T, Chen YP, Yin LH, Kleuser B, Yang XS, Adamski J, Hocher B. Fetal Serum Metabolites Are Independently Associated with Gestational Diabetes Mellitus. Cell Physiol Biochem. 2018 Jan 29;45(2):625-638. doi: 10.1159/000487119.
  • Lu YP, Reichetzeder C, Prehn C, Yin LH, Yun C, Zeng S, Chu C, Adamski J, Hocher B. Cord Blood Lysophosphatidylcholine 16: 1 is Positively Associated with Birth Weight. Cell Physiol Biochem. 2018 Jan 29;45(2):614-624. doi: 10.1159/000487118.
  • Schwiebs A, Thomas D, Kleuser B, Pfeilschifter JM, Radeke HH. Nuclear Translocation of SGPP-1 and Decrease of SGPL-1 Activity Contribute to Sphingolipid Rheostat Regulation of Inflammatory Dendritic Cells. Mediators Inflamm. 2017;2017:5187368. doi: 10.1155/2017/5187368.
  • Beaumont RN, Warrington NM, Cavadino A, Tyrrell J, Nodzenski M, Horikoshi M, Geller F, Myhre R, Richmond RC, Paternoster L, Bradfield JP, Kreiner-Møller E, Huikari V, Metrustry S, Lunetta KL, Painter JN, Hottenga JJ, Allard C, Barton SJ, Espinosa A, Marsh JA, Potter C, Zhang G, Ang W, Berry DJ, Bouchard L, Das S; Early Growth Genetics (EGG) Consortium, Hakonarson H, Heikkinen J, Helgeland Ø, Hocher B, Hofman A, Inskip HM, Jones SE, Kogevinas M, Lind PA, Marullo L, Medland SE, Murray A, Murray JC, Njølstad PR, Nohr EA, Reichetzeder C, Ring SM, Ruth KS, Santa-Marina L, Scholtens DM, Sebert S, Sengpiel V, Tuke MA, Vaudel M, Weedon MN, Willemsen G, Wood AR, Yaghootkar H, Muglia LJ, Bartels M, Relton CL, Pennell CE, Chatzi L, Estivill X, Holloway JW, Boomsma DI, Montgomery GW, Murabito JM, Spector TD, Power C, Järvelin MR, Bisgaard H, Grant SF, Sørensen TI, Jaddoe VW, Jacobsson B, Melbye M, McCarthy MI, Hattersley AT, Hayes MG, Frayling TM, Hivert MF, Felix JF, Hyppönen E, Lowe WL Jr, Evans DM, Lawlor DA, Feenstra B, Freathy RM. Genome-wide association study of offspring birth weight in 86,577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics. Hum Mol Genet. 2018 Jan 3. doi: 10.1093/hmg/ddx429. [Epub ahead of print]
  • Gutbier B, Schönrock SM, Ehrler C, Haberberger R, Dietert K, Gruber AD, Kummer W, Michalick L, Kuebler WM, Hocke AC, Szymanski K, Letsiou E, Lüth A, Schumacher F, Kleuser B, Mitchell TJ, Bertrams W, Schmeck B, Treue D, Klauschen F, Bauer TT, Tönnies M, Weissmann N, Hippenstiel S, Suttorp N, Witzenrath M; CAPNETZ Study Group. Sphingosine Kinase 1 Regulates Inflammation and Contributes to Acute Lung Injury in Pneumococcal Pneumonia via the Sphingosine-1-Phosphate Receptor 2. Crit Care Med. 2018 Jan 2. doi: 10.1097/CCM.0000000000002916. [Epub ahead of print]
  • Giulbudagian M, Yealland G, Hönzke S, Edlich A, Geisendörfer B, Kleuser B, Hedtrich S, Calderón M. Breaking the Barrier - Potent Anti-Inflammatory Activity following Efficient Topical Delivery of Etanercept using Thermoresponsive Nanogels. Theranostics. 2018 Jan 1;8(2):450-463. doi: 10.7150/thno.21668. eCollection 2018.

2017


  • Giulbudagian M, Hönzke S, Bergueiro J, Işık D, Schumacher F, Saeidpour S, Lohan SB, Meinke MC, Teutloff C, Schäfer-Korting M, Yealland G, Kleuser B, Hedtrich S, Calderón M. Enhanced topical delivery of dexamethasone by β-cyclodextrin decorated thermoresponsive nanogels. Nanoscale. 2017 Dec 11. doi: 10.1039/c7nr04480a. [Epub ahead of print]
  • von Websky K, Hasan AA, Reichetzeder C, Tsuprykov O, Hocher B. Impact of vitamin D on pregnancy-related disorders and on offspring outcome. J Steroid Biochem Mol Biol. 2017 Nov 21. pii: S0960-0760(17)30339-4. doi: 10.1016/j.jsbmb.2017.11.008. [Epub ahead of print]
  • Kakkassery V, Skosyrski S, Lüth A, Kleuser B, van der Giet M, Tate R, Reinhard J, Faissner A, Joachim SC, Kociok N. Etoposide Upregulates Survival Favoring Sphingosine-1-Phosphate in Etoposide-Resistant Retinoblastoma Cells. Pathol Oncol Res. 2017 Nov 15. doi: 10.1007/s12253-017-0360-x. [Epub ahead of print]
  • Reichetzeder C, Hocher B. DPP4 inhibition prevents AKI. Oncotarget. 2017 Aug 12;8(39):64655-64656. doi: 10.18632/oncotarget.20212.
  • Pischon H, Radbruch M, Ostrowski A, Schumacher F, Hönzke S, Kleuser B, Hedtrich S, Fluhr JW, Gruber AD, Mundhenk L. How Effective is Tacrolimus in the Imiquimod - Induced Mouse Model of Psoriasis? J Invest Dermatol. 2017 Sep 22. doi: 10.1016/j.jid.2017.09.019. [Epub ahead of print]
  • Fayyaz S, Japtok L, Schumacher F, Wigger D, Schulz TJ, Haubold K, Gulbins E, Völler H, Kleuser B. Lysophosphatidic Acid Inhibits Insulin Signaling in Primary Rat Hepatocytes via the LPA3 Receptor Subtype and is Increased in Obesity. Cell Physiol Biochem. 2017;43(2):445-456. doi: 10.1159/000480470.
  • Kachler K, Bailer M, Heim L, Schumacher F, Reichel M, Holzinger C, Trump S, Mittler S, Monti J, Trufa DI, Rieker RJ, Hartmann A, Sirbu H, Kleuser B, Kornhuber J, Finotto S. Enhanced acid sphingomyelinase activity drives immune evasion and tumor growth in non-small cell lung carcinoma. Cancer Res. 2017 Sep 7. doi: 10.1158/0008-5472.CAN-16-3313
  • Dwi Putra SE, Reichetzeder C, Meixner M, Liere K, Slowinski T, Hocher B. DNA methylation of the glucocorticoid receptor gene promoter in the placenta is associated with blood pressure regulation in human pregnancy. J Hypertens. 2017 Aug 16. doi: 10.1097/HJH.0000000000001450.
  • Speckmann B, Schulz S, Hiller F, Hesse D, Schumacher F, Kleuser B, Geisel J, Obeid R, Grune T, Kipp AP. Selenium increases hepatic DNA methylation and modulates one-carbon metabolism in the liver of mice. J Nutr Biochem. 2017;48:112-119. doi: 10.1016/j.jnutbio.2017.07.002.
  • Schumacher F, Neuber C, Finke H, Nieschalke K, Baesler J, Gulbins E, Kleuser B. The sphingosine 1-phosphate breakdown product, (2E)-hexadecenal, forms protein adducts and glutathione conjugates in vitro. J Lipid Res. 2017;58(8):1648-1660. doi: 10.1194/jlr.M076562
  • Reichetzeder C, Heunisch F, Einem GV, Tsuprykov O, Kellner KH, Dschietzig T, Kretschmer A, Hocher B. Pre-Interventional Kynurenine Predicts Medium-Term Outcome after Contrast Media Exposure Due to Coronary Angiography. Kidney Blood Press Res. 2017;42(2):244-256. doi: 10.1159/000477222
  • Reichetzeder C, von Websky K, Tsuprykov O, Mohagheghi Samarin A, Falke LG, Dwi Putra SE, Hasan AA, Antonenko V, Curato C, Rippmann J, Klein T, Hocher B. Head-to-head comparison of structurally unrelated dipeptidyl peptidase 4 inhibitors in the setting of renal ischemia reperfusion injury. Br J Pharmacol. 2017 Jul;174(14):2273-2286. doi: 10.1111/bph.13822
  • Wallmeyer L, Dietert K, Sochorová M, Gruber AD, Kleuser B, Vávrová K, Hedtrich S. TSLP is a direct trigger for T cell migration in filaggrin-deficient skin equivalents. Sci Rep. 2017 Apr 4;7(1):774. doi: 10.1038/s41598-017-00670-2
  • McVey MJ, Kim M, Tabuchi A, Srbely V, Japtok L, Arenz C, Rotstein O, Kleuser B, Semple JW, Kuebler WM. Acid sphingomyelinase mediates murine acute lung injury following transfusion of aged platelets. Am J Physiol Lung Cell Mol Physiol. 2017 May 1;312(5):L625-L637. doi: 10.1152/ajplung.00317.2016
  • Bernacchioni C, Ghini V, Cencetti F, Japtok L, Donati C, Bruni P, Turano P. NMR metabolomics highlights sphingosine kinase-1 as a new molecular switch in the orchestration of aberrant metabolic phenotype in cancer cells. Mol Oncol. 2017 May;11(5):517-533. doi: 10.1002/1878-0261.12048
  • Balzus B, Sahle FF, Hönzke S, Gerecke C, Schumacher F, Hedtrich S, Kleuser B, Bodmeier R. Formulation and ex vivo evaluation of polymeric nanoparticles for controlled delivery of corticosteroids to the skin and the corneal epithelium. Eur J Pharm Biopharm. 2017 Jun;115:122-130. doi: 10.1016/j.ejpb.2017.02.001
  • Neuber C, Schumacher F, Gulbins E, Kleuser B. Mass spectrometric determination of fatty aldehydes exemplified by monitoring the oxidative degradation of (2E)-hexadecenal in HepG2 cell lysates. In: Paul Wood (ed.) Lipidomics 2017;147-158. Neuromethods Vol. 125. Springer New York. doi: 10.1007/978-1-4939-6946-3_10
  • Gerecke C, Edlich A, Giulbudagian M, Schumacher F, Zhang N, Said A, Yealland G, Lohan SB, Neumann F, Meinke MC, Ma N, Calderón M, Hedtrich S, Schäfer-Korting M, Kleuser B. Biocompatibility and characterization of polyglycerol-based thermoresponsive nanogels designed as novel drug-delivery systems and their intracellular localization in keratinocytes. Nanotoxicology. 2017 Mar;11(2):267-277. doi: 10.1080/17435390.2017.1292371
  • Radbruch M, Pischon H, Ostrowski A, Volz P, Brodwolf R, Neumann F, Unbehauen M, Kleuser B, Haag R, Ma N, Alexiev U, Mundhenk L, Gruber AD. Dendritic Core-Multishell Nanocarriers in Murine Models of Healthy and Atopic Skin. Nanoscale Res Lett. 2017 Dec;12(1):64. doi: 10.1186/s11671-017-1835-0
  • Edlich A, Gerecke C, Giulbudagian M, Neumann F, Hedtrich S, Schäfer-Korting M, Ma N, Calderon M, Kleuser B. Specific uptake mechanisms of well-tolerated thermoresponsive polyglycerol-based nanogels in antigen-presenting cells of the skin. Eur J Pharm Biopharm. 2017 Jul;116:155-163. doi: 10.1016/j.ejpb.2016.12.016
  • Hoehn RS, Jernigan PL, Japtok L, Chang AL, Midura EF, Caldwell CC, Kleuser B, Lentsch AB, Edwards MJ, Gulbins E, Pritts TA. Acid Sphingomyelinase Inhibition in Stored Erythrocytes Reduces Transfusion-Associated Lung Inflammation. Ann Surg. 2017 Jan;265(1):218-226.

2016

  • Al Fadel F, Fayyaz S, Japtok L, Kleuser B. Involvement of Sphingosine 1-Phosphate in Palmitate-Induced Non-Alcoholic Fatty Liver Disease. Cell Physiol Biochem. 2016;40(6):1637-1645. doi: 10.1159/000453213. Epub 2016 Dec 23. 
  • Zhang N, Said A, Wischke C, Kral V, Brodwolf R, Volz P, Boreham A, Gerecke C, Li W, Neffe AT, Kleuser B, Alexiev U, Lendlein A, Monika-Schäfer-Korting. Poly[acrylonitrile-co-(N-vinyl pyrrolidone)] nanoparticles - composition-dependent skin penetration enhancement of a dye probe and biocompatibility. Eur J Pharm Biopharm. 2016 Oct 27. pii: S0939-6411(16)30734-2. doi: 10.1016/j.ejpb.2016.10.019. [Epub ahead of print]
  • Edlich A, Gerecke C, Giulbudagian M, Neumann F, Hedtrich S, Schäfer-Korting M, Ma N, Calderon M, Kleuser B. Specific uptake mechanisms of well-tolerated thermoresponsive polyglycerol-based nanogels in antigen-presenting cells of the skin. Eur J Pharm Biopharm. 2016 Dec 24. pii: S0939-6411(16)31012-8. doi: 10.1016/j.ejpb.2016.12.016. [Epub ahead of print]
  • Pischon H, Radbruch M, Ostrowski A, Volz P, Gerecke C, Unbehauen M, Hönzke S, Hedtrich S, Fluhr JW, Haag R, Kleuser B, Alexiev U, Gruber AD, Mundhenk L. Stratum corneum targeting by dendritic core-multishell-nanocarriers in a mouse model of psoriasis. Nanomedicine. 2016 Oct 1. pii: S1549-9634(16)30154-X. doi: 10.1016/j.nano.2016.09.004. [Epub ahead of print]
  • Hollmann C, Werner S, Avota E, Reuter D, Japtok L, Kleuser B, Gulbins E, Becker KA, Schneider-Schaulies J, Beyersdorf N. Inhibition of Acid Sphingomyelinase Allows for Selective Targeting of CD4+ Conventional versus Foxp3+ Regulatory T Cells. J Immunol. 2016 Oct 15;197(8):3130-3141.
  • Sahle FF, Gerecke C, Kleuser B, Bodmeier R. Formulation and comparative in vitro evaluation of various dexamethasone-loaded pH-sensitive polymeric nanoparticles intended for dermal applications. Int J Pharm. 2016 Nov 11. pii: S0378-5173(16)31081-X. doi: 10.1016/j.ijpharm.2016.11.029. [Epub ahead of print]
  • Nojima H, Konishi T, Freeman CM, Schuster RM, Japtok L, Kleuser B, Edwards MJ, Gulbins E, Lentsch AB. Chemokine Receptors, CXCR1 and CXCR2, Differentially Regulate Exosome Release in Hepatocytes. PLoS One. 2016 Aug 23;11(8):e0161443. doi: 10.1371/journal.pone.0161443.
  • Reichetzeder C, Dwi Putra SE, Li J, Hocher B. Developmental Origins of Disease - Crisis Precipitates Change. Cell Physiol Biochem. 2016;39(3):919-38. doi: 10.1159/000447801.
  • Reichetzeder C, Dwi Putra SE, Pfab T, Slowinski T, Neuber C, Kleuser B, Hocher B. Increased global placental DNA methylation levels are associated with gestational diabetes. Clin Epigenetics. 2016 Jul 26;8:82. doi: 10.1186/s13148-016-0247-9.
  • Döge N, Hönzke S, Schumacher F, Balzus B, Colombo M, Hadam S, Rancan F, Blume-Peytavi U, Schäfer-Korting M, Schindler A, Rühl E, Skov PS, Church MK, Hedtrich S, Kleuser B, Bodmeier R, Vogt A. Ethyl cellulose nanocarriers and nanocrystals differentially deliver dexamethasone into intact, tape-stripped or sodium lauryl sulfate-exposed ex vivo human skin - assessment by intradermal microdialysis and extraction from the different skin layers. J Control Release. 2016 Jul 6. pii: S0168-3659(16)30434-5. doi: 10.1016/j.jconrel.2016.07.009. [Epub ahead of print]
  • Sahle FF, Balzus B, Gerecke C, Kleuser B, Bodmeier R. Formulation and in vitro evaluation of polymeric enteric nanoparticles as dermal carriers with pH-dependent targeting potential. Eur J Pharm Sci. 2016 Sep 20;92:98-109. doi: 10.1016/j.ejps.2016.07.004.
  • Hönzke S, Gerecke C, Elpelt A, Zhang N, Unbehauen M, Kral V, Fleige E, Paulus F, Haag R, Schäfer-Korting M, Kleuser B, Hedtrich S. Tailored dendritic core-multishell nanocarriers for efficient dermal drug delivery: A systematic top-down approach from synthesis to preclinical testing. J Control Release. 2016 Jun 24. pii: S0168-3659(16)30407-2. doi: 10.1016/j.jconrel.2016.06.030. [Epub ahead of print]
  • Walter T, Collenburg L, Japtok L, Kleuser B, Schneider-Schaulies S, Müller N, Becam J, Schubert-Unkmeir A, Kong JN, Bieberich E, Seibel J. Incorporation and visualization of azido-functionalized N-oleoyl serinol in Jurkat cells, mouse brain astrocytes, 3T3 fibroblasts and human brain microvascular endothelial cells. Chem Commun (Camb). 2016 Jun 30;52(55):8612-4. doi: 10.1039/c6cc02879a.
  • Dong C, Liu Z, Liu J, Wu C, Neumann F, Wang H, Schäfer-Korting M, Kleuser B, Chang J, Li W, Ma N, Haag R. A Highly Photostable Hyperbranched Polyglycerol-Based NIR Fluorescence Nanoplatform for Mitochondria-Specific Cell Imaging. Adv Healthc Mater. 2016 Sep;5(17):2214-26. doi: 10.1002/adhm.201600212.
  • Hocher B, Haumann H, Rahnenführer J, Reichetzeder C, Kalk P, Pfab T, Tsuprykov O, Winter S, Hofmann U, Li J, Püschel GP, Lang F, Schuppan D, Schwab M, Schaeffeler E. Maternal eNOS deficiency determines a fatty liver phenotype of the offspring in a sex dependent manner. Epigenetics. 2016 Jul 2;11(7):539-52. doi: 10.1080/15592294.2016.1184800.
  • Tsuprykov O, Ando R, Reichetzeder C, von Websky K, Antonenko V, Sharkovska Y, Chaykovska L, Rahnenführer J, Hasan AA, Tammen H, Alter M, Klein T, Ueda S, Yamagishi S, Okuda S, Hocher B. The dipeptidyl peptidase inhibitor linagliptin and the angiotensin II receptor blocker telmisartan show renal benefit by different pathways in rats with 5/6 nephrectomy. Kidney Int. 2016 May;89(5):1049-61. doi: 10.1016/j.kint.2016.01.016.
  • Reinkensmeier A, Steinbrenner K, Homann T, Bußler S, Rohn S, Rawel HM. Monitoring the apple polyphenol oxidase-modulated adduct formation of phenolic and amino compounds. Food Chem. 2016 Mar 1;194:76-85. doi: 10.1016/j.foodchem.2015.07.145.
  • Ahlberg S, Rancan F, Epple M, Loza K, Höppe D, Lademann J, Vogt A, Kleuser B, Gerecke C, Meinke MC. Comparison of different methods to study effects of silver nanoparticles on the pro- and antioxidant status of human keratinocytes and fibroblasts. Methods. 2016 May 20. pii: S1046-2023(16)30145-1. doi: 10.1016/j.ymeth.2016.05.015. [Epub ahead of print]
  • Li J, Lu YP, Reichetzeder C, Kalk P, Kleuser B, Adamski J, Hocher B. Maternal PCaaC38:6 is Associated With Preterm Birth - a Risk Factor for Early and Late Adverse Outcome of the Offspring. Kidney Blood Press Res. 2016 Apr 22;41(3):250-257. [Epub ahead of print]
  • Folkesson M, Vorkapic E, Gulbins E, Japtok L, Kleuser B, Welander M, Länne T, Wågsäter D. Inflammatory cells, ceramides, and expression of proteases in perivascular adipose tissue adjacent to human abdominal aortic aneurysms. J Vasc Surg. 2016 Mar 6. pii: S0741-5214(16)00148-8. doi: 10.1016/j.jvs.2015.12.056. [Epub ahead of print]
  • Hoehn RS, Jernigan PL, Japtok L, Chang AL, Midura EF, Caldwell CC, Kleuser B, Lentsch AB, Edwards MJ, Gulbins E, Pritts TA. Acid Sphingomyelinase Inhibition in Stored Erythrocytes Reduces Transfusion-Associated Lung Inflammation. Ann Surg. 2016 Jan 27. [Epub ahead of print]
  • Tyrrell J, Richmond RC, Palmer TM, Feenstra B, Rangarajan J, Metrustry S, Cavadino A, Paternoster L, Armstrong LL, De Silva NM, Wood AR, Horikoshi M, Geller F, Myhre R, Bradfield JP, Kreiner-Møller E, Huikari V, Painter JN, Hottenga JJ, Allard C, Berry DJ, Bouchard L, Das S, Evans DM, Hakonarson H, Hayes MG, Heikkinen J, Hofman A, Knight B, Lind PA, McCarthy MI, McMahon G, Medland SE, Melbye M, Morris AP, Nodzenski M, Reichetzeder C, Ring SM, Sebert S, Sengpiel V,  Sørensen TI, Willemsen G, de Geus EJ, Martin NG, Spector TD, Power C, Järvelin MR, Bisgaard H, Grant SF, Nohr EA, Jaddoe VW, Jacobsson B, Murray JC, Hocher B, Hattersley AT, Scholtens DM, Davey Smith G, Hivert MF, Felix JF, Hyppönen E, Lowe WL Jr, Frayling TM, Lawlor DA, Freathy RM. Genetic Evidence for Causal Relationships Between Maternal Obesity-Related Traits and Birth Weight. JAMA. 2016 Mar 15;315(11):1129-40. doi: 10.1001/jama.2016.1975.
  • Collenburg L, Walter T, Burgert A, Müller N, Seibel J, Japtok L, Kleuser B, Sauer M, Schneider-Schaulies S. A Functionalized Sphingolipid Analogue for Studying Redistribution during Activation in Living T Cells. J Immunol. 2016 May 1;196(9):3951-62. doi: 10.4049/jimmunol.1502447.
  • Huston JP, Kornhuber J, Mühle C, Japtok L, Komorowski M, Mattern C, Reichel M, Gulbins E, Kleuser B, Topic B, De Souza Silva MA, Müller CP.  A sphingolipid mechanism for behavioral extinction. J . Neurochem. 2016 Jan 20. doi: 10.1111/jnc.13537.
  • Li C, Peng H, Japtok L, Seitz A, Riehle A, Wilker B, Soddemann M, Kleuser B, Edwards M, Lammas D, Zhang Y, Gulbins E, Grassme H. Inhibition of neutral sphingomyelinase protects mice against systemic tuberculosis. Front Biosci (Elite Ed). 2016 Jan 1;8:311-25.
  • Rakers C, Schumacher F, Meinl W, Glatt H, Kleuser B, Wolber G. In silico prediction of human sulfotransferase 1E1 activity guided by pharmacophores from molecular dynamics simulations. J Biol Chem. 2016 Jan 1;291(1):58-71. doi: 10.1074/jbc.M115.685610.
  • Nojima H, Freeman CM, Schuster RM, Japtok L, Kleuser B, Edwards MJ, Gulbins E, Lentsch AB. Hepatocyte exosomes mediate liver repair and regeneration via sphingosine-1-phosphate. J Hepatol. 2016 Jan;64(1):60-8. doi: 10.1016/j.jhep.2015.07.030.

2015

  • Schumacher F, Chakraborty S, Kleuser B, Gulbins E, Schwerdtle T, Aschner M, Bornhorst J. Highly sensitive isotope-dilution liquid-chromatography-electrospray ionization tandem-mass spectrometry approach to study the drug-mediated modulation of dopamine and serotonin levels in Caenorhabditis elegans. Talanta. 2015 Nov 1;144:71-9. doi: 10.1016/j.talanta.2015.05.057.
  • Reichel M, Hönig S, Liebisch G, Lüth A, Kleuser B, Gulbins E, Schmitz G, Kornhuber J. Alterations of plasma glycerophospholipid and sphingolipid species in male alcohol-dependent patients. Biochim Biophys Acta. 2015 Nov;1851(11):1501-10. doi: 10.1016/j.bbalip.2015.08.005.
  • Michels M, Japtok L, Alisjahbana B, Wisaksana R, Sumardi U, Puspita M, Kleuser B, de Mast Q, van der Ven AJ. Decreased plasma levels of the endothelial protective sphingosine-1-phosphate are associated with dengue-induced plasma leakage. J Infect. 2015 Oct;71(4):480-7. doi: 10.1016/j.jinf.2015.06.014.
  • Rouiller Y, Kleuser B, Toso E, Palinksy W, Rossi M, Rossatto P, Barberio D, Broly H. Reciprocal Translocation Observed in End-of-Production Cells of a Commercial CHO-Based Process. PDA J Pharm Sci Technol. 2015 Jul-Aug;69(4):540-52. doi: 10.5731/pdajpst.2015.01063.
  • Laurenzana A, Cencetti F, Serratì S, Bruno G, Japtok L, Bianchini F, Torre E, Fibbi G, Del Rosso M, Bruni P, Donati C. Endothelial sphingosine kinase/SPNS2 axis is critical for vessel-like formation by human mesoangioblasts. J Mol Med (Berl). 2015 Oct;93(10):1145-57. doi: 10.1007/s00109-015-1292-0.
  • Japtok L, Schmitz EI, Fayyaz S, Krämer S, Hsu LJ, Kleuser B. Sphingosine 1-phosphate counteracts insulin signaling in pancreatic β-cells via the sphingosine 1-phosphate receptor subtype 2 . FASEB J. 2015 Aug;29(8):3357-69. doi: 10.1096/fj.14-263194.
  • Gerecke C, Scholtka B, Löwenstein Y, Fait I, Gottschalk U, Rogoll D, Melcher R, Kleuser B. Hypermethylation of ITGA4, TFPI2 and VIMENTIN promoters is increased in inflamed colon tissue: putative risk markers for colitis-associated cancer. J Cancer Res Clin Oncol. 2015 Dec;141(12):2097-107. doi: 10.1007/s00432-015-1972-8.
  • Carpinteiro A, Becker KA, Japtok L, Hessler G, Keitsch S, Požgajovà M, Schmid KW, Adams C, Müller S, Kleuser B, Edwards MJ, Grassmé H, Helfrich I, Gulbins E. Regulation of hematogenous tumor metastasis by acid sphingomyelinase. EMBO Mol Med. 2015 Apr 7;7(6):714-34. doi: 10.15252/emmm.201404571.
  • Chakraborty S, Chen P, Bornhorst J, Schwerdtle T, Schumacher F, Kleuser B, Bowman AB, Aschner M.  Loss of pdr-1/parkin influences Mn homeostasis through altered ferroportin expression in C. elegans. Metallomics. 2015 May 13;7(5):847-56. doi: 10.1039/c5mt00052a.
  • Bruno G, Cencetti F, Pertici I, Japtok L, Bernacchioni C, Donati C, Bruni P. CTGF/CCN2 exerts profibrotic action in myoblasts via the up-regulation of sphingosine kinase-1/S1P3 signaling axis: Implications in the action mechanism of TGFβ. Biochim Biophys Acta. 2015 Feb;1851(2):194-202. doi: 10.1016/j.bbalip.2014.11.011.
  • Henry BD, Neill DR, Becker KA, Gore S, Bricio-Moreno L, Ziobro R, Edwards MJ, Muhlemann K, Steinmann J, Kleuser B, Japtok L, Luginbuhl M, Wolfmeier H, Scherag A, Gulbins E, Kadioglu A, Draeger A, Babiychuk EB. Engineered liposomes sequester bacterial exotoxins and protect from severe invasive infections in mice. Nat Biotechnol. 2015 Jan;33(1):81-8. doi: 10.1038/nbt.3037.
  • Schraplau A, Schewe B, Neuschafer-Rube F, Ringel S, Neuber C, Kleuser B, Puschel GP. Enhanced thyroid hormone breakdown in hepatocytes by mutual induction of the constitutive androstane receptor (CAR, NR1I3) and arylhydrocarbon receptor by benzo[a]pyrene and phenobarbital. Toxicology. 2015 Feb 3;328:21-8. doi: 10.1016/j.tox.2014.12.004.
  • Prufer N, Kleuser B, Giet MV. The role of serum amyloid A and sphingosine-1-phosphate on high-density lipoprotein functionality. Biol Chem. 2015 Jun;396(6-7):573-83. doi: 10.1515/hsz-2014-0192.
  • Tsuprykov O, Chaykovska L, Kretschmer A, Stasch JP, Pfab T, Krause-Relle K, Reichetzeder C, Kalk P, Adamski J, Hocher B. Endothelin-1 Overexpression Improves Renal Function in eNOS Knockout Mice. Cell Physiol Biochem. 2015;37(4):1474-90. doi: 10.1159/000438516.
  • Zirafi O, Kim KA, Ständker L, Mohr KB, Sauter D, Heigele A, Kluge SF, Wiercinska E, Chudziak D, Richter R, Moepps B, Gierschik P, Vas V, Geiger H, Lamla M, Weil T, Burster T, Zgraja A, Daubeuf F, Frossard N, Hachet-Haas M, Heunisch F, Reichetzeder C, Galzi JL, Pérez-Castells J, Canales-Mayordomo A, Jiménez-Barbero J, Giménez-Gallego G, Schneider M, Shorter J, Telenti A, Hocher B, Forssmann WG, Bonig H, Kirchhoff F, Münch J. Discovery and characterization of an endogenous CXCR4 antagonist. Cell Rep. 2015 May 5;11(5):737-47. doi: 10.1016/j.celrep.2015.03.061.
  • Hecht E, Freise C, Websky KV, Nasser H, Kretzschmar N, Stawowy P, Hocher B, Querfeld U. The matrix metalloproteinases 2 and 9 initiate uraemic vascular calcifications. Nephrol Dial Transplant. 2016 May;31(5):789-97. doi: 10.1093/ndt/gfv321.
  • Ong AC, von Websky K, Hocher B. Endothelin and tubulointerstitial renal disease. Semin Nephrol. 2015 Mar;35(2):197-207. doi: 10.1016/j.semnephrol.2015.03.004.
  • Dschietzig TB, Krause-Relle K, Hennequin M, von Websky K, Rahnenführer J, Ruppert J, Grön HJ, Armbruster FP, Bathgate RA, Aschenbach JR, Forssmann WG, Hocher B. Relaxin-2 does not ameliorate nephropathy in an experimental model of type-1 diabetes. Kidney Blood Press Res. 2015;40(1):77-88.

2014

  •  Keller J, Catala-Lehnen P, Huebner AK, Jeschke A, Heckt T, Lueth A, Krause M, Koehne T, Albers J, Schulze J, Schilling S, Haberland M, Denninger H, Neven M, Hermans-Borgmeyer I, Streichert T, Breer S, Barvencik F, Levkau B, Rathkolb B, Wolf E, Calzada-Wack J, Neff F, Gailus-Durner V, Fuchs H, de Angelis MH, Klutmann S, Tsourdi E, Hofbauer LC, Kleuser B, Chun J, Schinke T, Amling M. Calcitonin controls bone formation by inhibiting the release of sphingosine 1-phosphate from osteoclasts. Nat. Commun. 2014 Oct 21;5:5215. doi: 10.1038/ncomms6215
  • Sic H, Kraus H, Madl J, Flittner KA, von Munchow AL, Pieper K, Rizzi M, Kienzler AK, Ayata K, Rauer S, Kleuser B, Salzer U, Burger M, Zirlik K, Lougaris V, Plebani A, Romer W, Loeffler C, Scaramuzza S, Villa A, Noguchi E, Grimbacher B, Eibel H. Sphingosine-1-phosphate receptors control B-cell migration through signaling components associated with primary immunodeficiencies, chronic lymphocytic leukemia, and multiple sclerosis. J Allergy Clin Immunol. 2014 Aug;134(2):420-8. doi: 10.1016/j.jaci.2014.01.037.
  • Japtok L, Bäumer W, Kleuser B. Sphingosine-1-phosphate as signaling molecule in the skin: Relevance in atopic dermatitis. Allergo J Int. 2014;23(2):54-59.
  • Pewzner-Jung Y, Tavakoli Tabazavareh S, Grassmé H, Becker KA, Japtok L, Steinmann J, Joseph T, Lang S, Tuemmler B, Schuchman EH, Lentsch AB, Kleuser B, Edwards MJ, Futerman AH, Gulbins E. Sphingoid long chain bases prevent lung infection by Pseudomonas aeruginosa. EMBO Mol Med. 2014 Aug 1;6(9):1205-14. doi: 10.15252/emmm.201404075.
  • Pastukhov O, Schwalm S, Zangemeister-Wittke U, Fabbro D, Bornancin F, Japtok L, Kleuser B, Pfeilschifter J, Huwiler A. The ceramide kinase inhibitor NVP-231 inhibits breast and lung cancer cell proliferation by inducing M phase arrest and subsequent cell death. Br J Pharmacol. 2014 Dec;171(24):5829-44. doi: 10.1111/bph.12886.
  • Partosch F, Mielke H, Stahlmann R, Kleuser B, Barlow S, Gundert-Remy U. Internal threshold of toxicological concern values: enabling route-to-route extrapolation. Arch Toxicol. 2015 Jun;89(6):941-8. doi: 10.1007/s00204-014-1287-6.
  • Neuber C, Schumacher F, Gulbins E, Kleuser B. Method to simultaneously determine the sphingosine 1-phosphate breakdown product (2E)-hexadecenal and its fatty acid derivatives using isotope-dilution HPLC-electrospray ionization-quadrupole/time-of-flight mass spectrometry. Anal Chem. 2014 Sep 16;86(18):9065-73. doi: 10.1021/ac501677y.
  • Mendes-Braz M, Elias-Miro M, Kleuser B, Fayyaz S, Jimenez-Castro MB, Massip-Salcedo M, Gracia-Sancho J, Ramalho FS, Rodes J, Peralta C.. The effects of glucose and lipids in steatotic and non-steatotic livers in conditions of partial hepatectomy under ischaemia-reperfusion. Liver Int. 2014 Aug;34(7):e271-89. doi: 10.1111/liv.12348.
  • Imeri F, Fallegger D, Zivkovic A, Schwalm S, Enzmann G, Blankenbach K, Meyer zu Heringdorf D, Homann T, Kleuser B, Pfeilschifter J, Engelhardt B, Stark H, Huwiler A. Novel oxazolo-oxazole derivatives of FTY720 reduce endothelial cell permeability, immune cell chemotaxis and symptoms of experimental autoimmune encephalomyelitis in mice. Neuropharmacology. 2014 Oct;85:314-27. doi: 10.1016/j.neuropharm.2014.05.012.
  • Fayyaz S, Japtok L, Kleuser B. Divergent role of sphingosine 1-phosphate on insulin resistance. Cell Physiol Biochem. 2014;34(1):134-47. doi: 10.1159/000362990.
  • Fayyaz S, Henkel J, Japtok L, Kramer S, Damm G, Seehofer D, Puschel GP, Kleuser B.  Involvement of sphingosine 1-phosphate in palmitate-induced insulin resistance of hepatocytes via the S1P2 receptor subtype. Diabetologia. 2014 Feb;57(2):373-82. doi: 10.1007/s00125-013-3123-6.
  • Dwi Putra SE, Neuber C, Reichetzeder C, Hocher B, Kleuser B. Analysis of genomic DNA methylation levels in human placenta using liquid chromatography-electrospray ionization tandem mass spectrometry. Cell Physiol Biochem. 2014;33(4):945-52. doi: 10.1159/000358666.
  • Arlt O, Schwiebs A, Japtok L, Ruger K, Katzy E, Kleuser B, Radeke HH. Sphingosine-1-phosphate modulates dendritic cell function: focus on non-migratory effects in vitro and in vivo. Cell Physiol Biochem. 2014;34(1):27-44. doi: 10.1159/000362982.

2013

  • Schaper K, Dickhaut J, Japtok L, Kietzmann M, Mischke R, Kleuser B, Baumer W. Sphingosine-1-phosphate exhibits anti-proliferative and anti-inflammatory effects in mouse models of psoriasis. J Dermatol Sci. 2013 Jul;71(1):29-36. doi: 10.1016/j.jdermsci.2013.03.006.
  • Polzin A, Rassaf T, Bohm A, Luth A, Kleuser B, Zeus T, Kelm M, Kroemer HK, Schrör K, Rauch BH. Aspirin inhibits release of platelet-derived sphingosine-1-phosphate in acute myocardial infarction. Int J Cardiol. 2013 Dec 10;170(2):e23-4. doi: 10.1016/j.ijcard.2013.10.050.
  • Lotinun S, Kiviranta R, Matsubara T, Alzate JA, Neff L, Luth A, Koskivirta I, Kleuser B, Vacher J, Vuorio E, Horne WC, Baron R. Osteoclast-specific cathepsin K deletion stimulates S1P-dependent bone formation. J Clin Invest. 2013 Feb;123(2):666-81. doi: 10.1172/JCI64840.
  • Kleuser B, Japtok L. Sphingolipids and inflammatory diseases of the skin. Handb Exp Pharmacol. 2013;(216):355-72. doi: 10.1007/978-3-7091-1511-4_18.
  • Gulbins E, Palmada M, Reichel M, Luth A, Bohmer C, Amato D, Muller CP, Tischbirek CH, Groemer TW, Tabatabai G, Becker KA, Tripal P, Staedtler S, Ackermann TF, van Brederode J, Alzheimer C, Weller M, Lang UE, Kleuser B, Grassmé H, Kornhuber J. Acid sphingomyelinase-ceramide system mediates effects of antidepressant drugs. Nat Med. 2013 Jul;19(7):934-8. doi: 10.1038/nm.3214.
  • Gerecke C, Mascher C, Gottschalk U, Kleuser B, Scholtka B. Ultrasensitive detection of unknown colon cancer-initiating mutations using the example of the Adenomatous polyposis coli gene. Cancer Prev Res (Phila). 2013 Sep;6(9):898-907. doi: 10.1158/1940-6207.CAPR-13-0145.
  • Bohm A, Flosser A, Ermler S, Fender AC, Luth A, Kleuser B, Schror K, Rauch BH. Factor-Xa-induced mitogenesis and migration require sphingosine kinase activity and S1P formation in human vascular smooth muscle cells. Cardiovasc Res. 2013 Aug 1;99(3):505-13. doi: 10.1093/cvr/cvt112.
  • Bhabak KP, Kleuser B, Huwiler A, Arenz C. Effective inhibition of acid and neutral ceramidases by novel B-13 and LCL-464 analogues. Bioorg Med Chem. 2013 Feb 15;21(4):874-82. doi: 10.1016/j.bmc.2012.12.014.

2012

  •  Schmitz EI, Potteck H, Schuppel M, Manggau M, Wahydin E, Kleuser B. Sphingosine 1-phosphate protects primary human keratinocytes from apoptosis via nitric oxide formation through the receptor subtype S1P(3). Mol Cell Biochem. 2012 Dec;371(1-2):165-76. doi: 10.1007/s11010-012-1433-5.
  • Luth A, Neuber C, Kleuser B. Novel methods for the quantification of (2E)-hexadecenal by liquid chromatography with detection by either ESI QTOF tandem mass spectrometry or fluorescence measurement. Anal Chim Acta. 2012 Apr 13;722:70-9. doi: 10.1016/j.aca.2012.01.063.
  • Japtok L, Schaper K, Baumer W, Radeke HH, Jeong SK, Kleuser B. Sphingosine 1-phosphate modulates antigen capture by murine Langerhans cells via the S1P2 receptor subtype. PLoS One. 2012;7(11):e49427. doi: 10.1371/journal.pone.0049427.

bis einschließlich 2011

  • Baumer W, Rossbach K, Mischke R, Reines I, Langbein-Detsch I, Luth A, Kleuser B. Decreased concentration and enhanced metabolism of sphingosine-1-phosphate in lesional skin of dogs with atopic dermatitis: disturbed sphingosine-1-phosphate homeostasis in atopic dermatitis. J Invest Dermatol. 2011 Jan;131(1):266-8. doi: 10.1038/jid.2010.252.
  • Barcelo-Coblijn G, Martin ML, de Almeida RF, Noguera-Salva MA, Marcilla-Etxenike A, Guardiola-Serrano F, Lüth A, Kleuser B, Halver JE, Escribá PV. Sphingomyelin and sphingomyelin synthase (SMS) in the malignant transformation of glioma cells and in 2-hydroxyoleic acid therapy. Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):19569-74. doi: 10.1073/pnas.1115484108.
  • Prakash H, Luth A, Grinkina N, Holzer D, Wadgaonkar R, Gonzalez AP, Anes E, Kleuser B. Sphingosine kinase-1 (SphK-1) regulates Mycobacterium smegmatis infection in macrophages. PLoS One. 2010 May 17;5(5):e10657. doi: 10.1371/journal.pone.0010657.
  • Potteck H, Nieuwenhuis B, Luth A, van der Giet M, Kleuser B. Phosphorylation of the immunomodulator FTY720 inhibits programmed cell death of fibroblasts via the S1P3 receptor subtype and Bcl-2 activation. Cell Physiol Biochem. 2010;26(1):67-78. doi: 10.1159/000315107.
  • Nieuwenhuis B, Luth A, Kleuser B. Dexamethasone protects human fibroblasts from apoptosis via an S1P3-receptor subtype dependent activation of PKB/Akt and Bcl XL. Pharmacol Res. 2010 May;61(5):449-59. doi: 10.1016/j.phrs.2009.12.005.
  • Muller R, Berliner C, Leptin J, Portner D, Bialecki W, Kleuser B, Schumacher U, Milićević NM. Expression of sphingosine-1-phosphate receptors and lysophosphatidic acid receptors on cultured and xenografted human colon, breast, melanoma, and lung tumor cells. Tumour Biol. 2010 Aug;31(4):341-9. doi: 10.1007/s13277-010-0043-7.
  • Holtje M, Richartz A, Zdrazil B, Schwanke A, Dugovic B, Murruzzu C, Reissig HU, Korting HC, Kleuser B, Höltje HD, Schäfer-Korting M. Human polymerase alpha inhibitors for skin tumors. Part 2. Modeling, synthesis and influence on normal and transformed keratinocytes of new thymidine and purine derivatives. J Enzyme Inhib Med Chem. 2010 Apr;25(2):250-65. doi: 10.3109/14756360903059579.
  • Gil PR, Japtok L, Kleuser B. Sphingosine 1-phosphate mediates chemotaxis of human primary fibroblasts via the S1P-receptor subtypes S1P(1) and S1P(3) and Smad-signalling. Cytoskeleton (Hoboken). 2010 Dec;67(12):773-83. doi: 10.1002/cm.20486.
  • Forster A, Emmler T, Schwalm S, Ebadi M, Heringdorf DM, Nieuwenhuis B, Kleuser B, Huwiler A, Pfeilschifter J. Glucocorticoids protect renal mesangial cells from apoptosis by increasing cellular sphingosine-1-phosphate. Kidney Int. 2010 May;77(10):870-9. doi: 10.1038/ki.2010.62.
  • Becker KA, Riethmuller J, Luth A, Doring G, Kleuser B, Gulbins E. Acid sphingomyelinase inhibitors normalize pulmonary ceramide and inflammation in cystic fibrosis. Am J Respir Cell Mol Biol. 2010 Jun;42(6):716-24. doi: 10.1165/rcmb.2009-0174OC.
  • Wolf NB, Kuchler S, Radowski MR, Blaschke T, Kramer KD, Weindl G, Kleuser B, Haag R, Schäfer-Korting M. Influences of opioids and nanoparticles on in vitro wound healing models. Eur J Pharm Biopharm. 2009 Sep;73(1):34-42. doi: 10.1016/j.ejpb.2009.03.009.
  • Reines I, Kietzmann M, Mischke R, Tschernig T, Luth A, Kleuser B, Baumer W. Topical application of sphingosine-1-phosphate and FTY720 attenuate allergic contact dermatitis reaction through inhibition of dendritic cell migration. J Invest Dermatol. 2009 Aug;129(8):1954-62. doi: 10.1038/jid.2008.454.
  • Nieuwenhuis B, Luth A, Chun J, Huwiler A, Pfeilschifter J, Schafer-Korting M, Kleuser B. Involvement of the ABC-transporter ABCC1 and the sphingosine 1-phosphate receptor subtype S1P(3) in the cytoprotection of human fibroblasts by the glucocorticoid dexamethasone. J Mol Med (Berl). 2009 Jun;87(6):645-57. doi: 10.1007/s00109-009-0468-x.
  • Japtok L, Kleuser B. The role of sphingosine-1-phosphate receptor modulators in the prevention of transplant rejection and autoimmune diseases. Curr Opin Investig Drugs. 2009 Nov;10(11):1183-94.
  • van der Giet M, Tolle M, Kleuser B. Relevance and potential of sphingosine-1-phosphate in vascular inflammatory disease. Biol Chem. 2008 Nov;389(11):1381-90. doi: 10.1515/BC.2008.165.
  • Schuppel M, Kurschner U, Kleuser U, Schafer-Korting M, Kleuser B. Sphingosine 1-phosphate restrains insulin-mediated keratinocyte proliferation via inhibition of Akt through the S1P2 receptor subtype. J Invest Dermatol. 2008 Jul;128(7):1747-56. doi: 10.1038/sj.jid.5701259.
  • Schafer-Korting M, Mahmoud A, Lombardi Borgia S, Bruggener B, Kleuser B, Schreiber S, Mehnert W. Reconstructed epidermis and full-thickness skin for absorption testing: influence of the vehicles used on steroid permeation. Altern Lab Anim 2008;36:441-452.
  • Lichte K, Rossi R, Danneberg K, ter Braak M, Kurschner U, Jakobs KH, Kleuser B, Meyer zu Heringdorf D. Lysophospholipid receptor-mediated calcium signaling in human keratinocytes. J Invest Dermatol. 2008 Jun;128(6):1487-98. doi: 10.1038/sj.jid.5701207.
  • Kleuser B, Malek D, Gust R, Pertz HH, Potteck H. 17-Beta-estradiol inhibits transforming growth factor-beta signaling and function in breast cancer cells via activation of extracellular signal-regulated kinase through the G protein-coupled receptor 30. Mol Pharmacol. 2008 Dec;74(6):1533-43. doi: 10.1124/mol.108.046854.
  • Tolle M, Levkau B, Kleuser B, van der Giet M. Sphingosine-1-phosphate and FTY720 as anti-atherosclerotic lipid compounds. Eur J Clin Invest 2007;37:171-179.
  • Stecova J, Mehnert W, Blaschke T, Kleuser B, Sivaramakrishnan R, Zouboulis CC, Seltmann H, Korting HC, Kramer KD, Schäfer-Korting M. Cyproterone acetate loading to lipid nanoparticles for topical acne treatment: particle characterisation and skin uptake. Pharm Res 2007;24:991-1000.
  • Keller CD, Rivera Gil P, Tolle M, van der Giet M, Chun J, Radeke HH, Schafer-Korting M, Kleuser B. Immunomodulator FTY720 induces myofibroblast differentiation via the lysophospholipid receptor S1P3 and Smad3 signaling. Am J Pathol 2007;170:281-292.
  • Herzinger T, Kleuser B, Schafer-Korting M, Korting HC. Sphingosine-1-phosphate signaling and the skin. Am J Clin Dermatol 2007;8:329-336.
  • Gornemann T, von Wenckstern H, Kleuser B, Villalon CM, Centurion D, Jahnichen S, Pertz HH. Characterization of the postjunctional alpha 2C-adrenoceptor mediating vasoconstriction to UK14304 in porcine pulmonary veins. Br J Pharmacol 2007;151:186-194.
  • von Wenckstern H, Zimmermann K, Kleuser B. The role of the lysophospholipid sphingosine 1-phosphate in immune cell biology. Arch Immunol Ther Exp (Warsz). 2006 Jul-Aug;54(4):239-51.
  • Malek D, Gust R, Kleuser B. 17-Beta-estradiol inhibits transforming-growth-factor-beta-induced MCF-7 cell migration by Smad3-repression. Eur J Pharmacol 2006;534:39-47.
  • Haberland A, Schreiber S, Maia CS, Rubbelke MK, Schaller M, Korting HC, Kleuser B, Schimke I, Schäfer-Korting M. The impact of skin viability on drug metabolism and permeation -- BSA toxicity on primary keratinocytes. Toxicol In Vitro 2006;20:347-354.
  • Fischer A, Muller D, Zimmermann-Kordmann M, Kleuser B, Mickeleit M, Laabs S, Löwe W, Cantagrel F, Reutter W, Danker K. The ether lipid inositol-C2-PAF is a potent inhibitor of cell proliferation in HaCaT cells. Chembiochem 2006;7:441-449.
  • Schafer-Korting M, Kleuser B, Ahmed M, Holtje HD, Korting HC. Glucocorticoids for human skin: new aspects of the mechanism of action. Skin Pharmacol Physiol 2005;18:103-114.
  • Sauer B, Gonska H, Manggau M, Kim DS, Schraut C, Schafer-Korting M, Kleuser B. Sphingosine 1-phosphate is involved in cytoprotective actions of calcitriol in human fibroblasts and enhances the intracellular Bcl-2/Bax rheostat. Pharmazie. 2005 Apr;60(4):298-304.
  • Radeke HH, von Wenckstern H, Stoidtner K, Sauer B, Hammer S, Kleuser B. Overlapping signaling pathways of sphingosine 1-phosphate and TGF-beta in the murine Langerhans cell line XS52. J Immunol 2005;174:2778-2786.
  • Xin C, Ren S, Kleuser B, Shabahang S, Eberhardt W, Radeke H, Schafer-Korting M, Pfeilschifter J, Huwiler A. Sphingosine 1-phosphate cross-activates the Smad signaling cascade and mimics transforming growth factor-beta-induced cell responses. J Biol Chem 2004;279:35255-35262.
  • Sauer B, Vogler R, Zimmermann K, Fujii M, Anzano MB, Schafer-Korting M, Roberts AB, Kleuser B.  Lysophosphatidic acid interacts with transforming growth factor-beta signaling to mediate keratinocyte growth arrest and chemotaxis. J Invest Dermatol 2004;123:840-849.
  • Sauer B, Vogler R, von Wenckstern H, Fujii M, Anzano MB, Glick AB, Schafer-Korting M, Roberts AB, Kleuser B. Involvement of Smad signaling in sphingosine 1-phosphate-mediated biological responses of keratinocytes. J Biol Chem 2004;279:38471-38479.
  • Olah Z, Trier U, Sauer B, Schafer-Korting M, Kleuser B. New chimera proteins for fluorescence correlation spectroscopy. Pharmazie 2004;59:516-523.
  • Nofer JR, van der Giet M, Tolle M, Wolinska I, von Wnuck Lipinski K, Baba HA, Tietge UJ, Gödecke A, Ishii I, Kleuser B, Schäfers M, Fobker M, Zidek W, Assmann G, Chun J, Levkau B. HDL induces NO-dependent vasorelaxation via the lysophospholipid receptor S1P3. J Clin Invest 2004;113:569-581.
  • Kim DS, Kim SY, Kleuser B, Schafer-Korting M, Kim KH, Park KC. Sphingosine-1-phosphate inhibits human keratinocyte proliferation via Akt/protein kinase B inactivation. Cell Signal 2004;16:89-95.
  • Hammer S, Sauer B, Spika I, Schraut C, Kleuser B, Schafer-Korting M. Glucocorticoids mediate differential anti-apoptotic effects in human fibroblasts and keratinocytes via sphingosine-1-phosphate formation. J Cell Biochem 2004;91:840-851.
  • Vogler R, Sauer B, Kim DS, Schafer-Korting M, Kleuser B. Sphingosine-1-phosphate and its potentially paradoxical effects on critical parameters of cutaneous wound healing. J Invest Dermatol 2003;120:693-700.
  • Spika I, Hammer S, Kleuser B, Korting HC, Schafer-Korting M. Transcriptional activity of potent glucocorticoids: relevance of glucocorticoid receptor isoforms and drug metabolites. Skin Pharmacol Appl Skin Physiol 2003;16:143-150.
  • Sauer B, Ruwisch L, Kleuser B. Antiapoptotic action of 1alpha,25-dihydroxyvitamin D3 in primary human melanocytes. Melanoma Res 2003;13:339-347.
  • Hammer S, Spika I, Sippl W, Jessen G, Kleuser B, Holtje HD, Schafer-Korting M. Glucocorticoid receptor interactions with glucocorticoids: evaluation by molecular modeling and functional analysis of glucocorticoid receptor mutants. Steroids 2003;68:329-339.
  • Ruwisch L, Schafer-Korting M, Kleuser B. An improved high-performance liquid chromatographic method for the determination of sphingosine-1-phosphate in complex biological materials. Naunyn Schmiedebergs Arch Pharmacol 2001;363:358-363.
  • Manggau M, Kim DS, Ruwisch L, Vogler R, Korting HC, Schafer-Korting M, Kleuser B. 1Alpha,25-dihydroxyvitamin D3 protects human keratinocytes from apoptosis by the formation of sphingosine-1-phosphate. J Invest Dermatol 2001;117:1241-1249.
  • Kleuser B, Maceyka M, Milstien S, Spiegel S. Stimulation of nuclear sphingosine kinase activity by platelet-derived growth factor. FEBS Lett 2001;503:85-90.
  • Alemany R, Kleuser B, Ruwisch L, Danneberg K, Lass H, Hashemi R, Spiegel S, Jakobs KH, Meyer zu Heringdorf D. Depolarisation induces rapid and transient formation of intracellular sphingosine-1-phosphate. FEBS Lett 2001;509:239-244.
  • Lange K, Kleuser B, Gysler A, Bader M, Maia C, Scheidereit C, Korting HC, Schäfer-Korting M. Cutaneous inflammation and proliferation in vitro: differential effects and mode of action of topical glucocorticoids. Skin Pharmacol Appl Skin Physiol 2000;13:93-103.
  • Trier U, Olah Z, Kleuser B, Schafer-Korting M. Fusion of the binding domain of Raf-1 kinase with green fluorescent protein for activated Ras detection by fluorescence correlation spectroscopy. Pharmazie 1999;54:263-268.
  • Gysler A, Kleuser B, Sippl W, Lange K, Korting HC, Holtje HD. Skin penetration and metabolism of topical glucocorticoids in reconstructed epidermis and in excised human skin. Pharm Res 1999;16:1386-1391.
  • Kleuser B, Cuvillier O, Spiegel S. 1Alpha,25-dihydroxyvitamin D3 inhibits programmed cell death in HL-60 cells by activation of sphingosine kinase. Cancer Res 1998;58:1817-1824.
  • Edsall LC, Van Brocklyn JR, Cuvillier O, Kleuser B, Spiegel S. N,N-Dimethylsphingosine is a potent competitive inhibitor of sphingosine kinase but not of protein kinase C: modulation of cellular levels of sphingosine 1-phosphate and ceramide. Biochemistry 1998;37:12892-12898.
  • Lange K, Gysler A, Bader M, Kleuser B, Korting HC, Schafer-Korting M. Prednicarbate versus conventional topical glucocorticoids: pharmacodynamic characterization in vitro. Pharm Res 1997;14:1744-1749.
  • Meister A, Kleuser BP, Ollert MW, Gercken G. Betaine generation in cardiac myocytes after adrenergic activation of phosphatidylcholine hydrolysis. J Mol Cell Cardiol 1996;28:1109-1118.
  • Kleuser B, Meister A, Sternfeld L, Gercken G. Measurement of phospholipase A2 and 1-alkylglycerophosphocholine acetyltransferase activities in stimulated alveolar macrophages by HPLC analysis of NBD-labeled ether lipids. Chem Phys Lipids 1996;79:29-37.
  • Cuvillier O, Pirianov G, Kleuser B, Vanek PG, Coso OA, Gutkind S, Spiegel S. Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate. Nature 1996;381:800-803.
  • Kleuser B, Schmidt N, Gercken G. Synthesis of 1-O-(alkyl)-sn-glycerols and fluorescently labeled analogs from 2,5-O-methylene-D-mannitol as precursor. Chem. Phys. Lipids 1993, 66: 111-121.