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Further collaborations

We have several collaborations with groups in the Chemistry Department of the University of Potsdam and the Fraunhofer-Institut für Angewandte Polymerforschung (IAP). All publications derived from these collaborations are listed below. For example, we have worked on the visualisation of a new type of self-assembling biopolymers in cooperation with Dr. Liang Qiu (IAP). The polymers have potential application in biomedicine as drug carriers, biosensors or as artifical reaction containers for enzymatically driven catalysis. They are produced by reversible-addition-fragmentation chain-transfer polymerisation (RAFT-polymerisation) of well defined glycopolymeres at the IAP and imaged at our facility using room temperature as well as cryo electron microscopy. We were able to differentiate different polymerisation states going from small spherical morphologies (~20 nm) to larger continuous wire-like structures (see pictures), lamella or micell-like morphologies (~300 nm).

Highly Ordered Glyco‐Inside Nano‐Assemblies
Photo: Thomas Bick
Different morphologies of glycol-inside nano assemblies obtained by RAFT dispersion polymerisation

Publications:

  1. Nabiyan, A., Esfandiari, M., Ruickoldt, J., Wendler, P., Kulak, N., Schlaad, H. Diblock Copolypeptoid Micelles as Platform for Aqueous Photoredox Cyanation of Arenes. Journal of the American Chemical Society (2025) 147 (32), 29152-29161. doi: 10.1021/jacs.5c07882 
  2. Bekir M, Schenderlein M, Ruickoldt J, Wendler P, Kohlbrecher J, Hoffmann I, Reifarth M. A photo-switchable surfactant possessing a spiropyran-moiety in its backbone - unravelling the structure of micelles with small-angle neutron scattering (SANS) and transmission electron microscopy (TEM). Chem Commun Apr 8;61(30):5585-5588. (2025) doi: 10.1039/d5cc00577a.
  3. Bapolisi, A.M., Lehnen, A.-C., Machatschek R., Mangiapia G., Mark E., Moulin J.F., Wendler, P., Hall S. C. L., and Hartlieb, M. Antimicrobial Polymers at the Membrane Interface: Impact of Macromolecular Architecture. Small 2406534(2024) doi:10.1002/smll.202406534
  4. Martin J, Michaelis M, Petrović S, Lehnen AC, Müllers Y, Wendler P, Möller HM, Hartlieb M, Glebe U. Application of Sortase-Mediated Ligation for the Synthesis of Block Copolymers and Protein-Polymer Conjugates. Macromol Biosci. 2024 Oct 3:e2400316. (2024) doi: 10.1002/mabi.202400316. 
  5. Bapolisi, A.M., Kielb, P., Bekir, M., Lehnen, A.-C., Radon, C., Laroque, S., Wendler, P., Müller-Werkmeister, H.M. and Hartlieb, M., Antimicrobial Polymers of Linear and Bottlebrush Architecture: Probing the Membrane Interaction and Physicochemical Properties. Macromol. Rapid Commun. (2022) https://doi.org/10.1002/marc.202200288
  6. Schwieters MS, Mathieu-Gaedke M, Westphal M, Dalpke R, Dirksen M, Qi D, Grull M, Bick T, Taßler S, Sauer DF, Bonn M, Wendler P, Hellweg T, Beyer A, Gölzhäuser A, Schwaneberg U, Glebe U, Böker A. (2021) Protein Nanopore Membranes Prepared by a Simple Langmuir-Schaefer Approach. Small. doi: 10.1002/smll.202102975.
  7. Qiu L., H. Zhang, T. Bick, J. Martin, P. Wendler, A. Böker, U. Glebe, C. Xing (2021) Construction of Highly Ordered Glyco-Inside Nano-Assemblies through RAFT Dispersion Polymerization of Galactose-decorated Monomer. Angew. Chem. Int. Ed. https://doi.org/10.1002/anie.202015692