Peer-Reviewed Artikel

Schell M, Wardelmann K, Hauffe R, Rath M, Chopra S, Kleinridders A.Lactobaccillus rhamnosus Sex-specifically Attenuates Depressive-like Behavior and Mitigates Metabolic Consequences in Obesity. Biological Psychiatry Global Open Science April 2023, Volume 3, Issue 2. DOI: 10.1016/j.bpsgos.2023.02.011

Martin H, Bullich S, Martinat M, Chataigner M. Di Miceli M, Simon V, Clark S, Butler J, Schell M, Chopra S, Chaoulof F, Kleinridders A, Cota D, De Deurwaerdere P, Pénicaud L, Layé S, Guiard BP, and Fioramonti X. Insulin modulates emotional behavior through a serotonin-dependent mechanism. Molecular Psychiatry October 2022. DOI: 10.1038/s41380-022-01812-3

Moraes RCM, Lima GCA, Cardinali CAEF, Gonçalves AC, Portari GV, Guerra-Shinohara EM, Leboucher A, Donato Júnior J, Kleinridders A, and da Silva Torrão A. Benfotiamine protects against hypothalamic dysfunction in a STZ-induced model of neurodegeneration in rats. Life Sciences October 2022, Volume 306, 120841. DOI: 10.1016/j.lfs.2022.120841

Hauffe R, Rath M, Agyapong W, Jonas W, Vogel H, Schulz TJ, Schwarz M, Kipp AP, Blüher M, and Kleinridders A. Obesity Hinders the Protective Effect of Selenite Supplementation on Insulin Signaling. Antioxidants April 2022,  11(5), 862. DOI: 10.3390/antiox11050862

Hauffe R, Rath M, Schell M, Ritter K,  Kappert K, Deubel S, Ott C, Jähnert M, Jonas W, Schürmann A, and Kleinridders A. HSP60 reduction protects against diet-induced obesity by modulating energy metabolism in adipose tissue. Molecular Metabolism November 2021, Volume 53, 101276. DOI: 10.1016/j.molmet.2021.101276

Welcker D, Stein C, Feitosa NM, Armistead J, Zhang J, Lütke S, Kleinridders A, Brüning JC, Eming SA, Sengle G, Niehoff A, Bloch W, and Hammerschmidt M. Hemicentin-1 is an essential extracellular matrix component of the dermal–epidermal and myotendinous junctions. Scientific Reports September 2021, 11 (17926). DOI: 10.1038/s41598-021-96824-4

Xiao X, Yeghiazaryan G, Hess S, Klemm P, Sieben A, Kleinridders A, Morgan DA, Wunderlich FT, Rahmouni K,  ong D, Scammell TE, Lowell BB, Kloppenburg P, Brüning JC , and Hausen AC. Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity. Nature Communications  September 2021, 12 (5249). DOI: 10.1038/s41467-021-25380-2 

Wardelmann K, Rath M, Castro JP, Blümel S, Schell M, Hauffe R, Schumacher F, Flore T, Ritter K, Wernitz A, Hosoi T, Ozawa K, Kleuser B, Weiß J, Schürmann A, and Kleinridders A. Central Acting Hsp10 Regulates Mitochondrial Function, Fatty Acid Metabolism, and Insulin Sensitivity in the Hypothalamus. Antioxidants 2021, 10(5), 711. DOI: 10.3390/antiox10050711

Schell M, Wardelmann K, Kleinridders A. Untangling the effect of insulin action on brain mitochondria and metabolism. J Neuroendocrinol. 2021 Jan 28;e12932. DOI: 10.1111/jne.12932

Wei X, Franke J, Ost M, Wardelmann K, Börno S, Timmermann B, Meierhofer D, Kleinridders A, Klaus S, Stricker S. Cell autonomous requirement of neurofibromin (Nf1) for postnatal muscle hypertrophic growth and metabolic homeostasis. J Cachexia Sarcopenia Muscle. 2020 Dec;11(6):1758-1778. DOI: 10.1002/jcsm.12632

 Kullmann S, Kleinridders A, Small DM, Fritsche A, Häring HU, Preissl H, Heni M. Central nervous pathways of insulin action in the control of metabolism and food intake. Lancet Diabetes Endocrinol. 2020 Jun;8(6):524-534. DOI: 10.1016/s2213-8587(20)30113-3

Hauffe R, Stein V, Chudoba C, Flore T, Rath M, Ritter K, Schell M, Wardelmann K, Deubel S, Kopp JF, Schwarz M, Kappert K, Blüher M, Schwerdtle T, Kipp AP, Kleinridders A. GPx3 dysregulation impacts adipose tissue insulin receptor expression and sensitivity. JCI Insight. 2020 Jun 4;5(11):136283. DOI: 10.1172/jci.insight.136283

Schell M, Chudoba C, Leboucher A, Alfine E, Flore T, Ritter K, Weiper K, Wernitz A, Henkel J, Kleinridders A. Interplay of Dietary Fatty Acids and Cholesterol Impacts Brain Mitochondria and Insulin Action. Nutrients. 2020 May 23;12(5):E1518. DOI: 10.3390/nu12051518

Fernando R, Wardelmann K, Deubel S, Kehm R, Jung T, Mariotti M, Vasilaki A, Gladyshev VN, Kleinridders A, Grune T, Castro JP. Low steady-state oxidative stress inhibits adipogenesis by altering mitochondrial dynamics and decreasing cellular respiration. Redox Biol. 2020 May;32:101507. DOI: 10.1016/j.redox.2020.101507

Henkel J, Buchheim-Dieckow K, Castro JP, Laeger T, Wardelmann K, Kleinridders A, Jöhrens K, Püschel GP. Reduced Oxidative Stress and Enhanced FGF21 Formation in Livers of Endurance-Exercised Rats with Diet-Induced NASH. Nutrients. 2019 Nov 8;11(11):2709. DOI: 10.3390/nu11112709

Chen S, Henderson A, Petriello MC, Romano KA, Gearing M, Miao J, Schell M, Sandoval-Espinola WJ, Tao J, Sha B, Graham M, Crooke R, Kleinridders A, Balskus EP, Rey FE, Morris AJ, Biddinger SB. Trimethylamine N-Oxide Binds and Activates PERK to Promote Metabolic Dysfunction. Cell Metab. 2019 Dec 3;30(6):1141-1151.e5. DOI: 10.1016/j.cmet.2019.08.021

Kleinridders A, Pothos EN. Impact of Brain Insulin Signaling on Dopamine Function, Food Intake, Reward, and Emotional Behavior. Curr Nutr Rep. 2019 Jun;8(2):83-91. DOI: 10.1007/s13668-019-0276-z

Wardelmann K, Blümel S, Rath M, Alfine E, Chudoba C, Schell M, Cai W, Hauffe R, Warnke K, Flore T, Ritter K, Weiß J, Kahn CR, Kleinridders A. Insulin action in the brain regulates mitochondrial stress responses and reduces diet-induced weight gain. Mol Metab. 2019 Mar;21:68-81. DOI: 10.1016/j.molmet.2019.01.001

Chudoba C, Wardelmann K, Kleinridders A. Molecular effects of dietary fatty acids on brain insulin action and mitochondrial function. Biol Chem. 2019 Feb 28. DOI: 10.1515/hsz-2018-0477

Henkel J, Alfine E, Saín J, Jöhrens K, Weber D, Castro JP, König J, Stuhlmann C, Vahrenbrink M, Jonas W, Kleinridders A, Püschel GP. Soybean Oil-Derived Poly- Unsaturated Fatty Acids Enhance Liver Damage in NAFLD Induced by Dietary Cholesterol. Nutrients. 2018 Sep 18;10(9):1326. DOI: 10.3390/nu10091326

Cai W, Xue C, Sakaguchi M, Konishi M, Shirazian A, Ferris HA, Li ME, Yu R, Kleinridders A, Pothos EN, Kahn CR. Insulin regulates astrocyte gliotransmission and modulates behavior. J Clin Invest. 2018 Jul 2;128(7):2914-2926. DOI: 10.1172/JCI99366

Castro JP, Wardelmann K, Grune T, Kleinridders A. Mitochondrial Chaperones in the Brain: Safeguarding Brain Health and Metabolism? Front Endocrinol (Lausanne). 2018 Apr 26;9:196. doi: 10.3389/fendo.2018.00196. DOI: 10.3389/fendo.2018.00196

Kleinridders A, Ferris HA, Reyzer ML, Rath M, Soto M, Manier ML, Spraggins J, Yang Z, Stanton RC, Caprioli RM, Kahn CR. Regional differences in brain glucose metabolism determined by imaging mass spectrometry. Mol Metab. 2018 Jun;12:113-121. DOI: 10.1016/j.molmet.2018.03.013

Cai W, Sakaguchi M, Kleinridders A, Gonzalez-Del Pino G, Dreyfuss JM, O'Neill BT, Ramirez AK, Pan H, Winnay JN, Boucher J, Eck MJ, Kahn CR. Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression. Nat Commun. 2017 Mar 27;8:14892. DOI: 10.1038/ncomms14892

Kleinridders A. Deciphering Brain Insulin Receptor and Insulin-Like Growth Factor 1 Receptor Signalling. J Neuroendocrinol. 2016 Nov;28(11):10.1111/jne.12433. DOI: 10.1111/jne.12433 

O'Neill BT, Lee KY, Klaus K, Softic S, Krumpoch MT, Fentz J, Stanford KI, Robinson MM, Cai W, Kleinridders A, Pereira RO, Hirshman MF, Abel ED, Accili D, Goodyear LJ, Nair KS, Kahn CR. Insulin and IGF-1 receptors regulate FoxO- mediated signaling in muscle proteostasis. J Clin Invest. 2016 Sep 1;126(9):3433-46. DOI: 10.1172/jci86522

Boucher J, Softic S, El Ouaamari A, Krumpoch MT, Kleinridders A, Kulkarni RN, O'Neill BT, Kahn CR. Differential Roles of Insulin and IGF-1 Receptors in Adipose Tissue Development and Function. Diabetes. 2016 Aug;65(8):2201-13. DOI: 10.2337/db16-0212

Jais A, Solas M, Backes H, Chaurasia B, Kleinridders A, Theurich S, Mauer J, Steculorum SM, Hampel B, Goldau J, Alber J, Förster CY, Eming SA, Schwaninger M, Ferrara N, Karsenty G, Brüning JC. Myeloid-Cell-Derived VEGF Maintains Brain Glucose Uptake and Limits Cognitive Impairment in Obesity. Cell. 2016 Aug 25;166(5):1338-1340. DOI: 10.1016/j.cell.2016.08.010

Gupta MK, Teo AK, Rao TN, Bhatt S, Kleinridders A, Shirakawa J, Takatani T, Hu J, De Jesus DF, Windmueller R, Wagers AJ, Kulkarni RN. Excessive Cellular Proliferation Negatively Impacts Reprogramming Efficiency of Human Fibroblasts. Stem Cells Transl Med. 2015 Oct;4(10):1101-8. DOI: 10.5966/sctm.2014-0217

Kleinridders A, Cai W, Cappellucci L, Ghazarian A, Collins WR, Vienberg SG, Pothos EN, Kahn CR. Insulin resistance in brain alters dopamine turnover and causes behavioral disorders. Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):3463-8. DOI: 10.1073/pnas.1500877112

Vienberg SG, Kleinridders A, Suzuki R, Kahn CR. Differential effects of angiopoietin-like 4 in brain and muscle on regulation of lipoprotein lipase activity. Mol Metab. 2014 Nov 13;4(2):144-50. DOI: 10.1016/j.molmet.2014.11.003

Boucher J, Charalambous M, Zarse K, Mori MA, Kleinridders A, Ristow M, Ferguson-Smith AC, Kahn CR. Insulin and insulin-like growth factor 1 receptors are required for normal expression of imprinted genes. Proc Natl Acad Sci U S A. 2014 Oct 7;111(40):14512-7. DOI: 10.1073/pnas.1415475111

Ussar S, Lee KY, Dankel SN, Boucher J, Haering MF, Kleinridders A, Thomou T, Xue R, Macotela Y, Cypess AM, Tseng YH, Mellgren G, Kahn CR. ASC-1, PAT2, and P2RX5 are cell surface markers for white, beige, and brown adipocytes. Sci Transl Med. 2014 Jul 30;6(247):247ra103. DOI: 10.1126/scitranslmed.3008490

Kleinridders A, Ferris HA, Cai W, Kahn CR. Insulin action in brain regulates systemic metabolism and brain function. Diabetes. 2014 Jul;63(7):2232-43. DOI: 10.2337/db14-0568

Boucher J, Kleinridders A, Kahn CR. Insulin receptor signaling in normal and insulin-resistant states. Cold Spring Harb Perspect Biol. 2014 Jan 1;6(1):a009191. DOI: 10.1101/cshperspect.a009191

Kleinridders A, Lauritzen HP, Ussar S, Christensen JH, Mori MA, Bross P, Kahn CR. Leptin regulation of Hsp60 impacts hypothalamic insulin signaling. J Clin Invest. 2013 Nov;123(11):4667-80. DOI: 10.1172/jci67615

Jing E, O'Neill BT, Rardin MJ, Kleinridders A, Ilkeyeva OR, Ussar S, Bain JR, Lee KY, Verdin EM, Newgard CB, Gibson BW, Kahn CR. Sirt3 regulates metabolic flexibility of skeletal muscle through reversible enzymatic deacetylation. Diabetes. 2013 Oct;62(10):3404-17. DOI: 10.2337/db12-1650

Könner AC, Hess S, Tovar S, Mesaros A, Sánchez-Lasheras C, Evers N, Verhagen LA, Brönneke HS, Kleinridders A, Hampel B, Kloppenburg P, Brüning JC. Role for insulin signaling in catecholaminergic neurons in control of energy homeostasis. Cell Metab. 2011 Jun 8;13(6):720-8. DOI: 10.1016/j.cmet.2011.03.021

Mende Y, Jakubik M, Riessland M, Schoenen F, Rossbach K, Kleinridders A, Köhler C, Buch T, Wirth B. Deficiency of the splicing factor Sfrs10 results in early embryonic lethality in mice and has no impact on full-length SMN/Smn splicing. Hum Mol Genet. 2010 Jun 1;19(11):2154-67. DOI: 10.1093/hmg/ddq094

Bailly-Maitre B, Belgardt BF, Jordan SD, Coornaert B, von Freyend MJ, Kleinridders A, Mauer J, Cuddy M, Kress CL, Willmes D, Essig M, Hampel B, Protzer U, Reed JC, Brüning JC. Hepatic Bax inhibitor-1 inhibits IRE1alpha and protects from obesity-associated insulin resistance and glucose intolerance. J Biol Chem. 2010 Feb 26;285(9):6198-207. DOI: 10.1074/jbc.m109.056648

Kleinridders A, Könner AC, Brüning JC. CNS-targets in control of energy and glucose homeostasis. Curr Opin Pharmacol. 2009 Dec;9(6):794-804. DOI: 10.1016/j.coph.2009.10.006

Kleinridders A, Schenten D, Könner AC, Belgardt BF, Mauer J, Okamura T, Wunderlich FT, Medzhitov R, Brüning JC. MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity. Cell Metab. 2009 Oct;10(4):249-59. DOI: 10.1016/j.cmet.2009.08.013

Ernst MB, Wunderlich CM, Hess S, Paehler M, Mesaros A, Koralov SB, Kleinridders A, Husch A, Münzberg H, Hampel B, Alber J, Kloppenburg P, Brüning JC, Wunderlich FT. Enhanced Stat3 activation in POMC neurons provokes negative feedback inhibition of leptin and insulin signaling in obesity. J Neurosci. 2009 Sep 16;29(37):11582-93. DOI: 10.1523/jneurosci.5712-08.2009

Yazdanpanah B, Wiegmann K, Tchikov V, Krut O, Pongratz C, Schramm M, Kleinridders A, Wunderlich T, Kashkar H, Utermöhlen O, Brüning JC, Schütze S, Krönke M. Riboflavin kinase couples TNF receptor 1 to NADPH oxidase. Nature. 2009 Aug 27;460(7259):1159-63. DOI: 10.1038/nature08206

Kleinridders A, Pogoda HM, Irlenbusch S, Smyth N, Koncz C, Hammerschmidt M, Brüning JC. PLRG1 is an essential regulator of cell proliferation and apoptosis during vertebrate development and tissue homeostasis. Mol Cell Biol. 2009 Jun;29(11):3173-85. DOI: 10.1128/mcb.01807-08

Remedi MS, Kurata HT, Scott A, Wunderlich FT, Rother E, Kleinridders A, Tong A, Brüning JC, Koster JC, Nichols CG. Secondary consequences of beta cell inexcitability: identification and prevention in a murine model of K(ATP)-induced neonatal diabetes mellitus. Cell Metab. 2009 Feb;9(2):140-51. DOI: 10.1016/j.cmet.2008.12.005

Spohn G, Kleinridders A, Wunderlich FT, Watzka M, Zaucke F, Blumbach K, Geisen C, Seifried E, Müller C, Paulsson M, Brüning JC, Oldenburg J. VKORC1 deficiency in mice causes early postnatal lethality due to severe bleeding. Thromb Haemost. 2009 Jun;101(6):1044-50. DOI: 10.1160/TH09-03-0204

Seibler J, Kleinridders A, Küter-Luks B, Niehaves S, Brüning JC, Schwenk F. Reversible gene knockdown in mice using a tight, inducible shRNA expression system. Nucleic Acids Res. 2007;35(7):e54. DOI: 10.1093/nar/gkm122