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Publikationen und Patente



Prüfer, M., Stanke, S., Bier, F. F., & Hölzel, R. (2023). Catalytic activity of glucose oxidase after dielectrophoretic immobilization on nanoelectrodes. Electrophoresis.


Zhang, X., Waffo, A. F. T., Yarman, A., Kovács, N., Bognár, Z., Wollenberger, U., El-Sherbiny, I.M.,  Hassan, R.Y.A., Bier, F.F., Gyurcsányi, R.E., Zebger, I., & Scheller, F. W. (2022). How an ACE2 mimicking epitope-MIP nanofilm recognizes template-related peptides and the Receptor Binding Domain of SARS-CoV-2. Nanoscale 14 (48), 18106-18114

Peter, H., Mattig, E., Guest, P. C., & Bier, F. F. (2022). Lab-on-a-Chip Immunoassay for Prediction of Severe COVID-19 Disease. Methods in molecular biology (Clifton, NJ), 2511, 235-244.

Prüfer, M., Wenger, C., Bier, F. F., Laux, E. M., & Hölzel, R. (2022). Activity of AC electrokinetically immobilized horseradish peroxidase. Electrophoresis, 43(18-19), 1920-1933.

Agarwal, S., Warmt, C., Henkel, J., Schrick, L., Nitsche, A., Bier, FF. (2022), Lateral flow-based nucleic acid detection of SARS-CoV-2 using enzymatic incorporation of biotin-labeled dUTP for POCT use. Anal Bioanal Chem. 2022 Jan 19:1–10. DOI: 10.1007/s00216-022-03880-4Epub ahead of print.

Stanke S, Wenger C, Bier FF, Hölzel R (2022) AC electrokinetic immobilization of influenza virus. Electrophoresis 43(12): 1309-13021, https://doi.org/10.1002/elps.202100324

Zsófia Bognár; Ester Supala; Aysu Yarman; Xiaorong Zhang; Frank F. Bier; Frieder W. Scheller; Róbert Ervin Gyurcsanyi (2022) "Peptide epitope-imprinted polymer microarrays for selective protein recognition. Application for SARS-CoV-2 RBD protein recognition". Chemical Sciences 13: 1263-1269  (if=9.825) doi.org/10.1039/D1SC04502D

Kruse, M., Möser, C., Smith, D. M., Müller‐Landau, H., Rant, U., Hölzel, R., & Bier, F. F. (2022). Measuring influenza A virus and peptide interaction using electrically controllable DNA nanolevers. Advanced Materials Technologies, 7(5), 2101141.


Bognár, Z., Supala, E., Yarman, A., Zhang, X., Bier, F.F., Scheller, F., Gyurcsányi, R.E. (2021), Peptide epitope-imprinted polymer microarrays for selective protein recognition. Application for SARS-CoV-2 RBD protein. Chem. Sci. Accepted Author Manuscript. DOI: 10.1039/D1SC04502D

Warmt, C., Fenzel, C. K., Henkel, J., Bier, F.F. (2021) Using Cy5-dUTP labelling of RPA-amplicons with downstream microarray analysis for the detection of antibiotic resistance genes. Scientific Reports, 11, 1, 1-9 (20137).

Kruse, M., Möser, C., Smith, D.M., Müller‐Landau, H., Rant, U., Hölzel, R., Bier, F.F. (2021) Measuring Influenza A Virus and Peptide Interaction Using Electrically Controllable DNA Nanolevers. Advanced Materials Technologies, DOI: 10.1002/admt.202101141.

Holenya, P., Lange, P.J., Reimer, U., Woltersdorf, W., Panterodt, T., Glas, M., Wasner, M., Eckey, M., Drosch, M., Hollidt, J.‐M., Naumann, M., Kern, F., Wenschuh, H., Lange, R., Schnatbaum, K. and Bier, F.F. (2021), Peptide microarray based analysis of antibody responses to SARS‐CoV‐2 identifies unique epitopes with potential for diagnostic test development. Eur. J. Immunol. doi: 10.1002/eji.202049101


Bier FF, Adams F (2020) Testen – aber wie? COVID-19-Diagnostik: Werttreiber für die Pandemiebewältigung. Plattform LifeSciences 2/2020, pp. 24-25.

Laux, E. M., Wenger, C., Bier, F. F., & Hölzel, R. (2020). AC electrokinetic immobilization of organic dye molecules. Analytical and Bioanalytical Chemistry 412, 3859-3870. doi: 10.1007/s00216-020-02480-4

Jnana, A., Muthuraman, V., Varghese, V. K., Chakrabarty, S., Murali, T. S., Ramachandra, L., Shenoy K.R., Rodrigues G.S., Prasad S. S: Dendukuri D., Morschhauser A., Nestler J., Peter H., Bier F.F., Satyamoorthy K. (2020). Microbial Community Distribution and Core Microbiome in Successive Wound Grades of Individuals with Diabetic Foot Ulcers. Applied and Environmental Microbiology 86(6). DOI: 10.1128/AEM.02608-19; PMID: 31924616


Kagel, H., Bier, F.F., Frohme, M., & Glökler, J.F. (2019). A novel optical Method to Reversibly control enzymatic Activity Based on photoacids. Scientific Reports, 9(1), 1-6.

Behm LVJ, Gerike S, Grauel MK, Uhlig K, Pfisterer F, Baumann W, Bier FF, Duschl C, Kirschbaum M (2019) Micropatterned Thermoresponsive Cell Culture Substrates for Dynamically Controlling Neurite Outgrowth and Neuronal Connectivity in Vitro. ACS Appl. Bio Mater.27: 2853-2861.                         

Kagel, H.; Jacobs, H.; Bier, F.F.; Glökler, J.; Frohme, M. (2019) A Novel Microtiter Plate Format High Power Open Source LED Array. Photonics 2019, 6, 17. doi:10.3390/photonics6010017

van Belkum A, Bachmann TT, et al. with the JPIAMR AMR-RDT Working Group on Antimicrobial Resistance and Rapid Diagnostic Testing (2019) Developmental roadmap for antimicrobial susceptibility testing systems. Nature Reviews Microbiology 17: 51–62. doi: 10.1038/s41579-018-0098-9


Laux EM, Bier FF, Hölzel R. (2017) Electrode-based AC electrokinetics of proteins: A mini-review. Bioelectrochemistry. 120: 76-82. doi: 10.1016/j.bioelechem.2017.11.010, PMID: 9182911

Laux EM, Bier FF, Hölzel R. (2018) Dielectrophoretic Stretching of DNA. Methods Mol Biol.; 1811:199-208. doi: 10.1007/978-1-4939-8582-1_14, PMID: 29926455

Kersting S, Rausch V, Bier FF, von Nickisch-Rosenegk M. (2018) A recombinase polymerase amplification assay for the diagnosis of atypical pneumonia. Analytical Biochemistry 550: 54-60 doi.org/ 10.1016/j.ab.2018.04.014                           

Laux EM, Ermilova E, Pannwitz D, Gibbons J, Bier FF, Hölzel R. (2018) Dielectric Spectroscopy of Biomolecules up to 110 GHz. Frequenz 2018: 2-6. doi.org/10.1515/freq-2018-0010      

Peter H, Bistolas N, Schumacher S, Laurisch C, Guest PC, Höller U and Bier FF (2018) Lab-on-a-Chip Device for Rapid Measurement of Vitamin D Levels. Methods Molecular Biology, 1735: 477–486, Paul C. Guest (Ed): Investigations of Early Nutrition Effects on Long-Term Health, 978-1-4939-7613-3, 434706_1_En, (35); PMID: 29380338

Nestler J, Peter H, Bier F (2018) Towards a Fully Integrated Lab-on-a-Chip. Optik&Photonik 1/2018: 2-5, www.photonicsviews.com

Knigge X, Wenger C, Bier FF, Hölzel R (2018) Dielectrophoretic Immobilisation of Nanoparticles as Isolated Singles in Regular Arrays. Journal of Physics D: Applied Physics; Article reference: JPhysD-115190.R1


Soria J, Acera A, Merayo-LLoves J, Durán JA, González N, Rodriguez S, Bistolas N, Schumacher S, Bier FF, Peter H, Stöcklein W, Suárez T. (2017) Tear proteome analysis in ocular surface diseases using label-free LC-MS/MS and multiplexed-microarray biomarker validation. Sci Rep. 7: 17478. doi: 10.1038/s41598-017-17536-2. PMID: 29234088                         

Connor D, Danckert L, Hoppe S, Bier FF, von Nickisch-Rosenegk M (2017) Epitope determination of immunogenic proteins of Neisseria gonorrhoeae.PLoS One. 12(7): e0180962. doi: 10.1371/journal.pone.0180962. PMID: 28723967                    

Peter H, Wienke J, Guest PC, Bistolas N, Bier FF. (2017) Lab-on-a-Chip Proteomic Assays for Psychiatric Disorders. in: Proteomic Methods in Neuropsychiatric Research, Adv Exp Med Biol. 974:339-349. doi: 10.1007/978-3-319-52479-5_33. PMID: 28353254

Fischbach J, Loh Q, Bier FF, Lim TS, Frohme M, Glökler J. (2017) Alizarin Red S for Online Pyrophosphate Detection Identified by a Rapid Screening Method. Sci Rep. 7: 45085. doi: 10.1038/srep45085. PMID: 28338022

Peter H, Wienke J, Bier FF. (2017) Lab-on-a-Chip Multiplex Assays. Methods Mol Biol.1546: 283-294. PMID: 27896778


Memczak H, Lauster D, Kar P, Di Lella S, Volkmer R, Knecht V, Herrmann A, Ehrentreich-Förster E, Bier FF, Stöcklein WFM (2016) Anti-Hemagglutinin Antibody Derived Lead Peptides for Inhibitors of Influenza Virus Binding. PLoS ONE 11(7): e0159074. doi:10.1371/journal.pone.0159074; PMID: 27415624                     

Bader D, Klier DT, Hettrich C, Bier FF and Wessig P (2016) Detecting carbohydrate-lectin interactions using a fluorescent probe based on DBD dyes. Anal. Methods, 8: 1235-1238, doi:10.1039/C5AY02991K

Laux EM, Knigge X, Wenger C, Bier FF, Hölzel R (2016) Aligned immobilization of proteins using AC electric fields.Small 12: 1514–1520, doi: 10.1002/smll.201503052. [Epub: 2016 Jan 18] PMID: 26779699

Connor DO; Zantow J; Hust M; Bier FF; von Nickisch-Rosenegk M (2016) Identification of Novel Immunogenic Proteins of Neisseria gonorrhoeae by Phage Display.PloS ONE11(2): e0148986 doi: 10.1371/journal.pone.0148986. PMID: 26859666

Georgi V, Georgi L, Blechert M, Bergmeister M, Zwanzig M, Wuestenhagen D, Bier FF, Kubick S (2016) On-chip automation of cell-free protein synthesis: New opportunities due to a novel reaction mode.Lab Chip. 16: 269-281. doi: 10.1039/c5lc00700c. PMID: 26554896                                 

Cruz H, Grasnick B, Dinger H, Bier F and Meinel C (2016) Early detection of acute kidney injury with Bayesian networks. Meinel C (Ed.) 7th International Symposium on Semantic Mining in Biomedicine SMBM16, pdfs.semanticscolars.org, e1-8


Ermilova E, Bier FF, Hölzel R (2015) Broadband dielectric investigation of aequeous DNA solutions in the higher GHz range. Eur. Biophys. J. 44, S154 (2015)      

Uyen NHP, Gajovic-Eichelmann N, Bier FF, Thanh NVK (2015) A Novel Method of Immobilizing Antigens on Gold Electrode for Immunosensing. Comm. Phys.   DOI: 10.15625/0868-3166/25/2/6239

Tanne J, Jeoung J-H, Peng L, Yarman A, Dietzel B, Schulz B, Schad D, Dobbek H, Wollenberger U, Bier FF, Scheller FW (2015) Direct Electron Transfer and Bioelectrocatalysis by a Hexameric, Heme Protein at Nanostructured Electrodes. Electroanalysis, 27: 1-7, publ. online: 14JUL2015 DOI: 10.1002/elan.201500231  

Laux EM, Knigge X, Bier FF, Wenger C, Hölzel R (2015) Dielectrophoretic immobilization of proteins: Quantification by atomic force microscopy.
Electrophoresis.  36: 2094-2101, online: 23May15. doi: 10.1002/elps.201500108. PMID: 26010162

Jeenduang N, Porntadavity S, von Nickisch-Rosenegk M, Bier FF, Promptmas C (2015) Two-dye based arrayed primer extension for simultaneous multigene detection in lipid metabolism. Clin Chim Acta. 442: 36-43. doi: 10.1016/j.cca.2015.01.005. PMID: 25591965

Tan C, Schenk JA, Gajovic-Eichelmann N, Sellrie F, Bier FF, (2015) A new one step antigen heterologous homogeneous fluorescence immunoassay for progesterone detection in serum. Talanta, 134: 508–513 online 6 Dec 2014, doi: 10.1016/j.talanta.2014.11.062. PMID: 25618701

Hüttl C, Hettrich C, Riedel M, Henklein, P, Rawel H, & Bier FF (2015). Development of peptide lysine dendrons: 1,3 dipolare cycloaddition for peptide coupling and antibody recognition. Chem Biol Drug Des. 85:565-73. doi: 10.1111/cbdd.12444. Epub 2014 Oct 28. PMID: 25290586


Wenger, C.; Knigge, X.; Fraschke, M.; Wolansky, D.; Kulse, P.; Kaletta, U.; Wolff, A.; Mehr, W.; Laux, E.; Bier, F. and Hölzel, R. (2014). Label-free Immobilization of Nano-particles on Silicon based Electrodes for Single-biomolecule Studies. In Proceedings of the International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2014) ISBN 978-989-758-013-0, pages 176-180. DOI: 10.5220/0004888101760180

Bier FF, Ehrentreich-Förster E, Schumacher S (2014) Smart Systems Integration in Bioanalysis: Convergence of Technologies for Point-of-Care Testing. Michel B. (ed.) Smart systems integration for micro- and nanotechnologies: honorary volume on the occasion of Thomas Gessner's 60th birthday, Dresden: goldenbogen Verlag, ISBN 978-3-932434-78-5 

Tanne J, Kracher D, Dietzel B, Schulz B, Ludwig R, Lisdat F, Scheller FW and Bier FF (2014) Carboxylated or Aminated Polyaniline — Multiwalled Carbon Nanotubes Nanohybrids for Immobilization of Cellobiose Dehydrogenase on Gold Electrodes. Biosensors 2014, 4(4), 370-386. doi:10.3390/bios4040370

Hoppe S, Bier FF, von Nickisch-Rosenegk M.(2014) Identification of Antigenic Proteins of the Nosocomial Pathogen Klebsiella pneumoniae. PLoS One 9(10): e110703. doi: 10.1371/journal.pone.0110703. PMID: 25333280

Hovestädt M, Memczak H, Pleiner D, Zhang X, Rappich J, Bier FF, Stöcklein WF. (2014) Characterization of a new maleimido functionalization of gold for surface plasmon resonance spectroscopy. J Mol Recognit. 27: 707-713. doi: 10.1002/jmr.2396. PMID: 25319618

Rapsch K, Bier FF, and von Nickisch-Rosenegk M, (2014) Rational design of artificial ß-strand forming antimicrobial peptides with biocompatible properties. Mol. Pharmaceutics, 11: 3492-502. doi: 10.1021/mp500271c. Epub 2014 Sep 22. PMID: 25192319

Dechtrirat D, Gajovic-Eichelmann N, Bier FF, Scheller FW. (2014) Hybrid Material for Protein Sensing Based on Electrosynthesized MIP on a Mannose Terminated Self-Assembled Monolayer. Advanced Functional Materials, 24: 2233-2239        

Ermilova E, Bier FF and Hölzel R (2014) Dielectric measurements of aqueous DNA solutions up to 110 GHz. Phys. Chem. Chem. Phys., 16: 11256-11264, Advance Article doi: 10.1039/C3CP55272A

Kersting S, Rausch V, Bier FF, von Nickisch-Rosenegk M. (2014) Multiplex isothermal solid-phase recombinase polymerase amplification for the specific and fast DNA-based detection of three bacterial pathogens. Microchimica Acta, 181: 1715-1723, doi 10.1007/s00604-014-1198-5

Danckert L, Hoppe S, Bier FF, von Nickisch-Rosenegk M (2014) Rapid identification of novel antigens of Salmonella Enteritidis by microarray-based immunoscreening. Microchimica Acta 181: 1707-1714, doi: 10.1007/s00604-014-1197-6

Tanne J, Dietzel B, Scheller FW and Bier F (2014) Nanohybrid Materials Consisting of Poly[(3-aminobenzoic acid)-co-(3-aminobenzenesulfonic acid)-co-aniline] and Multiwalled Carbon Nanotubes for Immobilization of Redox Active Cytochrome c. Electroanalysis 26: 732-738. doi: 10.1002/elan.201300526

Kersting S, Rausch V, Bier FF, von Nickisch-Rosenegk M. (2014) Rapid detection of Plasmodium falciparum with isothermal recombinase polymerase amplification and lateral flow analysis. Malaria J., 13:99. (e1-e9) doi: 10.1186/1475-2875-13-99

Kozma P, Kehl F, Ehrentreich-Förster E, Stamm C, Bier FF. (2014) Integrated planar optical waveguide interferometer biosensors: A comparative review. Biosens Bioelectron. 58C:287-307. doi: 10.1016/j.bios.2014.02.049

Dechtrirat D, Gajovic-Eichelmann N, Wojcik F, Hartmann L, Bier FF, Scheller FW. (2014) Electrochemical displacement sensor based on ferrocene boronic acid tracer and immobilized glycan for saccharide binding proteins and E. Coli. Biosens Bioelectron. 58C:1-8. doi: 10.1016/j.bios.2014.02.028

Füllbrandt M, Ermilova E, Asadujjaman A, Hölzel R, Bier FF, von Klitzing R, Schönhals A. (2014) Dynamics of Linear Poly(N-isopropylacrylamide) in Water around the Phase Transition Investigated by Dielectric Relaxation Spectroscopy. J Phys Chem B. 118: 3750-3759. doi: 10.1021/jp501325x

Schmitz-Hertzberg ST, Liese R, Terjung C, Bier FF (2014) Towards a Smart Encapsulation System for Small-Sized Electronic Devices: A New Approach. International Journal of Polymer Science Volume 2014, Article ID 713603, 12 pages. doi: 10.1155/2014/713603                                                            

Otto S, Kaletta U, Bier FF, Wenger C, Hölzel R, (2014) Dielectrophoretic immobilisation of antibodies on microelectrode arrays. Lab Chip. 14:998-1004. doi: 10.1039/c3lc51190a

Rapsch K, Bier FF, Tadros M, von Nickisch-Rosenegk M., (2014) Identification of antimicrobial peptides and immobilization strategy suitable for a covalent surface coating with biocompatible properties. Bioconjug Chem. 25:308-319. doi: 10.1021/bc4004469

Laux EM, Kaletta UC, Bier FF, Wenger C, Hölzel R. (2014) Functionality of dielectrophoretically immobilized enzyme molecules. Electrophoresis. 35:459-466. doi: 10.1002/elps.201300447

Scheller FW, Yarman A, Bachmann T, Hirsch T, Kubick S, Renneberg R, Schumacher S, Wollenberger U, Teller C, Bier FF (2014) Future of Biosensors: A Personal View. Adv Biochem Eng Biotechnol. 140:1-28. doi: 10.1007/10_2013_251


Schmitz-Hertzberg, S.-T., Mak, W.C., Lai, K.K., Teller, C. and Bier, F.F.(2013) Multifactorial design of poly(d,l-lactic-co-glycolic acid) capsules with various release properties for differently sized filling agents. Journal of Applied Polymer Science 130: 4219–4228. doi: 10.1002/app.39537

Brödel A.K., J.A. Raymond, J.G. Duman, F.F. Bier,S. Kubick (2013) Functional evaluation of candidate ice structuring proteins using cell-free expression systems. Journal of Biotechnology 163: 301–310. doi: 10.1016/j.jbiotec.2012.11.001

Kozma, P., A. Lehmann, K. Wunderlich, D. Michel, S. Schumacher, E. Ehrentreich-Förster, F.F. Bier(2013) A novel handheld fluorescent microarray reader for point-of-care diagnostic. Biosensors and Bioelectronics 47, 415–420. doi: 10.1016/j.bios.2013.03.043                    

Hoppe, S., Bier, F.F., & Nickisch-Rosenegk, M.V. (2013). Rapid Identification of Novel Immunodominant Proteins and Characterization of a Specific Linear Epitope of Campylobacter jejuni. PloS one, 8(5), e65837      

Hüttl, C., Hettrich, C., Miller, R., Paulke, B.R., Henklein, P., Rawel, H., & Bier, F.F. (2013). Self-assembled peptide amphiphiles function as multivalent binder with increased hemagglutinin affinity. BMC Biotechnology, 13(1), 51.

Sachse, R., Wüstenhagen, D., Šamalíková, M., Gerrits, M., Bier, F.F., & Kubick, S. (2013). Synthesis of membrane proteins in eukaryotic cell‐free systems. Engineering in Life Sciences, 13: 39-48. doi: 10.1002/elsc.201100235

Bier FF, Schumacher S. (2013) Integration in Bioanalysis: Technologies for Point-of-Care Testing. Adv Biochem Eng Biotechnol. 133: 1-14. doi: 0.1007/10_2012_164

Schumacher S, Lüdecke C, Ehrentreich-Förster E, Bier FF. (2013) Platform Technologies for Molecular Diagnostics Near the Patient's Bedside. Adv Biochem Eng Biotechnol. 133: 75-87. doi: 10.1007/10_2012_165


Heise, C., Ehrentreich‐Förster, E., & Bier, F. (2012). Dansyl, a fluorescent photoprotecting group for microarray applications. Journal of Chemical Technology and Biotechnology, 87: 1584-1592.

Linck, L., Reiß, E., Bier, F., & Resch-Genger, U. (2012). Direct labeling rolling circle amplification as a straightforward signal amplification technique for biodetection formats. Analytical Methods, 4: 1215-1220.

Bier, F.F. (2012). Nanobiotechnology for integration in bioanalysis. New Biotechnology, 29, S33.

Schumacher, S., Sartorius, D., Ehrentreich‐Förster, E., & Bier, F.F. Miniaturization for Point-of-Care analysis: Platform technology for almost every biomedical assay. The Journal of the International Federation of Clinical Chemistry and Laboratory Medicine 23: 1-6.

Wollenberger, U., Renneberg, R., Bier, F.F., & Scheller, F.W. (2012). Analytische Biochemie: Eine praktische Einfuhrung in das Messen mit Biomolekülen. Wiley-VCH.

Bier, F., & Roth, G. (2012). Expertenpanel-Bioanalytik-Biosensorik-und PCR-Innovationen. Laborwelt - das Themenheft von Transkript, (4), 16.

Bier FF. (2012) Biomoleküle vom Band - Neue biotechnologische Verfahren für die Herstellung hochwertiger Produkte. in: Beckmann D., Meister A. (eds.): Technische Systeme für die Lebenswissenschaften, Proc. 16. Heiligenstaedter Kolloquium 24.-26.9.2012. (ISBN: 978-3-00-039458-4) Abstract. pp.5-6

Stech M, Merk H, Schenk JA, Stöcklein WF, Wüstenhagen DA, Micheel B, Duschl C, Bier FF, Kubick S. (2012)  Production of functional antibody fragments in a vesicle-based eukaryotic cell-free translation system. J Biotechnol. 2012 Sep 7. pii: S0168-1656(12)00622-0. doi: 10.1016/j.jbiotec.2012.08.020

Hoppe S, Bier FF, von Nickisch-Rosenegk M. (2012) Microarray-based method for screening of immunogenic proteins from bacteria. J Nanobiotechnology. 10, 12. doi: org/10.1186

von Nickisch-Rosenegk M, Teschke T, Bier FF. (2012) Construction of an artificial cell membrane anchor using DARC as a fitting for artificial extracellular functionalities of eukaryotic cells. J Nanobiotechnology 10: e1 (1-7).

Schumacher S, Nestler J, Otto T, Wegener M, Ehrentreich-Förster E, Michel D, Wunderlich K, Palzer S, Sohn K, Weber A, Burgard M, Grzesiak A, Teichert A, Brandenburg A, Koger B, Albers J, Nebling E, Bier FF. (2012) Highly-integrated lab-on-chip system for point-of-care multiparameter analysis. Lab Chip. 12: 464-473. (Epub 2011 Oct 28)


Breitenstein M, Nielsen PE, Hölzel R, Bier FF. (2011) DNA-nanostructure-assembly by sequential spotting. J Nanobiotechnology 9: e54. (pp10)

Stanke S, Bier FF, Hölzel R. (2011) Fluid streaming above interdigitated electrodes in dielectrophoresis experiments. Electrophoresis 32: 2448-2455. doi: 10.1002/elps.201100096

Bier FFund Teller C(2011) Biosensoren der Zukunft - in vitro-Diagnostik im Point-of-Care-Format für die personaliserte Medizin, Karsten Conrad, Dirk Roggenbuck, Werner Lehmann, Uwe Schedler, Günter Peine (Hrsg.): Multi­para­meter­analytik in Forschung und Praxis, Pabst Publishers Lengerich 2011 ISBN 978-3-89967-703-4, pp. 185-188.

Bier FF, Schumacher S. (2011) Biosensoren der Zukunft: Patientennahe in vitro-Diagnostik für personalisierte Medizin. Public Health Forum, 19: 26.e1-26.e4.

Bier FF. (2011) Autonomous Biosensors – Technologies that help to bring biomarkers to the patient. Clinical Chemistry and Laboratory Medicine, 49 Suppl. 1: S158.

Reiß E, Hölzel R, Bier FF. (2011) Preparation of DNA Nanostructures with Repetitive Binding Motifs by Rolling Circle Amplification. Methods Mol Biol. 749:151-168.


Nestler J, Otto T, Sommer J-P, Michel B, Gessner T, Bier FF (2010) Self-contained microfluidic cartridges for in-vitro diagnostic applications: Recent advances and improvements. Gessner T (ed.) Smart Systems Integration 2010 4th European Conference & Exhibition on Integration Issues of Miniaturized Systems – MEMS, MOEMS, ICs and Electronic Components, 23-24 March 2010, Como, Italy, VDE VERLAG, ISBN: 978-3-8007-3208-1

Tan C, Gajovic-Eichelmann N, Polzius R, Hildebrandt N, Bier FF. (2010) Direct detection of Δ9-tetrahydrocannabinol in aqueous samples using a homogeneous increasing fluorescence immunoassay (HiFi). Anal Bioanal Chem. 398(5): 2133-2140.

Henning, A.; Bier, F.F.; Hölzel, R. (2010) Dielectrophoresis of DNA: Quantification by impedance measurements. Biomicrofluidics 4, 022803 (9 pp.).

Nestler J, Morschhauser A, Otto T, Koger B, Brandenburg A, Wunderlich K, Ehrentreich-Förster E, Bier FF, Gessner T (2010) Highly integrated, low-cost in-vitro diagnostic platform for miniaturized assay development. µTAS 2010: 1223-1225.

Breitenstein M, Holzel R, Bier FF (2010) Immobilization of different biomolecules by atomic force microscopy. J Nanobiotechnology. 8, 10. doi: 10.1186/1477-3155-8-10

Grießner M, Hartig D, ChristmannA, Ehrentreich-Förster E, Warsinke A, Bier FF (2010) Surface regeneration of microfluidic microarray printheads through plasma techniques. J Micromech Microeng 20, 037002 (5pp) doi:10.1088/0960-1317/20/3/037002

Tan C, Gajovic-Eichelmann N, Stöcklein WF, Polzius R, Bier FF. (2010) Direct detection of Delta9-tetrahydrocannabinol in saliva using a novel homogeneous competitive immunoassay with fluorescence quenching. Anal Chim Acta.  658:187-192.


Andresen D, von Nickisch-Rosenegk M, Bier FF. (2009) Helicase-dependent amplification: use in OnChip amplification and potential for point-of-care diagnostics. Expert Rev Mol Diagn. 9:645-650.

Grießner M, Bröker P, Lehmann A, Ehrentreich-Förster E, Bier FF. (2009) Detection of angiotensin II type 1 receptor ligands by a cell-based assay. Anal Bioanal Chem. 395: 1937-1940.

Reiss E, Hölzel R and Bier FF (2009) Synthesis and Stretching of Rolling Circle Amplification Products in a Flow-Through System. Small 5: 2316-2322.

Andresen D, von Nickisch-Rosenegk M, Bier FF (2009) Helicase dependent OnChip-amplification and its use in multiplex pathogen detection. Clin Chim Acta 403: 244-248.

Andresen H, Bier FF (2009) Peptide microarrays for serum antibody diagnostics. Methods Mol Biol. 2009; 509: 123-34

Nagel, T., Ehrentreich-Förster, E., Bier, F.F. (2009) Label-free Serodiagnosis on a Grating Coupler. Methods Mol Biol. 2009; 503: 189-200.


Fritzsche, W., & Bier, F. (2008). DNA-based nanodevices: international symposium on DNA-based nanodevices. In American Institute of Physics Conference Series (Vol. 1062).

Bier FF and Hölzel R (2008) Introduction: Nucleic Acid Based Nanostructures —Recent Advancements and the Impact of NUCAN. AIP Conf. Proc. 1062: 3-12.

Breitenstein M, Christmann A, Hölzel R, and Bier FF (2008) Preparation of Nano-Arrays by an Atomic Force Microscope. AIP Conf. Proc. 1062: 43-48.

Henning A, Henkel J, Bier FF and Hölzel R (2008) Label-free electrical quantification of the dielectrophoretic response of DNA, PMC Biophysics 2008: 1-4. doi:10.1186/1757-5036.1-4

Ehrentreich-Förster, E., Orgel, D., Krause-Griep, A., Cech, B., Erdmann, V.A., Bier, F., Scheller F.W. and Rimmele, M. (2008) Biosensor-based on-site explosives detection using aptamers as recognition elements. Anal Bioanal Chem. 391: 1793-1800.

von Nickisch-Rosenegk M, Marschan X, Andresen D, Bier FF. (2008) Reverse transcription-polymerase chain reaction on a microarray: the integrating concept of "active arrays". Anal Bioanal Chem. 391:1671-1678.

Nagel T, Gajovic-Eichelmann N, Tobisch S, Schulte-Spechtel U, Bier FF. (2008) Serodiagnosis of Lyme borreliosis infection using surface plasmon resonance. Clin Chim Acta. 394(1-2):110-113.

Bier FF, von Nickisch-Rosenegk M, Ehrentreich-Förster E, Reiss E, Henkel J, Strehlow R, Andresen D. (2008) DNA microarrays. Adv Biochem Eng Biotechnol. 109:433-453.

Bier F und Hartwig K (2008) BioMicrosystem Technologies (bioMST) - Enabler for a More Individual Medicine, mstNEWS, 1/08: 6-8.

Nagel, T., Ehrentreich-Förster, E., Singh, M., Schmitt, K., Brandenburg, A., Berka, A., Bier, F. F. (2008) Direct Detection of Tuberculosis Infection in Blood Serum using three Optical Label-free Approaches. Sensors and Actuators B: Chemical 129: 934-940.


Bier, F.F., Andresen, D. (2007) Technical Challenges in Hardware Development for Modern in vitro Diagnostics and the Point of Care Testing. BioTOPics, Journal of Biotechnologie in Berlin-Brandenburg, 32, 14-15.

Antwerpen, M. H., Schellhase, M., Ehrentreich-Förster, E., Bier, F., Witte, W., Nübel, U. (2007) DNA Microarray for Detection of Antibiotic Resistance Determinants in Bacillus Anthracis and closely related Bacillus Cereus. Molecular and Cellular Probes, 21: 152-160.


Ruf H.H., Knoll T., Misiakos K., Haupt R.B., Denninger M., Larsen L.B, Petrou P.S., Kakabakos S.E., Ehrentreich-Förster E., Bier F.F., (2006) Biochip-compatible packaging and micro-fluidics for a silicon opto-electronic biosensor. Microelectronic Engineering 83, 1677-1680.

Du, M.-L., Bier F.F. and Hölzel R. (2006) Quantifying DNA-Electrophoresis, in: Fritzsche, W. (ed.) DNA-Based Nanoscale Integration. AIP Conf. Proc. 859, 65-72.

Reiß E., Hölzel R., von Nickisch‐Rosenegk M., and Bier F.F. (2006) Rolling Circle Amplification For Spatially Directed Synthesis Of A Solid Phase Anchored Single‐Stranded DNA Molecule. AIP Conference Proceedings 859, 25-30. doi: 10.1063/1.2360583

Andresen H, Zarse K, Grötzinger C, Hollidt JM, Ehrentreich-Förster E, Bier FF, Kreuzer OJ. (2006) Development of peptide microarrays for epitope mapping of antibodies against the human TSH receptor. J Immunol Methods 315(1-2):11-18.

Andresen H, Grötzinger C, Zarse K, Kreuzer OJ, Ehrentreich-Förster E, Bier FF. (2006) Functional peptide microarrays for specific and sensitive antibody diagnostics. Proteomics. 6: 1376-1384.

Bier, FF, Andresen D, Walter A (2006) DNA Based Bio–Micro-Electronic Mechanical Systems. in: G. Urban (ed.) BioMEMS, Springer, NewYork Heidelberg, pp. 167-198.

Andresen H, Grötzinger C, Zarse K, Birringer M., Hessenius C., Kreuzer OJ, Ehrentreich-Förster E, Bier FF. (2006). Peptide Microarrays with site-specifically immobilized synthetic Peptides for Antibody Diagnostics. Sensors & Actuators B 113, 655-663.

Hölzel R, Calander N, Chiragwandi Z, Willander M, Bier FF. (2006) Trapping single molecules - Holzel et al. Reply: Phys Rev Lett. 96: 199802.

Heise C, Bier FF (2006) Immobilization of DNA on Microarrays. Top Curr Chem 261: 1–25; DOI 10.1007/128_007           


Misiakos K, Petrou PS, Kakabakos SE, Ruf HH, Ehrentreich-Förster E and Bier FF (2005) A bioanalytical microsystem for protein and DNA sensing based on a monolithic silicon optoelectronic transducer. J. Phys.: Conf. Ser. 10 273-276.

Hölzel R, Calander N, Chiragwandi Z, Willander M, Bier FF. (2005) Trapping single molecules by dielectrophoresis. Phys Rev Lett. 95: 128102.

von Nickisch-Rosenegk M, Ehrentreich-Förster E, Strehlow R, Christmann A, Bier FF. (2005) Chemically synthesized zinc finger molecules as nano-addressable probes for double-stranded DNAs. J Nanobiotechnology. 3: 5.

Steffen J, von Nickisch-Rosenegk M, Bier FF. (2005) In vitro transcription of a whole gene on a surface-coupled template. Lab Chip. 5: 665-668.

Bier, F.F. (2005) Microsystems in Biotechnology. mstnews (Mikrosystem-Nachrichten des VDI), S I/05 – 22.

Gajovic-Eichelmann N., F.F. Bier, (2005) „Nanobiotechnologie“. In: Handbuch Biotechnologie (Herausg. Franken, Kroth, Lippert, Peine, Ratzel), Economica Verlag, Heidelberg, CV3510 S.1-28.

Steffen J, von Nickisch-Rosenegk M, Bier FF. (2005), „RNA- und Proteinsynthese auf Oberflächen“. Online-Veröffentlichung in der Aktuellen Wochenschau der GDCh Fachgruppe Analytische Chemie. www.aktuelle-wochenschau.de/woche37/woche37.html

Gajovic-Eichelmann N., F.F. Bier (2005) Novel Electrochemical Assay for H2O2 Determination in Aqueous Solutions: A Non Time-Critical Method for H2O2 Trace Level Detection. Electroanalysis 17: 1043-1050.

von Nickisch-Rosenegk M., X. Marschan, D. Andresen, A. Abraham, C. Heise and F.F. Bier (2005) On-chip PCR amplification of very long templates using immobilized primers on glassy surfaces. Biosensors & Bioelectronics 20, 1491-1498. doi:10.1016/j.bios.2004.07.007  


Hölzel R. and Bier F.F. (2004) Monitoring Dielectrophoretic Collection of DNA by Impedance Measurement, in: Fritzsche, W. (ed.) DNA-Based Molecular Electronics. AIP Conf. Proc. 725, 77-83.

Schwonbeck S., A. Krause-Griep, N. Gajovic-Eichelmann, E. Ehrentreich-Förster, W. Meinl, H. Glatt and F.F. Bier (2004) Cohort analysis of a single nucleotide polymorphism on DNA chips. Biosensors & Bioelectronics 20, 956-966.  doi:10.1016/j.bios.2004.06.012

Nübel U., P.M. Schmidt, E. Reiß, F. Bier, W. Beyer, D. Naumann (2004) Oligonucleotide microarray for identification of Bacillus anthracis based on intergenic transcribed spacers in ribosomal DNA. FEMS Microbiology Letters, 240, 215-223. doi: 10.1016/j.femsle.2004.09.042

Hölzel R. und Bier F.F. Dielectrophoresis of DNA, in: Zimmermann U. (Ed) Dielectrophoresis, 2004.

Ehrentreich-Förster E., C. Heise, N. Gajovic-Eichelmann, S. Schwonbeck, P.-M. Schmidt, F. F. Bier (2004) Biochips – Einsatzmöglichkeiten im Laboralltag. Laborpraxis – Journal für Labor, Analytik und Life Science 16–18, 28.

Bier F.F., E. Ehrentreich-Förster, P.M. Schmidt (2004) Trends. Real-time analysis on microarrays. Analytical and Bioanalytical Chemistry 378:52-53. doi: 10.1007/s00216-003-2375-2

Scheller FW, Bier FF. (2004) Analytical biochemistry, Editorial Anal Bioanal Chem. 378, 1 – 2. doi: 10.1007/s00216-003-2239-9


Hölzel R. und Bier F.F. (2003) Stretching DNA in AC fields. IEE Proc.-Nanotechnol., 150, 47-53. doi 10.1049/ip-nbt:20031006

Wollenberger, U, Renneberg R, Bier FF, Scheller FW, (2003) Analytische Biochemie – Eine praktische Einführung in das Messen mit Biomolekülen. VCH Wiley, Weinheim 2003, pp 312.

Ehrentreich-Förster E., S. Schwonbeck, P.-M. Schmidt, F. F. Bier (2003) Kinetische Analyse im Mikroarrayformat (Biochips). Nachrichten aus der Chemie 2003/10, 1106-1111.

Scheller F.W. und Bier F.F. (2003) Biosensoren, in: Enzyklopädie Naturwissenschaft und Technik, 8. Ergänzungslieferung, ecomed Verlag, Landsberg/Lech, pp 1-6.

Gajovic-Eichelmann N., Ehrentreich-Förster E., Bier F.F. (2003) Directed immobilization of nucleic acids at ultramicroelectrodes using a novel elctrodeposited polymer. Biosensors & Bioelectronics 19, 417-422.

Hölzel R., Gajovic-Eichelmann N., Bier F.F. (2003) Oriented and vectorial immobilization of linear M13 dsDNA between interdigitated electrodes - towards single molecule DNA nanostructures. Biosensors & Bioelectronics 18, 555-564.

Ehrentreich-Förster, E., F.W. Scheller, F.F. Bier (2003) Detection of steroids in whole blood samples. Biosensors & Bioelectronics 18, 375-380.


Schmidt P.M., Lehmannn, C., Matthes E. and Bier F.F. (2002) Detection of activity of telomerase in tumor cells using fibre optical biosensors. Biosensors & Bioelectronics, 17, 1081-1087.

Schmidt P.M., Matthes E., Scheller F.W., Bienert M., Ehrlich A. and Bier F.F. (2002) Real-time determination of telomerase activity in cell extracts using an optical biosensor. Biological Chemistry, 383, 1659-1666.

Bier, F.F., Kleinjung F., Schmidt P.M., and Scheller F.W. (2002) Determination of the turn-over number of the restriction endonuclease EcoRI using evanescent wave technology. Analytical and Bioanalytical Chemistry 372: 308-313.

Bier F.F., Gajovic-Eichelmann N., Hölzel R. (2002) Oriented Immobilization of Single DNA Molecules as a Nanostructuring Tool. In: Fritzsche, W. (ed.) DNA-Based Molecular Construction. AIP Conf. Proc. 640, 51-59.

Scheller F.W., Bauer. C.G., Makower A., Wollenberger U., Warsinke A., Bier F.F. (2002) Immunoassays using enzymatic amplification electrodes. In Gizeli E. and Lowe C.R. (eds.) Biomolecular Sensors, Taylor and Francis, London, New York 2002, pp. 207-238.

Bier, F.F. and R. Schmauder (2002) Nanometer addressable lateral surface structuring by use of nucleic acids, in Hoffmann, K.-H.(ed.): Coupling of Electronical and Biological Systems. Springer-Verlag, Berlin, Heidelberg 2002, pp. 23-28.


Bier F.F., und Kleinjung F. (2001) Feature-size limitations of microarray technology – a critical review. Fresenius´ Journal of Analytical Chemistry,371: 151-156.

Scheller F.W., C.G. Bauer, A. Makower, U. Wollenberger, A. Warsinke, F.F. Bier (2001) Coupling of immunoassays with enzymatic recycling electrodes. Analytical Letters, 34: 1233-1245.

Schmidt PM., E. Matthes, F. W. Scheller, F.F. Bier (2001) Nachweis der Telomeraseaktivität in Zellkulturen mittels faseroptischen Sensors. BIOspektrum, 7(5): 51-55.


Ehrentreich-Förster E., Kleinjung F., Bier F.F. (2000) Genanalytik Spezial: „Probleme und Lösungen“. BIOforum,23, 560.


Bier F.F., F. Kleinjung, E. Ehrentreich-Förster, F.W. Scheller (1999) Changing functionality of surfaces by directed self-assembly using oligonucleotides – the Oligo-Tag. BioTechniques 27, 752 – 760.


Scheller F.W., Kleinjung F., Bier F.F., Makower A., Neumann B., Wollenberger U., Kurochkin I., Eremenko A., Barmin A., Klußmann S., Fürste J.-P., Erdamnn V.A. und Mansuy D. (1998) New recognition Elements in Biosensing. Enzyme Engineering XIV, Ann. N. Y. Acad. Sci. 864, 37-45.

Kleinjung F., Klußmann S., Erdmann V.A., Scheller F.W., Fürste J.P. und Bier F.F. (1998) High affinity RNA as molecular recognition elements in biosensors. Analytical Chemistry 70, 328-331.

Bilitewski U., Bier F.F., Brandenburg A. (1998) Immunobiosensors based on grating couplers. In: Affinity Biosensors - Techniques andProtocols (K.R. Rogers, A. Mulchandani, Eds.) Humana Press, Totowa, 121-134.


Stöcklein WMF, Makower A, Bier FF, Scheller FW (1997) Enzyme sensors and enzyme amplifification systems. Biocybernetics and biomedical engineering 16,109 – 117.

Makower A., Barmin A., Morzunova T., Eremenko A., Kurochkin I., Bier F.F. und Scheller F.W. (1997) Affinity enzymometric assay for direct detection of phosphororganic compounds. Analytica Chimica Acta 357, 13-20.

Kleinjung, F., F. F. Bier, A. Warsinke und F. W. Scheller (1997) Fibre-optic genosensor for specific determination of femtomolar DNA oligomers. Analytica Chimica Acta 350, 51-59.

Bier, F. F., E. Ehrentreich-Förster, R. Dölling, A.V. Eremenko und F.W. Scheller (1997) A redox-label immunosensor on basis of a bi-enzyme electrode. Analytica Chimica Acta, 344, 119-124.

Bier F.F., F. Kleinjung und F.W. Scheller (1997) Real time measurement of nucleic acid hybridization using evanescent wave sensors - steps towards the genosensor. Sensors and Actuators B, 38-39, 78-82.

Bier F.F., Fürste J.P., Kleinjung F. Erdmann V.A., Scheller F.W. (1997) Nucleinsäuren als Basis für Biosensoren. BIOforum, 20/6, 251-255.

Polzius, R., E. Dießel, F.F. Bier und U. Bilitewski (1997) Real-time observation of affinity reactions using grating couplers: Determination of the detection limit and calculation of kinetic rate constants. Analytical Biochemistry 248, 269-276.

Scheller F.W., Bier, F.F., Gajovic, N., (1997) Biosensoren und Teststreifen für die Umwelt- und Lebensmittelanalytik. Lebensmittel- und Biotechnol. 1997/3, 95-97.

Bier F.F. und J.P. Fürste, (1997) Nucleic acid based sensors. In: Frontiers in Biosensorics (F.W. Scheller, F. Schubert und J. Fedrowitz, Hrsg.), Bd. 1, Birkhäuser, Basel 1997, S. 97-120.


Bauer, C.G., A.V. Eremenko, E. Ehrentreich-Förster, F.F. Bier, A. Makower, W.R. Heineman und F.W. Scheller (1996) Zeptomole-detecting biosensor for Alkaline Phosphatase in an electrochemical immunoassay for 2,4-dichlorophenoxyacetic acid. Analytical Chemistry 68, 2453-2458.

Bier, F.F. und F.W. Scheller (1996) Label-free observation of DNA-hybridisation and endonuclease activity on a wave guide surface using a grating coupler. Biosensors & Bioelectronics 11, 669-674.

Bier, F.F., E. Ehrentreich-Förster, C.G. Bauer und F.W. Scheller (1996) High sensitive competitive immunodetection of 2,4-dichlorophenoxyacetic acid using enzymatic amplification with electrochemical detection. Fresenius J. Anal. Chem. 354, 861-865.

Bier, F.F., E. Ehrentreich-Förster, A. Makower und F.W. Scheller (1996) An enzyme amplification cycle for high sensitive immunoassay for thyroid stimulating hormone (TSH). Analytica Chimica Acta 328, 27-32.

Bier, F.F., E. Ehrentreich-Förster und F.W. Scheller (1996) Amplifying bi-enzyme cycle linked immunoassays for determination of 2,4-dichlorophenoxyacetic acid. Enzyme Engineering XIII, Ann. N. Y. Acad. Sci. 799, 519-524.

Bier, F.F., E. Förster, F.W. Scheller, A. Makower, A. Eremenko, U. Wollenberger, C. Bauer, D. Pfeiffer und N. Michael (1996) Ultrasensitive Biosensors. Sensors and Actuators B 33, 5-12.

Wittmann, C., F.F. Bier, S.A. Eremin und R.D. Schmid (1996) Quantitative analysis of 2,4-dichlorophenoxyacetic acid in water samples by two immunosensing methods. Journal of Agricultural and Food Chemistry 44, 343-350.

Brandenburg, A., R. Polzius, F.F. Bier, U. Bilitewski und E. Wagner (1996) Direct observation of affinity reactions by reflected mode operation of integrated optical grating coupler. Sensors and Actuators B 30, 55-59.

Polzius, R., Th. Schneider, F.F. Bier, U. Bilitewski und W. Koschinski (1996) Optimization of biosensing using grating couplers: immobilization on tantalum oxide waveguides. Biosensors & Bioelectronics 11, 503-514.

Jin, W., U. Wollenberger, F.F. Bier, A. Makower und F.W. Scheller (1996) Electron transfer between cytochrome c and copper enzymes. Bioelectrochemistry and Bioenergetics 39, 221-225.


Jin, W., F. Bier, U. Wollenberger und F. Scheller (1995) Construction and characterization of a multi-layer enzyme electrode: Covalent binding of quinoprotein glucose dehydrogenase. Biosensors & Bioelectronics 10, 823-829.

Scheller F.W., F. Schubert und F.F. Bier, (1995) Vom Biosensor zur Nanobiotechnologie. In: Berichte und Abhandlungen der Berlin-Brandenburgischen Akademie der Wissenschaften, Bd. 1, Akademie Verlag, Berlin 1995, S. 103-118.

Scheller, F.W., A. Makower, A.L. Ghindilis, F.F. Bier, E. Förster, U. Wollenberger, C. Bauer, B. Micheel, D. Pfeiffer, J. Szeponik, N. Michael und H. Kaden (1995) Enzyme sensors for subnanomolar concentrations. Biosensor and Chemical Sensor Technology. Process Monitoring and Control (K.R. Rogers, A. Mulchandani, W. Zhou eds.), ACS Symp. Ser. 613, 70-81.

Song, M.I., Bier, F.F. und Scheller, F. W. (1995) A method to detect superoxide radicals using Teflon membrane and superoxide dismutase. Bioelectrochemistry and Bioenergetics 38, 419-422.

Scheller, F.W., A. Makower, F. Bier, U. Wollenberger, A. Ghindilis, A. Eremenko und D. Pfeiffer (1995) Enzymsensoren zur Bestimmung subnanomolarer Konzentrationen. GIT - Fachzeitschrift für das Laboratorium 39, 560-561.

Scheller, F.W., F.F. Bier und D. Pfeiffer (1995) Biosensoren: Grundlagen und Anwendungen. Technisches Messen 62, 213-219.

Bier, F.F., W.F.M. Stöcklein, E. Ehrentreich-Förster und F.W. Scheller (1995) Immunosensing of 2,4-dichlorophenoxyacetic acid using biochemical amplification. Influence of organic solvent on binding observed by evanescent field technology. Proc. SPIE 2504, 153-158.

Ghindilis, A.L., A. Makower, C.G. Bauer, F.F. Bier und F.W. Scheller (1995) Determination of p-aminophenol and catecholamine s at picomolar concentrations based on recycling enzyme amplification. Analytica Chimica Acta 304, 25-31.


Neumann B., F.W. Scheller und F.F. Bier, (1994) Biosensoren. In: Bioindikation in aquatischen Ökosystemen (G. Gunkel, Hrsg.), Kap. 4.1.9, Gustav Fischer, Jena 1994, S. 380-386.

Bier, F.F., R. Jockers und R.D. Schmid (1994) Integrated optical immunosensors for s-triazine determination: Regeneration, calibration and limitations. Analyst (London) 119, 437-441.

Bier, F.F. und R.D. Schmid (1994) Real time analysis of competitve binding using grating coupler immunosensors for pesticide detection. Biosensors & Bioelectronics 9, 125-130.


Bier, F.F., F.W. Scheller, M. Klingbeil und U. Oßwald (1993) Biosensoren und Teststreifen für die Umwelt- und Lebensmittelanalytik - Eine Übersicht. Chemie in Labor und Biotechnik 44, 514-518.

Polzius, R., F.F. Bier, U. Bilitewski, V. Jäger und R.D. Schmid (1993) On-line monitoring of monoclonal antibodies in animal cell culture using a grating coupler. Biotechnology and Bioengineering 42, 1287-1292.

Jockers, R., F.F. Bier und R.D. Schmid (1993) Enhancement of immunoassay sensitivity by molecular modification of competitors. Journal of Immunological Methods 163, 161-167.

Jockers, R., F.F. Bier und R.D. Schmid (1993) Specific binding of photosynthetic reaction centres to herbicide-modified grating couplers. Anal. Chim. Acta 280, 53-59.

Jockers, R., F.F. Bier, R.D. Schmid, J. Wachtveitl und D. Oesterhelt (1993) Herbicide biosensor based on photobleaching of the reaction centre of Rhodobacter sphaeroides.Anal. Chim. Acta 274, 185-190.


Gebbert A., Bier F.F. Stöcklein W.M.F. und Schmid R.D. (1992) Comparison of a capacitance and integrated direct immunosensor for fermentation control. DECHEMA Vol. Jahrestagung der Biotechnologen 1992.

Bier, F.F., W. Stöcklein und R.D. Schmid (1992) Direct observation of anti-atrazine antibody binding. GBF monogr. Biosensors: Fundamentals. Technologies and Applications (Hrsg: F. Scheller, R.D. Schmid) 17, 205-208.

Bilitewski, U., B. Beyersdorf-Radeck, F.F. Bier, R. Kindervater, P. Krämer, P. Rüger und R.D. Schmid (1992) New developments in the field of biosensors applied to the determination of pesticides in water. GBF monogr. Biosensors: Fundamentals. Technologies and Applications (Hrsg: F. Scheller, R.D. Schmid) 17, 189-198.

Bier, F.F., W. Stöcklein, M. Böcher, U. Bilitewski und R.D. Schmid (1992) Use of a fibre optic immunosensor for the determination of pesticides. Sensors and Actuators B 7, 509-512. Übersetzt als: Einsatz eines faseroptischen Immunosensors zur Bestimmung von Pestiziden. In: Biochemische Methoden zur Schadstofferfassung in Wasser (Fachgruppe Wasserchemie der GDCh, Hrsg.), Bd. -, Kap. 6.9, VCH, Weinheim 1993, S. 147-153.

1991 – 1987

Baier T.G., F.F. Bier, D. Schönberg (1990) Improved preparative separation of human B and T lymphocytes and determination of relative mobilities of B and lymphoblast cell lines by free flow electrophoresis. Applied and Theoretical Electrophoresis 1: 283 – 289.

Schaller R.K.A., R.B. Spieß, F.F. Bier, U. Bettag und C. Cremer (1990) Denaturation behaviour of DNA‑protein‑complexes detected in situ in metaphase chromosomes in suspension by Hoechst 33258 fluorescence. Biophysical Chemistry 38: 59‑65.

Cremer C., J. Dölle, M. Hausmann, F.F. Bier, P. Rohwer (1989) Laser in Cytometry: Applications in Flow Cytogenetics. Ber. Bunsenges. Phys. Chem. 93: 327‑335.

Bier FF (1989) Chromosomen im elektrischen Feld: Untersuchungen zur elektrophoretischen Beweglichkeit von DNA und Säugerchromosomen. Dissertation, Fakultät für Physik und Astronomie, Universität Heidelberg

Bier F.F., U. Bettag, T. Rheingans, H. Adrian, J. Barths, M. Hausmann, H.-J. Bühring, P. Rohwer, J. Dölle und C. Cremer (1989) Determination of the electrophoretic mobility of chromosomes by free flow electrophoresis. I. Morphology and stability. Electrophoresis 10: 690‑697.

Dudin G., T. Cremer, M. Schardin, M. Hausmann, F. Bier und C. Cremer (1987) A method for nucleic acid hybridization to isolated chromosomes in suspension. Human Genetics 76: 290‑292.


Memczak, Henry; Stöcklein, Walter F. M.; Ehrentreich-förster, Eva; Bier, Frank F.; Lauster, Daniel; Herrmann, Andreas: „Influenza Virus Binding Peptides“, Application Number: 15/528389; Publication Date: 03/15/2018; Filing Date: 11/19/2015, US 20180072770

Zahn, Dorothea, and Frank Bier. "Apparatus and method for examining sample liquids." WIPO Patent No. 2012119992. 14 Sep. 2012.

Zahn, Dorothea, & Bier Frank, “Apparatus and method for analyzing sample fluids” US9234883, granted 12. Jan 2016, Priority date 5. Mar 2012

Fuhr, Günter R., and Frank Bier. "Method, compositions and devices for controlling a chemical reaction by pressure, using high-pressure optimized biocomponents" European Patent No. EP 2440673. 18 Apr. 2012.

Bier, Frank, and Ralph Hölzel. "Method and device for directed immobilization of nano- and micro-objects on a substrate surface, immobilisates obtained thereby, and use thereof." WIPO Patent No. 2013071994. Priority 15. Nov 2011.

Duschl, C., Lankenau, A., Lutz, J. F., Laschewsky, A., Wischerhoff, E., Fuhr, G. R., & Bier, F. (2013).  "Substrate, culture facility and culture method for biological cells" European Patent No. EP 2550352. 30 Jan. 2013. Munich, Germany: European Patent Office

Kozma, Peter; Bier, Frank; Ehrentreich-Förster, Eva. Messeinrichtung und Messverfahren zur Messung einer Messgröße mittels einer Beugungsmessung Measuring device and measuring method for measuring an indicator by means of a bend analysis. Priority DE 102014000311 A1: 20140110

Nickisch-Rosenegk Markus Von, Frank Bier, Heiko Andresen. Means and methods for producing zinc fingers and concatemers thereof. EP 2130836 A1Priority 3. Jun 2008

Heiko Andresen, Frank Bier, Martin Katterle. Affinity structures for the specific binding of substances by means of non-covalent interaction types. DE200710056875 WO2008EP09984 EP 20100324215, US20080743385 Priority 25. Nov 2008

Ehwald, Rudolf; Helge Adleff, Frank Bier, Nenad Gajovic-Eichelmann, Max Ehwald, Assay by osmotically induced separation and concentration of high-molecular detectable substances and a fluid microsystem for carrying out said assay. US7892857, granted 22. Feb 2011, Priority 30. Aug. 2007

Marc Birringer, Nickisch-Rodenegk Markus von, Frank Bier. Synthetic zinc finger peptide ligature for forming binding proteins configured in series for addressing specific regions of double-stranded dna (zinc finger probes). WO 2006103106 A1, EP1707575A1, EP1863837A1, EP1863837B1, Priority 1. Apr 2005

Bier, Frank; Reiß, Edda.; Stöcklein, Walther. Signalgebende Bindemoleküle, Vorrichtung und Verfahren zu deren Verwendung. DE 102010010052 A

Bier, Frank F. Nanostrukturierung an Oberflächen mittels heterogener Polymere. DE 19917841 A1, 2001

Kleinjung, Frank, Frank Bier. Determining rate and dissociation constants, useful in binding assays, e.g. of nucleic acids, uses specific differential equations. DE200710056875, WO2008EP09984, Priority 28. Mar. 2000

Bier, Frank, Eva Ehrentreich-Förster. Koimmobilisierung mehrerer chemischer Spezies. DE 10002895 A1, Priority 17. Jan 2000

Bier, Frank. Structure with nanometer-scale organization, useful as arrays for performing hybridization assays, contains highly ordered polymers fixed at at least two points. DE19991017841 Priority 13. Apr 1999

Christian Bauer, Alexander Makower, Frieder Scheller, Frank Bier. Hochempfindlicher Enzym-Immunoassay zur Bestimmung von Haptenen und Antigenen und seine Verwendung. DE 19545974 C2, DE19545974A1, Priority 15. Jul 1995

Bier, Frank; Schillig, Henning; Detlev, Hanisch, Detlef. Flow cell for luminescence measurements. WO 1992002803 A1, DE4024162A1, Priority 30. Jul 1990