Arbeiten aus Publikationsorganen mit wissenschaftlicher Qualitätssicherung

2026

• Structure–activity relationships of ATCUN-based Cu(II) complexes with large chelate rings: Interplay of ROS generation, DNA binding, and nuclease activity
  J. Heinrich, J. Lück, D. Varlakhanov, R. Kumar, M. Stein, N. Kulak*
  Dalton Trans. 2026, angenommen.
• Ba²⁺-Selective and pH Stable Dibenzo-18-Crown-6 Equipped BODIPYs with Pronounced Fluorescence Enhancement in Aqueous Solution
  T. Schwarze,* T. Sprenger, M. Al Akrami, A. T. Lohoff, E. Sperlich, S. Eidner, M. U. Kumke, N. Kulak*
  ChemPhotoChem 2026, angemommen (mit Titelbild).
• Polyelectrolyte Copolymer Nanoreactors: From Colloidal Assembly to Photoredox Activity in Water
  A. Nabiyan,* M. Esfandiari, S. Kogikoski Jr., I. Bald, E. Titov, M. U. Kumke, N. Kulak, H. Schlaad
  ACS Appl. Mater. Interfaces 2026, 18, 19622-19634 (mit Titelbild).
• Amphiphilic Cu(II) oxacyclen complexes: From oxidative cleavage to condensation of DNA
  O. Verbitsky, S. Hinojosa, A. Mostafa, I. Bald, N. Kulak*
  ChemBioChem 2026, 27, e202500477.

2025

• A sodium ion-selective photosensitizer: dibrominated F-BODIPY as a fluorescence imaging and therapeutic agent
  T. Schwarze,* M. Al Akrami, J. Heinrich, V. Hergl, E. Sperlich, A. Kelling, T. Sprenger, N. Jahn, T. Klamroth, N. Kulak*
  Phys. Chem. Chem. Phys.  2025, 27, 24178-24183 (mit Titelbild).
• Silver dithiocarbamates derived from amino acid esters
  V. Behling, J. Heinrich, D. Díaz, E. H. P. Brohmer, J. Heinrich, N. Schloerer, S. Kupfer, N. Kulak, P. Köhler*
  Dalton Trans. 2025, 54, 12772-12783 (mit Titelbild).
• Diblock Copolypeptoid Micelles as Platform for Aqueous Photoredox Cyanation of Arenes
  A. Nabiyan,* M. Esfandiari, J. Ruickoldt, P. Wendler, N. Kulak, H. Schlaad
  J. Am. Chem. Soc.  2025, 147, 29152–29161.
• Separation of homogeneous oxidation catalysts from aqueous systems using nanofiltration
  H. Schröter, I. Prediger, N. Kulak, U. Kragl*
  Sep. Purif. Technol. 2025, 377, 134389.
• Investigation on the impact of potassium and mild transport limitations on the pyrolysis behavior of beech wood and its macrocomponents
  J. J. Rico, A. Dernbecher, J. M. de la Rosa, L. Hilfert, H. Almuina-Villar, N. Kulak, S. Lucia, A. Dieguez-Alonso*
  J. Anal. Appl. Pyrolysis  2025, 192, 107201.

2024

• Ascorbate: a forgotten component in the cytotoxicity of Cu(II) ATCUN peptide complexes
  J. Heinrich, E. Siddiqui, H. Eckstein, M. Naumann,* N. Kulak*
  J. Biol. Inorg. Chem. 2024, 29, 801-809.
• Gold(III) complexes with thiosemicarbazone ligands: insights into their cytotoxic effects on lung cancer cells
  M. Scaccaglia,* S. Pinelli, L. Manini, B. Ghezzi, M. Nicastro, J. Heinrich, N. Kulak, P. Mozzoni, G. Pelosi, F. Bisceglie
  J. Inorg. Biochem. 2024, 251, 112438.

2023

• Sustained Delivery of Cu(II)-Based DNA Intercalators by Nanometer-Sized Cyclodextrin-Based Porous Polymers
  T. Skorjanc,* J. Heinrich, D. Makuc, N. Kulak, M. Valant
  ACS Appl. Nano Mater.  2023, 6, 21162-21168.
• Bromo- and glycosyl-substituted BODIPYs for application in photodynamic therapy and imaging
  B. F. Hohlfeld, D. Steen, G. D. Wieland, K. Achazi, N. Kulak, R. Haag, A. Wiehe*
  Org. Biomol. Chem. 2023, 21, 3105-3120 (mit Titelbild).
• Experimental and computational investigation of heteroatom substitution in nucleolytic Cu(II) cyclen complexes for balancing stability and redox activity
  J. Hormann, O. Verbitsky, X. Zhou, B. Battistella, M. van der Meer, B. Sarkar, C. Zhao,* N. Kulak*
  Dalton Trans. 2023, 52, 3176-3187.
• Ability of Azathiacyclen Ligands To Stop Cu(Aβ)-Induced Production of Reactive Oxygen Species: [3N1S] Is the Right Donor Set
  K. P. Malikidogo, M. Drommi, E. Atrián-Blasco, J. Hormann, N. Kulak, C. Esmieu,* C. Hureau*
  Chem. Eur. J. 2023, 29, e202203667 (mit Titelbild).
• Impact of N-heteroaromatic N-termini in Cu(II) ATCUN metallopeptides on their biorelevant redox activity
  J. Barrera, H. H. Haeri, J. Heinrich, M. Stein, D. Hinderberger, N. Kulak*
  Dalton Trans. 2023, 52, 3279-3286 (mit Titelbild).

2022

• Investigating Alkylated Prodigiosenes and Their Cu(II)-Dependent Biological Activity: Interactions with DNA, Antimicrobial and Photoinduced Anticancer Activity
  S. Doniz Kettenmann, M. White, J. Colard-Thomas, M. Kraft, A. T. Feßler, K. Danz, G. Wieland, S. Wagner, S. Schwarz, A. Wiehe, N. Kulak*
  ChemMedChem 2022, 17, e202100702 (Special Issue "In Memory of Klaus Hafner").

2021

• Incorporation of β-Alanine in Cu(II) ATCUN Peptide Complexes Increases ROS Levels, DNA Cleavage and Antiproliferative Activity
  J. Heinrich, K. Bossak-Ahmad, M. Riisom, H. H. Haeri, T. R. Steel, V. Hergl, A. Langhans, C. Schattschneider, J. Barrera, S. M. F. Jamieson, M. Stein, D. Hinderberger, C. G. Hartinger, W. Bal, N. Kulak*
  Chem. Eur. J. 2021, 27, 18093–18102 ("top-downloaded article").
• Copper(II) Complexes with Tetradentate Piperazine-Based Ligands: DNA Cleavage and Cytotoxicity
  S. Doniz Kettenmann, Y. Nossol, F. R. Louka, J. R. Legrande, E. Marine, R. C. Fischer, F. A. Mautner, V. Hergl, N. Kulak,* S. S. Massoud*
  Inorganics 2021, 9, 12.
• Iron(III)-tCDTA derivatives as MRI contrast agents: Increased T₁ relaxivities at higher magnetic field strength and pH sensing
  J. Xie , A. Häckel, R. Hauptmann, I. Pryjomska Ray, C. Limberg, N. Kulak, B. Hamm, E. Schellenberger*
  Magn. Reson. Med. 2021, 85, 3370-3382.
• Forty Years after the Discovery of Its Nucleolytic Activity: [Cu(phen)₂]²⁺ Shows Unattended DNA Cleavage Activity upon Fluorination
  C. Lüdtke, S. Sobottka, J. Heinrich, P. Liebing, S. Wedepohl, B. Sarkar, N. Kulak*
  Chem. Eur. J. 2021, 27, 3273-3277.
• Dipyrrinato-Iridium(III) Complexes for Application in Photodynamic Therapy and Antimicrobial Photodynamic Inactivation
  B. F. Hohlfeld, B. Gitter, C. J. Kingsbury, K. J. Flanagan, D. Steen, G. D. Wieland, N. Kulak, M. O. Senge,* A. Wiehe*
  Chem. Eur. J. 2021, 27, 6440–6459 ("Hot paper" mit Titelbild).

2020

• Exploring the relationship between structure and activity in BODIPYs designed for antimicrobial phototherapy
  B. F. Hohlfeld, B. Gitter, K. Flanagan, C. J. Kingsbury, N. Kulak, M. O. Senge, A. Wiehe*
  Org. Biomol. Chem. 2020, 18, 2416–2431.

2019

• Synthesis of Porphyrinoids, BODIPYs, and (Dipyrrinato)ruthenium(II) Complexes from Prefunctionalized Dipyrromethanes
  B. F. Hohlfeld, K. J. Flanagan, N. Kulak, M. O. Senge, M. Christmann, A. Wiehe*
  Eur. J. Org. Chem. 2019, 4020–4033.
• Click chemistry on silicon nitride for biosensor fabrication
  P. M. Dietrich,* N. Lange, A. Lippitz, M. Holzweber, N. Kulak, W. E. S. Unger
  Appl. Surf. Sci. 2019, 481, 10–15.
• Flexible vs. rigid bis(2-benzimidazolyl) ligands in Cu(II) complexes: Impact on redox chemistry and oxidative DNA cleavage activity
  J. Heinrich, N. F. König, S. Sobottka, B. Sarkar, N. Kulak*
  J. Inorg. Biochem. 2019, 194, 223–232.
• Biological activity of amphiphilic metal complexes
  C. Schattschneider, S. Doniz Kettenmann, S. Hinojosa, J. Heinrich, N. Kulak*
  Coord. Chem. Rev. 2019, 385, 191–207.

2018

• Monoalkylated Cyclen Complexes for Efficient Proteolysis: Influence of Donor Atom Exchange
  S. Hinojosa, C. Weise, U. Albold, N. Kulak*
  ChemistrySelect 2018, 3, 12552–12559.
• A fluorescence assay for the detection of hydrogen peroxide and hydroxyl radicals generated by metallonucleases
  S. Leichnitz, J. Heinrich, N. Kulak*
  Chem. Commun. 2018, 54, 13411–13414.
• Pre-/post-functionalization in dipyrrin metal complexes – antitumor and antibacterial activity of their glycosylated derivatives
  C. S. Gutsche, S. Gräfe, B. Gitter, K. J. Flanagan, M. O. Senge, N. Kulak, A. Wiehe*
  Dalton Trans. 2018, 47, 12373–12384.
• Synthesis and Evaluation of Artificial DNA Scissors: An Interdisciplinary Undergraduate Experiment
  J. Hormann, S. Streller, N. Kulak*
  J. Chem. Educ. 2018, 95, 1848–1855.
• Efficient Artificial Nucleases for Mediating DNA Cleavage Based on Tuning the Steric Effect in the Pyridyl Derivatives of Tripod Tetraamine-Cobalt(II) Complexes
  S. Doniz Kettenmann, F. R. Louka, E. Marine, R. C. Fischer, F. A. Mautner, N. Kulak,* S. S. Massoud*
  Eur. J. Inorg. Chem. 2018, 2322–2338 ("Very Important Paper", Special Issue "20th Anniversary - Celebrating the Past, Present and Future").
• Multiply Intercalator-Substituted Cu(II) Cyclen Complexes as DNA Condensers and DNA/RNA Synthesis Inhibitors
  J. Hormann, J. Malina, O. Lemke, M. J. Hülsey, S. Wedepohl, J. Potthoff, C. Schmidt, I. Ott, B. G. Keller, V. Brabec, N. Kulak*
  Inorg. Chem. 2018, 57, 5004–5012.
• Cu(II) complexes with hydrazone-functionalized phenanthrolines as self-activating metallonucleases
  J. Heinrich, J. Stubbe, N. Kulak*
  Inorg. Chim. Acta 2018, 481, 79–86 (Special Issue "Bio-inorganic and bio-inspired chemistry of copper").

2017

• Sequential Nucleophilic Substitution of the α-Pyrrole and p-Aryl Position of meso-Pentafluorophenyl-Substituted BODIPYs
  C. S. Gutsche, B. F. Hohlfeld, K. J. Flanagan, M. O. Senge, N. Kulak, A. Wiehe*
  Eur. J. Org. Chem. 2017, 3187–3196.
• Synthesis of fluorine-containing 1,10-phenanthrolines using mild versions of Skraup and Doebner–von Miller reactions
  C. Lüdtke, A. Haupt, M. Wozniak, N. Kulak*
  J. Fluor. Chem. 2017, 193, 98–105.

2016

• Significantly enhanced proteolytic activity of cyclen complexes by monoalkylation
  C. Perera-Bobusch, J. Hormann, C. Weise, S. Wedepohl, J. Dernedde, N. Kulak*
  Dalton Trans. 2016, 45, 10500–10504.
• Nucleophilic Aromatic Substitution on Pentafluorophenyl-Substituted Dipyrranes and Tetrapyrroles as a Route to Multifunctionalized Chromophores for Potential Application in Photodynamic Therapy
  C. S. Gutsche, M. Ortwerth, S. Gräfe, K. J. Flanagan, M. O. Senge, H.-U. Reissig, N. Kulak, A. Wiehe*
  Chem. Eur. J. 2016, 22, 13953–13964.
• Tuning the DNA binding and cleavage of bpa Cu(II) complexes by ether tethers with hydroxyl and methoxy groups
  A. A. J. Sudarga Tjakraatmadja, C. Lüdtke, N. Kulak*
  Inorg. Chim. Acta 2016, 452, 159–169 (Special Issue "Metal-ion nucleic-acid interactions").
• New azidation methods for the functionalization of silicon nitride and application in copper-catalyzed azide-alkyne cycloaddition (CuAAC)
  N. Lange,* P.M. Dietrich, A. Lippitz, N. Kulak, W. E. S. Unger
  Surf. Interface Anal. 2016, 48, 621–625.
• Synchrotron-radiation XPS analysis of ultra-thin silane films: Specifying the organic silicon
  P. M. Dietrich,* S. Glamsch, C. Ehlert, A. Lippitz, N. Kulak, W. E. S. Unger
  Appl. Surf. Sci. 2016, 363, 406–411.

2015

• Quantification of Silane Molecules on Oxidized Silicon: Are there Options for a Traceable and Absolute Determination?
  P. M. Dietrich,* C. Streeck, S. Glamsch, C. Ehlert, A. Lippitz, A. Nutsch, N. Kulak, B. Beckhoff, W. E. S. Unger
  Anal. Chem. 2015, 87, 10117–10124.
• From Cyclen to 12-Crown-4 Copper(II) Complexes: Exchange of Donor Atoms Improves DNA Cleavage Activity
  J. Hormann, M. van der Meer, B. Sarkar, N. Kulak*
  Eur. J. Inorg. Chem. 2015, 4722–4730.
• Fluorophore ATCUN complexes: combining agent and probe for oxidative DNA cleavage
  C. Wende, N. Kulak*
  Chem. Commun. 2015, 51, 12395–12398.
• Mononuclear Cu(II) and Zn(II) complexes with a simple diamine ligand: synthesis, structure, phosphodiester binding and DNA cleavage studies
  P. Sureshbabu, A. A. J. Sudarga Tjakraatmadja, C. Hanmandlu, K. Elavarasan, N. Kulak,* S. Sabiah*
  RSC Adv. 2015, 5, 22405–22418.

2014

• Copper Complexes of N-Donor Ligands as Artificial Nucleases
  C. Wende, C. Lüdtke, N. Kulak*
  Eur. J. Inorg. Chem. 2014, 2597–2612 (eingeladener Review-Artikel mit Titelbild und Profil).

2013

• Reaction of a Bis(benzoylhydrazone) with Copper(II): Complex Formation, Hydroxylation, and DNA Cleavage Activity
  S. Rodríguez-Hermida, C. Wende, A. B. Lago, R. Carballo, N. Kulak,* E. M. Vázquez-López*
  Eur. J. Inorg. Chem. 2013, 5843–5853.
• Nanoparticle Encapsulation of Mitaplatin and the Effect Thereof on In Vivo Properties
  T. C. Johnstone, N. Kulak, E. M. Pridgen, O. C. Farokhzad, R. Langer, S. J. Lippard*
  ACS Nano 2013, 7, 5675–5683.
• Straightforward approach to efficient oxidative DNA cleaving agents based on Cu(II) complexes of heterosubstituted cyclens
  J. Hormann, C. Perera, N. Deibel, D. Lentz, B. Sarkar, N. Kulak*
  Dalton Trans. 2013, 42, 4357–4360.

2012

• Redox activation of metal-based prodrugs as a strategy for drug delivery
  N. Graf, S. J. Lippard*
  Adv. Drug Deliv. Rev. 2012, 64, 993–1004.
• α_Vβ₃ Integrin-Targeted PLGA-PEG Nanoparticles for Enhanced Anti-tumor Efficacy of a Pt(IV) Prodrug
  N. Graf, D. Bielenberg, N. Kolishetti, C. Muus, J. Banyard, O. C. Farokhzad, S. J. Lippard*
  ACS Nano 2012, 6, 4530–4539 (highlighted in "In Nano").
• Platinum(IV)-chlorotoxin (CTX) conjugates for targeting cancer cells
  N. Graf, T. E. Mokhtari, I. A. Papayannopoulos, S. J. Lippard*
  J.Inorg. Biochem. 2012, 110, 58–63.

2011

• Role of Endonucleases XPF and XPG in Nucleotide Excision Repair of Platinated DNA and Cisplatin/Oxaliplatin Cytotoxicity
  N. Graf, W. H. Ang, G. Zhu, M. Myint, S. J. Lippard*
  ChemBioChem 2011, 12, 1115–1123.

2010

• Amine species on self-assembled monolayers of ω-aminothiolates on gold as identified by XPS and NEXAFS spectroscopy
  P. M. Dietrich, N. Graf, T. Gross, A. Lippitz, S. Krakert, B. Schüpbach, A. Terfort, W. E. S. Unger*
  Surf. Interface Anal. 2010, 42, 1184–1187.
• Self-Assembled Monolayers of Aromatic ω-Aminothiols on Gold: Surface Chemistry and Reactivity
  P. M. Dietrich, N. Graf, T. Gross, A. Lippitz, B. Schüpbach, A. Bashir, C. Wöll, A. Terfort,* W. E. S. Unger*
  Langmuir 2010, 26, 3949–3954.
• Determination of accessible amino groups on surfaces by chemical derivatization with 3,5-bis(trifluoromethyl)phenyl isothiocyanate and XPS/NEXAFS analysis
  N. Graf,* A. Lippitz, T. Gross, F. Pippig, A. Holländer, W. E. S. Unger*
  Anal. Bioanal. Chem. 2010, 396, 725–738.

2009

• XPS and NEXAFS studies of aliphatic and aromatic amine species on functionalized surfaces
  N. Graf, E. Yeğen, T. Gross, A. Lippitz, W. Weigel, S. Krakert, A. Terfort, W. E. S. Unger*
  Surf. Sci. 2009, 603, 2849–2860.
• Application of XPS and ToF-SIMS for surface chemical analysis of DNA microarrays and their substrates
  N. Graf, T. Gross, T. Wirth, W. Weigel, W. E. S. Unger*
  Anal. Bioanal. Chem. 2009, 393, 1907–1912.

2008

• Optimization of cleaning and amino- silanization protocols for Si wafers to be used as platforms for biochip microarrays by surface analysis (XPS, ToF-SIMS and NEXAFS spectroscopy)
  N. Graf, E. Yeğen, A. Lippitz, D. Treu, T. Wirth, W. E. S. Unger*
  Surf. Interface Anal. 2008, 40, 180–183.
• Using enzymatic amplification by aldolase for the optical detection of DNA by an artificial signal cascade
  N. Graf, S. Kassube, R. Krämer*
  Bioorg. Med. Chem. Lett. 2008, 18, 4786–4788.

2006

• Enzymatic amplification in a bioinspired, autonomous signal cascade
  N. Graf, R. Krämer*
  Chem. Commun. 2006, 4375–4376 ("Hot paper").
• A Metal-Ion-Releasing Probe for DNA Detection by Catalytic Signal Amplification
  N. Graf, M. Göritz, R. Krämer*
  Angew. Chem., Int. Ed. 2006, 45, 4013–4015.