May 22nd, 2019

Excellent news from the DFG: The collaborative research center 958 “Scaffolding of Membranes - Molecular Mechanisms and Cellular Functions" will be supported for another funding Phase.

March 12th, 2019

Congratulations to Deepika Dogra for her co-authorship on a paper accepted with Nature Communications:

Chapman, EM, Lant, B,  Ohashi, Y, Yu, B, Schertzberg, M, Go, C, Dogra, D, Koskimäki, J, Girard, R, Li, Y, Fraser, AG, Awad, IA, Abdelilah-Seyfried, S, Gingras, AC, Derry, WB (2019) A conserved CCM complex promotes apoptosis non-autonomously by regulating zinc homeostasis in C. elegans. Nature Communications (in press).

March 1st, 2019

Kickoff for Marie Curie Training Network „V.A.Cure“! This network will train 14 Ph.D. students in Universities, Research Institutes, and private companies throughout Belgium, France, Germany, Sweden, and Finland (for more information see:

Dissertation Stefan Donat

February 22nd, 2019

A job well done! Stefan Donat successfully defended his Ph.D. at the Humboldt University in Berlin. Now, he continues his interest in imaging applications with a Postdoc position at the Advanced Medical BioImaging Facility of the Charité in Berlin.


Dissertation Stefan Donat


February 17th, 2019

Dorothee Bornhorst has been selected for a plenary talk at the joint meeting of the German and Israeli Societies of Developmental Biology in Vienna, Austria. Her talk is entitled: Intra-organ communication within the developing zebrafish heart involves mechanical coupling of myocardium and endocardium

January 28th, 2019
Great news for Melina Heise! Her paper has been accepted for publication with Scientific Reports.

Demal T J,  Heise M, Reiz B,  Dogra D, Brænne I, Reichenspurner H, Männer J, Aherrahrou Z,  Schunkert H, Erdmann J, Abdelilah-Seyfried S.(2019) A familial congenital heart disease with a possible multigenic origin involving a mutation in BMPR1A. Scientific Report (in press)

August 13th, 2018

Congratulations to Cécile Otten and all other co-authors of our paper that has now been accepted with EMBO Molecular Medicine!

Cécile Otten, Jessica Knox, Gwénola Boulday, Mathias Eymery, Marta Haniszewski, Martin Neuenschwander, Silke Radetzki, Ingo Vogt, Kristina Hähn, Coralie De Luca, Cécile Cardoso, Sabri Hamad, Carla Igual Gil, Peter Roy, Corinne Albiges-Rizo, Eva Faurobert, Jens P. von Kries, Mónica Campillos, Elisabeth Tournier-Lasserve, W. Brent Derry, and Salim Abdelilah-Seyfried (2018) Systematic pharmacological screens uncover novel pathways involved in cerebral cavernous malformations. EMBO Mol Med e9155 doi: 10.15252/emmm.201809155


July 06th - 09th, 2018


Claudia Rödel and Salim Seyfried are travelling to an annual CCMCURE and Angioma Alliance Canada meeting at the Hospital of the SickKids in Toronto, Canada.

03rd July, 2018

Congratulations to Claudia for her co-authorship on a paper on the complementary roles of Rock1 versus Rock2 signaling downstream of the CCM complex in endothelial cells. This work has been accepted with Journal of Cell Science.

VA.CURE_consortium in Helsinki

May 30st, 2018


The European Commission has received a recommendation for funding of the Marie Curie Training Network „V.A.Cure“. This network will train 14 Ph.D. students in Universities, Research Institutes, and private companies throughout Belgium, France, Germany, Sweden, and Finland. Two of the students will mainly be trained in our lab.

VA.CURE_consortium in Helsinki

May 15th-19th, 2018

Alessio Paolini and Salim Seyfried are travelling to this years’ Weinstein conference on Cardiovascular Development and Regeneration in Nara, Japan.

May 10th, 2018

Alessio Paolini receives news that his review paper has been accepted for publication with Current Opinions in Cell Biology:

Paolini A and Abdelilah-Seyfried S (2018) The mechanobiology of zebrafish cardiac valve leaflet formation. Current Opinion in Cell Biology, in press.

May 2018

Stefan Donat is successful with a co-authorship on a Nature Communications paper which is now in press:

Merks A, Swinarski M, Meyer A, Müller N, Ozcan I, Donat S, Burger A, Gilbert S, Mosimann C, Abdelilah-Seyfried S, and Panakova D (2018) Planar Cell Polarity signalling coordinates heart tube remodelling through tissue-scale polarisation of actomyosin activity. Nature communication, in press.

April 27th, 2018

Farewell dinner for Timm Haack at a lakeside restaurant in Potsdam. After 4 years in biomedical research in our team, Timm is now moving on to the Scientific Commission of the State of Lower Saxony in Hannover.

April 19th, 2018

Great news that Dorothee Bornhorst has earned a co-authorship in paper published with Stem Cell Reports. Dorothee has supported this stem cell project with her expertise in zebrafish embryology:

Olmer R, Engels L, Usman A, Menke S, Malik MNH, Pessler F, Göhring G, Bornhorst D, Bolten S, Abdelilah-Seyfried S, Scheper T, Kempf H, Zweigerdt R, Martin U. (2018) Differentiation of Human Pluripotent Stem Cells into Functional Endothelial Cells in Scalable Suspension Culture. Stem Cell Reports. pii: S2213-6711(18)30144-9. doi: 10.1016/j.stemcr.2018.03.017.

March 16th, 2018

Congratulations to Marta Lourenço for her excellent Ph.D. defense. After almost five years in Germany, Marta is now returning to Portugal.

February 1st, 2018

Congratulations to Stefan Donat, Marta Lourenço, and Alessio Paolini for their shared first-authorships on an Elife paper that has been published today:

Donat S, Lourenço M, Paolini A, Otten C, Renz M, Abdelilah-Seyfried S. (2018) Heg1 and Ccm1/2 proteins control endocardial mechanosensitivity during zebrafish valvulogenesis. Elife. 7. pii: e28939. doi: 10.7554/eLife.28939

January 12th, 2018

Ph.D. awarded to Melina Heise after giving an excellent presentation in her Ph.D. defense. Next, an exciting job as a program coordinator of the Masters’ program in Biomedicine at Hannover Medical School is lined up for her.

January 2nd, 2018

Welcome to Deepika Dogra who joins our team after finishing her Ph.D. thesis work in the lab of Prof. Didier Stainier at the Max Planck Institute for Heart and Lung Research in Bad Nauheim. During her Ph.D. thesis in Bad Nauheim, Deepika explored the mechanisms by which zebrafish can regenerate an injured heart.  

Prof. Dr. Brent Derry im Labor mit Prof. Dr. Salim Seyfried

June - November 2017

Welcome to Prof. W. Brent Derry from the Hospital of Sick Children (Toronto Canada) for a 6 months sabbatical in our lab. Brent is interested in studying the molecular and cellular causes of haemorrhagic stroke using the model organisms C.elegans and zebrafish.

Prof. Dr. Brent Derry im Labor mit Prof. Dr. Salim Seyfried

August 15th, 2017

The team receives a grant to study the role of hormonal regulation on zebrafish embryonic heart development. This is a twinning grant between our team and the group of Prof. Michael Bader at the Max Delbruck Center for Molecular Medicine which is funded by the German Centre for Cardiovascular Research (DZHK).

July 25th, 2017

Visit by Prof. Ralf Schnabel (Technische Universität Braunschweig). His seminar is entitled:

"Phainothea: Creation of form by cell focussing in the C.elegans Embryo"

July 17th, 2017

Prof. Kerstin Blank (Max Planck Institute for Colloid Research, Potsdam) visits the group and gives a seminar entitled:

"Coiled coils as mechanical building blocks"

July 2017

This years' annual CCMCURE retreat takes place in Paris! Claudia Rödel, Cécile Otten, and Salim Seyfried participate in this years' event which is hosted by the group of Prof. Tournier-Lasserve (Université Paris Diderot, INSERM).

June 27th, 2017

Melina Heise and Salim Seyfried visit Prof. Jörg Männer (Universität Göttingen) to learn about cardiac looping morphogenesis in higher vertebrates and man.

May 15th, 2017

Seminar by Hans-Georg Simon (Northwestern University, Chicago) entitled:

"A dynamic extracellular matrix instructs regenerative cell behaviour"

May 12th, 2017

Congratulations to Juliane Münch for winning a starting grant from the Einstein Center for Regenerative Therapies (ECRT) for a collaborative project together with Prof. Sigmar Stricker (Freie Universität, Berlin) and Prof. Ulf Landmesser (Charité- Universitätsmedizin Berlin).

Great Job!