Dr. Juliane Münch

Research Interests 

I am fascinated by cellular processes that enable the regeneration of different tissues and organs. Within previous studies using the adult zebrafish (Danio rerio) as a model system, I investigated on the role of the developmental signaling cascade Notch in the regenerating fin and the injured heart. I became especially interested in the implication of endocardial/ endothelial cells in regenerating organs and its interaction with surrounding tissues. As part of my project I am currently trying to understand the characteristics of endocardial cells and the signals that allow the communication with adjacent tissues in the heart. Further I am seeking to gain better insight in the developmental origin of endocardial cells and the molecules that drive cellular differentiation during cardiovascular development and regeneration. 

Education 

Universidad Autónoma de Madrid, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain
Ph.D. in Molecular Biology, 2015
Universidad Autónoma de Madrid, Spain 

MSc in biomedicine, 2010
Technische Universität Dresden, Germany

Diploma in Biology, 2009

Publications 

• Andrés-Delgado L, Ernst A, Galardi-Castilla M, Bazaga D, Peralta M, Münch J, González-Rosa JM, Marques I, Tessadori F, de la Pompa JL, Vermot J, Mercader N. (2019) Actin dynamics and the Bmp pathway drive apical extrusion of proepicardial cells. Development. 2019 Jun 7.doi: 10.1242/dev.174961

• MacGrogan D, Münch J, de la Pompa JL.Notch and interacting signalling pathways in cardiac development, disease, and regeneration. (2018) Nat Rev Cardiol. doi: 10.1038/s41569-018-0100-2 .

• Münch J, Grivas D, González-Rajal Á, Torregrosa-Carrión R, de la Pompa JL. Notch signalling restricts inflammation and serpine1 expression in the dynamic endocardium of the regenerating zebrafish heart. Development. 2017 Feb 27. doi: 10.1242/dev.143362. 

• Münch J, González-Rajal A, de la Pompa JL. Notch regulates blastema proliferation and prevents differentiation during adult zebrafish fin regeneration. Development. 2013 Apr. doi:10.1242/dev.087346.