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Dr. Claudia Rödel

Postdoctoral Research Associate in Zoophysiology Group 

Department of Biochemistry & Biology

University of Potsdam

Phone: (0331) 977 5523

Email: croedeluni-potsdamde

Weblink: www.researchgate.net/profile/Claudia_Roedel2

Education 

University of Potsdam, Germany 

Postdoc training, developmental biology of the cardiovascular system and formation of cerebral cavernous malformation 

  

Academy of Athen, Greece 

Postdoc training, developmental biology of cardiac valves in zebrafish, 2012-15, Biomedical Research Foundation 

  

University of Göttingen, Germany 

Ph.D., "Evolution of caudal translational repression in higher insects." 2011 

  

University of Göttingen, Germany 

Diploma, "Isolierung von Entwicklungsgenen der indischen Stabheuschrecke Carausius morosus" , 2006 

  

Research Interests 

My broad scientific interests lie in the study of molecular mechanisms during development and morphogenesis. I have enjoyed working with different animal systems such as the stick insect Carausius morosus, the Red flour beetle Tribolium castaneum, the fly Drosophila melanogaster and the zebrafish Danio rerio. 

Currently I am studying the molecular and genetic aspects of the vascular disease cerebral cavernous malformations (CCM). Patients with CCM lesions suffer from neurological deficits such as headaches and hemorrhagic stroke. Molecular pathways involved in this disease have been described, however, the very onset or triggers that cause CCM remain undetermined. The zebrafish embryo is an excellent vertebrate model that allows us to address questions on CCM lesion formation. A strong advantage of the zebrafish model is the availability of in vivo imaging techniques. The zebrafish embryo is completely transparent and can live for several days without a functional cardiovascular system. Hence, we can observe and study cellular and molecular processes that are dysfunctional under disease condition. 

Publications 

  • Lisowska J, Rödel CJ, Manet S, Miroshnikova YA, Boyault C, Planus E, De Mets R, Lee HH, Destaing O, Mertani H, Boulday G, Tournier-Lasserve E, Balland M, Abdelilah-Seyfried S, Albiges-Rizo C, Faurobert E. (2018) Cerebral Cavernous Malformation 1/2 complex controls ROCK1 and ROCK2 complementary functions for endothelial integrity. J Cell Sci.20. pii: jcs.216093. doi:10.1242/jcs.216093. [Epub ahead of print] PubMed PMID: 30030370.
  • Rödel C J, Gilles A F,  Averof M (2013) MicroRNAs act as cofactors in bicoid-mediated translational repression. Current Biology : CB, 23(16), 1579–1584. doi:10.1016/j.cub.2013.06.041  
  • Rödel C J, Otten C, Donat S, Lourenço M, Fischer D, Kuropka B, Paolini A, Freund C, Abdelilah-Seyfried S. (2019) Blood Flow Suppresses Vascular Anomalies in a Zebrafish Model of Cerebral Cavernous Malformations. Circulation Research 125. doi:10.1161/CIRCRESAHA.119.315076