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Our aim is to solve the conformational dynamics of molecular machines at the highest possible resolution using single particle cryo EM. Members of the large protein superfamily of AAA+ proteins (ATPases associated with various cellular activities) are at the core of many essential multi protein assemblies involved in re-organisation and recycling processes of membranes, proteins or DNA in the cell. They convert chemical energy into mechanical work, and our lab aims to obtain a structural view on the complex conformational dynamics of these fascinating molecular machines in action. In particular, we want to understand how allosteric interactions between AAA+ modules in the active oligomer regulate ATPase activity and how accessory factors influence complex activity. The ultimate goal is to integrate structural data obtained by cryo electron microscopy and X-ray crystallography with mutational analysis and biophysical experiments in order to tackle severe disorders and illnesses stemming from malfunctioning molecular machines.