• Professur Biologische Physik

Biological Physics Group

Ranging from the molecular and cellular scale to tissues, organisms, and whole ecosystems, the complexity of living systems poses some of the most fundamental challenges to current scientific research. In the Biological Physics Group, we focus on the level of individual cells, where we address biological questions with the tools of physics, relying, in particular, on microscopy and micromanipulation techniques as well as on the ideas and concepts of pattern formation in nonlinear systems.

ECC10

International Conference

The conference will cover the entire topical range of complex chemical systems

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EB60

International Symposium

The international symposium will bring together scientists from the fields of turbulence and pattern formation research

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News

Video microscopy of a cell division by protein waves in a 0.05x0.06 millimetre image section. The protein waves are stained green, the cell nuclei red. The waves move in the direction of the arrows, thereby dividing the cell into two daughter cells.
Photo: Source: Dr. Sven Flemming (modified taken from Flemming et al., 2020, PNAS)
Video microscopy of a cell division by protein waves in a 0.05x0.06 millimetre image section. The protein waves are stained green, the cell nuclei red. The waves move in the direction of the arrows, thereby dividing the cell into two daughter cells.

Recent Publication

Wave power – Biophysicists discover new form of cell division driven by protein waves

The Biological Physics group led by Professor Carsten Beta at the University of Potsdam has, in cooperation with Spanish scientists, discovered a new form of cell division caused by intracellular protein waves. It could be employed in synthetic biology in the future, for example in artificial cells. The group has now published its results in PNAS.

Cell shape is determined by a protein structure – the cytoskeleton. One of the most important proteins of the cytoskeleton called actin forms branched filament structures, which are continuously modified and reorganized by the cell. The filaments can increase or decrease in size and thereby cause the cell to change its shape. This mechanism is fundamental to the movement of white blood cells, for instance, but also for that of metastasizing tumor cells.
With the help of molecular genetics, the cytoskeleton can be rendered visible under a microscope. Biophysicists at the University of Potsdam have made use of this in order to observe dynamic changes in the cytoskeleton of Dictyostelium discoideum amoeba cells. Given certain conditions, clusters of cytoskeletal proteins can move through the cell in the form of a wave. When such a protein wave reaches the cell border, it pushes the membrane that surrounds the cell outwards. The resulting deformation eventually leads to the creation of a separate daughter cell the size of the filament wave.
In conventional cell division, also called mitosis, daughter cells are formed when they pinch off with the help of a contractile protein ring. This process is highly complex and requires a lot of coordination, for instance, in terms of the correct positioning of the protein ring. The advantage of the type of cell division now discovered by the scientists from Potsdam is that it is likely to be easier to reproduce in a laboratory. For current efforts to create artificial cells in the laboratory, in particular, this cell division driven by protein waves could offer a promising alternative. The Potsdam-based team’s Spanish cooperation partners from the Universitat Politècnica de Catalunya in Barcelona were already able to demonstrate this in a computer simulation. They developed a model which helped them reconstruct wave-mediated cell division in simulated cells, thereby creating a clearer understanding of the conditions that are necessary for this process.

Link to publication:
Flemming, S., Font, F., Alonso, S., Beta, C., How cortical waves drive fission of motile cells. PNAS (2020). https://doi.org/10.1073/pnas.1912428117   

Contact:
Prof. Dr. Carsten Beta, Institute for Physics and Astronomy, Phone: +49 331 977-5651, biophys@uni-potsdam.de
Dr. Sven Flemming, Institute for Physics and Astronomy, Phone: +49 331 977-5214

Image: Video microscopy of a wave-mediated cell division in an image detail with a size of 0.05x0.06 millimeters. Protein waves are colored green, cell nuclei are red. The waves move in the direction of the arrows and separate the cell into two daughter cells. Image:  Dr. Sven Flemming (modified image from Flemming et al., 2020, PNAS)

Media information: 12-03-2020 / Nr. 034

Video microscopy of a cell division by protein waves in a 0.05x0.06 millimetre image section. The protein waves are stained green, the cell nuclei red. The waves move in the direction of the arrows, thereby dividing the cell into two daughter cells.
Photo: Source: Dr. Sven Flemming (modified taken from Flemming et al., 2020, PNAS)
Video microscopy of a cell division by protein waves in a 0.05x0.06 millimetre image section. The protein waves are stained green, the cell nuclei red. The waves move in the direction of the arrows, thereby dividing the cell into two daughter cells.

Erasmus+ -Programm

Colloquium on Complex and Biological Systems

Participating groups:

  • Theoretical Physics 
  • Statistical Physics
  • Nonlinear Dynamics
  • Biological Physis
  • Mathematical Modelling
  • Systems Biology

Time:  Fridays 10:15 - 11:45 h

Location:  2.28.0.108

Seminar: Current Problems in Biological Physics

Target audience::

  • Bachelor students
  • Master students
  • PhD students
  • co-workers

Time:  Wednesday 10.15-11.45 h

Location:  2.28.1.001