Professur für Sozial- und Präventivmedizin

PM: Gutes Erwachen – Potsdamer Forschende belegen Erfolg von Delirprävention nach Operationen

2025

Schwefel, M. K., Kaufmann, C., Gutmann, G., Henze, R., Fydrich, T., Rapp, M. A., Ströhle, A., Heissel, A., & Heinzel, S. (2025). Effect of physical exercise training on neural activity during working memory in major depressive disorder. Journal of affective disorders, 372, 269–278. https://doi.org/10.1016/j.jad.2024.12.016

2024

Hoffmann, S., Tschorn, M., & Spallek, J. (2024). Social inequalities in early childhood language development during the COVID-19 pandemic: A descriptive study with data from three consecutive school entry surveys in Germany. International Journal for Equity in Health, 23(1), 1–13.

Mueckstein, M., Görgen, K., Heinzel, S., Granacher, U., Rapp, M. A., & Stelzel, C. (2024). Multitasking practice eliminates modality-based interference by separating task representations in sensory brain regions. The Journal of neuroscience : the official journal of the Society for Neuroscience, e0755242024. Advance online publication. https://doi.org/10.1523/JNEUROSCI.0755-24.2024

Neidhart, M., Kjelkenes, R., Jansone, K., Rehák Bučková, B., Holz, N., Nees, F., Walter, H., Schumann, G., Rapp, M. A., Banaschewski, T., Schwarz, E., & Marquand, A. et al. (2024). A protocol for data harmonization in large cohorts. Nature Mental Health, 2(10), 1134–1137. https://doi.org/10.1038/s44220-024-00315-0

Spanagel, R., Bach, P., Banaschewski, T., et al. (2024). The ReCoDe addiction research consortium: Losing and regaining control over drug intake—Findings and future perspectives. Addiction Biology, 29(7), e13419. doi.org/10.1111/adb.13419

Tschorn, M., Daedelow, L., Szalek, L., Banaschewski, T., Bokde, A. L. W., Desrivières, S., Flor, H., Grigis, A., Garavan, H., Gowland, P., Martinot, J. L., Martinot, M. P., Artiges, E., Nees, F., Orfanos, D. P., Poustka, L., Hohmann, S., Buechl, C., Smolka, M. N., Vaidya, N., … IMAGEN Consortium. (2024). Personality, social factors, brain functioning, familial risk, and trajectories of alcohol misuse in adolescence. JAMA Network Open, 7(8), e2425114. https://doi.org/10.1001/jamanetworkopen.2024.25114

2023

Arntz, F., Markov, A., Behm, D. G., Behrens, M., Negra, Y., Nakamura, M., ... & Chaabene, H. (2023). Chronic Effects of Static Stretching Exercises on Muscle Strength and Power in Healthy Individuals Across the Lifespan: A Systematic Review with Multi-level Meta-analysis. Sports Medicine, 53(3), 723-745.

Böttger, S. J., Förstner, B. R., Szalek, L., Koller-Schlaud, K., Rapp, M. A., & Tschorn, M. (2023). Mood and anxiety disorders within the Research Domain Criteria framework of Positive and Negative Valence Systems: A scoping review. Frontiers in Human Neuroscience, 17, 1184978. doi.org/10.3389/fnhum.2023.1184978

Förstner, B. R., Böttger, S. J., Moldavski, A., Bajbouj, M., Pfennig, A., Manook, A., . . . Tschorn, M. (2023). The associations of Positive and Negative Valence Systems, Cognitive Systems and Social Processes on disease severity in anxiety and depressive disorders. Frontiers in Psychiatry, 14, 1161097. doi.org/10.3389/fpsyt.2023.1161097

Förstner, B. R., Tschorn, M., Reinoso-Schiller, N., Maričić, L. M., Röcher, E., Kalman, J. L., Stroth, S., Mayer, A. V., Schwarz, K., Kaiser, A., Pfennig, A., Manook, A., Ising, M., Heinig, I., Pittig, A., Heinz, A., Mathiak, K., Schulze, T. G., Schneider, F., Kamp-Becker, I., … Rapp, M. A. (2023). Mapping Research Domain Criteria using a transdiagnostic mini-RDoC assessment in mental disorders: a confirmatory factor analysis. European archives of psychiatry and clinical neuroscience, 273(3), 527–539. https://doi.org/10.1007/s00406-022-01440-6

Heinen, D., Heissel, A., Heinzel, S., Fydrich, T., Ströhle, A., Rapp, M. A., & Vogel, H. (2023). Effect of acute and long-term exercise on leptin levels in depressed outpatients. BMC public health, 23(1), 2509. https://doi.org/10.1186/s12889-023-17362-4

Heinzel, S., Tschorn, M., Schulte-Hutner, M., Schäfer, F., Reese, G., Pohle, C., … & Bechtoldt, M. (2023). Anxiety in response to the climate and environmental crises: Validation of the Hogg Eco-Anxiety Scale in Germany. Frontiers in Psychology, 14.

Heissel, A., Heinen, D., Brokmeier, L., Skarabis, N., Kangas, M., Vancampfort, D., Stubbs, B., Firth, J., Ward, P., Rosenbaum, S., Hallgren, M., Schuch, F. (2023). Exercise as Medicine for Depressive Symptoms? A Systematic Review and Meta-analysis with Meta-regression. British Journal of Sports Medicine. http://dx.doi.org/10.1136/bjsports-2022-106282

Schwefel, M.K., Kaufmann, C., Gutmann, G., Henze, R., Fydrich, T., Rapp, M.A., Ströhle, A., Heissel, A., Heinzel, S. (2023). Physical fitness is associated with neural activity during working memory performance in major depressive disorder. NeuroImage: Clinical. https://doi.org/10.1016/j.nicl.2023.103401

Tschorn, M., Schulze, S., Förstner, B. R., Holmberg, C., Spallek, J., Heinz, A., & Rapp, M. A. (2023). Predictors and prevalence of hazardous alcohol use in middle-late to late adulthood in Europe. Aging & mental health, 27(5), 1001–1010. https://doi.org/10.1080/13607863.2022.2076208

2022

Deeken, F., Reichert, M., Zech, H., Wenzel, J., Wedemeyer, F., Aguilera, A., Aslan, A., Bach, P., Bahr, N. S., Ebrahimi, C., Fischbach, P. C., Ganz, M., Garbusow, M., Großkopf, C. M., Heigert, M., Hentschel, A., Karl, D., Pelz, P., Pinger, M., Riemerschmid, C., … ReCoDe Consortium (2022). Patterns of Alcohol Consumption Among Individuals With Alcohol Use Disorder During the COVID-19 Pandemic and Lockdowns in Germany. JAMA network open, 5(8), e2224641. https://doi.org/10.1001/jamanetworkopen.2022.24641

Deeken, F., Sánchez, A., Rapp, M. A., Denkinger, M., Brefka, S., Spank, J., Bruns, C., von Arnim, C. A. F., Küster, O. C., Conzelmann, L. O., Metz, B. R., Maurer, C., Skrobik, Y., Forkavets, O., Eschweiler, G. W., Thomas, C., & PAWEL Study Group (2022). Outcomes of a Delirium Prevention Program in Older Persons After Elective Surgery: A Stepped-Wedge Cluster Randomized Clinical Trial. JAMA surgery, 157(2), e216370. doi.org/10.1001/jamasurg.2021.6370

Desch, A., Förstner, B., Artmann, J., Häusler, A., Hauptmann, M., Altin, S., Rapp, M., & Holmberg, C. (2022). A theory of change of an innovation for therapeutic care and meaningful living in a German nursing home. BMC geriatrics, 22(1), 849. doi.org/10.1186/s12877-022-03462-0

Hoffmann, S., Tschorn, M., Michalski, N., Hoebel, J., Förstner, B. R., Rapp, M. A. & Spallek, J. (2022). Association of regional socioeconomic deprivation and rurality with global developmental delay in early childhood: Data from mandatory school entry examinations in Germany. Health & Place, 75, 102794. doi.org/10.1016/j.healthplace.2022.102794

2021

Schumann, G., Tschorn, M., Heinz, A., & Rapp, M. (2021). Jenseits von IMAGEN: populationsneurowissenschaftliche Strategien für klinische und globale Kohorten in den STRATIFY-und GIGA-Konsortien. Der Nervenarzt, 1-8.

Tschorn, M., Lorenz, R. C., O’Reilly, P. F., Reichenberg, A., Banaschewski, T., Bokde, A. L., ... & Rapp, M. A. (2021). Differential predictors for alcohol use in adolescents as a function of familial risk. Translational Psychiatry, 11(1), 1-11.

Pérez-Chaparro, C., Kangas, M., Zech, P., Schuch, F. B., Rapp, M., & Heissel, A. (2021). Recreational exercise is associated with lower prevalence of depression and anxiety and better quality of life in German people living with HIV. AIDS care, 1-6.

2020

Deeken, F., Banaschewski, T., Kluge, U., & Rapp, M. A. .Risk and Protective Factors for Alcohol Use Disorders Across the Lifespan.

Heinz, A., Kiefer, F., Smolka, M. N., Endrass, T., Beste, C., Beck, A., ... Rapp, M.A., …. (2020). Addiction Research Consortium: Losing and regaining control over drug intake (ReCoDe)—From trajectories to mechanisms and interventions. Addiction Biology, 25(2), e12866.

Heissel, A., Pietrek, A., Schwefel, M., Abula, K., Wilbertz, G., Heinzel, S., & Rapp, M. (2020). STEP. De study—a multicentre cluster-randomised effectiveness trial of exercise therapy for patients with depressive symptoms in healthcare services: study protocol. BMJ open, 10(4), e036287.

2019

Deeken, F., Rezo, A., Hinz, M., Discher, R., & Rapp, M. A. (2019). Evaluation of Technology-Based Interventions for Informal Caregivers of Patients With Dementia—A Meta-Analysis of Randomized Controlled Trials. The American Journal of Geriatric Psychiatry, 27(4), 426-445.

Heissel, A., Pietrek, A., Rapp, M. A., Heinzel, S., & Williams, G. (2019). Perceived Health Care Climate of Older People Attending an Exercise Program: Validation of the German Short Version of the Health Care Climate Questionnaire. Journal of aging and physical activity, 1(aop), 1-11.

Schad, D. J., Rapp, M. A., Garbusow, M., Nebe, S., Sebold, M., Obst, E., ... & Romanczuk-Seiferth, N. (2019). Dissociating neural learning signals in human sign-and goal-trackers. Nature human behaviour, 1-14.

Schad, D. J., Garbusow, M., Friedel, E., Sommer, C., Sebold, M., Hägele, C., ... & Rapp, M. A. (2019). Neural correlates of instrumental responding in the context of alcohol-related cues index disorder severity and relapse risk. European archives of psychiatry and clinical neuroscience, 269(3), 295-308.

Sánchez, A., Thomas, C., Deeken, F., Wagner, S., Klöppel, S., Kentischer, F., ... & Rapp, M. A.. (2019). Patient safety, cost-effectiveness, and quality of life: reduction of delirium risk and postoperative cognitive dysfunction after elective procedures in older adults—study protocol for a stepped-wedge cluster randomized trial (PAWEL Study). Trials, 20(1), 71.

2018

Deeken, F., Häusler, A., Nordheim, J., Rapp, M., Knoll, N., & Rieckmann, N. (2018). Psychometric properties of the Perceived Stress Scale in a sample of German dementia patients and their caregivers. International Psychogeriatrics, 30(1), 39–47. https://doi.org/10.1017/S1041610217001387

Gellert, P., Häusler, A., Suhr, R., Gholami, M., Rapp, M., Kuhlmey, A., & Nordheim, J. (2018). Testing the stress-buffering hypothesis of social support in couples coping with early-stage dementia. PloS One, 13(1), e0189849. https://doi.org/10.1371/journal.pone.0189849

Schad, D. J., Garbusow, M., Friedel, E., Sommer, C., Sebold, M., Hägele, C., … Rapp, M. A. (2018). Neural correlates of instrumental responding in the context of alcohol-related cues index disorder severity and relapse risk. European Archives of Psychiatry and Clinical Neuroscience. https://doi.org/10.1007/s00406-017-0860-4

2017

Deeken, F., Rezo, A., & Rapp, M. A. (2017). Prävention von Demenzerkrankungen. In E. Gräßel & A. Pendergrass (Hrsg.), Forschungsplattform Demenz: Ergebnisse eines Expertentreffens zu Präventions-, Therapie- und Versorgungsstrategien (1. Aufl., S. 7–24). Essen: NATUR UND MEDIZIN.

Gruebner, O., A. Rapp, M., Adli, M., Kluge, U., Galea, S., & Heinz, A. (2017). Cities and Mental Health. Deutsches Ärzteblatt International, 114(8), 121–127. https://doi.org/10.3238/arztebl.2017.0121

Gutzmann, H., & Rapp, M. (2017). Systematik organisch-symptomatischer Störungen. In H. J. Möller, G. Laux, & H. P. Kapfhammer (Hrsg.), Psychiatrie, Psychosomatik, Psychotherapie (S. 1351–1364). Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-49295-6_57

Heinzel, S., Lorenz, R. C., Duong, Q.-L., Rapp, M. A., & Deserno, L. (2017). Prefrontal-parietal effective connectivity during working memory in older adults. Neurobiology of Aging, 57, 18–27. https://doi.org/10.1016/j.neurobiolaging.2017.05.005

Heinzel, S., Rapp, M. A., Fydrich, T., Ströhle, A., Terán, C., Kallies, G., … Heissel, A. (2018). Neurobiological mechanisms of exercise and psychotherapy in depression: The SPeED study-Rationale, design, and methodological issues. Clinical Trials (London, England), 15(1), 53–64. https://doi.org/10.1177/1740774517729161

Rapp, M. A., Tschorn, M., Sebold, M., Garbusow, M., Smolka, M., & Heinz, A. (2017). Multivariate Prädiktion von Trinkverhalten: Das Ganze ist weniger als die Summe seiner Teile. In Suchttherapie (Bd. 18, S. S-11-04-11). Georg Thieme Verlag KG. https://doi.org/10.1055/s-0037-1604546

Sebold, M., Nebe, S., Garbusow, M., Guggenmos, M., Schad, D. J., Beck, A., … Heinz, A. (2017). When Habits Are Dangerous: Alcohol Expectancies and Habitual Decision Making Predict Relapse in Alcohol Dependence. Biological Psychiatry, 82(11), 847–856. https://doi.org/10.1016/j.biopsych.2017.04.019

Stelzel, C., Schauenburg, G., Rapp, M. A., Heinzel, S., & Granacher, U. (2017). Age-Related Interference between the Selection of Input-Output Modality Mappings and Postural Control-a Pilot Study. Frontiers in Psychology, 8, 613. https://doi.org/10.3389/fpsyg.2017.00613

2016

Bauer, M., Banaschewski, T., Heinz, A., Kamp-Becker, I., Meyer-Lindenberg, A., Padberg, F.,. . . Wittchen, H. (2016). Das deutsche Forschungsnetz zu psychischen Erkrankungen. Der Nervenarzt, 87(9), 989–1010. doi.org/10.1007/s00115-016-0169-y

Garbusow, M., Schad, D. J., Sebold, M., Friedel, E., Bernhardt, N., Koch, S. P.,. . . Heinz, A. (2016). Pavlovian-to-instrumental transfer effects in the nucleus accumbens relate to relapse in alcohol dependence. Addiction Biology, 21(3), 719–731. doi.org/10.1111/adb.12243

Häusler, A., Sánchez, A., Gellert, P., Deeken, F., Rapp, M. A., & Nordheim, J. (2016). Perceived stress and quality of life in dementia patients and their caregiving spouses: Does dyadic coping matter? International Psychogeriatrics, 28(11), 1857–1866. doi.org/10.1017/S1041610216001046

Heinz, A., Kluge, U., & Rapp, M. A. (2016). Heritability of living in deprived neighbourhoods. Translational Psychiatry, 6(11), e941. doi.org/10.1038/tp.2016.215

Heinz, A., Beck, A., & Rapp, M. A. (2016). Alcohol as an Environmental Mortality Hazard. JAMA Psychiatry, 73(6), 549. doi.org/10.1001/jamapsychiatry.2016.0399

Heinz, A., Voss, M., Lawrie, S. M., Mishara, A., Bauer, M., Gallinat, J.,. . . Galderisi, S. (2016). Shall we really say goodbye to first rank symptoms? European Psychiatry, 37, 8–13. doi.org/10.1016/j.eurpsy.2016.04.010

2015

Aichberger MC, Heredia Montesinos A, Bromand Z, Yesil R, Temur-Erman S, Rapp MA, Heinz A, Schouler-Ocak M. Suicide attempt rates and intervention effects in women of Turkish origin in Berlin. Eur Psychiatry. 2015 Jun;30(4):480-5. doi: 10.1016/j.eurpsy.2014.12.003. Epub 2015 Jan 14. PubMed PMID: 25596777.

Garbusow M, Schad DJ, Sebold M, Friedel E, Bernhardt N, Koch SP, Steinacher B, Kathmann N, Geurts DE, Sommer C, Müller DK, Nebe S, Paul S, Wittchen HU, Zimmermann US, Walter H, Smolka MN, Sterzer P, Rapp MA, Huys QJ, Schlagenhauf F, Heinz A. Pavlovian-to-instrumental transfer effects in the nucleus accumbens relate to relapse in alcohol dependence. Addict Biol. 2015 Apr 1. doi: 10.1111/adb.12243. [Epub ahead of print] PubMed PMID: 25828702.

Heinz A, Charlet K, Rapp MA. Public mental health: a call to action. World Psychiatry. 2015 Feb;14(1):49-50. doi: 10.1002/wps.20182. PubMed PMID: 25655154; PubMed Central PMCID: PMC4329893.

Rapp MA, Kluge U, Penka S, Vardar A, Aichberger MC, Mundt AP, Schouler-Ocak M, Mösko M, Butler J, Meyer-Lindenberg A, Heinz A. When local poverty is more important than your income: Mental health in minorities in inner cities. World Psychiatry. 2015 Jun;14(2):249-50. doi: 10.1002/wps.20221. PubMed PMID: 26043348.

2014

Garbusow M, Schad DJ, Sommer C, Jünger E, Sebold M, Friedel E, Wendt J, Kathmann N, Schlagenhauf F, Zimmermann US, Heinz A, Huys QJ, Rapp MA. Pavlovian-to-Instrumental Transfer in Alcohol Dependence: A Pilot Study. Neuropsychobiology. 2014;70(2):111-21.

Häusler, A., Krause-Köhler, K., Niemann-Mirmehdi, M., Nordheim, J., Rapp, M. Psychosoziale Therapie bei beginnender Demenz, Frankfurt: Mabuse, 2014.

Heinzel S, Lorenz RC, Brockhaus WR, Wüstenberg T, Kathmann N, Heinz A, Rapp MA. Working memory load-dependent brain response predicts behavioral training gains in older adults. J Neurosci. 2014 Jan 22;34(4):1224-33.

Heinzel S, Riemer TG, Schulte S, Onken J, Heinz A, Rapp MA. Catechol-O-methyltransferase (COMT) genotype affects age-related changes in plasticity in working memory: a pilot study. Biomed Res Int. 2014;2014:414351.

Schad DJ, Jünger E, Sebold M, Garbusow M, Bernhardt N, Javadi AH, Zimmermann US, Smolka MN, Heinz A, Rapp MA, Huys QJ. Processing speed enhances model-based over model-free reinforcement learning in the presence of high working memory functioning. Front Psychol. 2014 Dec 17;5:1450. doi: 10.3389/fpsyg.2014.01450. eCollection 2014. PubMed PMID: 25566131; PubMed Central PMCID: PMC4269125.

Schlagenhauf F, Huys QJ, Deserno L, Rapp MA, Beck A, Heinze HJ, Dolan R, Heinz A. Striatal dysfunction during reversal learning in unmedicated schizophrenia patients. Neuroimage. 2014 Apr 1;89:171-80.

Treusch Y, Majic T, Page J, Gutzmann H, Heinz A, Rapp MA. Apathy in nursing home residents with dementia: Results from a cluster-randomized controlled trial. Eur Psychiatry. 2014 Mar 13. [Epub ahead of print]

Zaytseva Y, Korsakova N, Gurovich IY, Heinz A, Rapp MA. Luria revisited: Complex motor phenomena in first episode schizophrenia and schizophrenia spectrum disorders. Psychiatry Res. 2014 Aug 27. [Epub ahead of print]

2013

Heinzel S, Schulte S, Onken J, Duong QL, Riemer TG, Heinz A, Kathmann N, Rapp MA. Working memory training improvements and gains in non-trained cognitive tasks in young and older adults. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2013 May 2. [Epub ahead of print]

Majić T, Gutzmann H, Heinz A, Lang UE, Rapp MA. Animal-Assisted Therapy and Agitation and Depression in Nursing Home Residents with Dementia: A Matched Case-Control Trial. Am J Geriatr Psychiatry. 2013 Jul 3. [Epub ahead of print]

Rapp MA, Mell T, Majic T, Treusch Y, Nordheim J, Niemann-Mirmehdi M, Gutzmann H, Heinz A. Agitation in Nursing Home Residents With Dementia (VIDEANT Trial): Effects of a Cluster-Randomized, Controlled, Guideline Implementation Trial. J Am Med Dir Assoc. 2013 Jul 1. [Epub ahead of print]

Schlagenhauf F, Rapp MA, Huys QJ, Beck A, Wüstenberg T, Deserno L, Buchholz HG, Kalbitzer J, Buchert R, Bauer M, Kienast T, Cumming P, Plotkin M, Kumakura Y, Grace AA, Dolan RJ, Heinz A. Ventral striatal prediction error signaling is associated with dopamine synthesis capacity and fluid intelligence. Hum Brain Mapp. 2013;34(6):1490-9.

vor 2013

Bromand Z, Temur-Erman S, Yesil R, Heredia Montesinos A, Aichberger MC, Kleiber D, Schouler-Ocak M, Heinz A, Kastrup MC, Rapp MA. Mental health of Turkish women in Germany: resilience and risk factors. Eur Psychiatry. 2012;27 Suppl 2:S17-21.

Krampe RT, Doumas M, Lavrysen A, Rapp MA. The costs of taking it slowly: fast and slow movement timing in older age. Psychol Aging. 2010;25(4):980-90

Rieckmann N, Rapp MA, Müller-Nordhorn J. Gene-environment interactions and depression. JAMA. 2009;302(17):1861

Rapp MA, Schnaider-Beeri M, Grossman HT, Sano M, Perl DP, Purohit DP, Gorman JM, Haroutunian V. Increased hippocampal plaques and tangles in patients with Alzheimer disease with a lifetime history of major depression. Arch Gen Psychiatry. 2006;63(2):161-7.