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Chair of Social and Preventive Medicine

Structural area of Cognitive Sciences – Department of Sport and Health Sciences

Publications (selection)


Hoffmann, S., Tschorn, M., Michalski, N., Hoebel, J.,

Förstner, B. R., Rapp, M. A. & Spallek, J. (2022). Association of regional socioeconomic deprivation and rurality with global developmental delay in early childhood: Data from mandatory school entry examinations in Germany. Health & Place, 75, 102794.


Deeken, F., Sánchez, A., Rapp, M. A., Denkinger, M., Brefka, S., Spank, J., Bruns, C., Arnim, C. A. F. von, Küster, O. C., Conzelmann, L. O., Metz, B. R., Maurer, C., Skrobik, Y., Forkavets, O., Eschweiler, G. W. & Thomas, C. (2022). Outcomes of a Delirium Prevention Program in Older Persons After Elective Surgery: A Stepped-Wedge Cluster Randomized Clinical Trial. JAMA surgery, 157(2), e216370.

Tschorn, M., Lorenz, R. C., O’Reilly, P. F., Reichenberg, A., Banaschewski, T., Bokde, A. L., ... & Rapp, M. A. (2021). Differential predictors for alcohol use in adolescents as a function of familial risk. Translational Psychiatry, 11(1), 1-11.

Schumann, G., Tschorn, M., Heinz, A., & Rapp, M. (2021). Jenseits von IMAGEN: populationsneurowissenschaftliche Strategien für klinische und globale Kohorten in den STRATIFY-und GIGA-Konsortien. Der Nervenarzt, 1-8.

Pérez-Chaparro, C., Kangas, M., Zech, P., Schuch, F. B., Rapp, M., & Heissel, A. (2021). Recreational exercise is associated with lower prevalence of depression and anxiety and better quality of life in German people living with HIV. AIDS care, 1-6.



Heinz, A., Kiefer, F., Smolka, M. N., Endrass, T., Beste, C., Beck, A., ... Rapp, M.A., …. (2020). Addiction Research Consortium: Losing and regaining control over drug intake (ReCoDe)—From trajectories to mechanisms and interventions. Addiction Biology25(2), e12866.

Heissel, A., Pietrek, A., Schwefel, M., Abula, K., Wilbertz, G., Heinzel, S., & Rapp, M. (2020). STEP. De study—a multicentre cluster-randomised effectiveness trial of exercise therapy for patients with depressive symptoms in healthcare services: study protocol. BMJ open10(4), e036287.

Deeken, F., Banaschewski, T., Kluge, U., & Rapp, M. A. .Risk and Protective Factors for Alcohol Use Disorders Across the Lifespan.



Schad, D. J., Rapp, M. A., Garbusow, M., Nebe, S., Sebold, M., Obst, E., ... & Romanczuk-Seiferth, N. (2019). Dissociating neural learning signals in human sign-and goal-trackers. Nature human behaviour, 1-14.

Deeken, F., Rezo, A., Hinz, M., Discher, R., & Rapp, M. A. (2019). Evaluation of Technology-Based Interventions for Informal Caregivers of Patients With Dementia—A Meta-Analysis of Randomized Controlled Trials. The American Journal of Geriatric Psychiatry27(4), 426-445.

Schad, D. J., Garbusow, M., Friedel, E., Sommer, C., Sebold, M., Hägele, C., ... & Rapp, M. A. (2019). Neural correlates of instrumental responding in the context of alcohol-related cues index disorder severity and relapse risk. European archives of psychiatry and clinical neuroscience269(3), 295-308.

Sánchez, A., Thomas, C., Deeken, F., Wagner, S., Klöppel, S., Kentischer, F., ... & Rapp, M. A.. (2019). Patient safety, cost-effectiveness, and quality of life: reduction of delirium risk and postoperative cognitive dysfunction after elective procedures in older adults—study protocol for a stepped-wedge cluster randomized trial (PAWEL Study). Trials20(1), 71.

Heissel, A., Pietrek, A., Rapp, M. A., Heinzel, S., & Williams, G. (2019). Perceived Health Care Climate of Older People Attending an Exercise Program: Validation of the German Short Version of the Health Care Climate Questionnaire. Journal of aging and physical activity1(aop), 1-11.


Gellert, P., Häusler, A., Suhr, R., Gholami, M., Rapp, M., Kuhlmey, A., & Nordheim, J. (2018). Testing the stress-buffering hypothesis of social support in couples coping with early-stage dementia. PloS One13(1), e0189849.

Schad, D. J., Garbusow, M., Friedel, E., Sommer, C., Sebold, M., Hägele, C., … Rapp, M. A. (2018). Neural correlates of instrumental responding in the context of alcohol-related cues index disorder severity and relapse risk. European Archives of Psychiatry and Clinical Neuroscience

Deeken, F., Häusler, A., Nordheim, J., Rapp, M., Knoll, N., & Rieckmann, N. (2018). Psychometric properties of the Perceived Stress Scale in a sample of German dementia patients and their caregivers. International Psychogeriatrics30(1), 39–47.



Deeken, F., Rezo, A., & Rapp, M. A. (2017). Prävention von Demenzerkrankungen. In E. Gräßel & A. Pendergrass (Hrsg.), Forschungsplattform Demenz: Ergebnisse eines Expertentreffens zu Präventions-, Therapie- und Versorgungsstrategien (1. Aufl., S. 7–24). Essen: NATUR UND MEDIZIN.

Gruebner, O., A. Rapp, M., Adli, M., Kluge, U., Galea, S., & Heinz, A. (2017). Cities and Mental Health. Deutsches Ärzteblatt International114(8), 121–127.

Gutzmann, H., & Rapp, M. (2017). Systematik organisch-symptomatischer Störungen. In H. J. Möller, G. Laux, & H. P. Kapfhammer (Hrsg.), Psychiatrie, Psychosomatik, Psychotherapie (S. 1351–1364). Springer, Berlin, Heidelberg.

Heinzel, S., Lorenz, R. C., Duong, Q.-L., Rapp, M. A., & Deserno, L. (2017). Prefrontal-parietal effective connectivity during working memory in older adults. Neurobiology of Aging57, 18–27.

Heinzel, S., Rapp, M. A., Fydrich, T., Ströhle, A., Terán, C., Kallies, G., … Heissel, A. (2018). Neurobiological mechanisms of exercise and psychotherapy in depression: The SPeED study-Rationale, design, and methodological issues. Clinical Trials (London, England)15(1), 53–64.

Rapp, M. A., Tschorn, M., Sebold, M., Garbusow, M., Smolka, M., & Heinz, A. (2017). Multivariate Prädiktion von Trinkverhalten: Das Ganze ist weniger als die Summe seiner Teile. In Suchttherapie (Bd. 18, S. S-11-04-11). Georg Thieme Verlag KG.

Sebold, M., Nebe, S., Garbusow, M., Guggenmos, M., Schad, D. J., Beck, A., … Heinz, A. (2017). When Habits Are Dangerous: Alcohol Expectancies and Habitual Decision Making Predict Relapse in Alcohol Dependence. Biological Psychiatry82(11), 847–856.

Stelzel, C., Schauenburg, G., Rapp, M. A., Heinzel, S., & Granacher, U. (2017). Age-Related Interference between the Selection of Input-Output Modality Mappings and Postural Control-a Pilot Study. Frontiers in Psychology8, 613.




Bauer, M., Banaschewski, T., Heinz, A., Kamp-Becker, I., Meyer-Lindenberg, A., Padberg, F.,. . . Wittchen, H. (2016). Das deutsche Forschungsnetz zu psychischen Erkrankungen. Der Nervenarzt, 87(9), 989–1010.

Garbusow, M., Schad, D. J.

, Sebold, M., Friedel, E., Bernhardt, N., Koch, S. P.,. . . Heinz, A. (2016). Pavlovian-to-instrumental transfer effects in the nucleus accumbens relate to relapse in alcohol dependence. Addiction Biology, 21(3), 719–731.

Häusler, A., Sánchez, A., Gellert, P., Deeken, F.Rapp, M. A.,

 & Nordheim, J. (2016). Perceived stress and quality of life in dementia patients and their caregiving spouses: Does dyadic coping matter? International Psychogeriatrics, 28(11), 1857–1866.

Heinz, A., Kluge, U., & Rapp, M. A

. (2016). Heritability of living in deprived neighbourhoods. Translational Psychiatry, 6(11), e941.

Heinz, A., Voss, M., Lawrie, S. M., Mishara, A., Bauer, M., Gallinat, J.,. . . Galderisi, S. (2016). Shall we really say goodbye to first rank symptoms? European Psychiatry, 37, 8–13.

Heinz, A., Beck, A., & Rapp, M. A.

 (2016). Alcohol as an Environmental Mortality Hazard. JAMA Psychiatry, 73(6), 549. 

Rapp MA, Kluge U, Penka S, Vardar A, Aichberger MC, Mundt AP, Schouler-Ocak M, Mösko M, Butler J, Meyer-Lindenberg A, Heinz A. When local poverty is more important than your income: Mental health in minorities in inner cities. World Psychiatry. 2015 Jun;14(2):249-50. doi: 10.1002/wps.20221. PubMed PMID: 26043348.

Heinz A, Charlet K, Rapp MA. Public mental health: a call to action. World Psychiatry. 2015 Feb;14(1):49-50. doi: 10.1002/wps.20182. PubMed PMID: 25655154; PubMed Central PMCID: PMC4329893.

Aichberger MC, Heredia Montesinos A, Bromand Z, Yesil R, Temur-Erman S, Rapp MAHeinz A, Schouler-Ocak M. Suicide attempt rates and intervention effects in women of Turkish origin in Berlin. Eur Psychiatry. 2015 Jun;30(4):480-5. doi: 10.1016/j.eurpsy.2014.12.003. Epub 2015 Jan 14. PubMed PMID: 25596777.

Schad DJ, Jünger E, Sebold M, Garbusow M, Bernhardt N, Javadi AH, Zimmermann US, Smolka MN, Heinz ARapp MA, Huys QJ. Processing speed enhances model-based over model-free reinforcement learning in the presence of high working memory functioning. Front Psychol. 2014 Dec 17;5:1450. doi: 10.3389/fpsyg.2014.01450. eCollection 2014. PubMed PMID: 25566131; PubMed Central PMCID: PMC4269125.

Garbusow M, Schad DJ, Sebold M, Friedel E, Bernhardt N, Koch SP, Steinacher B, Kathmann N, Geurts DE, Sommer C, Müller DK, Nebe S, Paul S, Wittchen HU, Zimmermann US, Walter H, Smolka MN, Sterzer P, Rapp MA, Huys QJ, Schlagenhauf F, Heinz A. Pavlovian-to-instrumental transfer effects in the nucleus accumbens  relate to relapse in alcohol dependence. Addict Biol. 2015 Apr 1. doi: 10.1111/adb.12243. [Epub ahead of print] PubMed PMID: 25828702.

Häusler, A.Krause-Köhler, K., Niemann-Mirmehdi, M., Nordheim, J., Rapp, M. Psychosoziale Therapie bei beginnender Demenz, Frankfurt: Mabuse, 2014.

Garbusow M, Schad DJ, Sommer C, Jünger E, Sebold M, Friedel E, Wendt J, Kathmann N, Schlagenhauf F, Zimmermann US, Heinz A, Huys QJ, Rapp MA. Pavlovian-to-Instrumental Transfer in Alcohol Dependence: A Pilot Study. Neuropsychobiology. 2014;70(2):111-21.

Zaytseva Y, Korsakova N, Gurovich IY, Heinz A, Rapp MA. Luria revisited: Complex motor phenomena in first episode schizophrenia and schizophrenia spectrum disorders. Psychiatry Res. 2014 Aug 27. [Epub ahead of print]

Heinzel S, Riemer TG, Schulte S, Onken J, Heinz A, Rapp MA. Catechol-O-methyltransferase (COMT) genotype affects age-related changes in plasticity in working memory: a pilot study. Biomed Res Int. 2014;2014:414351.

Schlagenhauf F, Huys QJ, Deserno L, Rapp MA, Beck A, Heinze HJ, Dolan R, Heinz A. Striatal dysfunction during reversal learning in unmedicated schizophrenia patients. Neuroimage. 2014 Apr 1;89:171-80.

Treusch Y, Majic T, Page J, Gutzmann H, Heinz A, Rapp MA. Apathy in nursing home residents with dementia: Results from a cluster-randomized controlled trial. Eur Psychiatry. 2014 Mar 13. [Epub ahead of print]

Heinzel S, Lorenz RC, Brockhaus WR, Wüstenberg T, Kathmann N, Heinz A, Rapp MA. Working memory load-dependent brain response predicts behavioral training gains in older adults. J Neurosci. 2014 Jan 22;34(4):1224-33.

Rapp MA, Mell T, Majic T, Treusch Y, Nordheim J, Niemann-Mirmehdi M, Gutzmann H, Heinz A. Agitation in Nursing Home Residents With Dementia (VIDEANT Trial): Effects of a Cluster-Randomized, Controlled, Guideline Implementation Trial. J Am Med Dir Assoc. 2013 Jul 1. [Epub ahead of print]

Majić T, Gutzmann H, Heinz A, Lang UE, Rapp MAAnimal-Assisted Therapy and Agitation and Depression in Nursing Home Residents with Dementia: A Matched Case-Control Trial. Am J Geriatr Psychiatry. 2013 Jul 3. [Epub ahead of print]

Heinzel S, Schulte S, Onken J, Duong QL, Riemer TG, Heinz A, Kathmann N, Rapp MAWorking memory training improvements and gains in non-trained cognitive tasks in young and older adults. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2013 May 2. [Epub ahead of print]

Schlagenhauf F, Rapp MA, Huys QJ, Beck A, Wüstenberg T, Deserno L, Buchholz HG, Kalbitzer J, Buchert R, Bauer M, Kienast T, Cumming P, Plotkin M, Kumakura Y, Grace AA, Dolan RJ, Heinz A. Ventral striatal prediction error signaling is associated with dopamine synthesis capacity and fluid intelligence. Hum Brain Mapp. 2013;34(6):1490-9.

Bromand Z, Temur-Erman S, Yesil R, Heredia Montesinos A, Aichberger MC, Kleiber D, Schouler-Ocak M, Heinz A, Kastrup MC, Rapp MAMental health of Turkish women in Germany: resilience and risk factors. Eur Psychiatry. 2012;27 Suppl 2:S17-21.

Krampe RT, Doumas M, Lavrysen A, Rapp MAThe costs of taking it slowly: fast and slow movement timing in older age. Psychol Aging. 2010;25(4):980-90

Rieckmann N, Rapp MA, Müller-Nordhorn J. Gene-environment interactions and depression. JAMA. 2009;302(17):1861

Rapp MA, Schnaider-Beeri M, Grossman HT, Sano M, Perl DP, Purohit DP, Gorman JM, Haroutunian V. Increased hippocampal plaques and tangles in patients with Alzheimer disease with a lifetime history of major depression. Arch Gen Psychiatry. 2006;63(2):161-7.