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Publications

Here you find Elke Dittmann's Google Scholar profile.

2019

Barchewitz, T., Guljamow, A., Meissner, S., Timm, S., Henneberg, M., Baumann, O., Hagemann, M., Dittmann, E. (2019) Non-canonical localization of RubisCO under high light conditions in the toxic cyanobacterium Microcystis aeruginosa PCC7806. BioRxiv preprint. DOI: 10.1101/695841

Dehm, D., Krumbholz, J., Baunach, M., Wiebach, V., Hinrichs, K., Guljamow, A., Tabuchi, R., Jenke-Kodama, H., Süssmuth, R.D., Dittmann, E. (2019) Unlocking the spatial control of secondary metabolism uncovers hidden natural product diversity in Nostoc punctiforme. ACS Chem Biol. doi: 10.1021/acschembio.9b00240 

Pancrace, C., Ishida, K., Briand, E., Gatte-Picchi, D., Weiz, A.R., Guljamow, A., Scalvenzi, T., Sassoon, N., Hertweck, C., Dittmann, E.*, Gugger, M.* (2018) A unique biosynthetic pathway in bloom-forming cyanobacterial genus Microcystis jointly assembles cytotoxic aeruginoguanidines and microguanidines. ACS Chem. Biol. 14: 67-75.

2018

Schuurmans J.M., Brinkmann, B.W., Makower, A.K., Dittmann, E., Huisman, J., Matthijs, H.C.P. (2018) Microcystin interfers with defense against oxidative stress in harmful cyanobacteria. Harmful Algae 78: 47-55.

Hackenberg, C., Hakanpää, J., Cai, F., Antonyuk, S., Eigner, S., Meissner, S., Laitaoja, M., Jänis, J., Kerfeld, C.A., Dittmann, E., Lamzin, V.S. (2018) Structural and functional insights into the unique CBS-CP12 fusion protein family in cyanobacteria. Proc. Natl. Acad. Sci. 115: 7141-7146

Hu, C., Ludsin, S.A., Martin, J.F., Dittmann, E., Lee, J (2018) Mycosporine-like amino acids (MAAs)-producing Microcystis in Lake Erie: Development of a qPCR assay and insight into its ecology Harmful Algae 77:1-10.

2017

Meyer, S., Mainz, A., Kehr, J.C., Suessmuth, R.D., Dittmann, E. (2017) Prerequisites of isopeptide bond formation in microcystin biosynthesis. ChemBioChem 18: 2376-2379.

Woodhouse, J.N., Makower, A.K., Grossart, H.P., Dittmann, E. (2017) Draft genome sequence of two uncultured Armatimonadetes associated with a Microcystis sp. (cyanobacteria) isolate. Genome Announc. 5 (40): pii: e00717-17

Guljamow, A., Kreische, M., Ishida, K., Liaimer, A., Altermark, B., Bähr, L., Hertweck, C., Ehwald, R., Dittmann, E. (2017) High density cultivation of terrestrial Nostoc strains leads to reprogramming of secondary metabolome. Appl. Environ. Microbiol, 83: e01510-17

Kurmayer et al. (Eds) (2017) Molecular Tools for the Detection and Quantification of Toxigenic Cyanobacteria. Wiley Weinheim, Germany. 

Ahmed, M.N., Reyna-González, E., Schmid, B., Wiebach, V., Suessmuth, R.D., Dittmann, E.*, Fewer, D.* (2017) Phylogenomic analysis of the microviridin biosynthetic pathway coupled with targeted chemoenzymatic synthesis yields potent protease inhibitors. ACS Chem. Biol. 12: 1538-1546. 

2016

Liaimer, A., Jensen, J.B., Dittmann, E. (2016) A Genetic and chemical perspective on symbiotic recruitment of cyanobacteria of the genus Nostoc into the host plant Blasia pusilla. Front. Microbiol., 7:1693. doi: 10.3389/fmib.2016.01693

Reyna-González, E., Schmid, B., Petras, D., Süssmuth, R.D., Dittmann, E. (2016) Leader peptide-free in vitro reconstitution of microviridin biosynthesis enables design of synthetic protease-targeted libraries. Angew. Chem. Int. Ed. 55: 9398-9401.

Pearson, L.A., Dittmann, E., Mazmouz, R., Ongley, S.E., D'Agostino, P.M., Neilan, B.A. (2016) The genetics, biosynthesis and regulation of toxic specialized metabolites of cyanobacteria. Harmful Algae 54: 98-111.

Meyer, S., Kehr, J-C., Mainz, A., Dehm, D., Petras, D., Süssmuth, R.D., Dittmann, E. (2016) Biochemical dissection of the natural diversification of microcystin provides lessons for synthetic biology of NRPS. Cell Chem. Biol. 23:462-471

2015

Dittmann, E., Gugger, M., Sivonen, K., Fewer, D. (2015) Natural product biosynthetic diversity and comparative genomics of the cyanobacteria. Trends Microbiol. 23: 642-652.

Kehr, J.C., Dittmann, E. (2015) Protective endosymbiont with extreme genome reduction. Environ. Microbiol. DOI: 10.1111/1462-2920.12941

Liaimer, A., Helfrich, E.J.N., Hinrichs, K., Guljamow, A., Ishida, K., Hertweck, C., Dittmann, E. (2015) Nostopeptolide plays a governing role during cellular differentiation of the symbiotic cyanobacterium Nostoc punctiforme. Proc. Natl. Acad. Sci. U.S.A. 112: 1862-1867.

Kehr, J.C., Dittmann, E. (2015) Biosynthesis and function of extracellular glycans in cyanobacteria. Life (Basel) 5: 164-180.

Makower, K., Schuurmans, J.M., Groth, D., Zilliges, Y., Matthijs, H.C.P., Dittmann, E. (2015) Transcriptomics aided dissection of the intracellular and the extracellular role of microcystin in M. aeruginosa PCC 7806. Appl. Environ. Microbiol., 81:544-554.

2014

Hu, C., Völler, G., Süßmuth, R., Dittmann, E., Kehr, J.C. (2014) Functional assessment of mycosporine-like amino acids in Microcystis aeruginosa strain PCC7806. Environ. Microbiol., doi: 10.1111/1462-2920.12577

Meissner, S., Steinhauser, D., Dittmann, E. (2014) Metabolomic analysis indicates a pivotal role of the hepatotoxin microcystin in high light adaptation of Microcystis. Environ. Microbiol., DOI: 10.1111/1462-2920.12565

Gatte-Picchi, D., Weiz, A., Ishida, K., Hertweck, C., Dittmann, E. (2014) Functional analysis of environmental DNA derived miroviridins provides new insights into the diversity of the tricyclic peptide family. Appl. Environ. Microbiol., 80:1380-1387.

Weiz, A., Ishida, K., Quitterer, F., Meyer, S., Müller, K., Groll, M., Hertweck, C., Dittmann, E. (2014) Harnessing the evolvability of tricyclic microviridins to dissect protease-inhibitor interactions. Angew. Chem. Int. Ed. 53: 3735-3738.

2013

Voß, B., Bolhuis, H., Fewer, D.P., Kopf, M., Möke, F., Haas, F., El-Shehawy, R.,  Hayes, P., Bergman, B., Sivonen, K., Dittmann, E., Scanlan, D.J., Hagemann, M.,  Stal, L.J., Hess, W.R. (2013) Insights into the physiology and ecology of the brackish-water-adapted cyanobacterium Nodularia spumigena CCY9414 based on a genome-transcriptome analysis. PLoS One doi: 10.1371/journal.pone.0060224.

 Kehr, J.C., Dittmann, E. (2013) Cyanobakterielle Toxine: Von der Biosynthese zur Funktion. Biospektrum 19: 16-18.

 Meissner, S., Fastner, J., Dittmann, E. (2013) Microcystin production re-visited: Conjugate formation makes a major contribution. Environ. Microbiol. 15: 1810-1820.

 Dittmann, E., Fewer, D., Neilan, B.A. (2013) Cyanobacterial Toxins: Biosynthetic Routes and Evolutionary Roots. FEMS Microbiol. Rev. 37: 23-43.

 van der Donk, W.A. et al. (2013) Ribosomally synthesized and posttranslationally modified peptide natural products: overview and recommendations for a universal nomenclature. Nat. Prod. Rep. 30: 108-160.

2012

Welker, M., Dittmann, E., von Döhren, H. (2012) Cyanobacteria as source for natural products. Meth. Enzymol. 517:23-46.

Kaplan, A., Harel, M., Kaplan-Levy,R.N., Hadas, O., Sukenik, A. Dittmann, E (2012) The languages spoken in the water body (or the biological role of cyanobacterial toxins). Front. Microbio. 3:138. doi: 10.3389/fmicb.2012.00138

Harel, M., Weiss, G., Daniel, E., Wilenz, A., Hadas, O., Sukenik, A., Sedmak,  B., Dittmann, E., Braun, S., Kaplan, A. (2012) Casting a net: fibres produced by Microcystis sp. in field and laboratory populations. Environ. Microbiol. Rep. 4 (3): 342-349.

Neilan, B.A., Pearson, L.A., Muenchhoff, J., Moffitt, M.C., Dittmann, E. (2012) Environmental conditions that influence toxin biosynthesis in cyanobacteria. Environ. Microbiol. 15: 1239-1253.

Guljamow, A., Delissen, F., Baumann, O., Thünemann, A.F., Dittmann, E. (2012) Unique properties of eukaryotic-type actin and profilin horizontally transferred to cyanobacteria. PLoS ONE 7(1): e29926. doi:10.1371/journal.pone.0029926

2011

Kehr, J.C., Gatte-Picchi, D., Dittmann, E. (2011) Natural product biosyntheses in cyanobacteria: A treasure trove of unique enzymes. Beilstein J. Org. Chem. 7: 1622-1635.

Weiz, A., Ishida, K., Makower, K., Ziemert, N., Hertweck, C., Dittmann, E. (2011) Leader peptide and a membrane protein scaffold guide the biosynthesis of tricyclic depsipeptides in cyanobacteria. Chem. Biol. 18: 1413-1421.

Liaimer, A., Jenke-Kodama. H., Ishida, K., Hinrichs, K., Stangeland, J., Hertweck, C., Dittmann, E. (2011) A polyketide interfers with cellular differentiation in the symbiotic cyanobacterium Nostoc punctiforme. Environ. Microbiol. Rep. 3: 550-558.

Férir, G., Vermeire, K., Huskens, D., Balzarini, J., Van Damme, E.J., Kehr, J.C., Dittmann, E., Swanson, M.D., Markovitz, D.M., Schols, D. (2011) Synergistic in vitro anti-HIV type 1 activity of tenofovir with carbohydrate-binding agents (CBAs). Antiviral Res. 90: 200-204.

Zilliges, I., Kehr, J.C., Meissner, S., Ishida, K., Mikkat, S., Hagemann, M., Kaplan, A., Börner, T., Dittmann, E. (2011) The cyanobacteriel hepatotoxin microcystin binds to proteins and increases the fitness under oxidative stress conditions. PLoS One 10.1371/journal.pone.0017615

2010

Huskens, D., Ferir, G., Vermeire, K., Kehr, J.-C., Balzarini, J., Dittmann, E., Schols, D. (2010) Microvirin, a novel alpha (1,2)-mannose-specific lectin isolated from Microcystis aeruginosa, has comparable anti-HIV-1 activity as cyanovirin-N, but a much higher safety profile. J. Biol. Chem., 285:24845-24854.

 Ziemert, N., Ishida, K., Weiz, A., Hertweck, C., Dittmann, E. (2010) Exploiting the natural diversity of microviridin gene clusters for the discovery of novel tricyclic depsipeptides. Appl. Environ. Microbiol. 76:3568-3574.

2009

Jenke-Kodama, H., Dittmann, E. (2009) Evolution of metabolic diversity: Insights from microbial polyketide synthases. Phytochem. 70:1858-1866.

Jenke-Kodama, H., Dittmann, E. (2009) Bioinformatic perspectives on NRPS/PKS megasynthases: Advances and challenges. Nat. Prod. Rep. 26:874-883.

Ishida, K., Welker, M., Christiansen, G., Cadel-Six, S., Bouchier, C., Dittmann, E., Hertweck, C., Tandeau de Marsac, N. (2009) Plasticity and evolution of aeruginosin biosynthesis in cyanobacteria. Appl. Environ. Microbiol. 75: 2017-2026.

2008

Ziemert, N., Ishida, K., Liaimer, A., Hertweck, C., Dittmann, E. (2008) Ribosomal synthesis of tricyclic depsipeptides in bloom-forming cyanobacteria. Angew. Chem. Int. Ed. Engl. 47: 7756-7759.

Frangeul, L., Quillardet, P., Castets, A.M., Humbert, J.F., Matthijs, H.C., Cortez, D., Tolonen, A., Zhang, C.C., Gribaldo, S., Kehr, J.C., Zilliges, Y., Ziemert, N., Becker, S., Talla, E., Latifi, A., Billault, A., Lepelletier, A., Dittmann, E., Bouchier, C., de Marsac, N.T.(2008) Highly plastic genome of Microcystis aeruginosa PCC 7806, a ubiquitous toxic freshwater cyanobacterium. BMC Genomics 9:274.

Zilliges, Y., Kehr, J.C., Mikkat, S., Bouchier, C., Tandeau de Marsac, N., Börner, T., Dittmann, E. (2008) An extracellular glycoprotein is implicated in cell-cell contacts in the toxic cyanobacterium Microcystis aeruginosa PCC 7806. J. Bacteriol. 190: 2871-2879.

Ziemert, N., Ishida, K., Quillardet, P., Bouchier, C., Hertweck, C., Tandeau de Marsac, N., Dittmann, E. (2008) Microcyclamide biosynthesis in two strains of Microcystis aeruginosa: from structure to genes and vice versa. Appl. Environ. Microbiol. 74: 1791-1797.

Nguyen, T., Ishida, K., Jenke-Kodama, H., Dittmann, E., Gurgui, C., Hochmuth, T., Taudien, S., Platzer, M., Hertweck, C., Piel, J. (2008) Exploiting the mosaic structure of trans-acyltransferase polyketide synthases for natural product discovery and pathway dissection. Nat. Biotechnol. 26: 225-233.

Jenke-Kodama, H., Müller, R., Dittmann, E. (2008) Evolutionary Mechanisms underlying secondary metabolite diversity. In: Petersen, F. and Amstutz, R. (Eds) Progress in Drug Research. Vol. 65, pp. 119-141.

2007

Traitcheva, N., Jenke-Kodama, H., He, J., Dittmann, E., Hertweck, C. (2007) Non-Colinear Polyketide Biosynthesis in the Aureothin and Neoaureothin Pathways: An Evolutionary Perspective. Chembiochem. 8: 1841-1849

Guljamow, A., Jenke-Kodama, H., Saumweber, H., Quillardet, P., Frangeul, L., Castets, A,M., Bouchier, C., Tandeau de Marsac, N., Dittmann, E. (2007) Horizontal gene transfer of two cytoskeletal elements from a eukaryote to a cyanobacterium. Curr. Biol. 17(17):R757-759.

Ishida, K., Christiansen, G., Yoshida, W., Welker, M., Hertweck, C., Bonjoch, J., Börner,T., Hemscheidt, T., Dittmann, E. (2007). Biosynthetic pathway and structure analysis of aeruginoside 126A and B, cyanobacterial peptides bearing an unusual 2-carboxy-6-hydroxyoctahydroindole moiety. Chem. Biol. 14: 565-576.

Schatz, D., Keren, Y., Vardi, A., Sukenik, A., Carmeli, S., Börner, T., Dittmann, E. and Kaplan, A. (2007) Towards clarification of the biological role of microcystins, a family of cyanobacterial toxins. Environ. Microbiol. 9: 965-970.

Sandmann, A., Dickschat, J., Jenke-Kodama, H., Kunze, B., Dittmann, E., and Müller, R. (2007) A type II polyketide synthase from the Gram negative bacterium Stigmatella aurantiaca is involved in aurachin alkaloid biosynthesis. Angew. Chem. Int. Ed. 46: 2712-2716.

2006

Jenke-Kodama, H., Börner, T., Dittmann, E. (2006) Natural Biocombinatorics in the Polyketide Synthase Genes of the Actinobacterium Streptomyces avermitilis. PLoS Comp. Biol. 2:e132

Carre-Mlouka, A., Mejean, A., Quillardet, P. Ashida, H., Saito, Y., Yokota, A., Callebaut, I., Sekowska, A., Dittmann, E., Bouchier, C., Tandeau de Marsac, N. (2006) A new rubisco-like protein coexists with a photosynthetic rubisco in the planktonic cyanobacteria microcystis. J. Biol. Chem. 281:24462-24471.

Kehr, J.-C., Zilliges, Y., Disney, M.D. Ratner, D.M. Bouchier, C., Seeberger, P.H., Tandeau de Marsac, N., Dittmann, E. (2006) A mannan-binding lectin is involved in cell-cell attachment in a toxic strain of Microcystis aeruginosa. Mol. Microbiol. 59: 893-906.

Gross, F., Luniak, N., Gottschalk, D., Perlova, O., Gaitatzis, N., Gerth, K., Jenke-Kodama, H., Dittmann, E. and Müller, R. (2006) Bacterial type III polyketide synthases: Phylogenetic analysis and potential for the production of novel secondary metabolites by heterologous expression in Pseudomonads. Arch. Microbiol. 185: 28-38.

Dittmann, E., Wiegand, C., (2006) Cyanobacterial Toxins - Occurrence, Biosynthesis and Impact on Human Affairs. Invited Review. Molecular Nutrition and Food Research 50: 7-17.

2005

Jenke-Kodama, H., Dittmann, E. (2005) Combinatorial polyketide biosynthesis at higher stage. Molecular Systems Biology, News and Views Comment., doi:10.1038/msb4100033.

Saker, M.L., Fastner, J., Dittmann, E., Christiansen, G. and V. M. Vasconcelos (2005) Toxicological variation between strains of the cyanobacterium Microcystis aeruginosa isolated from a Portuguese river. J. Appl. Microbiol., 99: 749-755.

Tonk, L., Visser, P.M., Christiansen, G., Dittmann, E., Weijerman, M., Snelder, E.O.F.M., Wiedner, C., Mur, L.R., Huisman, J. (2005) The cyanobacterium Planktothrix agardhii changes its microcystin composition towards a more toxic variant with increasing irradiance. Appl. Environ. Microbiol., 71: 5177-5181.

Jenke-Kodama, H., Sandmann, A., Müller, R., Dittmann, E. (2005) Evolutionary Implications of Bacterial Polyketide Synthases. Mol. Biol. Evol. 22: 2027-2039.

Rohrlack, T., Christoffersen, K., Dittmann, E., Nogueira, I., Vasconcelos V., Borner, T. (2005) Ingestion of microcystins by Daphnia: Intestinal uptake and toxic effects. Limnology and Oceanography 50 : 440-448.

Dittmann, E., Börner, T. (2005) Genetic contributions to the risk assessment of microcystin in the environment - lessons from biosynthesis genes. Toxicol. Appl. Pharmacol. 203: 192-200.

2004

Via-Ordorika, L., Fastner, J., Hisbergues, M., Dittmann, E., Komarek, J., Kurmayer, R., Chorus, I. (2004) Distribution of microcystin-producing and non-microcystin-producing Microcystis in European freshwater bodies: detection of microcystins and mcy genes in single colonies. Syst. Appl. Microbiol. 27: 592-602.

Pearson, L., Hisbergues, M., Börner, T., Dittmann, E. Neilan, B.A. (2004) Inactivation of the ABC transporter gene mcyH results in the loss of microcystin in Microcystis aeruginosa PCC 7806. Appl. Environ. Microbiol., 70: 6370-6378.

2003

Sielaff H, Dittmann E, Tandeau De Marsac N, Bouchier C, Von Döhren H, Börner T, Schwecke T. (2003) The mcyF gene of the microcystin biosynthetic gene cluster from Microcystis aeruginosa encodes an aspartate racemase. Biochem J. 373: 909-916.

Christiansen, G., Fastner, J., Erhard, M., Börner, T., Dittmann, E. (2003) Microcystin biosynthesis in Planktothrix: genes, evolution and manipulation. J Bacteriol. 185: 564-572.

2002

Kurmayer, R., Dittmann, E., Fastner, J., Chorus, I. (2002) Diversity of microcystin genes in lake Wannsee (Germany), Microbial. Ecol. 43: 107-118

Kaebernick, M., Dittmann, E., Börner, T., Neilan, B.A. (2002) Transcriptional analysis of the microcystin synthetase gene cluster in the cyanobacterium Microcystis aeruginosa, Appl. Environ. Microbiol, 68: 449-455.

2001

Hesse K, Dittmann E, Börner T (2001) Consequences of impaired microcystin production for light-dependent growth and pigmentation of Microcystis aeruginosa PCC 7806 FEMS Microbiol. Ecol. 37: 39-43

Dittmann, E., Erhard, M., Kaebernick, M., Scheler, C., Neilan, B.A., von Döhren, H. and Börner, T. (2001) Altered expression of two light dependent genes in a microcystin deficient mutant of Microcystis aeruginosa PCC7806. Microbiology 147: 3113-3119

Rohrlack T, Dittmann E, Börner T, Christoffersen K. (2001) Effects of Cell-Bound Microcystins on Survival and Feeding of Daphnia spp. Appl. Environ. Microbiol. 67:3523-3529

Christiansen, G, Dittmann, E., Via Ordorika, L., Rippka, R., Herdman, M., Börner, T. (2001) Nonribosomal peptide synthetase genes occur in most cyanobacterial genera as evidenced by their distribution in axenic strains of the PCC Arch. Microbiol. 176: 452-458

Dittmann, E., Neilan, B.A., Börner, T. (2001) Molecular biology of peptide and polyketide biosynthesis in cyanobacteria. Appl. Microbiol. Biotechnol. 57: 467-473

Dittmann, E; Erhard, M; Tillett, D; Neilan, BA; von Dohren, H; Börner, T. (2001) Characterization of microcystin synthetase genes in Microcystis aeruginosa In: CYANOTOXINS: OCCURRENCE CAUSES CONSEQUENCES, 142-147

1996-2000

Kaebernick, M., Neilan, B.A., Börner, T and Dittmann, E. (2000)

The effect of light on the regulation of microcystin biosynthesis genes, Appl. Environ. Microbiol. 66:3387-3392

Tillett, D. Dittmann, E., Erhard, M., von Döhren, H, Börner, T., Neilan, B.A. (2000)

Structural organization of microcystin biosynthesis in Microcystis aeruginosa PCC7806: An integrated peptide-polyketide synthetase system. Chem. Biol. 7:753-764

Dittmann, E., Christiansen, G., Neilan, B.A. Fastner, J.Rippka, R., amd Börner, T. (1999) Peptide synthetase genes occur in various species of cyanobacteria. In: Peschek et al. (eds) The Phototrophic Prokaryotes, Kluwer Academic/ Plenum Publishers, New York: 615-621

Rohrlack, T., Dittmann, E., Henning, M., Börner, T. and Kohl J.G. (1999)

Role of microcystins in poisoning and food ingestion inhibition of Daphnia galeata caused by the cyanobacterium Microcystis aeruginosa, Appl. Environ.Microbiol 65: 737-739

Neilan, B.A., Dittmann, E., Rouhiainen, L., Bass, R.L., Schaub, V. Sivonen, K. and Börner, T. (1999) Nonribosomal peptide synthesis and toxigenicity of cyanobacteria, J. Bacteriol. 181: 4089-4097

Dittmann, E., Neilan, B. A., Erhard, M., von Döhren, H., Börner, T. (1997)

Insertional mutagenesis of a peptide synthetase gene that is responsible for hepatotoxin production in Microcystis aeruginosa PCC 7806, Mol. Microbiol. 26: 779-784

Meißner, K., Dittmann,E., Börner, T. (1996)

Toxic and nontoxic strains of the cyanobacterium Microcystis aeruginosa contain sequences homologous to peptide synthetase genes, FEMS Microbiol. Lett. 135: 295-303

Dittmann, E., Meißner, K., Börner, T. (1996)

Conserved sequences of peptide synthetase genes in the cyanobacterium Microcystis aeruginosa, Phycologia 35 (6): 62-67

Börner, T., Dittmann, E., Meißner, K., Pohlers, M. (1996) "Giftfabrik" Blaualge, Humboldt-Spektrum 3: 14-19