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Intrinsically Disordered Proteins - Publications

Please also refer to: pubmed.ncbi.nlm.nih.gov

Wojciechowska I, Mukherjee T, Knox-Brown P, Hu X, Khosla A, Subedi B, Ahmad B, Mathews G, Panagakis A, Thompson K, Peery S, Szlachetko J, Thalhammer A, Hincha D, Skirycz A, Schrick K. Arabidopsis PROTODERMAL FACTOR2 binds lysophosphatidylcholines and transcriptionally regulates phospholipid metabolism, New Phytologist 2024, accepted.

Skoulas D, Ojo OM, Thalhammer A, Kochovski Z, Schlaad H. Solution behavior of glyco-copoly(L-glutamic acid)s in dilute saline solution, Biomacromolecules 2024, accepted.

Hernández-Sánchez I, Rindfleisch T, Alpers J, Dulle M, Garvey CJ, Knox-Brown P, Miettinen MS, Nagy G, Pusterla JM, Rekas A, Shou K, Stadler AM, Walther D, Wolff M, Zuther E, Thalhammer A. Functional in vitro diversity of an intrinsically disordered plant protein during freeze-thawing is encoded by its structural plasticity. Protein Sci. 2024;33(5):e4989.

Uflewski M, Rindfleisch T, Korkmaz K, Tietz E, Mielke S, Correa Galvis V, Dünschede B, Luzarowski M, Skirycz A, Schwarzländer M, Strand DD, Hertle AP, Schünemann D, Walther D, Thalhammer A, Wolff M, Armbruster U. The thylakoid proton antiporter KEA3 regulates photosynthesis in response to the chloroplast energy status. Nat Commun. 2024;15(1):2792.

Thalhammer A, Bröker NK. Biophysical Approaches for the Characterization of Protein-Metabolite Interactions. Methods Mol Biol. 2023;2554:199-229.

Hernández-Sánchez IE, Maruri-López I, Martinez-Martinez C, Janis B, Jiménez-Bremont JF, Covarrubias AA, Menze MA, Graether SP, Thalhammer A. LEAfing through literature: late embryogenesis abundant proteins coming of age-achievements and perspectives. J Exp Bot. 2022;73(19):6525-6546.

Wolff M, Gast K, Evers A, Kurz M, Pfeiffer-Marek S, Schüler A, Seckler R, Thalhammer A. A conserved hydrophobic moiety and helix–helix interactions drive the self-assembly of the incretin analog Exendin-4. Biomolecules. 2021; 11(9):1305

Thalhammer A, Pagter M, Hincha DK, Zuther E. Measuring freezing tolerance of leaves and rosettes: Electrolyte leakage and chlorophyll fluorescence assays. Methods Mol Biol. 2020;2156:9-21.

Knox-Brown P, Rindfleisch T, Günther A, Balow K, Bremer A, Walther D, Miettinen MS, Hincha DK, Thalhammer A. Similar yet different-structural and functional diversity among Arabidopsis thaliana LEA_4 proteins. Int J Mol Sci. 2020;21(8):2794.

Wolff M, Schüler A, Gast K, Seckler R, Evers A, Pfeiffer-Marek S, Kurz M, Nagel N, Haack T, Wagner M, Thalhammer A. Self-assembly of Exendin-4-derived dual peptide agonists is mediated by acylation and correlated to the length of conjugated fatty acyl chains. Mol Pharm. 2020;17(3):965-978.

Shou K, Bremer A, Rindfleisch T, Knox-Brown P, Hirai M, Rekas A, Garvey CJ, Hincha DK, Stadler AM, Thalhammer A. Conformational selection of the intrinsically disordered plant stress protein COR15A in response to solution osmolarity - an X-ray and light scattering study. Phys Chem Chem Phys. 2019;21(34):18727-18740

Sowemimo OT, Knox-Brown P, Borcherds W, Rindfleisch T, Thalhammer A, Daughdrill GW. Conserved Glycines Control Disorder and Function in the Cold-Regulated Protein, COR15A. Biomolecules. 2019;9(3). pii: E84

Stuchfield D, France AP, Migas LG, Thalhammer A, Bremer A, Bellina B, Barran PE. The Use of Mass Spectrometry to Examine IDPs: Unique Insights and Caveats. Methods Enzymol. 2018;611:459-50

Navarro-Retamal C, Bremer A, Ingólfsson HI, Alzate-Morales J, Caballero J, Thalhammer A, González W, Hincha DK. Folding and lipid composition determine membrane interaction of the disordered protein COR15A. Biophys J. 2018;115(6):968-980

Broeker NK, Kiele F, Casjens SR, Gilcrease EB, Thalhammer A, Koetz J, Barbirz S. In Vitro Studies of Lipopolysaccharide-Mediated DNA Release of Podovirus HK620. Viruses. 2018 May 29;10(6).

Sprenger H, Erban A, Seddig S, Rudack K, Thalhammer A, Le MQ, Walther D, Zuther E, Köhl KI, Kopka J, Hincha DK. Metabolite and transcript markers for the prediction of potato drought tolerance. Plant Biotechnol J. 2018;16(4):939-950

Gast K, Schüler A, Wolff M, Thalhammer A, Berchtold H, Nagel N, Lenherr G, Hauck G, Seckler R. Rapid-acting and human insulins: Hexamer dissociation kinetics upon dilution of the pharmaceutical formulation. Pharm Res. 2017;34(11):2270-2286

Bremer A, Kent B, Hauß T, Thalhammer A, Yepuri NR, Darwish TA, Garvey CJ, Bryant G, Hincha DK. Intrinsically disordered stress protein COR15A resides at the membrane surface during dehydration. Biophys J. 2017;113(3):572-579

Braig F, Kriegs M, Voigtlaender M, Habel B, Grob T, Biskup K, Blanchard V, Sack M, Thalhammer A, Ben Batalla I, Braren I, Laban S, Danielczyk A, Goletz S, Jakubowicz E, Märkl B, Trepel M, Knecht R, Riecken K, Fehse B, Loges S, Bokemeyer C, Binder M. Cetuximab resistance in head and neck cancer is mediated by EGFR-K(521) polymorphism. Cancer Res. 2017;77(5):1188-1199.

Bremer A, Wolff M, Thalhammer A, Hincha DK. Folding of intrinsically disordered plant LEA proteins is driven by glycerol-induced crowding and the presence of membranes. FEBS J. 2017;284(6):919-936

Navarro-Retamal C, Bremer A, Alzate-Morales J, Caballero J, Hincha DK, González W, Thalhammer A. Molecular dynamics simulations and CD spectroscopy reveal hydration-induced unfolding of the intrinsically disordered LEA proteins COR15A and COR15B from Arabidopsis thaliana. Phys Chem Chem Phys. 2016;18(37):25806-16

Thalhammer A, Hincha DK. A mechanistic model of COR15 protein function in plant freezing tolerance: integration of structural and functional characteristics. Plant Signal Behav. 2014;9(12):e977722

Thalhammer A, Bryant G, Sulpice R, Hincha DK. Disordered cold regulated15 proteins protect chloroplast membranes during freezing through binding and folding, but do not stabilize chloroplast enzymes in vivo. Plant Physiol. 2014;166(1):190-201

Thalhammer A, Hincha DK, Zuther E. Measuring freezing tolerance: electrolyte leakage and chlorophyll fluorescence assays. Methods Mol Biol. 2014;1166:15-24

Thalhammer A, Hincha DK.  Plant and microbe adaptations to cold in a changing world. New York: Springer; 2013. Chapter 8, The Function and Evolution of Closely Related COR/LEA (Cold-Regulated/Late Embryogenesis Abundant) Proteins in Arabidopsis thaliana; p. 89-105

Hincha DK, Thalhammer A. LEA proteins: IDPs with versatile functions in cellular dehydration tolerance. Biochem Soc Trans. 2012;40(5):1000-3. Review.

Thalhammer A, Hundertmark M, Popova AV, Seckler R, Hincha DK. Interaction of two intrinsically disordered plant stress proteins (COR15A and COR15B) with lipid membranes in the dry state. Biochim Biophys Acta. 2010;1798(9):1812-20.