Dorothee is now a Postdoctoral fellow in the Zon lab at the Boston Children’s Hospital (Longwood Medical Area in Boston) and Harvard University (Cambridge).
Dorothee Bornhorst Ph.D. student
Education
PhD Student at Hannover Medical School (MHH), since 2015
Hannover, Germany
Master of Science,2014
Ruprecht-Karls University Heidelberg, Germany
Bachelor of Science, 2012
University Osnabrück, Germany
Research Interests
My research focuses on chamber development of the endocardium, a specialized endothelium that is lining the interior of the heart and that responds to biomechanical stimuli exerted by blood flow through activation of specific gene expression programs. I investigate endocardial development in context with the surrounding myocardium and the underlying mechanical forces. Zebrafish as a model system allows me to use a highly flexible combination of genetic tools, fluorescence reporter-based transgenic lines with genetic fate-mapping strategies and RNAseq based techniques in vivo.
Awards
EuFishBioMed Travel Grant 2017
Publications
- Kirchmaier S, Höckendorf B, Möller EK, Bornhorst D, Spitz F, Wittbrodt J (2013). Efficient site-specific transgenesis and enhancer activity tests in medaka using PhiC31 integrase, Developmentdoi: 10.1242/dev.096081.
- Paolini A, Duchemin AL, Albadri S, Patzel E, Bornhorst D, Gonzalez Avalos P, Lemke S, Machate A, Brand M, Sel S, Di Donato V,Del Bene F, Zolessi FR, Ramialison M, Poggi L (2015). Asymmetric inheritance of the apical domain and self-renewal of retinal ganglion cell progenitors depend on Anillin function. Development doi: 10.1242/dev.118612.
- Blaas L, Pucci F, Messal HA, Andersson AB, Josue Ruiz E, Gerling M, Douagi I, Spencer-Dene B, Musch A, Mitter R, Bhaw L, Stone R, Bornhorst D, Sesay AK, Jonkers J, Stamp G, Malanchi I, Toftgård R, Behrens A (2016). Lgr6 labels a rare population of mammary gland progenitor cells that are able to originate luminal mammary tumours. Nature Cell Biologydoi: 10.1038/ncb3434.
- Olmer R, Engels L, Usman A, Menke S, Malik MNH, Pessler F, Göhring G, Bornhorst D, Bolten S, Abdelilah-Seyfried S, Scheper T, Kempf H, Zweigerdt R, Martin U (2018). Differentiation of Human Pluripotent Stem Cells into Functional Endothelial Cells in Scalable Suspension Culture. Stem Cell Reports doi: 10.1016/j.stemcr.2018.03.017.