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Isothermal Titration calorimetry (ITC)
ITC is a powerful technique to determine the enthalpy of a process like ligand binding. Our work with ITC focuses on the binding of O-antigen fragments to tailspike proteins from bacteriophages. For our protein-carbohydrate binding pairs we get different thermodynamic signatures helping to investigate general driving forces of protein-carbohydrate binding.
Other groups at our University also used ITC to investigate demicellization and surfactant-polymer interactions.
We have a Malvern MicroCal VP-ITC.
Differential Scanning calorimetry (DSC)