Dr. Anja Thalhammer

Dr. Anja Thalhammer
Photo: Dr. Nina Bröker

Dr. Anja Thalhammer

Email:   anja.thalhammeruni-potsdamde

Phone:  0331-9775267

University of Potsdam

Institute of Biochemistry and Biology - Physical Biochemistry

Karl-Liebknecht-Str. 24-25, H 25, B0.09

14476 Potsdam

Researchgate profile

 

Education

PhD in Biology, 2013, University of Potsdam, Germany

Diploma in Biology, 2008, Free University Berlin, Germany

 

Research interests

 

Publications

Wolff M, Schüler A, Gast K, Seckler R, Evers A, Pfeiffer-Marek S, Kurz M, Nagel N, Haack T, Wagner M, Thalhammer A. Self-assembly of Exendin-4-derived dual peptide agonists is mediated by acylation and correlated to the length of conjugated fatty acyl chains. Mol Pharm. 2020;17(3):965-978.

Shou K, Bremer A, Rindfleisch T, Knox-Brown P, Hirai M, Rekas A, Garvey CJ, Hincha DK, Stadler AM, Thalhammer A. Conformational selection of the intrinsically disordered plant stress protein COR15A in response to solution osmolarity - an X-ray and light scattering study. Phys Chem Chem Phys. 2019;21(34):18727-18740

Sowemimo OT, Knox-Brown P, Borcherds W, Rindfleisch T, Thalhammer A, Daughdrill GW. Conserved Glycines Control Disorder and Function in the Cold-Regulated Protein, COR15A. Biomolecules. 2019;9(3). pii: E84

Stuchfield D, France AP, Migas LG, Thalhammer A, Bremer A, Bellina B, Barran PE. The Use of Mass Spectrometry to Examine IDPs: Unique Insights and Caveats. Methods Enzymol. 2018;611:459-50

Navarro-Retamal C, Bremer A, Ingólfsson HI, Alzate-Morales J, Caballero J, Thalhammer A, González W, Hincha DK. Folding and lipid composition determine membrane interaction of the disordered protein COR15A. Biophys J. 2018;115(6):968-980

Broeker NK, Kiele F, Casjens SR, Gilcrease EB, Thalhammer A, Koetz J, Barbirz S. In Vitro Studies of Lipopolysaccharide-Mediated DNA Release of Podovirus HK620. Viruses. 2018 May 29;10(6).

Sprenger H, Erban A, Seddig S, Rudack K, Thalhammer A, Le MQ, Walther D, Zuther E, Köhl KI, Kopka J, Hincha DK. Metabolite and transcript markers for the prediction of potato drought tolerance. Plant Biotechnol J. 2018;16(4):939-950

Gast K, Schüler A, Wolff M, Thalhammer A, Berchtold H, Nagel N, Lenherr G, Hauck G, Seckler R. Rapid-acting and human insulins: Hexamer dissociation kinetics upon dilution of the pharmaceutical formulation. Pharm Res. 2017;34(11):2270-2286

Bremer A, Kent B, Hauß T, Thalhammer A, Yepuri NR, Darwish TA, Garvey CJ, Bryant G, Hincha DK. Intrinsically disordered stress protein COR15A resides at the membrane surface during dehydration. Biophys J. 2017;113(3):572-579

Braig F, Kriegs M, Voigtlaender M, Habel B, Grob T, Biskup K, Blanchard V, Sack M, Thalhammer A, Ben Batalla I, Braren I, Laban S, Danielczyk A, Goletz S, Jakubowicz E, Märkl B, Trepel M, Knecht R, Riecken K, Fehse B, Loges S, Bokemeyer C, Binder M. Cetuximab resistance in head and neck cancer is mediated by EGFR-K(521) polymorphism. Cancer Res. 2017;77(5):1188-1199.

Bremer A, Wolff M, Thalhammer A, Hincha DK. Folding of intrinsically disordered plant LEA proteins is driven by glycerol-induced crowding and the presence of membranes. FEBS J. 2017;284(6):919-936

Navarro-Retamal C, Bremer A, Alzate-Morales J, Caballero J, Hincha DK, González W, Thalhammer A. Molecular dynamics simulations and CD spectroscopy reveal hydration-induced unfolding of the intrinsically disordered LEA proteins COR15A and COR15B from Arabidopsis thaliana. Phys Chem Chem Phys. 2016;18(37):25806-16

Thalhammer A, Hincha DK. A mechanistic model of COR15 protein function in plant freezing tolerance: integration of structural and functional characteristics. Plant Signal Behav. 2014;9(12):e977722

Thalhammer A, Bryant G, Sulpice R, Hincha DK. Disordered cold regulated15 proteins protect chloroplast membranes during freezing through binding and folding, but do not stabilize chloroplast enzymes in vivo. Plant Physiol. 2014;166(1):190-201

Thalhammer A, Hincha DK, Zuther E. Measuring freezing tolerance: electrolyte leakage and chlorophyll fluorescence assays. Methods Mol Biol. 2014;1166:15-24

Thalhammer A, Hincha DK.  Plant and microbe adaptations to cold in a changing world. New York: Springer; 2013. Chapter 8, The Function and Evolution of Closely Related COR/LEA (Cold-Regulated/Late Embryogenesis Abundant) Proteins in Arabidopsis thaliana; p. 89-105

Hincha DK, Thalhammer A. LEA proteins: IDPs with versatile functions in cellular dehydration tolerance. Biochem Soc Trans. 2012;40(5):1000-3. Review.

Thalhammer A, Hundertmark M, Popova AV, Seckler R, Hincha DK. Interaction of two intrinsically disordered plant stress proteins (COR15A and COR15B) with lipid membranes in the dry state. Biochim Biophys Acta. 2010;1798(9):1812-20. 

 

Dr. Anja Thalhammer
Photo: Dr. Nina Bröker