Peer-Reviewed Articles

2020

M. Schwarz, K. Lossow, K. Schirl, J. Hackler, J. F. Kopp, K. Renko, T. Schwerdtle, L. Schomburg, A. P. Kipp
Copper interferes with selenoprotein synthesis and activity.
Redox Biol.; Oct. 2020
doi: 10.1016/j.redox.2020.101746

N. Winkelbeiner, V.  K. Wandt, F. Ebert, K. Lossow, E. E. Bankoglu, M. Martin, A. Mangerich, H. Stopper, J. Bornhorst, A. P. Kipp, T. Schwerdtle
A Multi-Endpoint Approach to Base Excision Repair Incision Activity Augmented by PARylation and DNA Damage Levels in Mice: Impact of Sex and Age.
Int. J. Mol. Sci.; Sep 2020; 21, 6600
doi: 10.3390/ijms21186600

Y. Wang, E. Rijntjes, Q. Wu, H. Lv, C. Gao, B. Shi, L. Schomburg
Selenium deficiency is linearly associated with hypoglycemia in healthy adults.
Redox Biol.; Sep 2020; 37: 101709
doi: 10.1016/j.redox.2020.101709               

M. Outzen, A. Tjønneland, DJ Hughes, M. Jenab, K. Frederiksen, L. Schomburg, S. Morris, K. Overvad, A. Olsen 
Toenail selenium, plasma selenoprotein P and risk of advanced prostate cancer: A nested case-control study.
INT J CANCER; Aug 2020
doi: 10.1002/ijc.33267                  

H. Finke, N. Winkelbeiner, K. Lossow, B. Hertel, V. K. Wandt, M. Schwarz, G. Pohl, J. F. Kopp, F. Ebert, A. P. Kipp, T. Schwerdtle
Effects of a Cumulative, Suboptimal Supply of Multiple Trace Elements in Mice: Trace Element Status, Genomic Stability, Inflammation, and Epigenetics.
Mol. Nutr. Food Res.; July 2020; 64, 2000325
doi: 10.1002/mnfr.202000325

 A. Moghaddam, RA Heller, Q. Sun, J. Seelig, A. Cherkezov, L. Seibert, J. Hackler, P. Seemann, J. Diegmann, M. Pilz, M. Bachmann, WB Minich, L. Schomburg
Selenium Deficiency Is Associated with Mortality Risk from COVID-19.
Nutrients; July 2020; 12 (7): 2098
doi: 10.3390/nu12072098

Q. Sun, J. Hackler, J. Hilger, H. Gluschke, A. Muric, S. Simmons, L. Schomburg, E. Siegert
Selenium and Copper as Biomarkers for Pulmonary Arterial Hypertension in Systemic Sclerosis.
Nutrients; June 2020;12 (6): 1894
doi: 10.3390/nu12061894.           

K. Lossow, J.F. Kopp, M. Schwarz, H. Finke , N. Winkelbeiner , K. Renko , X. Meçi , Ch. Ott , W. Alker , J. Hackler, T. Grune, L. Schomburg, H. Haase, T. Schwerdtle, A. P. Kipp
Aging affects sex- and organ-specific trace element profiles in mice.
AgING; July 2020
doi: 10.18632/aging.103572

H. Finke, V. K. Wandt, F. Ebert, N. Guttenberger, R. A. Glabonjat, M. Stiboller, K. A. Francesconi, G. Raber, T. Schwerdtle
Toxicological assessment of arsenic-containing phosphatidylcholines in HepG2 cells.
Metallomics; May 2020
doi: 10.1039/D0MT00073F

R. Hauffe, V. Stein, Ch. Chudoba, T. Flore, M. Rath, K. Ritter, M. Schell, K. Wardelmann, S. Deubel, J. F. Kopp, M. Schwarz, K. Kappert, M. Blüher, T. Schwerdtle, A. P. Kipp, A.Kleinridders
GPx3 dysregulation impacts adipose tissue insulin receptor expression and sensitivity.
JCI insight; May 2020; 5(11):e136283
doi: 10.1172/jci.insight.136283

R.A. Heller, A. Sperl, J. Seelig, P. Haubruck, T. Bock, T. Werner, A. Besseling, Q. Sun, L. Schomburg, A. Moghaddam, B. Biglari.
Zinc Concentration Dynamics Indicate Neurological Impairment Odds after Traumatic Spinal Cord Injury.
Antioxidants (Basel); May 2020; 9(5):421
doi: 10.3390/antiox9050421

O. Brodin, J. Hackler, S. Misra, S. Wendt, Q. Sun, E. Laaf, C. Stoppe, M. Björnstedt, L. Schomburg.
Selenoprotein P as Biomarker of Selenium Status in Clinical Trials with Therapeutic Dosages of Selenite.
Nutrients; Apr 2020; 12(4)
doi: 10.3390/nu12041067

S. Gachkar, R. Oelkrug,  B. Herrmann, T.S. Scanlan, Q. Sun, H. Biebermann, C.S. Hoefig, L. Schomburg , J. Mittag.
N- and O-Acetylated 3-Iodothyronamines Have No Metabolic or Thermogenic Effects in Male Mice.
European Thyroid Journal; Feb 2020; 9(2):57-66
doi: 10.1159/000504887

S. Nock, K. Johann, L. Harder, E.K. Wirth, K. Renko, C. Höfig, V. Kracke, J. Hackler, B. Engelmann, M. Rauner, J. Köhrle, L. Schomburg, G. Homuth, U. Völker, G. Brabant, J. Mittag
CD5L constitutes a novel biomarker for integrated hepatic thyroid hormone action.
Thyroid; Mar 2020; 30 (6)
doi: 10.1089/thy.2019.0635

C. Schwiebert, P. Kühnen, N.P. Becker, T. Welsink, T. Keller, W.B. Minich, S. Wiegand, L. Schomburg
Antagonistic Autoantibodies to Insulin-Like Growth Factor-1 Receptor Associate with Poor Physical Strength.
International Journal of Molecular Sciences; Jan 2020; 21(2)
doi: 10.3390/ijms21020463

S. Mehl, Q. Sun, C.L. Görlich, J. Hackler, J.F. Kopp, K. Renko, J. Mittag, T. Schwerdtle, L. Schomburg
Cross-sectional analysis of trace element status in thyroid disease.
Journal of Trace Elements in Medicine and Biology; Mar 2020; 58, 126430
doi: 10.1016/j.jtemb.2019.126430

L. Schomburg
The other view: the trace element selenium as a micronutrient in thyroid disease, diabetes, and beyond.
Hormones (Athens); Mar 2020; 19(1):15-24
doi: 10.1007/s42000-019-00150-4

J. Hackler, M. Wisniewska, L. Greifenstein-Wiehe, W.B. Minich, M. Cremer, C. Bührer, L. Schomburg
Copper and selenium status as biomarkers of neonatal infections.
Journal of Trace Elements in Medicine and Biology; Mar 2020; 58, 126437
doi: 10.1016/j.jtemb.2019.126437

T. Bednarczuk, L. Schomburg
Challenges and perspectives of selenium supplementation in Graves' disease and orbitopathy.
Hormones (Athens); Mar 2020; 19(1):31-39
doi: 10.1007/s42000-019-00133-5

J. Seelig, R.A. Heller, J. Hackler, P. Haubruck, A. Moghaddam, B. Biglari, L. Schomburg 
Selenium and copper status - potential signposts for neurological remission after traumatic spinal cord injury.
Journal of Trace Elements in Medicine and Biology; Jan 2020; 57, 126415
doi: 10.1016/j.jtemb.2019.126415

C. Neumann, J. Baesler, G. Steffen, M. M. Nicolai, T. Zubel, M. Aschner, A. Bürkle, A. Mangerich, T. Schwerdtle, J. Bornhorst
The role of poly(ADP-ribose) polymerases in manganese exposed Caenorhabditis elegans.
Journal of Trace Elements in Medicine and Biology; Jan 2020; 57:21-27
doi: 10.1016/j.jtemb.2019.09.001

S.M. Müler, C. Dawczynski, J. Wiest, S. Lorkowski, A.P. Kipp, T. Schwerdtle
Functional Biomarkers for the Selenium Status in a Human Nutritional Intervention Study.
Nutrients; Mar 2020; 12(3)
doi: 10.3390/nu12030676

B. Witt, D. Schaumlöffel, T. Schwerdtle
Subcellular localization of copper – cellular bioimaging with focus on neurological disorders.
International Journal of Molecular Sciences; Mar 2020;  21, 2341
doi: 10.3390/ijms21072341

M. Braunstein, T. Kusmenkov, C. Zuck, M. Angstwurm, N. P. Becker, W. Böcker, L. Schomburg, V. Bogner-Flatz
Selenium and Selenoprotein P Deficiency Correlates with Complications and Adverse Outcome After Major Trauma.
Shock; Jan 2020
doi: 10.1097/SHK.0000000000001344

2019

S. C. Koeberle, A. Gollowitzer, J. Laoukili, O. Kranenburg, O. Werz, A. Koeberle, A. P. Kipp
Distinct and overlapping functions of glutathione peroxidases 1 and 2 in limiting NF-κB-driven inflammation through redox-active mechanisms.
Redox Biology; Nov 2019
doi: 10.1016/j.redox.2019.101388

J. Baudry, J. F. Kopp, H. Boeing, A. P. Kipp, T. Schwerdtle, M. B. Schulze
Changes of trace element status during aging: results of the EPIC-Potsdam cohort study.
European Journal of Nutrition; Nov 2019
doi: 10.1007/s00394-019-02143-w

K. Lossow, T. Schwerdtle, A. Kipp
Selenium and iodine - essential trace elements for the thyroid.
ERNÄHRUNGS UMSCHAU; Sep 2019; 66 (9): 175-180
doi: 10.4455/eu.2019.032

M. Schwarz, K. Lossow, J. F. Kopp, T. Schwerdtle, A. P. Kipp
Crosstalk of Nrf2 with the Trace Elements Selenium, Iron, Zinc, and Copper.
Nutrients; Sep 2019; 11: 2112
doi: 10.3390/nu11092112

W. Alker, T. Schwerdtle, L. Schomburg, H. Haase
A Zinpyr-1-based Fluorimetric Microassay for Free Zinc in Human Serum.
International Journal of Molecular Sciences; Aug 2019, 20 (16): 4006
doi: 10.3390/ijms20164006

L. Schomburg, M. Orho-Melander, J. Struck, A. Bergmann, O. Melander
Selenoprotein-P Deficiency Predicts Cardiovaskular Disease and Death.
Nutritients; Aug 2019;11 (8): 1852
doi: 10.3390/nu11081852

J. Baesler, J. F. Kopp, G. Pohl, M. Aschner, H. Haase, T. Schwerdtle, J. Bornhorst
Zn homeostasis in genetic models of Parkinson’s disease in Caenorhabditis elegans.
Journal of Trace Elements in Medicine and Biology; Sep 2019; 55: 44-49
doi: 10.1016/j.jtemb.2019.05.005

J. F. Kopp, S. M. Müller, G. Pohl, K. Lossow, A. P. Kipp, T. Schwerdtle
A quick and simple method for the determination of six trace elements in mammalian serum samples using ICP-MS/MS.
Journal of Trace Elements in Medicine and Biology; July 2019; 54: 221-225
doi: 10.1016/j.jtemb.2019.04.015

M. T. Jacques, J. Bornhorst, M. V. Soares, T. Schwerdtle, S. Garcia, D. S. Ávila.
Reprotoxicity of glyphosate-based formulation in Caenorhabditis elegans is not due to the active ingredient only.
Environmental Pollution; June 2019; 252(Pt B): 1854-1862.
doi: 10.1016/j.envpol.2019.06.099

S. Wendt, L. Schomburg, W. Manzanares, C. Stoppe
Selenium in Cardiac Surgery.
Nutrition in Clinical Practice; June 2019
doi: 10.1002/ncp.10326

V. Fedirko, M. Jenab, C. Méplan, J. S. Jones, W. Zhu, L. Schomburg, A. Siddiq, S. Hybsier, K. Overvad,
A. Tjønneland, H. Omichessan, V. Perduca, M. C. Boutron-Ruault, T. Kühn, V.  Katzke, K. Aleksandrova,
A. Trichopoulou, A. Karakatsani, A. Kotanidou, R. Tumino, S. Panico, G. Masala, C. Agnoli, A. Naccarati,
B. Bueno-de-Mesquita, R. Ch. Vermeulen, E. Weiderpass,  G. Skeie, T. H. Nøst, L. Lujan-Barroso, J. R. Quirós,
J. M. Huerta, M. Rodríguez-Barranco, A. Barricarte, B. Gylling, S. Harlid, K. E. Bradbury, N. Wareham, K. T. Khaw,
M. Gunter, N. Murphy, H. Freisling, K. Tsilidis, D. Aune, E. Riboli, J. E. Hesketh, D. J. Hughes
Association of Selenoprotein and Selenium Pathway Genotypes with Risk of Colorectal Cancer and Interaction with Selenium Status.
Nutrients; Apr 2019; 11 (4): 935
doi: 10.3390/nu11040935

I. Rohn, N. Kroepfl, J. Bornhorst, D. Kuehnelt, T. Schwerdtle
Side-Directed Transfer and Presystemic Metabolism of Selenoneine in a Human Intestinal Barrier Model.
Molecular Nutrition Food Research; Apr 2019
doi: 10.1002/mnfr.201900080

E. C. Kühn, A. Slagman, E. C. D. Kühn-Heid, J. Seelig, C. Schwiebert, W. B. Minich, C. Stoppe, M. Möckel, L. Schomburg
Circulating levels of selenium-binding protein 1 (SELENBP1) are associated with risk for major adverse cardiac events and death.
Journal of Trace Elements in Medicine and Biology; Mar 2019; 52: 247-253
doi: 10.1016/j.jtemb.2019.01.005

J. Bornhorst, E. J. Nustede, S. Fudickar
Mass-Surveilance of C. elegans - A Smartphone-based DIY Microscope and Machine Learning-based Approach for Worm Detection.
Sensors, Smartphone-Based Biosensing; Mar 2019; 19 (6): 1468
doi: 10.3390/s19061468

I. Rohn, S. Raschke, M. Aschner, S. Tuck, D. Kuehnelt, A. P. Kipp, T. Schwerdtle, J. Bornhorst
Treatment of Caenorhabditis elegans with Small Selenium Species Enhances Antioxidant Defense Systems.
Molecular Nutrution Food Research; Feb 2019; 63 (9): 1801304
doi: 10.1002/mnfr.201801304

Y. Wang, F. Zhao, E. Rijntjes, L. Wu, Q. Wu, J. Sui, Y. Liu, M. Zhang, M. He, P. Chen, S. Hu, P. Hou, L. Schomburg,
B. Shi
Role of Selenium Intake for Risk and Development of Hyperthyroidism.
The Journal of Clinical Endocrinology & Metabolism; Feb 2019; 104 (2): 568-580
doi: 10.1210/jc.2018-01713

L. Schomburg , O. Melander
Letter by Schomburg and Melander Regarding Article, "Selenoprotein P Promotes the Development of Pulmonary Arterial Hypertension: A Possible Novel Therapeutic Target."
Circulation; Jan 2019; 139: 722–723
doi: 10.1161/CIRCULATIONAHA.118.035782

R. A. Hellera, J. Seelig, T. Bock, P. Haubruck, P. A. Grützner, L. Schomburg, A. Moghaddam, B. Biglari
Relation of selenium status to neuro-regeneration after traumatic spinal cord injury.
Journal of Trace Elements in Medicine and Biology; Jan 2019; 51: 141-149
doi: 10.1016/j.jtemb.2018.10.006

2018

D. J. Hughes , T. Kunická, L. Schomburg, V Liška, N. Swan, P. Souček
Expression of Selenoprotein Genes and Association with Selenium Status in Colorectal Adenoma and Colorectal Cancer.
Nutrients; Nov 2018; 10 (11): 1812
doi: 10.3390/nu10111812

M. Maares, C. Keil, J. Koza, S. Straubing, T. Schwerdtle, H. Haase
In vitro studies on zinc binding and buffering by intestinal mucins.
International Journal of Molecular Sciences; Sep 2018; 19 (9): 2662
doi: 10.3390/ijms19092662

S. Meyer, M. Markova, G. Pohl, TA Marschall, O. Pivovarova, AFH Pfeiffer, T. Schwerdtle
Development, validation and application of an ICP-MS/MS method to quantify minerals and (ultra-)trace elements in human serum.
Journal of Trace Elements in Medicine and Biology; Sep 2018; 49: 157-163
doi: 10.1016/j.jtemb.2018.05.012

S. Trame, I. Wessels, H. Haase, L. Rink
A short 18 items food frequency questionnaire biochemically validated to estimate zinc status in humans.
Journal of Trace Elements in Medicine and Biology; Sep 2018; 49: 285-295
doi: 10.1016/j.jtemb.2018.02.020

M. Maares, C. Keil, S. Thomsen, D. Günzel, B. Wiesner, H. Haase
Characterization of Caco-2 cells stably expressing the protein-based zinc probe eCalwy-5 as a model system for investigating intestinal zinc transport.
Journal of Trace Elements in Medicine and Biology; Sep 2018; 49: 296-304
doi: 10.1016/j.jtemb.2018.01.004

J. Bornhorst, A. P. Kipp, H. Haase, S. Meyer, T. Schwerdtle
The crux of inept biomarkers for risks and benefits of trace elements.
Trends in Analytical Chemistry; July 2018; 104: 183-190
doi: 10.1016/j.trac.2017.11.007

W. Alker, H. Haase
Zinc and Sepsis.
Nutrients; July 2018, 10 (8): 976
doi: 10.3390/nu10080976

M. Maares, A. Duman, C. Keil, T. Schwerdtle, H. Haase
The impact of apical and basolateral albumin on intestinal zinc resorption in the Caco-2/HT-29-MTX co-culture model.
Metallomics; June 2018; 10(7): 979-991
doi: 10.1039/C8MT00064F

I. Rohn, TA Marschall, N. Kroepfl, KB Jensen, M. Aschner, S. Tuck, D. Kuehnelt, T. Schwerdtle, J. Bornhorst
Selenium species-dependent toxicity, bioavailability and metabolic transformations in Caenorhabditis elegans.
Metallomics; May 2018; 10(6): 818-827
doi: 10.1039/C8MT00066B

R. Muecke, O. Micke, L. Schomburg, J. Buentzel, K. Kisters, I. A. Adamietz, AKTE
Selenium in Radiation Oncology - 15 Years of Experiences in Germany.
Nutrients; Apr 2018; 10 (4), 483
doi: 10.3390/nu10040483

H. Haase
Innate Immune Cells Speak Manganese.
Immunity;
Apr 2018; 48(4), 616-618
doi: 10.1016/j.immuni.2018.03.031

2017

S. Meyer, A. Lopez-Serrano, H. Mitze, N. Jakubowski, T. Schwerdtle
Single-cell analysis by ICP-MS/MS as fast tool for cellular bioavailability studies of arsenite (iAsIII).
Metallomics; Dec 2017, 10: 73-76
doi: 10.1039/C7MT00285H