Peer-Reviewed Articles

2020

R. Hauffe, V. Stein, Ch. Chudoba, T. Flore, M. Rath, K. Ritter, M. Schell, K. Wardelmann, S. Deubel, J. F. Kopp, M. Schwarz, K. Kappert, M. Blüher, T. Schwerdtle, A. P. Kipp, A.Kleinridders.
GPx3 dysregulation impacts adipose tissue insulin receptor expression and sensitivity.
JCI insight. 2020 May 5(11):e136283
doi: 10.1172/jci.insight.136283

R.A. Heller, A. Sperl, J. Seelig, P. Haubruck, T. Bock, T. Werner, A. Besseling, Q. Sun, L. Schomburg, A. Moghaddam, B. Biglari.
Zinc Concentration Dynamics Indicate Neurological Impairment Odds after Traumatic Spinal Cord Injury.
Antioxidants (Basel). 2020 May 13;9(5):421
doi: 10.3390/antiox9050421

O. Brodin, J. Hackler, S. Misra, S. Wendt, Q. Sun, E. Laaf, C. Stoppe, M. Björnstedt, L. Schomburg.
Selenoprotein P as Biomarker of Selenium Status in Clinical Trials with Therapeutic Dosages of Selenite.
Nutrients. 2020 Apr 12;12(4)
doi: 10.3390/nu12041067

S. Gachkar, R. Oelkrug,  B. Herrmann, T.S. Scanlan, Q. Sun, H. Biebermann, C.S. Hoefig, L. Schomburg , J. Mittag.
N- and O-Acetylated 3-Iodothyronamines Have No Metabolic or Thermogenic Effects in Male Mice.
European Thyroid Journal. 2020 Feb;9(2):57-66
doi: 10.1159/000504887

S. Nock, K. Johann, L. Harder, E.K. Wirth, K. Renko, C. Höfig, V. Kracke, J. Hackler, B. Engelmann, M. Rauner, J. Köhrle, L. Schomburg, G. Homuth, U. Völker, G. Brabant, J. Mittag
CD5L constitutes a novel biomarker for integrated hepatic thyroid hormone action.
Thyroid. 2020 Mar 18; 30 (6)
doi: 10.1089/thy.2019.0635

C. Schwiebert, P. Kühnen, N.P. Becker, T. Welsink, T. Keller, W.B. Minich, S. Wiegand, L. Schomburg
Antagonistic Autoantibodies to Insulin-Like Growth Factor-1 Receptor Associate with Poor Physical Strength.
International Journal of Molecular Sciences. 2020 Jan 11;21(2)
doi: 10.3390/ijms21020463

S. Mehl, Q. Sun, C.L. Görlich, J. Hackler, J.F. Kopp, K. Renko, J. Mittag, T. Schwerdtle, L. Schomburg
Cross-sectional analysis of trace element status in thyroid disease.
Journal of Trace Elements in Medicine and Biology 2020 Mar, 58, 126430
doi: 10.1016/j.jtemb.2019.126430

L. Schomburg
The other view: the trace element selenium as a micronutrient in thyroid disease, diabetes, and beyond.
Hormones (Athens). 2020 Mar;19(1):15-24
doi: 10.1007/s42000-019-00150-4

J. Hackler, M. Wisniewska, L. Greifenstein-Wiehe, W.B. Minich, M. Cremer, C. Bührer, L. Schomburg
Copper and selenium status as biomarkers of neonatal infections.
Journal of Trace Elements in Medicine and Biology 2020 Mar., 58, 126437
doi: 10.1016/j.jtemb.2019.126437

T. Bednarczuk, L. Schomburg
Challenges and perspectives of selenium supplementation in Graves' disease and orbitopathy.
Hormones (Athens). 2020 Mar;19(1):31-39
doi: 10.1007/s42000-019-00133-5

J. Seelig, R.A. Heller, J. Hackler, P. Haubruck, A. Moghaddam, B. Biglari, L. Schomburg 
Selenium and copper status - potential signposts for neurological remission after traumatic spinal cord injury.
Journal of Trace Elements in Medicine and Biology;  2020 Jan., 57, 126415
doi: 10.1016/j.jtemb.2019.126415

C. Neumann, J. Baesler, G. Steffen, M. M. Nicolai, T. Zubel, M. Aschner, A. Bürkle, A. Mangerich, T. Schwerdtle, J. Bornhorst
The role of poly(ADP-ribose) polymerases in manganese exposed Caenorhabditis elegans.
Journal of Trace Elements in Medicine and Biology;  2020 Jan., 57:21-27
doi: 10.1016/j.jtemb.2019.09.001

S.M. Müler, C. Dawczynski, J. Wiest, S. Lorkowski, A.P. Kipp, T. Schwerdtle
Functional Biomarkers for the Selenium Status in a Human Nutritional Intervention Study.
Nutrients, 2020, 12(3)
doi: 10.3390/nu12030676

B. Witt, D. Schaumlöffel, T. Schwerdtle
Subcellular localization of copper – cellular bioimaging with focus on neurological disorders
International Journal of Molecular Sciences, 2020,  21, 2341
doi: 10.3390/ijms21072341

2019

S. C. Koeberle, A. Gollowitzer, J. Laoukili, O. Kranenburg, O. Werz, A. Koeberle, A. P. Kipp
"Distinct and overlapping functions of glutathione peroxidases 1 and 2 in limiting NF-κB-driven inflammation through redox-active mechanisms"
Redox Biology; Nov 2019
doi: 10.1016/j.redox.2019.101388

J. Baudry, J. F. Kopp, H. Boeing, A. P. Kipp, T. Schwerdtle, M. B. Schulze
"Changes of trace element status during aging: results of the EPIC-Potsdam cohort study"
European Journal of Nutrition; Nov. 2019
doi: 10.1007/s00394-019-02143-w

S. Mehl, Q. Sun, Ch. L. Goerlich, J. Hackler, J. F. Kopp, K. Renko, J. Mittag, T. Schwerdtle, L. Schomburg
"Cross-sectional analysis of trace element status in thyroid disease"
Journal of Trace Elements in Medicine and Biology; Nov. 2019
doi: 10.1016/j.jtemb.2019.126430

K. Lossow, T. Schwerdtle, A. Kipp
"Selenium and iodine - essential trace elements for the thyroid"
ERNÄHRUNGS UMSCHAU; Sep 2019, 66 (9): 175-180
doi: 10.4455/eu.2019.032

 M. Schwarz, K. Lossow, J. F. Kopp, T. Schwerdtle, A. P. Kipp
"Crosstalk of Nrf2 with the Trace Elements Selenium, Iron, Zinc, and Copper"
Nutrients;
 2019, 11: 2112
doi: 10.3390/nu11092112

W. Alker, T. Schwerdtle, L. Schomburg, H. Haase
"A Zinpyr-1-based Fluorimetric Microassay for Free Zinc in Human Serum"
International Journal of Molecular Sciences;
2019, 20 (16): 4006
doi: 10.3390/ijms20164006

L. Schomburg, M. Orho-Melander, J. Struck, A. Bergmann, O. Melander
"Selenoprotein-P Deficiency Predicts Cardiovaskular Disease and Death"
Nutritients; August 2019; 11 (8): 1852
doi: 10.3390/nu11081852

J. Baesler, J. F. Kopp, G. Pohl, M. Aschner, H. Haase, T. Schwerdtle, J. Bornhorst
"Zn homeostasis in genetic models of Parkinson’s disease in Caenorhabditis elegans"
Journal of Trace Elements in Medicine and Biology; 2019, 55: 44-49
doi: 10.1016/j.jtemb.2019.05.005

J. F. Kopp, S. M. Müller, G. Pohl, K. Lossow, A. P. Kipp, T. Schwerdtle
"A quick and simple method for the determination of six trace elements in mammalian serum samples using ICP-MS/MS"
Journal of Trace Elements in Medicine and Biology; July 2019, 54: 221-225
doi: 10.1016/j.jtemb.2019.04.015

M. T. Jacques, J. Bornhorst, M. V. Soares, T. Schwerdtle, S. Garcia, D. S. Ávila.
Reprotoxicity of glyphosate-based formulation in Caenorhabditis elegans is not due to the active ingredient only.
Environmental Pollution 2019 Jun 27;252(Pt B):1854-1862.
doi: 10.1016/j.envpol.2019.06.099

S. Wendt, L. Schomburg, W. Manzanares, C. Stoppe
"Selenium in Cardiac Surgery"
Nutrition in Clinical Practice; June 2019
doi: 10.1002/ncp.10326

V. Fedirko, M. Jenab, C. Méplan, J. S. Jones, W. Zhu, L. Schomburg, A. Siddiq, S. Hybsier, K. Overvad,
A. Tjønneland, H. Omichessan, V. Perduca, M. C. Boutron-Ruault, T. Kühn, V.  Katzke, K. Aleksandrova,
A. Trichopoulou, A. Karakatsani, A. Kotanidou, R. Tumino, S. Panico, G. Masala, C. Agnoli, A. Naccarati,
B. Bueno-de-Mesquita, R. Ch. Vermeulen, E. Weiderpass,  G. Skeie, T. H. Nøst, L. Lujan-Barroso, J. R. Quirós,
J. M. Huerta, M. Rodríguez-Barranco, A. Barricarte, B. Gylling, S. Harlid, K. E. Bradbury, N. Wareham, K. T. Khaw,
M. Gunter, N. Murphy, H. Freisling, K. Tsilidis, D. Aune, E. Riboli, J. E. Hesketh, D. J. Hughes
"Association of Selenoprotein and Selenium Pathway Genotypes with Risk of Colorectal Cancer and Interaction with Selenium Status"
Nutrients; Apr 2019, 11 (4): 935
doi: 10.3390/nu11040935

M. Braunstein, T. Kusmenkov, C. Zuck, M. Angstwurm, N. P. Becker, W. Böcker, L. Schomburg, V. Bogner-Flatz
"Selenium and Selenoprotein P Deficiency Correlates with Complications and Adverse Outcome After Major Trauma"
Shock; Apr 2019, [Epub ahead of print]
doi: 10.1097/SHK.0000000000001344

I. Rohn, N. Kroepfl, J. Bornhorst, D. Kuehnelt, T. Schwerdtle
"Side-Directed Transfer and Presystemic Metabolism of Selenoneine in a Human Intestinal Barrier Model"
Molecular Nutrition Food Research; Apr 2019
doi: 10.1002/mnfr.201900080

E. C. Kühn, A. Slagman, E. C. D. Kühn-Heid, J. Seelig, C. Schwiebert, W. B. Minich, C. Stoppe, M. Möckel, L. Schomburg
"Circulating levels of selenium-binding protein 1 (SELENBP1) are associated with risk for major adverse cardiac events and death"
Journal of Trace Elements in Medicine and Biology; Mar 2019, 52: 247-253
doi: 10.1016/j.jtemb.2019.01.005

 J. Bornhorst, E. J. Nustede, S. Fudickar
"Mass-Surveilance of C. elegans - A Smartphone-based DIY Microscope and Machine Learning-based Approach for Worm Detection"
Sensors, Smartphone-Based Biosensing; Mar 2019, 19 (6): 1468
doi: 10.3390/s19061468

I. Rohn, S. Raschke, M. Aschner, S. Tuck, D. Kuehnelt, A. P. Kipp, T. Schwerdtle, J. Bornhorst
"Treatment of Caenorhabditis elegans with Small Selenium Species Enhances Antioxidant Defense Systems"
Molecular Nutrution Food Research; Feb 2019, 63 (9): 1801304
doi: 10.1002/mnfr.201801304

Y. Wang, F. Zhao, E. Rijntjes, L. Wu, Q. Wu, J. Sui, Y. Liu, M. Zhang, M. He, P. Chen, S. Hu, P. Hou, L. Schomburg,
B. Shi
"Role of Selenium Intake for Risk and Development of Hyperthyroidism"
The Journal of Clinical Endocrinology & Metabolism; Feb 2019, 104 (2): 568-580
doi: 10.1210/jc.2018-01713

L. Schomburg , O. Melander
Letter by Schomburg and Melander Regarding Article, "Selenoprotein P Promotes the Development of Pulmonary Arterial Hypertension: A Possible Novel Therapeutic Target".
Circulation; Jan 2019, 139: 722–723
doi: 10.1161/CIRCULATIONAHA.118.035782

 

R. A. Hellera, J. Seelig, T. Bock, P. Haubruck, P. A. Grützner, L. Schomburg, A. Moghaddam, B. Biglari
"Relation of selenium status to neuro-regeneration after traumatic spinal cord injury"
Journal of Trace Elements in Medicine and Biology; Jan 2019, 51: 141-149
doi: 10.1016/j.jtemb.2018.10.006

2018

D. J. Hughes , T. Kunická, L. Schomburg, V Liška, N. Swan, P. Souček
"Expression of Selenoprotein Genes and Association with Selenium Status in Colorectal Adenoma and Colorectal Cancer"
Nutrients; Nov 2018, 10 (11): 1812
doi: 10.3390/nu10111812

M. Maares, C. Keil, J. Koza, S. Straubing, T. Schwerdtle, H. Haase
"In vitro studies on zinc binding and buffering by intestinal mucins"
International Journal of Molecular Sciences; Sep 2018, 19 (9): 2662
doi: 10.3390/ijms19092662

S. Meyer, M. Markova, G. Pohl, TA Marschall, O. Pivovarova, AFH Pfeiffer, T. Schwerdtle
"Development, validation and application of an ICP-MS/MS method to quantify minerals and (ultra-)trace elements in human serum"
Journal of Trace Elements in Medicine and Biology; Sep 2018, 49: 157-163
doi: 10.1016/j.jtemb.2018.05.012
PMID: 29895367

S. Trame, I. Wessels, H. Haase, L. Rink
"A short 18 items food frequency questionnaire biochemically validated to estimate zinc status in humans"
Journal of Trace Elements in Medicine and Biology; Sep 2018, 49: 285-295
doi: 10.1016/j.jtemb.2018.02.020

M. Maares, C. Keil, S. Thomsen, D. Günzel, B. Wiesner, H. Haase
"Characterization of Caco-2 cells stably expressing the protein-based zinc probe eCalwy-5 as a model system for investigating intestinal zinc transport"
Journal of Trace Elements in Medicine and Biology; Sep 2018, 49: 296-304
doi: 10.1016/j.jtemb.2018.01.004

J. Bornhorst, A. P. Kipp, H. Haase, S. Meyer, T. Schwerdtle
"The crux of inept biomarkers for risks and benefits of trace elements"
Trends in Analytical Chemistry; July 2018, 104: 183-190
doi: 10.1016/j.trac.2017.11.007

W. Alker, H. Haase
"Zinc and Sepsis"
Nutrients; July 2018, 10 (8): 976
doi: 10.3390/nu10080976

M. Maares, A. Duman, C. Keil, T. Schwerdtle, H. Haase
"The impact of apical and basolateral albumin on intestinal zinc resorption in the Caco-2/HT-29-MTX co-culture model"
Metallomics; June 2018, 10(7): 979-991
doi: 10.1039/C8MT00064F
PMID: 29931006

I. Rohn, TA Marschall, N. Kroepfl, KB Jensen, M. Aschner, S. Tuck, D. Kuehnelt, T. Schwerdtle, J. Bornhorst
"Selenium species-dependent toxicity, bioavailability and metabolic transformations in Caenorhabditis elegans"
Metallomics; May 2018, 10(6): 818-827
doi: 10.1039/C8MT00066B

R. Muecke, O. Micke, L. Schomburg, J. Buentzel, K. Kisters, I. A. Adamietz, AKTE
"Selenium in Radiation Oncology - 15 Years of Experiences in Germany"
Nutrients; Apr 2018: 10 (4), 483
doi: 10.3390/nu10040483

H. Haase
"Innate Immune Cells Speak Manganese"
Immunity;
Apr 2018, 48(4), 616-618
doi: 10.1016/j.immuni.2018.03.031

2017

S. Meyer, A. Lopez-Serrano, H. Mitze, N. Jakubowski, T. Schwerdtle
"Single-cell analysis by ICP-MS/MS as fast tool for cellular bioavailability studies of arsenite (iAsIII)"
Metallomics; Dec 2017, 10: 73-76
doi: 10.1039/C7MT00285H