Nastasja Grdseloff

RESEARCH INTERESTS

In the framework of the MSCA Innovative Training Network V.A. Cure, I am investigating the tissular mechanisms of vascular anomalies using the zebrafish as an animal model. In particular, I am interested in Cerebral Cavernous Malformations (CCM), a pathology where timing and site-specificity of disease onset are not yet well understood. Here, I am focusing on the role of biomechanical parameters and their influence on molecular processes involved in the disease as well as in physiological conditions.

EDUCATION

Master of Science in Engineering, 2019
Master Thesis in the lab of Sasha Mandjan, IMBA Vienna, Austria
“Derivation of human adipogenic epicardium – Epicardial specification from human pluripotent stem cells”
Medical and Pharmaceutical Biotechnology 
IMC University of Applied Sciences Krems, Austria

Bachelor of Science, 2015
Bachelor Thesis in the lab of Mario Stevenson, University of Miami, Miller School of Medicine, USA
“Optimization of mycobacterial and HIV-1 in vitro co-infection”
Biomedicine and Biotechnology
University of Veterinary Medicine Vienna, Austria

PUBLICATIONS

Grdseloff N, Boulday G, Rödel CJ, Otten C, Vanneíert DR, Cardoso C, Faurobert E, Dogra D, Tournier-Lasserve E, Abdelilah-Seyfried S. (2023) Impaired retinoic acid signaling in cerebral cavernous malformations. Sci Rep. https://www.nature.com/articles/s41598-023-31905-0

Hofbauer P, Jahnel SM, Papai N, Giesshammer M, Deyett A, Schmidt C, Penc M, Tavernini K, Grdseloff N, Meledeth C, Ginistrelli LC, Ctortecka C, Šalic Š, Novatchkova M, Mendjan S. Cardioids reveal self-organizing principles of human cardiogenesis. Cell. 2021 Jun 10;184(12):3299-3317.e22. doi: 10.1016/j.cell.2021.04.034. Epub 2021 May 20. PMID: 34019794.