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Investigating the relationship between chronic psychosocial stress and osteoporosis using an interdisciplinary (biological, radiological, and psychosocial) approach.
Osteoporosis is a disease defined by a loss of bone mass and bone quality, which then lead to increases in fracture risk. For affected patients, osteoporosis can have a significant impact on quality of life, as well as life expectancy. Unfortunately, the pathology of osteoporosis is still poorly understood; however, recent research has identified chronic psychosocial stress as a risk factor for osteoporosis. By causing imbalances in the hypothalamic–pituitary–adrenal axis (HPA) and various intermediary factors, chronic psychosocial stress blunts bone turnover. However, many of these studies were performed in animal models and a proof of concept in humans is lacking. In this study, we transfer results of animal models into a study on humans.
In collaboration with Prof. Karin Würtz-Kozak of the ETH Zurich and PD Dr. Hupperts of Ernst von Bergmann Klinikum (Potsdam), this study aims to investigate the relationship between chronic psychosocial stress and osteoporosis development using an interdisciplinary (biological, radiological & psychosocial) approach and modern statistical methods in humans. Participants will be asked to complete a set of questionnaires, which will include a comprehensive chronic psychosocial stress assessment, before their bone mineral density is measured by DEXA. Blood samples will also be obtained and assayed for biomarkers of bone turnover.
Financed by: Forschungsförderung Universität Potsdam, siehe Universitätsmagazin Portal 02/2017.