Sie verwenden einen veralteten Browser mit Sicherheitsschwachstellen und können die Funktionen dieser Webseite nicht nutzen.

Hier erfahren Sie, wie einfach Sie Ihren Browser aktualisieren können.

Peer-Reviewed Artikel


W. Alker, T. Schwerdtle, L. Schomburg, H. Haase
A zinpyr-1-based fluorimetric microassay for free zink in human serum
Int. J. Mol. Sci. 2019, 20(16):4006,

J.F. Kopp, S.M. Müller, G. Pohl, K. Lossow, A.P. Kipp, T. Schwerdtle
A quick and simple method for the determination of six trace elements in mammulian serum samples using ICP-MS/MS
Journal of Trace Elements in Medicine and Biology, accepted for publication April 2019, doi: 10.1016/j.jtemb.2019.04.015

I. Rohn, N. Kroepfl, J. Bornhorst, D. Kuehnelt, T. Schwerdtle
Side-directed transfer and presystemic metabolism of selenoneine in a human intestinal barrier model.
Molecular Nutrition & Food Research, 2019, Epub ahead of print, doi: 10.1002/mnfr.201900080

A. Schutkowski, B. König, H. Kluge, F. Hirche, A. Henze, T. Schwerdtle, S. Lorkowski, C. Dawczynski, A. Gabel, I. Groß, G. I. Stangl,
Metabolic footprint and intestinal microbial changes in response to dietary proteins in a pig model,
The Journal of Nutritional Biochemistry, 2019, 67:149-160, doi.org/10.1016/j.jnutbio.2019.02.004

I. Rohn, S. Raschke, M. Aschner, S. Tuck, D. Kuehnelt, A. Kipp, T.  Schwerdtle, J. Bornhorst,
Treatment of Caenorhabditis elegans with Small Selenium Species Enhances Antioxidant Defense Systems,
Molecular Nutrition & Food Research, 2019, 63:1801304, doi: 10.1002/mnfr.201801304

Y. Duydu, N. Başaran, C.Ö. Yalçın,A.  Üstündağ, S. Aydın, H.G. Anlar, M. Bacanlı, K. Aydos, C.S. Atabekoğlu, K. Golka, K. Ickstadt, T. Schwerdtle, M. Werner ,H.M. Bolt,
Boron-exposed male workers in Turkey: no change in sperm Y:X chromosome ratio and in offspring's sex ratio,
Archives of Toxicology, 2019, 93(3):743-751, doi: 10.1007/s00204-019-02391-z

T.V. Peres, K.J. Horning, J. Bornhorst, T. Schwerdtle, A.B. Bowman, M. Aschner,
Small Molecule Modifiers of In Vitro Manganese Transport Alter Toxicity In Vivo,
Biological Trace Element Research, 2019, 188:127-134, doi: 10.1007/s12011-018-1531-7

J.A. Ruszkiewicz, G. Teixeira de Macedo, A. Miranda-Vizuete, A.B. Bowman, J. Bornhorst, T. Schwerdtle, F.A. Antunes Soares, M. Aschner,
Sex-Specific Response of Caenorhabditis elegans to Methylmercury Toxicity,
Neurotoxicity Research, 2019, 35:208-216, doi: 10.1007/s12640-018-9949-4

N. Basaran, Y. Duydu, A. Üstündag, G. Taner, S. Aydin Dilsiz, H.G. Anlar, C.Ö. Yalcin, M. Bacanli, K. Golka, T. Schwerdtle, H.M. Bolt,
Environmental boron exposure does not induce DNA damage in lymphocytes and buccal cells of females: DNA damage in lymphocytes and buccal cells of boron exposed females,
Journal of Trace Elements in Medicine and Biology, 2019, 53:150-153, doi: 10.1016/j.jtemb.2019.03.004

N. Kroepfl, K. A. Francesconi, T. Schwerdtle, D. Kuehnelt, 
Selenoneine and ergothioneine in human blood cells determined simultaneously by HPLC/ICP-QQQ-MS,
Journal of Analytical Atomic Spectrometry, 2019, 34:127-134, doi: 10.1039/C8JA00276B 


M.W. Werno, I. Wilhelmi, B. Kuropka, F. Ebert, C. Freund, A. Schürmann,
The GTPase ARFRP1 affects lipid droplet protein composition and triglyceride release from intracellular storage of intestinal Caco-2 cells,
Biochemical and Biophysical Research Communications, 2018, 506(1):259-265, doi: 10.1016/j.bbrc.2018.10.092

N. Turrini, N. Kroepfl, K. Jensen, T. C. Reiter, K. A. Francesconi, T. Schwerdtle, W. Kroutil and D. Kuehnelt,
Biosynthesis and Isolation of Selenoneine from Genetically Modified Fission Yeast,
Metallomics, 2018, 10:1532-1538, doi: 10.1039/C8MT00200B

M. Maares, C. Keil, J. Koza, S. Straubing, T. Schwerdtle H. Haase.
In vitro studies on zinc binding and buffering by intestinal mucins
International Journal of Molecular Sciences, 2018, 19, pii: E2662, doi: 10.3390/ijms19092662

K. E. Nachman, T. Punshon, L. Rardin, A. J. Signes-Pastor, C. J. Murray, B. P. Jackson, M. Lou Guerinot, T. A. Burke, C. Y. Chen, H. Ashan, M. Argos, K. L. Cottingham, F. Cubadda, G. L. Ginsberg, B. C. Goodale, M. Kurzius-Spencer, A. A. Meharg, M. D. Miller, A. E. Nigra, C. B. Pendergrast, A. Raab, K. Reimer, K. G. Scheckel, T. Schwerdtle, V. F. Taylor, E. J. Tokar, T. M. Warczak, M. R. Karagas,
Opportunities and challenges for dietary arsenic intervention,
Environmental Health Perspective
, 2018, 126(8):84503, https://ehp.niehs.nih.gov/doi/10.1289/EHP3997doi: 10.1289/EHP3997

M. Maares, A. Duman, C. Keil, T. Schwerdtle, H. Haase,
The impact of apical and basolateral albumin on intestinal zinc resorption in the Caco-2/HT-29-MTX co-culture model,
Metallomics, 2018, 10(7):979-991, doi: 10.1039/c8mt00064f

Y. Duydu, N. Başaran, A. Üstündağ, S. Aydın, C. Ö. Yalçın, H.G. Anlar, M. Bacanlı, K. Aydos, C. S. Atabekoğlu, K. Golka, K. Ickstadt, T. Schwerdtle, M. Werner,  S. Meyer, H. M. Bolt,
Birth weights of newborns and pregnancy outcomes of environmentally boron-exposed females in Turkey,
Archives of Toxicology, 2018, 92(10):3051-3059, doi: 10.1007/s00204-018-2238-4

S. Meyer, M. Markova, G. Pohl, T. A. Marschall, O. Pivovarova, A. F. H. Pfeiffer, T. Schwerdtle,
Development, validation and application of an ICP-MS/MS method to quantify minerals and (ultra-)trace elements in human serum,
Journal of Trace Elements in Medicine and Biology, 2018, 49:157-163, doi: 10.1016/j.jtemb.2018.05.012

I. Rohn, T. A. Marschall, N. Kroepfl, K. B. Jensen, M. Aschner, S. Tuck, D. Kuehnelt, T. Schwerdtle, J. Bornhorst,
Selenium species-dependent toxicity, bioavailability and metabolic transformations in Caenorhabditis elegans,
2018, 10(6):818-827, doi: 10.1039/C8MT00066B

S.M. Müller, F. Ebert, J. Bornhorst, H. J. Galla, K. A. Francesconi, T. Schwerdtle,
Arsenic-containing hydrocarbons disrupt a model in vitro blood-cerebrospinal fluid barrier,
Journal of Trace Elements in Medicine and Biology, 2018, 49:171-177, doi: 10.1016/j.jtemb.2018.01.020

S. M. Müller, H. Finke, F. Ebert, J. F. Kopp, F. Schumacher, B. Kleuser, K. A. Francesconi, G. Raber, T. Schwerdtle,
Arsenic-containing hydrocarbons: effects on gene Expression, epigenetics, and biotransformation in HepG2 cells,
Archives of Toxicology, 2018, 92(5):1751-1765, doi: 10.1007/s00204-018-2194-z

K. Nowotny, J. P. Castro, M. Hugo, S. Braune, D. Weber, M. Pignitter, V. Somoza, J. Bornhorst, T. Schwerdtle, T. Grune,
Oxidants produced by methylglyoxal-modified collagen trigger ER stress and apoptosis in skin fibroblasts,
Free Radical Biology and Medicine, 2018, 120:102-113, doi: 10.1016/j.freeradbiomed.2018.03.022

S. Meyer, A. Lopez-Serrano, H. Mitze, N. Jakubowski, T. Schwerdtle,
Single-cell analysis by ICP-MS/MS as fast tool for cellular bioavailability studies of arsenite (iAsIII),
Metallomics, 2018, 10:73-76, doi: 10.1039/C7MT00285H

S. M. Müller, F. Ebert, G. Raber, S. Meyer, J. Bornhorst, S. Hüwel, H.-J. Galla, K. A. Francesconi, T. Schwerdtle, Effects of arsenolipids on in vitro blood-brain barrier model,
Archives of Toxicology, 2018, 92(2):823-832, doi: 10.1007/s00204-017-2085-8

Y. Duydu, N. Başaran, S. Aydın, A. Üstündağ, C. Ö. Yalçın, H.G. Anlar, M. Bacanlı, K. Aydos, C.S. Atabekoğlu, K. Golka, K. Ickstadt, T. Schwerdtle, M. Werner,  S. Meyer, H.M. Bolt,
Evaluation of FSH, LH, testosterone levels and semen parameters in male boron workers under extreme exposure conditions,
Arch Toxicol, 2018, 92(10):3051-3059, doi: 10.1007/s00204-018-2296-7

J.A. Ruszkiewicz, G. Teixeira de Macedo, A. Miranda-Vizuete, J.B. Teixeira de Rocha, A.B. Bowman, J. Bornhorst, T. Scwerdtle, M. Ascher,
The cytoplasmic thioredoxin system in Caenorhabditis elegans affords protection from methylmercury in an age-specific manner,
Neurotoxicology, 2018, 68:189-202, doi: 10.1016/j.neuro.2018.08.007

T.V. Peres, L.P. Arantes, M.R. Miah, J. Bornhorst, T. Schwerdtle, A.B. Bowmann, R.B. Leal, M. Aschner,
Role of Caenorhabditis elegens AKT-1/2 and SGK-1 in Manganese Toxicity,
Neurotox Res., 2018, 34(3):584-596, doi: 10.1007/s12640-018-9915-1


J. Bornhorst, A.P. Kipp, H. Haase, S. Meyer, T. Schwerdtle, The crux of inept biomarkers for risks and benefits of trace Elements,
Trends in Analytical Chemistry, 2017, 104:183-190, doi.org/10.1016/j.trac.2017.11.007

M. Li, L Gao, C. Schlaich, J. Zhang, I.S. Donskyi, G. Yu, W. Li, Z. Tu, J. Rolff, T. Schwerdtle, R. Haag, N. Ma,
Construction of Functional Coatings with durable and Broad-Spectrum Antibacterial Potential Based on Mussle-Insprired Dendiritic Polyglycerol and in Situ-Formed Copper Nanoparticles.
ACS Appl Mater Interfaces., 2017, 9(40):35411-35418, doi: 10.1021/acsami.7b10541

B. Witt, F. Ebert, S. Meyer, K.A. Francesconi, T. Schwerdtle,
Assessing neurodevelopmental effects of arsenolipids in pre-differentiated human neurons,
Molecular Nutrition and Food Research, 2017, 61(11), doi: 10.1002/mnfr.201700199

J. Strehlau, T. Weber, C. Lürenbaum, J. Bornhorst, H. J. Galla, T. Schwerdtle, M. Winter, S. Nowak, Towards quantification of toxicity of lithium ion battery electrolytes - development and validation of a liquid-liquid extraction GC-MS method for the determination of organic carbonates in cell culture materials,
Analalytical Bioanalytical Chemistry,
2017, 409(26):6123-6131, doi: 10.1007/s00216-017-0549-6

N. Kroepfl, T. Marschall, K.A. Francesconi, T. Schwerdtle, D. Kuehnelt,
Quantitative determination of the sulfur-containing antioxidant ergothioneine by HPLC/ICP-QQQ-MS,
Journal of Analytical Atomic Spectrometry, 2017, 32:1571-1581, doi: 10.1039/C7JA00030H

B. Witt, J. Bornhorst, H. Mitze, F. Ebert, S. Meyer, K.A. Francesconi, T. Schwerdtle,
Arsenolipids exert less toxicity in a human neuron astrocyte co-culture as compared to the respective monocultures,
Metallomics, 2017, 9(5):442-446, doi: 10.1039/c7mt00036g

K. Frede, F. Ebert, A. Kipp, T. Schwerdtle, S. Baldermann,
Lutein Activates the Transcription Factor Nrf2 in Human Retinal Pigment Epithelial Cells,
Journal of Agricultural and Food Chemistry
, 2017, 65(29):5944-5952, doi: 10.1021/acs.jafc.7b01929

T.A. Marschall, N. Kroepf, K.B. Jensen, J. Bornhorst, B. Meermann, D. Kuehnelt, T. Schwerdtle,
Tracing cytotoxic effects of small organic Se species in human liver cells back to total cellular Se and Se metabolites,
Metallomics, 2017, 9(3):268-277, doi: 10.1039/c6mt00300a

B. Witt, S. Meyer, F. Ebert, K.A. Francesconi, T. Schwerdtle,
Toxicity of two classes of arsenolipids and their water-soluble metabolites in human differentiated neurons,
Archives of Toxicology, 2017, 91(9):3121-3134, doi: 10.1007/s00204-017-1933-x

V. Taylor, B. Goodale, A. Raab, T. Schwerdtle, K. Reimer, S. Conklin, M. R. Karagas, K. A. Francesconi,
Human exposure to organic arsenic species from seafood,
Science of the Total Environment, 2017, 580:266-282, doi: 10.1016/j.scitotenv.2016.12.113

M. Aschner, C. Palinski, M. Sperling, U. Karst, T. Schwerdtle, J. Bornhorst,
Imaging metals in Caenorhabditis elegans,
Metallomics, 2017, 9(4):357-364, doi: 10.1039/c6mt00265j


H. Lohren, J. Bornhorst, R. Fitkau, G. Pohl, T. Schwerdtle,
Effects on and transfer across the blood-brain barrier in vitro-Comparison of organic and inorganic mercury species,
BMC Pharmacology and Toxicology, 2016, 17(1):63, doi: 10.1186/s40360-016-0106-5

A. Henze, T. Homann, I. Rohn, M. Aschner, C. D. Link, B. Kleuser, F. Schweigert, T. Schwerdtle, J. Bornhorst,
Caenorhabditis elegans
as a model system to study post-translational modifications of human transthyretin,
Scientific Reports, 2016, 6:37346, doi: 10.1038/srep37346

T. A. Marschall, J. Bornhorst, D. Kühnelt, T. Schwerdtle,
Differing cytotoxicity and bioavailability of selenite, methylselenocysteine, selenomethionine, selenosugar 1 and trimethylselenonium ion and their underlying metabolic transformations in human cells,
Molecular Nutrition and Food Research, 2016, 60(12), 2622-2636, doi:10.1002/mnfr.201600422

F. Ebert, M. Thomann, B. Witt, S.M. Müller, S. Meyer, T. Weber, M. Christmann, T. Schwerdtle (2016),
Evaluating long-term cellular effects of the arsenic species thio-DMAV: qPCR-based gene expression as screening tool,
Journal of Trace Elements in Medicine and Biology, 2016, Sep;37:78-84., doi: 10.1016/j.jtemb.2016.06.004

A.-C. Niehoff, J. Schulz, J. Soltwisch, S. Meyer, H. Kettling, M. Sperling, A. Jeibmann, K. Dreisewerd, K.A. Francesconi, T. Schwerdtle, U. Karst (2016),
Imaging by Elemental and Molecular Mass Spectrometry Reveals the Uptake of an Arsenolipid in the Brain of Drosophila melanogaster,
Analytical Chemistry, 2016, 17;88(10):5258-63, doi: 10.1021/acs.analchem.6b00333

F. Ebert, S. Meyer, L. Leffers, G. Raber, K.A. Francesconi, T. Schwerdtle (2016),
Toxicological characterisation of a thio-arsenosugar-glycerol in human cells,
Journal of Trace Elements in Medicine and Biology, 2016, 38:150-156., doi: 10.1016/j.jtemb.2016.04.013

E. Rosenkranz, M. Maywald, R.-D. Hilgers, A. Brieger, T. Clarner, M. Kipp, B. Plümäkers, S. Meyer, T. Schwerdtle, L. Rink (2016),
Induction of regulatory T cells in Th1-/Th17-driven experimental autoimmune encephalomyelitis by zinc administration,
Nutritional Biochemistry, 2016, 29, 116-123, doi:10.1016/j.jnutbio.2015.11.010

R. Bzymek, M. Horsthemke, K. Isfort, S. Mohr, K. Tjaden, C. Müller-Tidow, M. Unterberg, T. Schwerdtle, M. Bähler, A. Schwab & P. J. Hanley (2016)
Real-time two- and three-dimensional imaging of monocytemotility and navigation on planar surfaces and in collagen matrices: roles of Rho,
Nature Scientific Reports, 2016, 6:25016, doi: 10.1038/srep25016


P. Gubert, B. Puntel, T. Lehmen, J. Bornhorst, D. S. Avila, M. Aschner, F. A. A. Soares (2015),
Reversible reprotoxic effects of manganese through DAF-16 transcription factor activation and vitellogenin downregulation in Caenorhabditis elegans,
Life Sciences, 2015, S0024-3205(16)30167-9, doi:10.1016/j.lfs.2016.03.016

T.V. Peres, H. Eyng, S.C. Lopes, D. Colle, F.M. Gonçalves, D.K. Venske, M.W. Lopes, J. Ben, J. Bornhorst, T. Schwerdtle, M. Aschner, M. Farina, R.D. Prediger, R. B. Leal (2015),
Developmental exposure to manganese induces lasting motor and cognitive impairment in rats,
Neurotoxicology, 2015, 50:28-37, doi: 10.1016/j.neuro.2015.07.005

F. Schumacher, S. Chakraborty, B. Kleuser, E. Gulbins, T. Schwerdtle, M. Aschner, J. Bornhorst (2015),
Highly sensitive isotope-dilution liquid-chromatography–electrospray ionization tandem-mass spectrometry approach to study the drug-mediated modulation of dopamine and serotonin levels in Caenorhabditis elegans,
Talanta, 2015, 144, 71-7, doi: 10.1016/j.talanta.2015.05.057

B. Crone, M. Aschner, T. Schwerdtle, U. Karst, J. Bornhorst (2015),
Elemental bioimaging of Cisplatin in Caenorhabditis elegans by LA-ICP-MS,
Metallomics, 2015, 7(7):1189-9, doi: 10.1039/c5mt00096c

S. Chakraborty, P. Chen, J. Bornhorst, T. Schwerdtle, F. Schumacher, B. Kleuser, A. B. Bowman, M. Aschner (2015),
Loss of pdr-1/parkin influences Mn homeostasis through altered ferroportin expression in C. elegans,
Metallomics, 2015, 7(5):847-56, doi: 10.1039/c5mt00052a

A.C. Niehoff, O. Bauer, S. Kröger, S. Fingerhut, J. Schulz, S. Meyer, M. Sperling, A. Jeibmann, T. Schwerdtle, U. Karst (2015),
Quantitative Bioimaging to Investigate the Uptake of Mercury Species in Drosophila melanogaster,
Analytical Chemistry, 2015, 87(20): 10392-6, doi: 10.1021/acs.analchem.5b02500

H. Lohren, J. Bornhorst, H.-J. Galla, T. Schwerdtle (2015),
The blood-cerebrospinal fluid barrier - first evidence for an active transport of organic mercury compounds out of the brain,
, 2015, 7(10):1420-30, doi: 10.1039/c5mt00171d

H. Lohren, L. Blagojevic, R. Fitkau, F. Ebert, S. Schildknecht, M. Leist, T. Schwerdtle (2015),
Toxicity of organic and inorganic mercury species in differentiated human neurons and human astrocytes,
Journal of Trace Elements in Medicine and Biology, 2015 Oct; 32:200-8., doi: 10.1016/j.jtemb.2015.06.008

S. Meyer, G. Raber, F. Ebert, M. S. Taleshi, K. A. Francesconi, T. Schwerdtle (2015),
Arsenic-containing hydrocarbons and arsenic-containing fatty acids: transfer across and presystemic metabolism in the Caco-2 intestinal barrier model,
Molecular Nutrition and Food Research, 2015, Oct; 59(10):2044-56., doi: 10.1002/mnfr.201500286

S. Meyer, G. Raber, F. Ebert, L. Leffers, S. M. Müller, M. S. Taleshi, K. A. Francesconi, T. Schwerdtle (2015),
In vitro
toxicological characterisation of arsenic-containing fatty acids and three of their metabolites,
Toxicology Research, 2015, 4, 1289-1296, doi: 10.1039/C5TX00122F

K. K. Kumar, C. R. Goodwin, M. A. Uhouse, J. Bornhorst, T. Schwerdtle, M. Aschner, J. A. McLeanb, A. B. Bowman (2015),
Untargeted metabolic profiling identifies interactions between Huntington’s disease and neuronal manganese status,
Metallomics : integrated biometal science
, 2015, 7(2):363-70, doi: 10.1039/C4MT00223


F. Draude, M. Körsgen, A. Pelster, T. Schwerdtle, J. Müthing, H. F. Arlinghaus (2014),
Characterization of freeze-fractured epithelial plasma membranes on nanometer scale with ToF-SIMS,
Anal Bioanal Chem, 2014, 407(8):2203-11, doi: 10.1007/s00216-014-8334-2

S. Cramer, S. Tacke, J. Bornhorst, A. K Sachan, J. Klingauf, T. Schwerdtle, H.-J. Galla (2014),
The Influence of Silver Nanoparticles on the Blood-Brain and the Blood-Cerebrospinal Fluid Barrier in vitro,
Journal of Nanomedicine & Nanotechnology, 2014, 5:225, doi: 10.4172/2157-7439.1000225

S. Meyer, J. Schulz, A. Jeibmann, M. S. Taleshi, F. Ebert, K. A. Francesconi, T. Schwerdtle (2014),
Arsenic-containing hydrocarbons are toxic in the in vivo model Drosophila melanogaster,
, 2014, Nov;6(11):2010-4, doi: 10.1039/c4mt00249k

M. Unterberg, L. Leffers, F. Hübner, H.-U. Humpf, K. Lepikhov, J. Walter, F. Ebert, T. Schwerdtle (2014),
Toxicity of arsenite and thio-DMAV after long-term (21 days) incubation of human urothelial cells: cytotoxicity, genotoxicity and epigenetics,
Toxicology Research, 2014, 3:456-464, doi: 10.1039/C4TX00036F

Y. Koehler, E. M. Luther, S. Meyer, T. Schwerdtle, R. Dringen (2014),
Uptake and toxicity of arsenite and arsenate in cultured brain astrocytes,
Journal of Trace Elements in Medicine and Biology
, 2014, 28(3):238-237, doi: 10.1016/j.jtemb.2014.04.007

L.S. Mayer, P. Uciechowski, S. Meyer, T. Schwerdtle, L. Rink, H. Haase (2014),
Differential impact of zinc deficiency on phagocytosis, oxidative burst, and production of pro-inflammatory cytokines by human monocytes,
, 2014, 6(7):1288-1295, doi: 10.1039/c4mt00051j

S. Meyer, M. Matissek, S. M. Müller, M. S. Taleshi, F. Ebert, K. A. Francesconi, T. Schwerdtle (2014),
In vitro
toxicological characterisation of three arsenic-containing hydrocarbons,
, 2014, 6(5):1023-1033, doi: 10.1039/c4mt00061g

M.S. Taleshi, R.K. Seidler-Egdal, K.B. Jensen, T. Schwerdtle, K.A. Francesconi (2014),
Synthesis and Characterization of Arsenolipids: Naturally Occurring Arsenic Compounds in Fish and Algae,
Organometallics, 2014, 33(6):1397-1403, doi: 10.1021/om4011092

I. Pieper, C. A. Wehe, J. Bornhorst, F. Ebert, L. Leffers, M. Holtkamp, P. Höseler, T. Weber, A. Mangerich, A. Bürkle, U. Karst, T. Schwerdtle (2014),
Mechanisms of Hg species induced toxicity in cultured human astrocytes: genotoxicity and DNA-damage response,
Metallomics, 2014 Mar,6(3):662-71., doi: 10.1039/c3mt00337j

J. Bornhorst, S. Chakraborty, S. Meyer, H. Lohren, S. Große Brinkhaus, A. L. Knight, K. A. Caldwell, G. A. Caldwell, U. Karst, T. Schwerdtle, A. Bowman, M. Aschner (2014),
The effects of pdr1, djr1.1 and pink1 loss in manganese-induced toxicity and the role of α-synuclein in C. elegans,
, 2014 Jan 22., 6(3):476-490, doi: 10.1039/c3mt00325f

C. A. Wehe, I. Pieper, M. Holtkamp, G. M. Thyssen, M. Sperling, T. Schwerdtle, U. Karst (2014),
On-line species-unspecific isotope dilution analysis in the picomolar range reveals the time- and species-depending mercury uptake in human astrocytes,
Analytical and Bioanalytical Chemistry, 2014, 406(7):1909-16, doi: 10.1007/s00216-013-7608-4

C. Pieper, J. J. Marek, M. Unterberg, T. Schwerdtle, H.-J. Galla (2014),
Brain capillary pericytes contribute to the immune defense in response to cytokines or LPS in vitro,
Brain Research, 2014, 1550:1-8, doi: 10.1016/j.brainres.2014.01.004

F. Ebert, L. Leffers, T. Weber, S. Berndt, A. Mangerich, S. Beneke, A. Bürkle, T. Schwerdtle (2014),
Toxicological properties of the thiolated inorganic arsenic and arsenosugar metabolite thio-dimethylarsinic acid in human bladder cells,
Journal of Trace Elements in Medicine and Biology, 2014, 28(2):138-46, doi:10.1016/j.jtemb.2013.06.004


L. Leffers, C. A. Wehe, S. Hüwel, M. Bartel, F. Ebert, M. S. Taleshi, H.-J. Galla, U. Karst, K. A. Francesconi, T. Schwerdtle (2013),
In vitro intestinal bioavailability of arsenosugar metabolites and presystemic metabolism of thio-dimethylarsinic acid in Caco-2 cells,
Metallomics, 2013, 5(8):1031-42, doi: 10.1039/c3mt00039g

L. Leffers, F.  Ebert, M.S. Taleshi, K.A. Francesconi, T. Schwerdtle (2013),
In vitro toxicological characterization of two arsenosugars and their metabolites,
Journal of Molecular Nutrition and Food Research, 57(7):1270-82

M. Weidner, S. Hüwel, F. Ebert, T. Schwerdtle, H.-J. Galla, H.-U. Humpf (2013),
Influence of T-2 and HT-2 Toxin on the Blood-Brain Barrier In Vitro: New Experimental Hints for Neurotoxic Effects,
PLoS One., 2013, 8(3):e60484, doi: 10.1371/journal.pone.0060484

J. Bornhorst, S. Meyer, T. Weber, C. Böker, T. Marschall, A. Mangerich, S. Beneke, A. Bürkle, T. Schwerdtle (2013),
Molecular mechanisms of Mn induced neurotoxicity; RONS generation, genotoxicity and DNA damage response,
Journal of Molecular Nutrition and Food Research, 2013, 57(7):1255-1269, doi: 10.1002/mnfr.201200758

L. Leffers, M. Unterberg, M. Bartel, C. Hoppe, H.-U. Humpf, T. Schwerdtle (2013),
In vitro toxicological characterisation of the S-containing inorganic arsenic metabolites thiodimethylarsinic acid and DMAG,
Toxicology, 2013, 305:109-19, doi: 10.1016/j.tox.2013.01.007

D. Mulac, S. Lepski, F. Ebert, T. Schwerdtle, H.-U. Humpf (2013),
Cytotoxicity and fluorescence visualization of ergot alkaloids in human cell lines,
Journal of Agricultural and Food Chemistry, 2013, 61(2):462-71, doi: 10.1021/jf304569


J. Diederich, M. Brielmeier, T. Schwerdtle, B. Michalke (2012),
Manganese and iron species in Sprague-Dawley rats exposed with MnCl2·4 H2O (i.v.),
Microchemical Journal, 2012, 105:115-123, doi:10.1016/j.microc.2012.03.015

J. Bornhorst, C. A. Wehe, S. Hüwel, H.-J. Galla, U. Karst, T. Schwerdtle (2012),
Impact of manganese on and transfer across the blood-brain and blood-CSF barrier in vitro,
The Journal of Biological Chemistry, 2012, 287(21):17140-51, doi: 10.1074/jbc.M112.344093

J. Bornhorst, F. Ebert, H. Lohren, H.-U. Humpf, U. Karst, T. Schwerdtle (2012),
Effect of manganese and arsenic species on the level of energy related nucleotides in human cells,
Metallomics, 2012, 4(3):297-306, doi: 10.1039/c2mt00164


C.A. Wehe, J. Bornhorst, M. Holtkamp, M. Sperling, H.-J. Galla, T. Schwerdtle, U. Karst (2011),
Fast and low sample consuming quantification of manganese in cell nutrient solutions by flow injection ICP-QMS,
Metallomics, 2011, 3(12):1291-6, doi: 10.1039/c1mt00170a

K. Isfort, F. Ebert, J. Bornhorst, S. Sargin, R. Kardakaris, M. Pasparakis, M. Bähler, T. Schwerdtle, A. Schwab, P. Hanley (2011),
Real-time imaging reveals that P2Y2 and P2Y12 receptor agonists are not chemoattractants and macrophage chemotaxis to complement C5a is Phosphatidylinositol 3-Kinase (PI3K)- and p38 mitogen-activated protein kinase (MAPK)-independent,
The Journal of Biological Chemistry, 2011, 286(52):44776-87, doi: 10.1074/jbc.M111.289793

M. Bartel, F. Ebert, L. Leffers, U. Karst, T. Schwerdtle (2011),
Toxicological characterization of the inorganic and organic arsenic metabolite thio-DMAV in cultured human lung cells,
Journal of Toxicology, 2011, 2011:373141, doi: 10.1155/2011/373141

F. Ebert, A. Weiss, M. Bültemeyer, I. Hamann, A. Hartwig, T. Schwerdtle (2011),
Arsenicals affect base excision repair by several mechanisms,
Mutation Research, 2011, 715(1- 2):32-41, doi: 10.1016/j.mrfmmm.2011.07.004

R. Janzen, M. Schwarzer, M. Sperling, M. Vogel, T. Schwerdtle, U. Karst (2011),
Adduct formation of Thimerosal with human and rat hemoglobin: a study using liquid chromatography coupled to electrospray time-of-flight mass spectrometry (LC/ESI-TOF-MS),
Metallomics, 2011, 3(8):847-52, doi: 10.1039/c1mt00043h

V.M. Arlt, T. Schwerdtle (2011),
UKEMS/Dutch EMS-sponsored workshop on biomarkers of exposure and oxidative DNA damage & 7th GUM-32P-postlabelling workshop, University of Münster, Münster, Germany, 28-29 March 2011,
Mutagenesis, 2011, 26(5):679-85, doi: 10.1093/mutage/ger03


J. Bornhorst, F. Ebert, A. Hartwig, B Michalke, T. Schwerdtle (2010),
Manganese and poly(ADP-ribosyl)ation in human cells: a possible mechanism behind manganese-induced toxicity?,
Journal of Environmental Monitoring, 2010, 12(11):2062-9, doi: 10.1039/c0em00252f

A. Hartwig, T. Schwerdtle, W. Bal (2010),
Biophysical analysis of the interaction of toxic metal ions and oxidants with the zinc finger domain of XPA,
Methods in Molecular Biology, 2010, 649:399-410, doi: 10.1007/978-1-60761-753-2_25

C. Großkopf, T. Schwerdtle, L.H.F. Mullenders, A. Hartwig (2010),
Antimony impairs nucleotide excision repair – XPA and XPE as potential molecular targets,
Chemical Research in Toxicology, 2010, 23(7):1175-83, doi: 10.1021/tx100106x

T. Schwerdtle, F. Ebert, C. Thuy, C. Richter, L.H.F. Mullenders, A. Hartwig (2010),
Genotoxicity of soluble and particulate cadmium compounds: impact on oxidative DNA damage and nucleotide excision repair,
Chemical Research in Toxicology, 2010, 23(2):432-42, doi: 10.1021/tx900444


I. Hamann, T. Schwerdtle, A. Hartwig (2009),
Establishment of a non-radioactive cleavage assay to assess the DNA repair capacity towards oxidative DNA damage in subcellular and cellular systems and the impact of copper,
Mutation Research
, 2009, 669(1-2):122-30, doi: 10.1016/j.mrfmmm.2009.05.011

M. Nollen, F. Ebert, J. Moser, L.H.F. Mullenders, A. Hartwig, T. Schwerdtle (2009),
Impact of arsenic on nucleotide excision repair: XPC function, protein level and gene expression,
Molecular Nutrition and Food Research, 2009, 53(5):572-82, doi: 10.1002/mnfr.20080048


M.L. Simoes, S.L. Hockley, T. Schwerdtle, G. Gamboa, D.H. Phillips, V.M. Arlt (2008),
The human carcinogen aristolochic acid exerts expression profiles in human cancer cells that are dependent or independent of TP53,
Toxicology and Applied Pharmacology, 2008, 232:86-98, doi: 10.1016/j.taap.2008.06.006

K. Piatek, T. Schwerdtle, A. Hartwig, W. Bal (2008),
Monomethylarsonous acid destroys a tetrathiolate zinc finger much more efficiently than inorganic arsenite. Mechanistic considerations and consequences for DNA repair inhibition,
Chemical Research in Toxicology, 2008, 21(3):600-606, doi: 10.1021/tx7003135

B. Briviba, A. Bub, J. Möseneder, T. Schwerdtle, A. Hartwig, S. Kulling, B. Watzl (2008),
No differences in DNA damage and antioxidant capacity between intervention groups of healthy, non-smoking men receiving 2, 5 or 8 servings/day of vegetables and fruit,
Nutrition and Cancer, 2008, 60(2):164-170, doi: 10.1080/01635580701621346


T. Schwerdtle, I. Hamann, G. Jahnke, I. Walter, C. Richter. J.L. Parsons, G.L. Dianov,  A. Hartwig (2007),
Impact of copper on the induction and repair of oxidative DNA damage, poly(ADP-ribosyl)ation and PARP-1 activity,
Molecular Nutrition and Food Research, 2007, 51(2):201-10, doi: 10.1002/mnfr.200600107

* I. Walter, *T. Schwerdtle, C. Thuy, J.L. Parsons, G.L. Dianov, A. Hartwig (2007),
Impact of arsenite and its methylated metabolites on PARP-1 activity, PARP-1 gene expression and poly(ADP-ribosyl)ation in cultured human cells,
DNA Repair, 2007, 6(1):61-70, doi:10.1016/j.dnarep.2006.08.008 *gleichberechtigte Erstautorenschaft


T. Schwerdtle, A. Hartwig (2006),
Bioavailability and genotoxicity of soluble and particulate nickel compounds in cultured human lung cells,
Materials Science and Engineering Technology, 2006, 37 (6):521-525, doi: 10.1002/mawe.200600030

J. Dubois, P. Duez, L. Kouegnigan, J.-F. Rees, S. Loft, P. Moller, A. Jensen, H. Poulsen, B. Riis, A. Weimann, J. Cadet, T. Douki, J.-L. Ravanat, S. Sauvaigo, H. Faure, I. Morel, B. Morin, B. Epe, I. Eckert, A. Hartwig, T. Schwerdtle, P. Dolara, L. Giovannelli, M. Lodovici, F. Guglielmi, R. Olinski, K. Bialkowski, M. Foksinski, D. Gackowski, Z. Duracková, J. Muchová, P. Korytar, M. Sivonová, M. Dusinská, C. Mislanová, H. Petrovská, B. Smolková, J. Vina, A. Lloret, G. Sáez, L. Möller, T. Hofer, H. Eriksson, E. Gremoud, K. Herbert, C. Wild, F. Kelly, C. Dunster, A. White, S. Wood, N. Vaughan, C.M. Gedik, A. Collins (ESCODD) (2005),
Establishing the background level of base oxidation in human lymphocyte DNA: results of an interlaboratory validation study,
The FASEB Journal, 2005, 19(1):82-84, doi: 10.1096/fj.04-1767fj


E. Kopera, T. Schwerdtle, A. Hartwig, W. Bal (2004),
Co(II) and Cd(II) substitute for Zn(II) in the zinc finger derived from the DNA repair protein XPA, demonstrating a variety of potential mechanisms of toxicity,
Chemical Research in Toxicology
, 2004, 17 (11):1452-1458, doi: 10.1021/tx049842s

B. Burmeister, T. Schwerdtle, I. Poser, E. Hoffmann, A. Hartwig, WU. Muller, AW. Rettenmeier, NH. Seemayer, E. Dopp (2004),
Effects of asbestos on initiation of DNA damage, induction of DNA-strand breaks, p53-expression and apoptosis in primary, SV40-transformed and malignant human mesothelial cells,
Mutation Research, 2004, 558 (1-2):81-92, doi:10.1016/j.mrgentox.2003.11.00


T. Schwerdtle, I. Walter, A. Hartwig (2003),
Arsenite and its biomethylated metabolites interfere with the formation and repair of stable BPDE-induced DNA adducts in human cells and impair XPAzf and Fpg,
DNA Repair, 2003, 2 (12):1449-1463, doi:10.1016/j.dnarep.2003.09.001

A. Collins, C. Gedik, N. Vaughan, S. Wood, A. White, J. Dubois, JF. Rees, S. Loft, P. Moller, H. Poulsen, J. Cadet, T. Douki, JL. Ravanat, S. Sauvaigo, H. Faure, I. Morel, B. Morin, B. Epe, N. Phoa, A. Hartwig, T. Schwerdtle, P. Dolara, L. Giovannelli, M. Lodovici, R. Olinski, K. Bialkowski, M. Foksinski, Z. Durackova, L. Hlincikova, P. Korytar, M. Sivonova, M. Dusinska, C. Mislanova, J. Vina, L. Moller, T. Hofer, J. Nygren, E. Gremaud, K. Herbert, J. Lunec, C. Wild, L. Hardie, J.  Olliver, E. Smith (ESCODD) (2003),
Measurement of DNA oxidation in human cells by chromatographic and enzymic methods,
Free Radical Biology & Medicine, 2003, 34(8):1089-1099, doi:10.1016/S0891-5849(03)00041-8

A. Hartwig, H. Blessing, T. Schwerdtle, I. Walter (2003),
Modulation of DNA repair processes by arsenic and selenium compounds,
Toxicology, 2003, 193 (1-2):161-169, doi:10.1016/j.tox.2003.08.004

T. Schwerdtle, I. Walter, I. Mackiw, A. Hartwig (2003),
Induction of oxidative DNA damage by arsenite and its trivalent and pentavalent methylated metabolites in cultured human cells and isolated DNA,
Carcinogenesis, 2003, 24 (5):967-974, doi: 10.1093/carcin/bgg01


W. Bal, T. Schwerdtle, A. Hartwig (2002),
Mechanism of nickel assault on the zinc finger of DNA repair protein XPA,
Chemical Research in Toxicology, 2002, 16(2):242-248, doi: 10.1021/tx025639q

A. Hartwig, M. Assmus, I. Ehleben, U. Herzer, D. Kostelac, T. Schwerdtle, A. Bürkle (2002),
Interference by toxic metal ions with DNA repair processes and cell cycle control: molecular mechanisms,
Environmental Health Perspectives, 2002, 110 (5) 797-9

A. Hartwig, T. Schwerdtle (2002),
Interactions by carcinogenic metal compounds with DNA repair processes: toxicological implications,
Toxicology Letters, 2002, 127 (1-3):47-54, doi:10.1016/S0378-4274(01)00482-9

T. Schwerdtle, A. Seidel, A. Hartwig (2002),
Effect of soluble and particulate nickel compounds on the formation and repair of stable benzo[a]pyrene DNA adducts in human lung cells,
Carcinogenesis, 2002, 23:47-53, doi: 10.1093/carcin/23.1.47

Nach oben