Recent developments in molecular biology and modern analytical methods have increased the knowledge about the ubiquitous role of carbohydrates in animals, plants, and bacteria. Aim of this course is an insight into the interdisciplinary field of glycobiology. It will present an actual survey of the biochemistry of sugar building blocks, oligo- and polysaccharides in pro- and eukaryotic systems. Moreover, qualitative and quantitative carbohydrate analytics will be covered as well as the fundamental biophysical principles underpinning interactions of carbohydrates with proteins. Subject areas: Fundamentals on glycoconjugates. Structural and functional principles of the glycan conformational space. N-and O-linked glycosylation. Glycan analysis. Lectins and carbohydrate binding modules. Physicochemical principles of protein-carbohydrate interactions. Glycan arrays. Microbial glycobiology and pathogenesis.
Course format: Lectures, seminars and two-week lab course with biophysical and analytical research problems.
Necessary requirements and study background: Bachelor of Science and/or advanced biochemistry lab or molecular biology lab course. Basic text book knowledge on carbohydrate chemistry. If you feel unsure whether you should assist please inquire if this course is compatible with your study background.