Synthetic Biology

Group Leader: Dr. Lena Hochrein

Many technically, pharmaceutically or medically relevant products originate from slow growing or difficult to cultivate hosts, for example plants. The biotechnological production of these compounds in non-native hosts, e.g. bacteria or yeasts, can help to improve the production process under economic and ecological aspects. This usually requires a variety of genomic manipulations like the insertion of foreign genes, which are necessary to synthesize the desired compound, and the deletion of native genes, which might negatively interfere with the foreign biochemical pathway.

Furthermore, precise tools to regulate the expression levels of the gene products are needed to optimize product yield. In our group, we designed a toolbox which simplifies and speeds up those steps in the budding yeast Saccharomyces cerevisiae, a powerful and favored host for biotechnological purposes due to its short generation time, the availability of methods for its cheap and easy manipulation, and its well-known genome.

If you are interested in joining our lab as a PhD student or postdoc, please contact Dr. Lena Hochrein by sending your CV and a letter of motivation detailing your interest in our work. There are frequent possibilities for applying for fellowships through EMBO, Marie Sklodowska Curie, DAAD, IMPRS calls, etc. Please consider contacting us early enough before the submission deadlines so that we can together plan a suitable research project.

If you are interested in joining our lab as a bachelor or master student, please contact Dr. Lena Hochrein or Dr. Katrin Czempinski. We continuously have topics for master and bachelor thesis projects available.

With our toolkit we can tackle the following challenges: