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Interactions among intracellular signaling pathways

In various animal cells, external stimuli activate the InsP3/Ca2+ and cAMP signaling pathways in parallel. These pathways may interact in complex, reciprocal modes that are still elusive. In salivary glands of the blowfly Calliphora vicina, the hormone serotonin (5-HT) binds to two subtypes of 5-HT receptors, Cv5-HT2 und Cv5-HT7. 5-HT thus leads to rise in the cytosolic concentrations of cAMP and Ca2+, with at least the latter occurring in a complex spatiotemporal pattern. We analyze in vivo the various crosstalk mechanisms between both signaling pathways, and the physiological impact of these crosstalk mechanisms.

selected publications:

  • Heindorff K, Baumann O (2014) Calcineurin is part of a negative feedback loop in the InsP3/Ca2+ signalling pathway in blowfly salivary glands. Cell Calcium 56, 215-224
  • Fechner L, Baumann O, Walz B (2013) Activation of the cyclic AMP pathway promotes serotonin-induced Ca2+ oscillations in salivary glands of the blowfly Calliphora vicina. Cell Calcium 53, 94-101
  • Röser C, Jordan N, Balfanz S, Baumann A, Walz B, Baumann O, Blenau W (2012) Molecular and pharmacological characterization of serotonin 5‑HT2α and 5‑HT7 receptors in the salivary glands of the blowfly Calliphora vicina. PLoS ONE 7(11): e49459
  • Heindorff K, Blenau W, Walz B, Baumann O (2012) Characterization of a Ca2+/calmodulin-dependent AC1 adenylyl cyclase in a non-neuronal tissue, the blowfly salivary gland. Cell Calcium 52, 103-112