Peer-Reviewed Artikel
2024
D. Pellowski, P. Kusch, T. Henning, B. Kochlik, M. Maares, A. Schmiedeskamp, G. Pohl, M. Schreiner, S. Baldermann, H. Haase, T. Schwerdtle, T. Grune, D. Weber
Postprandial Micronutrient Variability and Bioavailability: An Interventional Meal Study in Young vs. Old Participants
Nutrients, 2024, 16(5): 625; https://doi.org/10.3390/nu16050625
S. Friese, G. Ranzini, M. Tuchtenhagen, K. Lossow, B. Hertel, G. Pohl, F. Ebert, J. Bornhorst, A.P. Kipp, T. Schwerdtle
Long-term suboptimal dietary trace element supply does not affect trace element homeostasis in murine cerebellum
Metallomics, 2024, 16(2): mfae003; https://doi.org/10.1093/mtomcs/mfae003
2023
T.-C. Brembach, R. Sabat, K. Witte, T. Schwerdtle, K. Wolk
Molecular and functional changes in neutrophilic granulocytes induced by nicotine: a systematic review and critical evaluation
Frontiers in Immunology, 2023, 14:1281685; https://doi.org/10.3389/fimmu.2023.1281685
M.T. Jacques, M.V. Soares, M. Farina, J. Bornhorst, T. Schwerdtle, D.S. Ávila
Impaired physiological responses and neurotoxicity induced by a chlorpyrifos-based formulation in Caenorhabditis elegans are not solely dependent on the active ingredient
Environmental Toxicology and Pharmacology, 2023, 101: 104196; https://doi.org/10.1016/j.etap.2023.104196
A.-K. Weishaupt, L. Kubens, L. Ruecker, T. Schwerdtle, M. Aschner, J. Bornhorst
A Reliable Method Based on Liquid Chromatography–Tandem Mass Spectrometry for the Simultaneous Quantification of Neurotransmitters in Caenorhabditis elegans
Molecules, 2023, 28(14): 5373; https://doi.org/10.3390/molecules28145373
K. Lossow, W. Schlörmann, M. Tuchtenhagen, M. Schwarz, T. Schwerdtle, A.P. Kipp
Measurement of trace elements in murine liver tissue samples: Comparison between ICP-MS/MS and TXRF
Journal of Trace Elements in Medicine and Biology, 2023, 78: 127167; https://doi.org/10.1016/j.jtemb.2023.127167
A. Thiel, A.-K. Weishaupt, M.M. Nicolai, K. Lossow, A.P. Kipp, T. Schwerdtle, J. Bornhorst
Simultaneous quantitation of oxidized and reduced glutathione via LC-MS/MS to study the redox state and drug-mediated modulation in cells, worms and animal tissue
Journal of Chromatography B, 2023, 1225: 123742; https://doi.org/10.1016/j.jchromb.2023.123742
V. Michaelis, S. Kasper, L. Naperkowski, J. Pusse, A. Thiel, F. Ebert, M. Aschner, T. Schwerdtle, H. Haase, J. Bornhorst
The Impact of Zinc on Manganese Bioavailability and Cytotoxicity in HepG2 Cells
Molecular Nutrition & Food Research, 2023, 67(7): 2200283; https://doi.org/10.1002/mnfr.202200283
S. Raschke, J. Bornhorst, T. Schwerdtle
Se supplementation to an in vitro blood-brain barrier does not affect Cu transfer into the brain
Journal of Trace Elements in Medicine and Biology, 2023, 78: 127180; https://doi.org/10.1016/j.jtemb.2023.127180
S. Raschke, F. Ebert, A.P. Kipp, J. Kopp, T. Schwerdtle
Selenium homeostasis in human brain cells: Effects of copper (II) and Se species
Journal of Trace Elements in Medicine and Biology, 2023, 78: 127149; https://doi.org/10.1016/j.jtemb.2023.127149
C. Hackethal, U. Pabel, C. Jung, T. Schwerdtle, O. Lindtner
Chronic dietary exposure to total arsenic, inorganic arsenic and water-soluble organic arsenic species based on results of the first German total diet study
Science of The Total Environment, 2023, 859(1): 160261; https://doi.org/10.1016/j.scitotenv.2022.160261
EFSA Panel on Contaminants in the Food Chain (CONTAM): D. Schrenk, M. Bignami, L. Bodin, J.K.C.J. Del Mazo, B. Grasl-Kraupp, C. Hogstrand, J.C. Leblanc, E. Nielsen, E. Ntzani, A. Petersen, S. Sand, T. Schwerdtle, C. Vleminckx, H. Wallace, S. Dänicke, C.S. Nebbia, I.P. Oswald, E. Rovesti, H. Steinkellner, L.R. Hoogenboom
Assessment of information as regards the toxicity of deoxynivalenol for horses and poultry
EFSA Journal, 2023, 21(2): e07806; https://doi.org/10.2903/j.efsa.2023.7806
V. Michaelis, S. Kasper, L. Naperkowski, J. Pusse, A. Thiel, F. Ebert, M. Aschner, T. Schwerdtle, H. Haase, J. Bornhorst
The Impact of Zinc on Manganese Bioavailability and Cytotoxicity in HepG2 Cells
Molecular Nutrition & Food Research, 2023, 67(6): 2200283; https://doi.org/10.1002/mnfr.202200283
M. Stiboller, A. Cofré, S. Scholz, G. Raber, T. Schwerdtle
Isolation and purification of arsenolipids from natural marine sources for use in speciation and toxicological studies
Environmental Chemistry, published online 19 January 2023 ; https://doi.org/10.1071/EN22071
2022
V. Michaelis, L. Aengenheister, M. Tuchtenhagen, J. Rinklebe, F. Ebert, T. Schwerdtle, T. Buerki-Thurnherr, J. Bornhorst
Differences and Interactions in Placental Manganese and Iron Transfer across an In Vitro Model of Human Villous Trophoblasts
International Journal of Molecular Sciences, 2022, 23(6): 3296; https://doi.org/10.3390/ijms23063296
EFSA Panel on Contaminants in the Food Chain (CONTAM): D. Schrenk, M. Bignami, L. Bodin, J.K. Chipman, J. Del Mazo, B. Grasl-Kraupp, L.R. Hoogenboom, J.C. Leblanc, C.S. Nebbia, E. Nielsen, E. Ntzani, A. Petersen, S. Sand, T. Schwerdtle, C. Vleminckx, H. Wallace, M. Rose, B. Cottrill, A.K. Lundebye, M. Metzler, A. Christodoulidou, C. Hogstrand
Decontamination process for dioxins and dioxin-like PCBs from fish oil and vegetable oils and fats by a physical process with activated carbon
EFSA Journal, 2022, 20(9): e07524; https://doi.org/10.2903/j.efsa.2022.7524
O.M. Ijomone, J.D. Iroegbu, P. Morcillo, A.J. Ayodele, O.K. Ijomone, J. Bornhorst, T. Schwerdtle, M. Aschner
Sex-dependent metal accumulation and immunoexpression of Hsp70 and Nrf2 in rats' brain following manganese exposure
Environmental Toxicology, 2022, 37(9): 2167-2177; https://doi.org/10.1002/tox.23583
P. Chen, H. Cheng, F. Zheng, S. Li, J. Bornhorst, B. Yang, K.H. Lee, T. Ke, Y. Li, T. Schwerdtle, X. Yang, A.B. Bowman, M. Aschner
BTBD9 attenuates manganese-induced oxidative stress and neurotoxicity by regulating insulin growth factor signaling pathway
Human Molecular Genetics, 2022, 31(13): 2207-2222; https://doi.org/10.1093/hmg/ddac025
L. Knoche, J. Lisec, T. Schwerdtle, M. Koch
LC-HRMS-Based Identification of Transformation Products of the Drug Salinomycin Generated by Electrochemistry and Liver Microsome
Antibiotics, 2022, 11(2): 155; https://doi.org/10.3390/antibiotics11020155
S. Jäger, M. Cabral, J.F. Kopp, P. Hoffmann, E. Ng, J.B. Whitfield, A.P. Morris, L. Lind, T. Schwerdtle, M.B. Schulze
Blood copper and risk of cardiometabolic diseases: a Mendelian randomization study
Human Molecular Genetics, 2022, 31(5): 783-791; https://doi.org/10.1093/hmg/ddab275
EFSA Panel on Contaminants in the Food Chain (CONTAM): D. Schrenk, M. Bignami, L. Bodin, J.K. Chipman, J. Del Mazo, B. Grasl-Kraupp, C. Hogstrand, J.C. Leblanc, E. Nielsen, E. Ntzani, A. Petersen, S. Sand, T. Schwerdtle, C. Vleminckx, H. Wallace, S. Daenicke, C.S. Nebbia, I.P. Oswald, E. Rovesti, H. Steinkellner, L.R. Hoogenboom
Assessment of information as regards the toxicity of T-2 and HT-2 toxin for ruminants
EFSA Journal, 2022, 20(9); e07564; https://doi.org/10.2903/j.efsa.2022.7564
EFSA Panel on Contaminants in the Food Chain (CONTAM): D. Schrenk, M. Bignami, L. Bodin, J.K. Chipman, J. Del Mazo, B. Grasl-Kraupp, C. Hogstrand, J.C. Leblanc, E. Nielsen, E. Ntzani, A. Petersen, S. Sand, T. Schwerdtle, C. Vleminckx, H. Wallace, S. Daenicke, C.S. Nebbia, I.P. Oswald, E. Rovesti, H. Steinkellner, L.R. Hoogenboom
Assessment of information as regards the toxicity of fumonisins for pigs, poultry and horses
EFSA Journal, 2022, 20(8): e07534; https://doi.org/10.2903/j.efsa.2022.7534
A. Varão Moura, A. Aparecido Rosini Silva, J. Domingos Santo da Silva, L. Aleixo Leal Pedroza, J. Bornhorst, M. Stiboller, T. Schwerdtle, P. Gubert
Determination of ions in Caenorhabditis elegans by ion chromatography
Journal of Chromatography B, 2022, 1204: 123312; https://doi.org/10.1016/j.jchromb.2022.123312
S. Borchard, S. Raschke, K.M. Zak, C. Eberhagen, C. Einer, E. Weber, S.M. Müller, B. Michalke, J. Lichtmannegger, A. Wieser, T. Rieder, G.M. Popowicz, J. Adamski, M. Klingenspor, A.H. Coles, R. Viana, M.H. Vendelbo, T.D. Sandahl, T. Schwerdtle, T. Plitz, H. Zischka
Bis-choline tetrathiomolybdate prevents copper-induced blood-brain barrier damage
Life Science Alliance, 2022, 5(3): e202101164; https://doi.org/10.26508/lsa.202101164
M.M. Nicolai, B. Witt, S. Friese, V. Michaelis, L. Hölzl-Armstrong, M. Martin, F. Ebert, T. Schwerdtle, J. Bornhorst
Mechanistic studies on the adverse effects of manganese overexposure in differentiated LUHMES cells
Food and Chemical Toxicology, 2022, 161: 112822; https://doi.org/10.1016/j.fct.2022.112822
2021
P. Chen, J. Bornhorst, S. Patton, K. Bagai, R. Nitin, M. Miah,D.J. Hare, K. Kysenius, P.J. Crouch, L. Xiong, G.A. Rouleau, T. Schwerdtle, J. Connor, M. Aschner, A.B. Bowman, A.S. Walters
A potential role for zinc in restless legs syndrome
Sleep, 2021, 44(4): zsaa236; https://doi.org/10.1093/sleep/zsaa236
V.K. Wandt, N. Winkelbeiner, J. Bornhorst, B. Witt, S. Raschke, L. Simon, F. Ebert, A.P. Kipp, T. Schwerdtle
A matter of concern - Trace element dyshomeostasis and genomic stability in neurons
Redox Biology, 2021, 41: 101877; https://doi.org/10.1016/j.redox.2021.101877
E. Drobyshev, S. Raschke, R.A. Glabonjat, J. Bornhorst, F. Ebert, D. Kuehnelt, T. Schwerdtle
Capabilities of selenoneine to cross the in vitro blood-brain barrier model
Metallomics, 2021, 13(1): mfaa007; https://doi.org/10.1093/mtomcs/mfaa007
F. Sandgruber, A. Gielsdorf, A.C. Baur, B. Schenz, S.M. Müller, T. Schwerdtle, G.I. Stangl, C. Griehl, S. Lorkowski, C. Dawczynski
Variability in Macro- and Micronutrients of 15 Commercially Available Microalgae Powders
Marine Drugs, 2021, 19(6): 310; https://doi.org/10.3390/md19060310
M.M. Nicolai, A.K. Weishaupt, J. Baesler, V. Brinkmann, A. Wellenberg, N. Winkelbeiner, A. Gremme, M. Aschner, G. Fritz, T. Schwerdtle, J. Bornhorst
Effects of Manganese on Genomic Integrity in the Multicellular Model Organism Caenorhabditis elegans
International Journal of Molecular Sciences, 2021, 22(20): 10905; https://doi.org/10.3390/ijms222010905
N. Seiwert, J. Adam, P. Steinberg, S. Wirtz, T. Schwerdtle, P. Adams-Quack, N. Hövelmeyer, B. Kaina, S. Foersch, J. Fahrer
Chronic intestinal inflammation drives colorectal tumor formation triggered by dietary heme iron in vivo
Archives of Toxicology, 2021, 95(7): 2507-2522; https://doi.org/10.1007/s00204-021-03064-6
Y. Pan, X. Ma, C. Liu, J. Xing, S. Zhou, B. Parshad, T. Schwerdtle, W. Li, A. Wu, R. Haag
Retinoic Acid-Loaded Dendritic Polyglycerol-Conjugated Gold Nanostars for Targeted Photothermal Therapy in Breast Cancer Stem Cells
ACS Nano, 2021, 15(9): 15069-15084; https://doi.org/10.1021/acsnano.1c05452
M.M. Nicolai, B. Witt, A. Hartwig, T. Schwerdtle, J. Bornhorst
A fast and reliable method for monitoring genomic instability in the model organism Caenorhabditis elegans
Archives of Toxicology, 2021, 95(10): 3417-3424; https://doi.org/10.1007/s00204-021-03144-7
K. Lossow, K. Renko, M. Schwarz, L. Schomburg, T. Schwerdtle, A.P. Kipp
The Nutritional Supply of Iodine and Selenium Affects Thyroid Hormone Axis Related Endpoints in Mice
Nutrients, 2021, 13(11): 3773; https://doi.org/10.3390/nu13113773
E.C. Kuhn, M.T. Jacques, D. Teixeira, S. Meyer, T. Gralha, R. Roehrs, S. Camargo, T. Schwerdtle, J. Bornhorst, D.S. Ávila
Ecotoxicological assessment of Uruguay River and affluents pre- and post-pesticides' application using Caenorhabditis elegans for biomonitoring
Environmental Science and Pollution Research, 2021, 28(17): 21730-21741; https://doi.org/10.1007/s11356-020-11986-4
Q. Cheng, A. Roveri, G. Cozza, L. Bordin, I. Rohn, T. Schwerdtle, A. Kipp, F. Ursini, M. Maiorino, G. Miotto, E.S.I. Arnér
Production and purification of homogenous recombinant human selenoproteins reveals a unique codon skipping event in E. coli and GPX4-specific affinity to bromosulfophthalein
Redox Biology, 2021, 46: 102070; https://doi.org/10.1016/j.redox.2021.102070
S. Borchard, S. Raschke, K.M. Zak, C. Eberhagen, C. Einer, E. Weber, S.M. Müller, B. Michalke, J. Lichtmannegger, A. Wieser, T. Rieder, G.M. Popowicz, J. Adamski, M. Klingenspor, A.H. Coles, R. Viana, M.H. Vendelbo, T.D. Sandahl, T. Schwerdtle, T. Plitz, H. Zischka
Bis-choline tetrathiomolybdate prevents copper-induced blood-brain barrier damage
Life Science Alliance, 2021, 5(3): e202101164; https://doi.org/10.26508/lsa.202101164
M. Cabral, O. Kuxhaus, F. Eichelmann, J.F. Kopp, W. Alker, J. Hackler, A.P. Kipp, T. Schwerdtle, H. Haase, L. Schomburg, M.B. Schulze
Trace element profile and incidence of type 2 diabetes, cardiovascular disease and colorectal cancer: results from the EPIC-Potsdam cohort study
European Journal of Nutrition, 2021, 60(6): 3267-3278; https://doi.org/10.1007/s00394-021-02494-3
A.K. Rausch, R. Brockmeyer, T. Schwerdtle
Development and validation of a liquid chromatography tandem mass spectrometry multi-method for the determination of 41 free and modified mycotoxins in beer
Food Chemistry, 2021, 338: 127801; https://doi.org/10.1016/j.foodchem.2020.127801
N. Crawford, M. Martell, T. Nielsen, B. Khalil, F. Imtiaz, E. Nguidjo, J.L. Newell-Caito, J. Bornhorst, T. Schwerdtle, S.W. Caito
Methylmercury-Induced Metabolic Alterations in Caenorhabditis elegans Are Diet-Dependent
Toxics, 2021, 9(11), 287; https://doi.org/10.3390/toxics9110287
S. Jäger, M. Cabral, J.F. Kopp, P. Hoffmann, E. Ng, J.B. Whitfield, A.P. Morris, L. Lind, T. Schwerdtle, M.B. Schulze
Blood copper and risk of cardiometabolic diseases: a Mendelian randomization study
Human Molecular Genetics, 2021, ddab275; https://doi.org/10.1093/hmg/ddab275
V.K. Wand, N. Winkelbeiner, K. Lossow, J.F. Kopp, M. Schwarz, W. Alker, M.M. Nicolai, L. Simon, C. Dietzel, B. Hertel, G. Pohl, F. Ebert, L. Schomburg, J. Bornhorst, H. Haase, A.P. Kipp, T. Schwerdtle
Ageing-associated effects of a long-term dietary modulation of four trace elements in mice
Redox Biology, 2021, 102083; https://doi.org/10.1016/j.redox.2021.102083
J. Baesler, V. Michaelis, M. Stiboller, H. Haase, M. Aschner, T. Schwerdtle, S.R. Sturzenbaum, J. Bornhorst
Nutritive Manganese and Zinc Overdosing in Aging C. elegans Result in a Metallothionein-Mediated Alteration in Metal Homeostasis
Molecular Nutrition & Food Research, 2021, 65(8): 2001176; https://doi.org/10.1002/mnfr.202001176
A.-K. Rausch, R. Brockmeyer, T. Schwerdtle
Development, Validation, and Application of a Multi-Method for the Determination of Mycotoxins, Plant Growth Regulators, Tropane Alkaloids, and Pesticides in Cereals by Two-Dimensional Liquid Chromatography Tandem Mass Spectrometry
Analytical and Bioanalytical Chemistry, 2021, 413: 3041-3054; https://doi.org/10.1007/s00216-021-03239-1
J. Menzel, K. Abraham, G.I. Stangle, P.M. Ueland, R. Obeid, M.B. Schulze, I. Herter-Aeberli, T. Schwerdtle, C. Weikert
Vegan Diet and Bone Health—Results from the Cross-Sectional RBVD Study
Nutrients, 2021, 13 (2): 685; https://doi.org/10.3390/nu13020685
C. Hackethal, J.F. Kopp, I. Sarvan, T. Schwerdtle, O. Lindtner
Total arsenic and water-soluble arsenic species in foods of the first German total diet study (BfR MEAL Study)
Food Chemistry, 2021, 346: 128913; https://doi.org/10.1016/j.foodchem.2020.128913
B. Witt, M. Stiboller, S. Raschke, S. Friese, F. Ebert, T. Schwerdtle
Characterizing effects of excess copper levels in a human astrocytic cell line with focus on oxidative stress markers
Journal of Trace Elements in Medicine and Biology, 2021, 65: 126711; https://doi.org/10.1016/j.jtemb.2021.126711
2020
N. Winkelbeiner, V.K. Wandt, F. Ebert, K. Lossow, E.E. Bankoglu, M. Martin, A. Mangerich, H. Stopper, J. Bornhorst, A.P. Kipp, T. Schwerdtle
A Multi-Endpoint Approach to Base Excision Repair Incision Activity Augmented by PARylation and DNA Damage Levels in Mice: Impact of Sex and Age
International Journal of Molecular Sciences, 2020, 21(18): 6600; https://doi.org/10.3390/ijms21186600
S. Zhou, Y. Pan, J. Zhang, Y. Li, F. Neimann, T. Schwerdtle, W. Li, R. Haag
Dendritic polyglycerol-conjugated gold nanostars with different densities of functional groups to regulate osteogenesis in human mesenchymal stem cells
Nanoscale, 2020, 12(47): 24006-24019; https://doi.org/10.1039/D0NR06570F
A.K. Müller, U. Helms, C. Rohrer, M. Möhler, F. Hellwig, M. Glei, T. Schwerdtle, S. Lorkowski, C. Dawczynski
Nutrient Composition of Different Hazelnut Cultivars Grown in Germany
Foods, 2020, 9(11): 1596; https://doi.org/10.3390/foods9111596
T. Wolfram, M. Schwarz, M. Reuss, K. Lossow, M. Ost, S. Klaus, T. Schwerdtle, A.P. Kipp
N-acetylcysteine as modulator of the essential trace elements copper and zinc
Antioxidants, 2020, 9 (11): 1117; https://doi.org/10.3390/antiox9111117
P. Chen, J. Bornhorst, S. Patton, K. Bagai, R. Nitin, M. Miah, D. Hare, K. Kysenius, P. Crouch, L. Xiong, G. Rouleau, T. Schwerdtle, J. Connor, M. Aschner, A. Bowman, A. Walters
A potential role for Zinc in Restless Legs Syndrome
Sleep, 2020, zsaa236; https://doi.org/10.1093/sleep/zsaa236
E. Pojarillo, J. Johnson Jr, A. Rizor, I. Nyarko-Danquah, G. Adinew, J. Bornhorst, M. Stiboller, T. Schwerdtle, D.-S. Son, M. Aschner, E. Lee
Astrocyte-specific deletion of the transcription factor Yin Yang 1 in murine substantia nigra mitigates manganese-induced dopaminergic neurotoxicity
Journal of Biological Chemistry, 2020, 295(46): 15662-15676; https://doi.org/10.1074/jbc.RA120.015552
C. Volk, C. Brandsch, U. Schlegelmich, M. Wensch-Dorendorf, F. Hirsche, A. Simm, O. Gargum, C. Wiecek, P.G. Braun, J.F. Kopp, T. Schwerdtle, H. Treede, G.I. Stangl
Postprandial Metabolic Response to Rapeseed Protein in Healthy Subjects
Nutrients, 2020, 12(8): 2270; https://doi.org/10.3390/nu12082270
A.-K. Rausch, R. Brockmeyer, T. Schwerdtle
Development and Validation of a Liquid Chromatography Tandem Mass Spectrometry Multi-Method for the Determination of 41 Free and Modified Mycotoxins in Beer
Food Chemistry, 2021, 338: 127801; https://doi.org/10.1016/j.foodchem.2020.127801
H. Finke, N. Winkelbeiner, K. Lossow, B. Hertel, V.K. Wandt, M. Schwarz, G. Pohl, J.F. Kopp, F. Ebert, A.P. Kipp, T. Schwerdtle
Effects of a cumulative, suboptimal supply of multiple trace elements in mice: trace element status, genomic stability, inflammation, and epigenetics
Molecular Nutrition & Food Research, 2020, 64(16): 2000325; https://doi.org/10.1002/mnfr.202000325
K. Lossow, J.F. Kopp, M. Schwarz, H. Finke, N. Winkelbeiner, K. Renko, X. Meçi, C. Ott, W. Alker, J. Hackler, T. Grune, L. Schomburg, H. Haase, T. Schwerdtle, A.P. Kipp
Aging affects sex- and organ-specific trace element profiles in mice
Aging (Albany NY), 2020, 12(13): 13762-13790; https://doi.org/10.18632/aging.103572
C. Weikert, I. Trefflich, J. Menzel, R. Obeid, A. Longree, J. Dierkes, K. Meyer, I. Herter-Aeberli, K. Mai, G.I. Stangl, S.M. Müller, T. Schwerdtle, A. Lampen, K. Abraham
Der Versorgungsstatus mit Vitaminen und Mineralstoffen bei veganer Ernährungsweise
Deutsches Ärzteblatt, 2020, 117: 575-582; https://doi.org/10.3238/arztebl.2020.0575
F. Ebert, V. Ziemann, V.K. Wandt, B. Witt, S.M. Müller, N. Guttenberger, E.E. Bankoglu, H. Stopper, G. Raber, K.A. Francesconi, T. Schwerdtle
Cellular toxicological characterization of a thioxolated arsenic-containing hydrocarbon
Journal of Trace Elements in Medicine and Biology, 2020, 61: 126563; https://doi.org/10.1016/j.jtemb.2020.126563
H. Finke, V.K. Wandt, F. Ebert, N. Guttenberger, R.A. Glabonjat, M. Stiboller, K.A. Francesconi, G. Raber, T. Schwerdtle
Toxicological assessment of arsenic containing phosphatidylcholines in HepG2 cells
Metallomics, 2020, 7: 1159-1170; https://doi.org/10.1039/D0MT00073F
R. Hauffe, V. Stein, C. Chudoba, T. Flore, M. Rath, K. Ritter, M. Schell, K. Wardelmann, S. Deubel, J.F. Kopp, M. Schwarz, K. Kappert, M. Blüher, T. Schwerdtle, A.P. Kipp, A. Kleinridders
GPx3 dysregulation impacts adipose tissue insulin receptor expression and sensitivity
JCI Insight, 2020, 5(11): e136283; https://doi.org/10.1172/jci.insight.136283
T. Ke, J. Bornhorst, T. Schwerdtle, A. Santamaría, F.A.A. Soare, J.B.T. Rocha, M. Farina, A.B. Bowman, M. Aschner
Therapeutic efficacy of the N,N’ bis-(2-mercaptoethyl) isophthalamide chelator for methylmercury intoxication in Caenorhabditis elegans
Neurotoxicity Research, 2020, 38: 133-144; https://doi.org/10.1007/s12640-020-00194-0
S. Dünkelberg, M. Maywald, A.K. Schmitt, T. Schwerdtle, S. Meyer, L. Rink
The Interaction of Sodium and Zinc in the Priming of T Cell Subpopulations Regarding Th17 and Treg Cells
Molecular Nutrition & Food Research, 2020, 64(2): 1900245; https://doi.org/10.1002/mnfr.201900245
A.-K. Rausch, R. Brockmeyer, T. Schwerdtle
Development and validation of a QuEChERS-based liquid chromatography tandem mass spectrometry multi-method for the determination of 38 native and modified mycotoxins in cereals
Journal of Agricultural and Food Chemistry, 2020, 68(16): 4657-4669; https://doi.org/10.1021/acs.jafc.9b07491
S.M. Müler, C. Dawczynski, J. Wiest, S. Lorkowski, A.P. Kipp, T. Schwerdtle
Functional Biomarkers for the Selenium Status in a Human Nutritional Intervention Study
Nutrients, 2020, 12(3): 676; https://doi.org/10.3390/nu12030676
B. Witt, D. Schaumlöffel, T. Schwerdtle
Subcellular localization of copper – cellular bioimaging with focus on neurological disorders
International Journal of Molecular Sciences, 2020, 21(7): 2341; https://doi.org/10.3390/ijms21072341
J. Bornhorst, F. Ebert, S. Meyer, V. Ziemann, C. Xiong, N. Guttenberg, A. Raab, J. Baesler, M. Aschner, J. Feldmann, K.A. Francesconi, G. Raber, T. Schwerdtle
Toxicity of three types of arsenolipids: species-specific effects in Caenorhabditis elegans
Metallomics, 2020, 12(5): 794-798; https:/doi.org/10.1039/D0MT00039F
S. Mehl, Q. Sun, C.L. Goerlich, J. Hackler, J.F. Kopp, K. Renko, J. Mittag, T. Schwerdtle, L. Schomburg
Cross-sectional analysis of trace element status in thyroid disease
Journal of Trace Elements in Medicine and Biology, 2019, 58: 126430; https://doi.org/10.1016/j.jtemb.2019.126430
L. Kotthoff, S.-L. O´Callaghan, J. Lisec, T. Schwerdtle, M. Koch
Structural annotation of electro- and photochemically generated transformation products of moxidectin using high resolution mass spectrometry
Analytical and Bioanalytical Chemistry, 2020, 412: 3141-3152; https://doi.org/10.1007/s00216-020-02572-1
C. Neumann, J. Baesler, G. Steffen, M.M. Nicolai, T. Zubel, M. Aschner, A. Bürkle, A. Mangerich, T. Schwerdtle, J. Bornhorst
The role of poly(ADP-ribose) polymerases in manganese exposed Caenorhabditis elegans
Journal of Trace Elements in Medicine and Biology, 2020, 57: 21-27; https://doi.org/10.1016/j.jtemb.2019.09.001
2019
M.J. Li, C. Schleich, M.W. Kulka, I.S. Dosnkyi, T. Schwerdtle, W.E.S. Unger, R. Haag
Mussel-inspired coatings with tunable wettability, for enhanced antibacterial efficiency and reduced bacterial adhesion
Jourmal of Materials Chemistry B, 2019, 7(21): 3438-3445; https://doi.org/10.1039/c9tb00534j
N. Basaran, Y. Duydu, A. Üstündag, G. Taner, S. Aydin, A.G. Anlar, C.Ö. Yalcin, M. Bacanli, K. Aydos, C.S. Atabekoglu, K. Golka, K. Ickstadt, T. Schwerdtle, M. Werner, S. Meyer, S.M. Bolt
Evaluation of the DNA damage in lymphocytes, sperm and buccal cells of workers under environmental and occupational boron exposure conditions
Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2019, 843: 33-39; https://doi.org/10.1016/j.mrgentox.2018.12.013
L. Kotthoff, J. Lisec, T. Schwerdtle, M. Koch
Prediction of Transformation Products of Monensin by Electrochemistry Compared to Microsomal Assay and Hydrolysis
Molecules, 2019, 24(15): 2732; https://doi.org/10.3390/molecules24152732
I. Rohn, N. Kroepfl, M. Aschner, J. Bornhorst, D. Kuehnelt, T. Schwerdtle
Selenoneine ameliorates peroxide-induced oxidative stress in C. elegans
Journal of Trace Elements in Medicine and Biology, 2019, 55: 78-81; https://doi.org/10.1016/j.jtemb.2019.05.012
M. Stiboller, F.P. Freitas, K.A. Francesconi, T. Schwerdtle, A.J.A. Nogueira, G. Raber
Lipid-soluble arsenic species identified in the brain of the marine fish skipjack tuna (Katsuwonus pelamis) using a sequential extraction and HPLC/mass spectrometry
Journal of Analytical Atomic Spectrometry, 2019, 34(12): 2440-2450; https://doi.org/10.1039/c9ja00249a
J. Baudry, J.F. Kopp, H. Boeing, A.P. Kipp, T. Schwerdtle, M.B. Schulze
Changes of trace element status during aging: results of the EPIC-Potsdam cohort study
European Journal of Nutrition, 2020, 59: 3045-3058; https://doi.org/10.1007/s00394-019-02143-w
J. Baesler, J.F. Kopp, G. Pohl, M. Aschner, H. Haase, T. Schwerdtle, J. Bornhorst
Zn homeostasis in genetic models of Parkinson´s disease in Caenorhabditis elegans
Journal of Trace Elements in Medicine and Biology, 2019, 55: 44-49; https://doi.org/10.1016/j.jtemb.2019.05.005
K. Lossow, T. Schwerdtle, A. Kipp
Selenium and iodine: essential trace elements for the thyroid
Ernährungs Umschau, 2019, 9: M531-M536; https://doi.org/10.4455/eu.2019.032
W. Alker, T. Schwerdtle, L. Schomburg, H. Haase
A zinpyr-1-based fluorimetric microassay for free zink in human serum
International Journal of Molecular Sciences, 2019, 20(16): 4006; https://doi.org/10.3390/ijms20164006
M.T. Jacques, J. Borhorst, M.V. Soares, T. Schwerdtle, S. Garcia, D.S. Ávila,
Reprotoxicity of glyphosate-based formulation in Caenorhabditis elegans is not due to the active ingredient only
Environmental Pollution, 2019, 252(Part B): 1854-1862; https://doi.org/10.1016/j.envpol.2019.06.099
M. Schwarz, K. Lossow, J.F. Kopp, T. Schwerdtle, A.P. Kipp
Crosstalk of Nrf2 with the Trace Elements Selenium, Iron, Zinc, and Copper
Nutrients, 2019, 11(9): 2112; https://doi.org/10.3390/nu11092112
J.F. Kopp, S.M. Müller, G. Pohl, K. Lossow, A.P. Kipp, T. Schwerdtle
A quick and simple method for the determination of six trace elements in mammulian serum samples using ICP-MS/MS
Journal of Trace Elements in Medicine and Biology, 2019, 54: 221-225; https://doi.org/10.1016/j.jtemb.2019.04.015
I. Rohn, N. Kroepfl, J. Bornhorst, D. Kuehnelt, T. Schwerdtle
Side-directed transfer and presystemic metabolism of selenoneine in a human intestinal barrier model
Molecular Nutrition & Food Research, 2019, 63(12): 1900080; https://doi.org/10.1002/mnfr.201900080
A. Schutkowski, B. König, H. Kluge, F. Hirche, A. Henze, T. Schwerdtle, S. Lorkowski, C. Dawczynski, A. Gabel, I. Groß, G.I. Stangl
Metabolic footprint and intestinal microbial changes in response to dietary proteins in a pig model
The Journal of Nutritional Biochemistry, 2019, 67: 149-160; https://doi.org/10.1016/j.jnutbio.2019.02.004
I. Rohn, S. Raschke, M. Aschner, S. Tuck, D. Kuehnelt, A. Kipp, T. Schwerdtle, J. Bornhorst
Treatment of Caenorhabditis elegans with Small Selenium Species Enhances Antioxidant Defense Systems
Molecular Nutrition & Food Research, 2019, 63(9): 1801304; https://doi.org/10.1002/mnfr.201801304
Y. Duydu, N. Başaran, C.Ö. Yalçın, A. Üstündağ, S. Aydın, H.G. Anlar, M. Bacanlı, K. Aydos, C.S. Atabekoğlu, K. Golka, K. Ickstadt, T. Schwerdtle, M. Werner, H.M. Bolt
Boron-exposed male workers in Turkey: no change in sperm Y:X chromosome ratio and in offspring's sex ratio
Archives of Toxicology, 2019, 93: 743-751; https://doi.org/10.1007/s00204-019-02391-z
T.V. Peres, K.J. Horning, J. Bornhorst, T. Schwerdtle, A.B. Bowman, M. Aschner
Small Molecule Modifiers of In Vitro Manganese Transport Alter Toxicity In Vivo
Biological Trace Element Research, 2019, 188: 127-134; https://doi.org/10.1007/s12011-018-1531-7
N. Basaran, Y. Duydu, A. Üstündag, G. Taner, S. Aydin Dilsiz, H.G. Anlar, C.Ö. Yalcin, M. Bacanli, K. Golka, T. Schwerdtle, H.M. Bolt
Environmental boron exposure does not induce DNA damage in lymphocytes and buccal cells of females: DNA damage in lymphocytes and buccal cells of boron exposed females
Journal of Trace Elements in Medicine and Biology, 2019, 53: 150-153; https://doi.org/10.1016/j.jtemb.2019.03.004
J.A. Ruszkiewicz, G. Teixeira de Macedo, A. Miranda-Vizuete, A.B. Bowman, J. Bornhorst, T. Schwerdtle, F.A. Antunes Soares, M. Aschner
Sex-Specific Response of Caenorhabditis elegans to Methylmercury Toxicity
Neurotoxicity Research, 2019, 35: 208-216; https://doi.org/10.1007/s12640-018-9949-4
N. Kroepfl, K.A. Francesconi, T. Schwerdtle, D. Kuehnelt
Selenoneine and ergothioneine in human blood cells determined simultaneously by HPLC/ICP-QQQ-MS
Journal of Analytical Atomic Spectrometry, 2019, 34(1): 127-134; https://doi.org/10.1039/C8JA00276B
K.M. Rund, D. Heylmann, N. Seiwert, S. Wecklein, C. Oger, J.M. Galano, T. Durand, R. Chen, F. Gueler, J. Fahrer, J. Bornhorst, N.H. Schebb
Formation of trans-epoxy fatty acids correlates with formation of isoprostanes and could serve as biomarker of oxidative stress
Prostaglandins and other Lipid Mediators, 2019, 144: 106334; https://doi.org/10.1016/j.prostaglandins.2019.04.004
J. Bornhorst, E.J. Nustede, S. Fudickar
Mass Surveilance of C. elegans-Smartphone-Based DIY Microcope and Machine Learning-Based Approach for Worm Detection
Sensors, 2019, 19(6): 1468; https://doi.org/10.3390/s19061468
2018
M.W. Werno, I. Wilhelmi, B. Kuropka, F. Ebert, C. Freund, A. Schürmann
The GTPase ARFRP1 affects lipid droplet protein composition and triglyceride release from intracellular storage of intestinal Caco-2 cells
Biochemical and Biophysical Research Communications, 2018, 506(1): 259-265; https://doi.org/10.1016/j.bbrc.2018.10.092
N. Turrini, N. Kroepfl, K. Jensen, T.C. Reiter, K.A. Francesconi, T. Schwerdtle, W. Kroutil, D. Kuehnelt
Biosynthesis and Isolation of Selenoneine from Genetically Modified Fission Yeast
Metallomics, 2018, 10(10): 1532-1538; https://doi.org/10.1039/C8MT00200B
M. Maares, C. Keil, J. Koza, S. Straubing, T. Schwerdtle, H. Haase
In vitro studies on zinc binding and buffering by intestinal mucins
International Journal of Molecular Sciences, 2018, 19(9): 2662; https://doi.org/10.3390/ijms19092662
K.E. Nachman, T. Punshon, L. Rardin, A.J. Signes-Pastor, C.J. Murray, B.P. Jackson, M. Lou Guerinot, T.A. Burke, C.Y. Chen, H. Ashan, M. Argos, K.L. Cottingham, F. Cubadda, G.L. Ginsberg, B.C. Goodale, M. Kurzius-Spencer, A.A. Meharg, M.D. Miller, A.E. Nigra, C.B. Pendergrast, A. Raab, K. Reimer, K.G. Scheckel, T. Schwerdtle, V.F. Taylor, E.J. Tokar, T.M. Warczak, M.R. Karagas
Opportunities and challenges for dietary arsenic intervention
Environmental Health Perspective, 2018, 126(8): 084503; https://doi.org/10.1289/EHP3997
M. Maares, A. Duman, C. Keil, T. Schwerdtle, H. Haase
The impact of apical and basolateral albumin on intestinal zinc resorption in the Caco-2/HT-29-MTX co-culture model
Metallomics, 2018, 10(7): 979-991; https://doi.org/10.1039/c8mt00064f
Y. Duydu, N. Başaran, A. Üstündağ, S. Aydın, C.Ö. Yalçın, H.G. Anlar, M. Bacanlı, K. Aydos, C.S. Atabekoğlu, K. Golka, K. Ickstadt, T. Schwerdtle, M. Werner, S. Meyer, H.M. Bolt
Birth weights of newborns and pregnancy outcomes of environmentally boron-exposed females in Turkey
Archives of Toxicology, 2018, 92: 2475-2485;https://doi.org/10.1007/s00204-018-2238-4
S. Meyer, M. Markova, G. Pohl, T.A. Marschall, O. Pivovarova, A.F.H. Pfeiffer, T. Schwerdtle
Development, validation and application of an ICP-MS/MS method to quantify minerals and (ultra-)trace elements in human serum
Journal of Trace Elements in Medicine and Biology, 2018, 49: 157-163; https://doi.org/10.1016/j.jtemb.2018.05.012
I. Rohn, T.A. Marschall, N. Kroepfl, K.B. Jensen, M. Aschner, S. Tuck, D. Kuehnelt, T. Schwerdtle, J. Bornhorst
Selenium species-dependent toxicity, bioavailability and metabolic transformations in Caenorhabditis elegans
Metallomics, 2018, 10(6): 818-827; https://doi.org/10.1039/C8MT00066B
S.M. Müller, F. Ebert, J. Bornhorst, H.J. Galla, K.A. Francesconi, T. Schwerdtle
Arsenic-containing hydrocarbons disrupt a model in vitro blood-cerebrospinal fluid barrier
Journal of Trace Elements in Medicine and Biology, 2018, 49: 171-177; https://doi.org/10.1016/j.jtemb.2018.01.020
S.M. Müller, H. Finke, F. Ebert, J.F. Kopp, F. Schumacher, B. Kleuser, K.A. Francesconi, G. Raber, T. Schwerdtle
Arsenic-containing hydrocarbons: effects on gene Expression, epigenetics, and biotransformation in HepG2 cells
Archives of Toxicology, 2018, 92: 1751-1765; https://doi.org/10.1007/s00204-018-2194-z
K. Nowotny, J.P. Castro, M. Hugo, S. Braune, D. Weber, M. Pignitter, V. Somoza, J. Bornhorst, T. Schwerdtle, T. Grune
Oxidants produced by methylglyoxal-modified collagen trigger ER stress and apoptosis in skin fibroblasts
Free Radical Biology and Medicine, 2018, 120: 102-113; https://doi.org/10.1016/j.freeradbiomed.2018.03.022
S. Meyer, A. Lopez-Serrano, H. Mitze, N. Jakubowski, T. Schwerdtle
Single-cell analysis by ICP-MS/MS as fast tool for cellular bioavailability studies of arsenite
Metallomics, 2018, 10(1): 73-76; https://doi.org/10.1039/C7MT00285H
Y. Duydu, N. Başaran, S. Aydın, A. Üstündağ, C.Ö. Yalçın, H.G. Anlar, M. Bacanlı, K. Aydos, C.S. Atabekoğlu, K. Golka, K. Ickstadt, T. Schwerdtle, M. Werner, S. Meyer, H.M. Bolt
Evaluation of FSH, LH, testosterone levels and semen parameters in male boron workers under extreme exposure conditions
Archives of Toxicology, 2018, 92: 3051-3059; https://doi.org/10.1007/s00204-018-2296-7
J.A. Ruszkiewicz, G. Teixeira de Macedo, A. Miranda-Vizuete, J.B. Teixeira de Rocha, A.B. Bowman, J. Bornhorst, T. Schwerdtle, M. Ascher
The cytoplasmic thioredoxin system in Caenorhabditis elegans affords protection from methylmercury in an age-specific manner
NeuroToxicology, 2018, 68: 189-202; https://doi.org/10.1016/j.neuro.2018.08.007
T.V. Peres, L.P. Arantes, M.R. Miah, J. Bornhorst, T. Schwerdtle, A.B. Bowmann, R.B. Leal, M. Aschner
Role of Caenorhabditis elegens AKT-1/2 and SGK-1 in Manganese Toxicity
Neurotoxicity Research, 2018, 34: 584-596; https://doi.org/10.1007/s12640-018-9915-1
S.M. Müller, F. Ebert, G. Raber, S. Meyer, J. Bornhorst, S. Hüwel, H.-J. Galla, K.A. Francesconi, T. Schwerdtle
Effects of arsenolipids on in vitro blood-brain barrier model
Archives of Toxicology, 2018, 92: 823-832; https://doi.org/10.1007/s00204-017-2085-8
2017
J. Bornhorst, A.P. Kipp, H. Haase, S. Meyer, T. Schwerdtle
The crux of inept biomarkers for risks and benefits of trace Elements
TrAC Trends in Analytical Chemistry, 2017, 104: 183-190; https://doi.org//10.1016/j.trac.2017.11.007
M. Li, L. Gao, C. Schlaich, J. Zhang, I.S. Donskyi, G. Yu, W. Li, Z. Tu, J. Rolff, T. Schwerdtle, R. Haag, N. Ma
Construction of Functional Coatings with durable and Broad-Spectrum Antibacterial Potential Based on Mussle-Insprired Dendiritic Polyglycerol and in Situ-Formed Copper Nanoparticles
ACS Applied Materials & Interfaces, 2017, 9(40): 35411-35418; https://doi.org/10.1021/acsami.7b10541
J. Strehlau, T. Weber, C. Lürenbaum, J. Bornhorst, H.J. Galla, T. Schwerdtle, M. Winter, S. Nowak
Towards quantification of toxicity of lithium ion battery electrolytes - development and validation of a liquid-liquid extraction GC-MS method for the determination of organic carbonates in cell culture materials
Analalytical Bioanalytical Chemistry, 2017, 409: 6123-6131; https://doi.org/10.1007/s00216-017-0549-6
B. Witt, F. Ebert, S. Meyer, K.A. Francesconi, T. Schwerdtle
Assessing neurodevelopmental effects of arsenolipids in pre-differentiated human neurons
Molecular Nutrition and Food Research, 2017, 61(11): 1700199; https://doi.org/10.1002/mnfr.201700199
N. Kroepfl, T. Marschall, K.A. Francesconi, T. Schwerdtle, D. Kuehnelt
Quantitative determination of the sulfur-containing antioxidant ergothioneine by HPLC/ICP-QQQ-MS
Journal of Analytical Atomic Spectrometry, 2017, 32(8): 1571-1581; https://doi.org/10.1039/C7JA00030H
K. Frede, F. Ebert, A. Kipp, T. Schwerdtle, S. Baldermann
Lutein Activates the Transcription Factor Nrf2 in Human Retinal Pigment Epithelial Cells
Journal of Agricultural and Food Chemistry, 2017, 65(29): 5944-5952; https://doi.org/10.1021/acs.jafc.7b01929
B. Witt, J. Bornhorst, H. Mitze, F. Ebert, S. Meyer, K.A. Francesconi, T. Schwerdtle
Arsenolipids exert less toxicity in a human neuron astrocyte co-culture as compared to the respective monocultures
Metallomics, 2017, 9(5): 442-446; https://doi.org/10.1039/c7mt00036g
T.A. Marschall, N. Kroepf, K.B. Jensen, J. Bornhorst, B. Meermann, D. Kuehnelt, T. Schwerdtle
Tracing cytotoxic effects of small organic Se species in human liver cells back to total cellular Se and Se metabolites
Metallomics, 2017, 9(3): 268-277; https://doi.org/10.1039/c6mt00300a
B. Witt, S. Meyer, F. Ebert, K.A. Francesconi, T. Schwerdtle
Toxicity of two classes of arsenolipids and their water-soluble metabolites in human differentiated neurons
Archives of Toxicology, 2017, 91; 3121-3134; https://doi.org/10.1007/s00204-017-1933-x
V. Taylor, B. Goodale, A. Raab, T. Schwerdtle, K. Reimer, S. Conklin, M.R. Karagas, K.A. Francesconi
Human exposure to organic arsenic species from seafood
Science of the Total Environment, 2017, 580: 266-282; https://doi.org/10.1016/j.scitotenv.2016.12.113
M. Aschner, C. Palinski, M. Sperling, U. Karst, T. Schwerdtle, J. Bornhorst
Imaging metals in Caenorhabditis elegans
Metallomics, 2017, 9(4): 357-364; https://doi.org/10.1039/c6mt00265j
2016
H. Lohren, J. Bornhorst, R. Fitkau, G. Pohl, T. Schwerdtle
Effects on and transfer across the blood-brain barrier in vitro-Comparison of organic and inorganic mercury species
BMC Pharmacology and Toxicology, 2016, 17: 63; https://doi.org/10.1186/s40360-016-0106-5
A. Henze, T. Homann, I. Rohn, M. Aschner, C.D. Link, B. Kleuser, F. Schweigert, T. Schwerdtle, J. Bornhorst
Caenorhabditis elegans as a model system to study post-translational modifications of human transthyretin
Scientific Reports, 2016, 6: 37346; https://doi.org/10.1038/srep37346
T.A. Marschall, J. Bornhorst, D. Kühnelt, T. Schwerdtle
Differing cytotoxicity and bioavailability of selenite, methylselenocysteine, selenomethionine, selenosugar 1 and trimethylselenonium ion and their underlying metabolic transformations in human cells
Molecular Nutrition and Food Research, 2016, 60(12); 2622-2636; https://doi.org/10.1002/mnfr.201600422
F. Ebert, M. Thomann, B. Witt, S.M. Müller, S. Meyer, T. Weber, M. Christmann, T. Schwerdtle
Evaluating long-term cellular effects of the arsenic species thio-DMAV: qPCR-based gene expression as screening tool
Journal of Trace Elements in Medicine and Biology, 2016, 37: 78-84; https://doi.org/10.1016/j.jtemb.2016.06.004
A.-C. Niehoff, J. Schulz, J. Soltwisch, S. Meyer, H. Kettling, M. Sperling, A. Jeibmann, K. Dreisewerd, K.A. Francesconi, T. Schwerdtle, U. Karst
Imaging by Elemental and Molecular Mass Spectrometry Reveals the Uptake of an Arsenolipid in the Brain of Drosophila melanogaster
Analytical Chemistry, 2016, 88(10): 5258-5263; https://doi.org/10.1021/acs.analchem.6b00333
F. Ebert, S. Meyer, L. Leffers, G. Raber, K.A. Francesconi, T. Schwerdtle
Toxicological characterisation of a thio-arsenosugar-glycerol in human cells
Journal of Trace Elements in Medicine and Biology, 2016, 38: 150-156; https://doi.org/10.1016/j.jtemb.2016.04.013
E. Rosenkranz, M. Maywald, R.-D. Hilgers, A. Brieger, T. Clarner, M. Kipp, B. Plümäkers, S. Meyer, T. Schwerdtle, L. Rink
Induction of regulatory T cells in Th1-/Th17-driven experimental autoimmune encephalomyelitis by zinc administration
Nutritional Biochemistry, 2016, 29: 116-123; https://doi.org/10.1016/j.jnutbio.2015.11.010
R. Bzymek, M. Horsthemke, K. Isfort, S. Mohr, K. Tjaden, C. Müller-Tidow, M. Unterberg, T. Schwerdtle, M. Bähler, A. Schwab, P.J. Hanley
Real-time two- and three-dimensional imaging of monocytemotility and navigation on planar surfaces and in collagen matrices: roles of Rho
Scientific Reports, 2016, 6: 25016; https://doi.org/10.1038/srep25016
2015
P. Gubert, B. Puntel, T. Lehmen, J. Bornhorst, D.S. Avila, M. Aschner, F.A.A. Soares
Reversible reprotoxic effects of manganese through DAF-16 transcription factor activation and vitellogenin downregulation in Caenorhabditis elegans
Life Sciences, 2015, 151: 218-223; https://doi.org/10.1016/j.lfs.2016.03.016
T.V. Peres, H. Eyng, S.C. Lopes, D. Colle, F.M. Gonçalves, D.K. Venske, M.W. Lopes, J. Ben, J. Bornhorst, T. Schwerdtle, M. Aschner, M. Farina, R.D. Prediger, R. B. Leal
Developmental exposure to manganese induces lasting motor and cognitive impairment in rats
NeuroToxicology, 2015, 50: 28-37; https://doi.org/10.1016/j.neuro.2015.07.005
F. Schumacher, S. Chakraborty, B. Kleuser, E. Gulbins, T. Schwerdtle, M. Aschner, J. Bornhorst
Highly sensitive isotope-dilution liquid-chromatography–electrospray ionization tandem-mass spectrometry approach to study the drug-mediated modulation of dopamine and serotonin levels in Caenorhabditis elegans
Talanta, 2015, 144: 71-79; https://doi.org/10.1016/j.talanta.2015.05.057
B. Crone, M. Aschner, T. Schwerdtle, U. Karst, J. Bornhorst
Elemental bioimaging of Cisplatin in Caenorhabditis elegans by LA-ICP-MS
Metallomics, 2015, 7(7): 1189-1195; https://doi.org/10.1039/c5mt00096c
S. Chakraborty, P. Chen, J. Bornhorst, T. Schwerdtle, F. Schumacher, B. Kleuser, A.B. Bowman, M. Aschner
Loss of pdr-1/parkin influences Mn homeostasis through altered ferroportin expression in C. elegans
Metallomics, 2015, 7(5): 847-856; https:/doi.org/10.1039/c5mt00052a
A.C. Niehoff, O. Bauer, S. Kröger, S. Fingerhut, J. Schulz, S. Meyer, M. Sperling, A. Jeibmann, T. Schwerdtle, U. Karst
Quantitative Bioimaging to Investigate the Uptake of Mercury Species in Drosophila melanogaster
Analytical Chemistry, 2015, 87(20): 10392-10396; https://doi.org/10.1021/acs.analchem.5b02500
H. Lohren, J. Bornhorst, H.-J. Galla, T. Schwerdtle
The blood-cerebrospinal fluid barrier - first evidence for an active transport of organic mercury compounds out of the brain
Metallomics, 2015, 7(10): 1420-1430; https://doi.org/10.1039/c5mt00171d
H. Lohren, L. Blagojevic, R. Fitkau, F. Ebert, S. Schildknecht, M. Leist, T. Schwerdtle
Toxicity of organic and inorganic mercury species in differentiated human neurons and human astrocytes
Journal of Trace Elements in Medicine and Biology, 2015, 32: 200-208; https://doi.org/10.1016/j.jtemb.2015.06.008
S. Meyer, G. Raber, F. Ebert, M. S. Taleshi, K. A. Francesconi, T. Schwerdtle
Arsenic-containing hydrocarbons and arsenic-containing fatty acids: transfer across and presystemic metabolism in the Caco-2 intestinal barrier model
Molecular Nutrition and Food Research, 2015, 59(10): 2044-2056; https://doi.org/10.1002/mnfr.201500286
S. Meyer, G. Raber, F. Ebert, L. Leffers, S.M. Müller, M.S. Taleshi, K.A. Francesconi, T. Schwerdtle
In vitro toxicological characterisation of arsenic-containing fatty acids and three of their metabolites
Toxicology Research, 2015, 4(5): 1289-1296, https://doi.org/10.1039/C5TX00122F
K.K. Kumar, C.R. Goodwin, M.A. Uhouse, J. Bornhorst, T. Schwerdtle, M. Aschner, J.A. McLean, A.B. Bowman
Untargeted metabolic profiling identifies interactions between Huntington’s disease and neuronal manganese status
Metallomics, 2015, 7(2): 363-370; https://doi.org/10.1039/c4mt00223g
2014
F. Draude, M. Körsgen, A. Pelster, T. Schwerdtle, J. Müthing, H.F. Arlinghaus
Characterization of freeze-fractured epithelial plasma membranes on nanometer scale with ToF-SIMS
Analytical and Bioanalytical Chemistry, 2014, 407: 2203-2211; https://doi.org/10.1007/s00216-014-8334-2
S. Cramer, S. Tacke, J. Bornhorst, A.K Sachan, J. Klingauf, T. Schwerdtle, H.-J. Galla
The Influence of Silver Nanoparticles on the Blood-Brain and the Blood-Cerebrospinal Fluid Barrier in vitro
Journal of Nanomedicine & Nanotechnology, 2014, 5(5): 1000225; https://doi.org/10.4172/2157-7439.1000225
S. Meyer, J. Schulz, A. Jeibmann, M.S. Taleshi, F. Ebert, K.A. Francesconi, T. Schwerdtle
Arsenic-containing hydrocarbons are toxic in the in vivo model Drosophila melanogaster
Metallomics, 2015, (11): 2010-2014; https://doi.org/10.1039/c4mt00249k
M. Unterberg, L. Leffers, F. Hübner, H.-U. Humpf, K. Lepikhov, J. Walter, F. Ebert, T. Schwerdtle
Toxicity of arsenite and thio-DMAV after long-term (21 days) incubation of human urothelial cells: cytotoxicity, genotoxicity and epigenetics
Toxicology Research, 2014, 3: 456-464; https://doi.org/10.1039/C4TX00036F
Y. Koehler, E. M. Luther, S. Meyer, T. Schwerdtle, R. Dringen
Uptake and toxicity of arsenite and arsenate in cultured brain astrocytes
Journal of Trace Elements in Medicine and Biology, 2014, 28(3): 238-237; https://doi.org/10.1016/j.jtemb.2014.04.007
L.S. Mayer, P. Uciechowski, S. Meyer, T. Schwerdtle, L. Rink, H. Haase
Differential impact of zinc deficiency on phagocytosis, oxidative burst, and production of pro-inflammatory cytokines by human monocytes
Metallomics, 2014, 6(7): 1288-1295; https://doi.org/10.1039/c4mt00051j
S. Meyer, M. Matissek, S.M. Müller, M.S. Taleshi, F. Ebert, K.A. Francesconi, T. Schwerdtle
In vitro toxicological characterisation of three arsenic-containing hydrocarbons
Metallomics, 2014, 6(5): 1023-1033; https://doi.org/10.1039/c4mt00061g
M.S. Taleshi, R.K. Seidler-Egdal, K.B. Jensen, T. Schwerdtle, K.A. Francesconi
Synthesis and Characterization of Arsenolipids: Naturally Occurring Arsenic Compounds in Fish and Algae
Organometallics, 2014, 33(6): 1397-1403; https://doi.org/10.1021/om4011092
I. Pieper, C. A. Wehe, J. Bornhorst, F. Ebert, L. Leffers, M. Holtkamp, P. Höseler, T. Weber, A. Mangerich, A. Bürkle, U. Karst, T. Schwerdtle
Mechanisms of Hg species induced toxicity in cultured human astrocytes: genotoxicity and DNA-damage response
Metallomics, 2014, 6(3): 662-671; https://doi.org/10.1039/c3mt00337j
J. Bornhorst, S. Chakraborty, S. Meyer, H. Lohren, S. Große Brinkhaus, A.L. Knight, K.A. Caldwell, G.A. Caldwell, U. Karst, T. Schwerdtle, A. Bowman, M. Aschner
The effects of pdr1, djr1.1 and pink1 loss in manganese-induced toxicity and the role of α-synuclein in C. elegans
Metallomics, 2014, 6(3): 476-490; https://doi.org/10.1039/c3mt00325f
C.A. Wehe, I. Pieper, M. Holtkamp, G.M. Thyssen, M. Sperling, T. Schwerdtle, U. Karst
On-line species-unspecific isotope dilution analysis in the picomolar range reveals the time- and species-depending mercury uptake in human astrocytes
Analytical and Bioanalytical Chemistry, 2014, 406: 1909-1916; https://doi.org/10.1007/s00216-013-7608-4
C. Pieper, J.J. Marek, M. Unterberg, T. Schwerdtle, H.-J. Galla
Brain capillary pericytes contribute to the immune defense in response to cytokines or LPS in vitro
Brain Research, 2014, 1550: 1-8; https://doi.org/10.1016/j.brainres.2014.01.004
F. Ebert, L. Leffers, T. Weber, S. Berndt, A. Mangerich, S. Beneke, A. Bürkle, T. Schwerdtle
Toxicological properties of the thiolated inorganic arsenic and arsenosugar metabolite thio-dimethylarsinic acid in human bladder cells
Journal of Trace Elements in Medicine and Biology, 2014, 28(2): 138-146; https://doi.org/10.1016/j.jtemb.2013.06.004
2013
L. Leffers, C.A. Wehe, S. Hüwel, M. Bartel, F. Ebert, M.S. Taleshi, H.-J. Galla, U. Karst, K.A. Francesconi, T. Schwerdtle
In vitro intestinal bioavailability of arsenosugar metabolites and presystemic metabolism of thio-dimethylarsinic acid in Caco-2 cells
Metallomics, 2013, 5(8): 1031-1042; https://doi.org/10.1039/c3mt00039g
L. Leffers, F. Ebert, M.S. Taleshi, K.A. Francesconi, T. Schwerdtle
In vitro toxicological characterization of two arsenosugars and their metabolites
Molecular Nutrition & Food Research, 57(7): 1270-1282; https://doi.org/10.1002/mnfr.201200821
M. Weidner, S. Hüwel, F. Ebert, T. Schwerdtle, H.-J. Galla, H.-U. Humpf
Influence of T-2 and HT-2 Toxin on the Blood-Brain Barrier In Vitro: New Experimental Hints for Neurotoxic Effects
PLoS One, 2013, 8(3): e60484; https://doi.org/10.1371/journal.pone.0060484
J. Bornhorst, S. Meyer, T. Weber, C. Böker, T. Marschall, A. Mangerich, S. Beneke, A. Bürkle, T. Schwerdtle
Molecular mechanisms of Mn induced neurotoxicity; RONS generation, genotoxicity and DNA damage response
Molecular Nutrition & Food Research, 2013, 57(7): 1255-1269; https://doi.org/10.1002/mnfr.201200758
L. Leffers, M. Unterberg, M. Bartel, C. Hoppe, H.-U. Humpf, T. Schwerdtle
In vitro toxicological characterisation of the S-containing inorganic arsenic metabolites thiodimethylarsinic acid and DMAG
Toxicology, 2013, 305: 109-119; https://doi.org/10.1016/j.tox.2013.01.007
D. Mulac, S. Lepski, F. Ebert, T. Schwerdtle, H.-U. Humpf
Cytotoxicity and fluorescence visualization of ergot alkaloids in human cell lines
Journal of Agricultural and Food Chemistry, 2013, 61(2): 462-471; https://doi.org/10.1021/jf304569q
2012
J. Diederich, M. Brielmeier, T. Schwerdtle, B. Michalke
Manganese and iron species in Sprague-Dawley rats exposed with MnCl2·4 H2O (i.v.)
Microchemical Journal, 2012, 105: 115-123; https://doi.org/10.1016/j.microc.2012.03.015
J. Bornhorst, C.A. Wehe, S. Hüwel, H.-J. Galla, U. Karst, T. Schwerdtle
Impact of manganese on and transfer across the blood-brain and blood-CSF barrier in vitro
Journal of Biological Chemistry, 2012, 287(21): 17140-17151; https://doi.org/10.1074/jbc.M112.344093
J. Bornhorst, F. Ebert, H. Lohren, H.-U. Humpf, U. Karst, T. Schwerdtle
Effects of manganese and arsenic species on the level of energy related nucleotides in human cells
Metallomics, 2012, 4(3): 297-306; https://doi.org/10.1039/c2mt00164k
2011
C.A. Wehe, J. Bornhorst, M. Holtkamp, M. Sperling, H.-J. Galla, T. Schwerdtle, U. Karst
Fast and low sample consuming quantification of manganese in cell nutrient solutions by flow injection ICP-QMS
Metallomics, 2011, 3(12): 1291-1296; https://doi.org/10.1039/c1mt00170a
K. Isfort, F. Ebert, J. Bornhorst, S. Sargin, R. Kardakaris, M. Pasparakis, M. Bähler, T. Schwerdtle, A. Schwab, P. Hanley
Real-time imaging reveals that P2Y2 and P2Y12 receptor agonists are not chemoattractants and macrophage chemotaxis to complement C5a is Phosphatidylinositol 3-Kinase (PI3K)- and p38 mitogen-activated protein kinase (MAPK)-independent
Journal of Biological Chemistry, 2011, 286(52): 44776-44787; https://doi.org/10.1074/jbc.M111.289793
M. Bartel, F. Ebert, L. Leffers, U. Karst, T. Schwerdtle
Toxicological characterization of the inorganic and organic arsenic metabolite thio-DMAV in cultured human lung cells
Journal of Toxicology, 2011, 2011: 373141; https://doi.org/10.1155/2011/373141
F. Ebert, A. Weiss, M. Bültemeyer, I. Hamann, A. Hartwig, T. Schwerdtle
Arsenicals affect base excision repair by several mechanisms
Mutation Research / Fundamental and Molekular Mechanisms of Mutagenesis, 2011, 715(1-2): 32-41; https://doi.org/10.1016/j.mrfmmm.2011.07.004
R. Janzen, M. Schwarzer, M. Sperling, M. Vogel, T. Schwerdtle, U. Karst
Adduct formation of Thimerosal with human and rat hemoglobin: a study using liquid chromatography coupled to electrospray time-of-flight mass spectrometry (LC/ESI-TOF-MS)
Metallomics, 2011, 3(8): 847-852; https://doi.org/10.1039/c1mt00043h
V.M. Arlt, T. Schwerdtle
UKEMS/Dutch EMS-sponsored workshop on biomarkers of exposure and oxidative DNA damage & 7th GUM-32P-postlabelling workshop, University of Münster, Münster, Germany, 28-29 March 2011
Mutagenesis, 2011, 26(5): 679-685; https://doi.org/10.1093/mutage/ger036
2010
J. Bornhorst, F. Ebert, A. Hartwig, B. Michalke, T. Schwerdtle
Manganese and poly(ADP-ribosyl)ation in human cells: a possible mechanism behind manganese-induced toxicity?
Journal of Environmental Monitoring, 2010, 12(11): 2062-2069; https://doi.org/10.1039/c0em00252f
A. Hartwig, T. Schwerdtle, W. Bal
Biophysical analysis of the interaction of toxic metal ions and oxidants with the zinc finger domain of XPA
Methods in Molecular Biology, 2010, 649: 399-410; https://doi.org/10.1007/978-1-60761-753-2_25
C. Großkopf, T. Schwerdtle, L.H.F. Mullenders, A. Hartwig
Antimony impairs nucleotide excision repair – XPA and XPE as potential molecular targets
Chemical Research in Toxicology, 2010, 23(7): 1175-1183; https://doi.org/10.1021/tx100106x
T. Schwerdtle, F. Ebert, C. Thuy, C. Richter, L.H.F. Mullenders, A. Hartwig
Genotoxicity of soluble and particulate cadmium compounds: impact on oxidative DNA damage and nucleotide excision repair
Chemical Research in Toxicology, 2010, 23(2): 432-442; https://doi.org/10.1021/tx900444w
2009
I. Hamann, T. Schwerdtle, A. Hartwig
Establishment of a non-radioactive cleavage assay to assess the DNA repair capacity towards oxidative DNA damage in subcellular and cellular systems and the impact of copper
Mutation Research / Fundamental and Molecular Mechanisms of Mutagenesis, 2009, 669(1-2): 122-130; https://doi.org/10.1016/j.mrfmmm.2009.05.011
M. Nollen, F. Ebert, J. Moser, L.H.F. Mullenders, A. Hartwig, T. Schwerdtle
Impact of arsenic on nucleotide excision repair: XPC function, protein level and gene expression
Molecular Nutrition & Food Research, 2009, 53(5): 572-582; https://doi.org/10.1002/mnfr.200800480
2008
M.L. Simoes, S.L. Hockley, T. Schwerdtle, G. Gamboa, D.H. Phillips, V.M. Arlt
The human carcinogen aristolochic acid exerts expression profiles in human cancer cells that are dependent or independent of TP53
Toxicology and Applied Pharmacology, 2008, 232(1): 86-98; https://doi.org/10.1016/j.taap.2008.06.006
K. Piatek, T. Schwerdtle, A. Hartwig, W. Bal
Monomethylarsonous acid destroys a tetrathiolate zinc finger much more efficiently than inorganic arsenite. Mechanistic considerations and consequences for DNA repair inhibition
Chemical Research in Toxicology, 2008, 21(3): 600-606; https://doi.org/10.1021/tx7003135
B. Briviba, A. Bub, J. Möseneder, T. Schwerdtle, A. Hartwig, S. Kulling, B. Watzl
No differences in DNA damage and antioxidant capacity between intervention groups of healthy, non-smoking men receiving 2, 5 or 8 servings/day of vegetables and fruit
Nutrition and Cancer, 2008, 60(2): 164-170; https://doi.org/10.1080/01635580701621346
2007
T. Schwerdtle, I. Hamann, G. Jahnke, I. Walter, C. Richter. J.L. Parsons, G.L. Dianov, A. Hartwig
Impact of copper on the induction and repair of oxidative DNA damage, poly(ADP-ribosyl)ation and PARP-1 activity
Molecular Nutrition & Food Research, 2007, 51(2): 201-210; https://doi.org/10.1002/mnfr.200600107
*I. Walter, *T. Schwerdtle, C. Thuy, J.L. Parsons, G.L. Dianov, A. Hartwig
Impact of arsenite and its methylated metabolites on PARP-1 activity, PARP-1 gene expression and poly(ADP-ribosyl)ation in cultured human cells
DNA Repair, 2007, 6(1): 61-70; https://doi.org/10.1016/j.dnarep.2006.08.008
*gleichberechtigte Erstautorenschaft
2006
T. Schwerdtle, A. Hartwig
Bioavailability and genotoxicity of soluble and particulate nickel compounds in cultured human lung cells
Materials Science & Engineering Technology, 2006, 37(6): 521-525; https://doi.org/10.1002/mawe.200600030
J. Dubois, P. Duez, L. Kouegnigan, J.-F. Rees, S. Loft, P. Moller, A. Jensen, H. Poulsen, B. Riis, A. Weimann, J. Cadet, T. Douki, J.-L. Ravanat, S. Sauvaigo, H. Faure, I. Morel, B. Morin, B. Epe, I. Eckert, A. Hartwig, T. Schwerdtle, P. Dolara, L. Giovannelli, M. Lodovici, F. Guglielmi, R. Olinski, K. Bialkowski, M. Foksinski, D. Gackowski, Z. Duracková, J. Muchová, P. Korytar, M. Sivonová, M. Dusinská, C. Mislanová, H. Petrovská, B. Smolková, J. Vina, A. Lloret, G. Sáez, L. Möller, T. Hofer, H. Eriksson, E. Gremoud, K. Herbert, C. Wild, F. Kelly, C. Dunster, A. White, S. Wood, N. Vaughan, C.M. Gedik, A. Collins (ESCODD)
Establishing the background level of base oxidation in human lymphocyte DNA: results of an interlaboratory validation study
The FASEB Journal, 2005, 19(1): 82-84; https://doi.org/10.1096/fj.04-1767fje
2004
E. Kopera, T. Schwerdtle, A. Hartwig, W. Bal
Co(II) and Cd(II) substitute for Zn(II) in the zinc finger derived from the DNA repair protein XPA, demonstrating a variety of potential mechanisms of toxicity
Chemical Research in Toxicology, 2004, 17(11): 1452-1458; https://doi.org/10.1021/tx049842s
B. Burmeister, T. Schwerdtle, I. Poser, E. Hoffmann, A. Hartwig, W.U. Muller, A.W. Rettenmeier, N.H. Seemayer, E. Dopp
Effects of asbestos on initiation of DNA damage, induction of DNA-strand breaks, p53-expression and apoptosis in primary, SV40-transformed and malignant human mesothelial cells
Mutation Research / Genetic Toxicology and Environmental Mutagenesis, 2004, 558(1-2): 81-92; https://doi.org/10.1016/j.mrgentox.2003.11.003
2003
T. Schwerdtle, I. Walter, A. Hartwig
Arsenite and its biomethylated metabolites interfere with the formation and repair of stable BPDE-induced DNA adducts in human cells and impair XPAzf and Fpg
DNA Repair, 2003, 2(12): 1449-1463; https://doi.org/10.1016/j.dnarep.2003.09.001
A. Collins, C. Gedik, N. Vaughan, S. Wood, A. White, J. Dubois, JF. Rees, S. Loft, P. Moller, H. Poulsen, J. Cadet, T. Douki, JL. Ravanat, S. Sauvaigo, H. Faure, I. Morel, B. Morin, B. Epe, N. Phoa, A. Hartwig, T. Schwerdtle, P. Dolara, L. Giovannelli, M. Lodovici, R. Olinski, K. Bialkowski, M. Foksinski, Z. Durackova, L. Hlincikova, P. Korytar, M. Sivonova, M. Dusinska, C. Mislanova, J. Vina, L. Moller, T. Hofer, J. Nygren, E. Gremaud, K. Herbert, J. Lunec, C. Wild, L. Hardie, J. Olliver, E. Smith (ESCODD)
Measurement of DNA oxidation in human cells by chromatographic and enzymic methods
Free Radical Biology and Medicine, 2003, 34(8): 1089-1099; https://doi.org/10.1016/S0891-5849(03)00041-8
A. Hartwig, H. Blessing, T. Schwerdtle, I. Walter
Modulation of DNA repair processes by arsenic and selenium compounds
Toxicology, 2003, 193(1-2): 161-169; https://doi.org/10.1016/j.tox.2003.08.004
T. Schwerdtle, I. Walter, I. Mackiw, A. Hartwig
Induction of oxidative DNA damage by arsenite and its trivalent and pentavalent methylated metabolites in cultured human cells and isolated DNA
Carcinogenesis, 2003, 24(5): 967-974; https:doi.org/10.1093/carcin/bgg018
2002
W. Bal, T. Schwerdtle, A. Hartwig
Mechanism of nickel assault on the zinc finger of DNA repair protein XPA
Chemical Research in Toxicology, 2002, 16(2): 242-248; https://doi.org/10.1021/tx025639q
A. Hartwig, M. Assmus, I. Ehleben, U. Herzer, D. Kostelac, T. Schwerdtle, A. Bürkle
Interference by toxic metal ions with DNA repair processes and cell cycle control: molecular mechanisms
Environmental Health Perspectives, 2002, 110(5): 797-799; https://doi.org/10.1289/ehp.02110s5797
A. Hartwig, T. Schwerdtle
Interactions by carcinogenic metal compounds with DNA repair processes: toxicological implications
Toxicology Letters, 2002, 127(1-3): 47-54; https://doi.org/10.1016/S0378-4274(01)00482-9
T. Schwerdtle, A. Seidel, A. Hartwig
Effect of soluble and particulate nickel compounds on the formation and repair of stable benzo[a]pyrene DNA adducts in human lung cells
Carcinogenesis, 2002, 23(1): 47-53; https://doi.org/10.1093/carcin/23.1.47